ID

45631

Descrizione

Principal Investigator: Sharon L.R. Kardia, PhD, University of Michigan, Ann Arbor, MI, USA MeSH: Hypertension,Aging,Arterial Pressure,Arteriosclerosis,Atherosclerosis,Biomarkers,Blood Pressure,Cardiovascular Diseases,Cholesterol,Cholesterol, HDL,Cholesterol, LDL,Coronary Artery Disease,Diabetes Mellitus,Echocardiography,Endophenotypes,Hyperglycemia,Hyperinsulinism,Hypertrophy, Left Ventricular,Inflammation,Kidney Failure, Chronic,Leukoaraiosis,Lipids,Obesity,Obesity, Abdominal,Peripheral Arterial Disease,Renal Insufficiency, Chronic,Triglycerides,Vascular Calcification https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001345 The Genetic Epidemiology Network of Arteriopathy (GENOA) is one of four networks in the NHLBI Family-Blood Pressure Program (FBPP). GENOA's long-term objective is to elucidate the genetics of target organ complications of hypertension, including both atherosclerotic and arteriolosclerotic complications involving the heart, brain, kidneys, and peripheral arteries. The longitudinal GENOA Study recruited European-American and African-American sibships with at least 2 individuals with clinically diagnosed essential hypertension before age 60 years. All other members of the sibship were invited to participate regardless of their hypertension status. Participants were diagnosed with hypertension if they had either 1) a previous clinical diagnosis of hypertension by a physician with current anti-hypertensive treatment, or 2) an average systolic blood pressure = 140 mm Hg or diastolic blood pressure = 90 mm Hg based on the second and third readings at the time of their clinic visit. Only participants of the African-American Cohort were sequenced through TOPMed. The Family Blood Pressure Program (FBPP), GENOA's parent program, is an unprecedented collaboration to identify genes influencing blood pressure (BP) levels, hypertension, and its target-organ damage. This program has conducted over 21,000 physical examinations, assembled a shared database of several hundred BP and hypertension-related phenotypic measurements, completed genome-wide linkage analyses for BP, hypertension, and hypertension associated risk factors and complications, and published over 130 manuscripts on program findings. The FBPP emerged from what was initially funded as four independent networks of investigators (HyperGEN, GenNet, SAPPHIRe and GENOA) competing to identify genetic determinants of hypertension in multiple ethnic groups. Realizing the greater likelihood of success through collaboration, the investigators created a single confederation with program-wide and network-specific goals. Comprehensive phenotypic data for GENOA study participants are available through dbGaP phs001238.

collegamento

dbGaP study = phs001345

Keywords

versioni (1)
  1. 05/03/23 05/03/23 - Simon Heim
Titolare del copyright

Sharon L.R. Kardia, PhD, University of Michigan, Ann Arbor, MI, USA

Caricato su

5 marzo 2023

DOI

Per favore, per richiedere un accesso.

Licenza

Creative Commons BY 4.0
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dbGaP phs001345 NHLBI TOPMed: Genetic Epidemiology Network of Arteriopathy (GENOA)

Inglese

Eligibility Criteria

4 moduli  
Inclusion and exclusion criteria
Descrizione

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
*Selection into GENOA*
Descrizione

*Selection into GENOA*

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C3846158
At least two siblings in each sibship needed to have essential hypertension diagnosed prior to age 60 years of age, defined as: 1) average of the last 2 out of 3 systolic BP readings = 140mmHg, or 2) an average of the last 2 out of 3 diastolic BP readings = 90 mmHg, or 3) previous diagnosis of hypertension and antihypertensive medication prescribed by a physician to be taken daily during the last month.
Descrizione

At least two siblings in each sibship needed to have essential hypertension diagnosed prior to age 60 years of age, defined as: 1) average of the last 2 out of 3 systolic BP readings = 140mmHg, or 2) an average of the last 2 out of 3 diastolic BP readings = 90 mmHg, or 3) previous diagnosis of hypertension and antihypertensive medication prescribed by a physician to be taken daily during the last month.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0037047
UMLS CUI [1,2]
C0085580
UMLS CUI [1,3]
C0011900
UMLS CUI [1,4]
C0001779
UMLS CUI [1,5]
C1704788
UMLS CUI [1,6]
C1510992
UMLS CUI [1,7]
C0871470
UMLS CUI [1,8]
C0428883
UMLS CUI [1,9]
C0332132
UMLS CUI [1,10]
C0020538
UMLS CUI [1,11]
C0003364
UMLS CUI [1,12]
C0278329
UMLS CUI [1,13]
C0031831
UMLS CUI [1,14]
C0332173
UMLS CUI [1,15]
C1512806
The definition of essential hypertension excluded those with diagnosis of hypertension = 60 yrs of age, or secondary causes of hypertension including but not limited to prior knowledge of renal parenchymal disease or serum creatinine = 2.5 mg/dL, renal vascular disease, primary aldosteronism, pheochromocytoma, coarctation of aorta, hypertension associated with current use of oral contraceptive agents, prescription or non-prescription drugs, or active alcohol abuse.
Descrizione

