ID
45710
Description
Principal Investigator: Michael P. Snyder, PhD, Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA MeSH: Esophageal Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001214 Paired DNA and RNA profiling is increasingly employed in genomics research to uncover molecular mechanisms of disease and to explore personal genotype and phenotype correlations. We developed a novel simultaneous DNA and RNA sequencing approach (Simul-seq) that enables comprehensive genomic and transcriptomic profiles from small quantities of cells or tissues. In this study, Simul-seq was performed on patient-derived fibroblast cells as well as an esophageal adenocarcinoma tumor sample and compared with standard DNA and RNA-sequencing approaches.
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Versions (1)
- 17/05/2023 17/05/2023 - Chiara Middel
Détendeur de droits
Michael P. Snyder, PhD, Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
Téléchargé le
17 mai 2023
DOI
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Licence
Creative Commons BY 4.0
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dbGaP phs001214 DNA and RNA Profiling Using Simultaneous Sequencing (Simul-seq)
The subject consent data table contains subject IDs, consent group information, subject source, and affection status for esophageal adenocarcinoma.
- StudyEvent: SEV1
- The subject consent data table contains subject IDs, consent group information, subject source, and affection status for esophageal adenocarcinoma.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample source and sample use.
- This subject phenotype table includes gender and race of participant.
- This sample attributes table includes body site where sample was collected, analyte type, histological type, tumor status, metastasis status, tumor location, histologic and pathologic staging, tumor treatment, and sequencing center.
Similar models
The subject consent data table contains subject IDs, consent group information, subject source, and affection status for esophageal adenocarcinoma.
- StudyEvent: SEV1
- The subject consent data table contains subject IDs, consent group information, subject source, and affection status for esophageal adenocarcinoma.
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample source and sample use.
- This subject phenotype table includes gender and race of participant.
- This sample attributes table includes body site where sample was collected, analyte type, histological type, tumor status, metastasis status, tumor location, histologic and pathologic staging, tumor treatment, and sequencing center.
C0441833 (UMLS CUI [1,2])
C0242481 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,2])
C0681850 (UMLS CUI [1,3])