The definition of essential hypertension excluded those with diagnosis of hypertension = 60 yrs of age, or secondary causes of hypertension including but not limited to prior knowledge of renal parenchymal disease or serum creatinine = 2.5 mg/dL, renal vascular disease, primary aldosteronism, pheochromocytoma, coarctation of aorta, hypertension associated with current use of oral contraceptive agents, prescription or non-prescription drugs, or active alcohol abuse.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0034510
UMLS CUI [1,2]
C1704788
UMLS CUI [1,3]
C0085580
UMLS CUI [1,4]
C2828389
UMLS CUI [1,5]
C0011900
UMLS CUI [1,6]
C0020538
UMLS CUI [1,7]
C0001779
UMLS CUI [1,8]
C0155616
UMLS CUI [1,9]
C1841992
UMLS CUI [1,10]
C0201976
UMLS CUI [1,11]
C0268790
UMLS CUI [1,12]
C2874194
UMLS CUI [1,13]
C0031511
UMLS CUI [1,14]
C0003492
UMLS CUI [1,15]
C0745125
UMLS CUI [1,16]
C0013231
UMLS CUI [1,17]
C0278329
UMLS CUI [1,18]
C0085762
Exclusion criteria for all participants included secondary hypertension, alcoholism or drug abuse, pregnancy, breast feeding, and type I diabetes mellitus (juvenile onset, insulin dependent) or active malignancy.
Descrizione

Exclusion criteria for all participants included secondary hypertension, alcoholism or drug abuse, pregnancy, breast feeding, and type I diabetes mellitus (juvenile onset, insulin dependent) or active malignancy.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0155616
UMLS CUI [1,3]
C0013146
UMLS CUI [1,4]
C0699757
UMLS CUI [1,5]
C0032961
UMLS CUI [1,6]
C0006147
UMLS CUI [1,7]
C0011854
UMLS CUI [1,8]
C0006826
UMLS CUI [1,9]
C0679217
*Selection into TOPMed*
Descrizione

*Selection into TOPMed*

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C3846158
Every participant with an echocardiogram was selected for WGS. We then selected 106 participants who had a computed tomography scan for coronary artery calcification but not an echocardiogram or were a sibling of someone already selected for WGS. Finally, we excluded individuals whom we knew were already being whole genome sequenced through TOPMed or another sequencing effort (GENOA participants who overlap with ARIC or JHS participants). GENOA has phenotypes and omic data for these overlapping participants.
Descrizione

Every participant with an echocardiogram was selected for WGS. We then selected 106 participants who had a computed tomography scan for coronary artery calcification but not an echocardiogram or were a sibling of someone already selected for WGS. Finally, we excluded individuals whom we knew were already being whole genome sequenced through TOPMed or another sequencing effort (GENOA participants who overlap with ARIC or JHS participants). GENOA has phenotypes and omic data for these overlapping participants.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0679646
UMLS CUI [1,2]
C0013516
UMLS CUI [1,3]
C3640076
UMLS CUI [1,4]
C0040405
UMLS CUI [1,5]
C1611184
UMLS CUI [1,6]
C0037047
UMLS CUI [1,7]
C2828389
UMLS CUI [1,8]
C3846158
UMLS CUI [1,9]
C1948020
UMLS CUI [1,10]
C0031437
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Similar models

Eligibility Criteria

4 moduli
Name
genere
Description | Question | Decode (Coded Value)
Tipo di dati
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
*Selection into GENOA*
Item
*Selection into GENOA*
boolean
C3846158 (UMLS CUI [1,1])
At least two siblings in each sibship needed to have essential hypertension diagnosed prior to age 60 years of age, defined as: 1) average of the last 2 out of 3 systolic BP readings = 140mmHg, or 2) an average of the last 2 out of 3 diastolic BP readings = 90 mmHg, or 3) previous diagnosis of hypertension and antihypertensive medication prescribed by a physician to be taken daily during the last month.
Item
At least two siblings in each sibship needed to have essential hypertension diagnosed prior to age 60 years of age, defined as: 1) average of the last 2 out of 3 systolic BP readings = 140mmHg, or 2) an average of the last 2 out of 3 diastolic BP readings = 90 mmHg, or 3) previous diagnosis of hypertension and antihypertensive medication prescribed by a physician to be taken daily during the last month.
boolean
C0037047 (UMLS CUI [1,1])
C0085580 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
C0001779 (UMLS CUI [1,4])
C1704788 (UMLS CUI [1,5])
C1510992 (UMLS CUI [1,6])
C0871470 (UMLS CUI [1,7])
C0428883 (UMLS CUI [1,8])
C0332132 (UMLS CUI [1,9])
C0020538 (UMLS CUI [1,10])
C0003364 (UMLS CUI [1,11])
C0278329 (UMLS CUI [1,12])
C0031831 (UMLS CUI [1,13])
C0332173 (UMLS CUI [1,14])
C1512806 (UMLS CUI [1,15])
The definition of essential hypertension excluded those with diagnosis of hypertension = 60 yrs of age, or secondary causes of hypertension including but not limited to prior knowledge of renal parenchymal disease or serum creatinine = 2.5 mg/dL, renal vascular disease, primary aldosteronism, pheochromocytoma, coarctation of aorta, hypertension associated with current use of oral contraceptive agents, prescription or non-prescription drugs, or active alcohol abuse.
Item
The definition of essential hypertension excluded those with diagnosis of hypertension = 60 yrs of age, or secondary causes of hypertension including but not limited to prior knowledge of renal parenchymal disease or serum creatinine = 2.5 mg/dL, renal vascular disease, primary aldosteronism, pheochromocytoma, coarctation of aorta, hypertension associated with current use of oral contraceptive agents, prescription or non-prescription drugs, or active alcohol abuse.
boolean
C0034510 (UMLS CUI [1,1])
C1704788 (UMLS CUI [1,2])
C0085580 (UMLS CUI [1,3])
C2828389 (UMLS CUI [1,4])
C0011900 (UMLS CUI [1,5])
C0020538 (UMLS CUI [1,6])
C0001779 (UMLS CUI [1,7])
C0155616 (UMLS CUI [1,8])
C1841992 (UMLS CUI [1,9])
C0201976 (UMLS CUI [1,10])
C0268790 (UMLS CUI [1,11])
C2874194 (UMLS CUI [1,12])
C0031511 (UMLS CUI [1,13])
C0003492 (UMLS CUI [1,14])
C0745125 (UMLS CUI [1,15])
C0013231 (UMLS CUI [1,16])
C0278329 (UMLS CUI [1,17])
C0085762 (UMLS CUI [1,18])
Exclusion criteria for all participants included secondary hypertension, alcoholism or drug abuse, pregnancy, breast feeding, and type I diabetes mellitus (juvenile onset, insulin dependent) or active malignancy.
Item
Exclusion criteria for all participants included secondary hypertension, alcoholism or drug abuse, pregnancy, breast feeding, and type I diabetes mellitus (juvenile onset, insulin dependent) or active malignancy.
boolean
C0680251 (UMLS CUI [1,1])
C0155616 (UMLS CUI [1,2])
C0013146 (UMLS CUI [1,3])
C0699757 (UMLS CUI [1,4])
C0032961 (UMLS CUI [1,5])
C0006147 (UMLS CUI [1,6])
C0011854 (UMLS CUI [1,7])
C0006826 (UMLS CUI [1,8])
C0679217 (UMLS CUI [1,9])
*Selection into TOPMed*
Item
*Selection into TOPMed*
boolean
C3846158 (UMLS CUI [1,1])
Every participant with an echocardiogram was selected for WGS. We then selected 106 participants who had a computed tomography scan for coronary artery calcification but not an echocardiogram or were a sibling of someone already selected for WGS. Finally, we excluded individuals whom we knew were already being whole genome sequenced through TOPMed or another sequencing effort (GENOA participants who overlap with ARIC or JHS participants). GENOA has phenotypes and omic data for these overlapping participants.
Item
Every participant with an echocardiogram was selected for WGS. We then selected 106 participants who had a computed tomography scan for coronary artery calcification but not an echocardiogram or were a sibling of someone already selected for WGS. Finally, we excluded individuals whom we knew were already being whole genome sequenced through TOPMed or another sequencing effort (GENOA participants who overlap with ARIC or JHS participants). GENOA has phenotypes and omic data for these overlapping participants.
boolean
C0679646 (UMLS CUI [1,1])
C0013516 (UMLS CUI [1,2])
C3640076 (UMLS CUI [1,3])
C0040405 (UMLS CUI [1,4])
C1611184 (UMLS CUI [1,5])
C0037047 (UMLS CUI [1,6])
C2828389 (UMLS CUI [1,7])
C3846158 (UMLS CUI [1,8])
C1948020 (UMLS CUI [1,9])
C0031437 (UMLS CUI [1,10])
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