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ID

45624

Description

Principal Investigator: David Van Essen, PhD, Washington University School of Medicine, St. Louis, MO, USA MeSH: Connectome,Magnetic Resonance Imaging,Behavioral Research,Magnetoencephalography,Healthy Volunteers https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001364 The Human Connectome Project (HCP) has acquired vast amounts of data about the pattern of long-distance connections (wiring) in the brains of large numbers of healthy participants aged 22-35 using cutting-edge MRI and MEG neuroimaging, and extensive behavioral testing. Types of MR data collected included diffusion MRI (dMRI), resting-state functional MRI (r-fMRI), and structural MRI at both 3T and 7T, and task-evoked functional MRI (t-fMRI) at 3T. Following an extensive period of development and optimization of data acquisition and analysis methods, at Washington University in St. Louis we studied 1,206 participants comprising twins and their non-twin siblings. A subset of 184 twins was scanned again at the University of Minnesota using a 7T scanner. A different subset of 95 twins was studied at St. Louis University using combined resting state and/or task-activated MEG. We were able to collect genetic data on 1142 of our 1206 participants, including 149 pairs of genetically-confirmed monozygotic twins (298 participants) and 94 pairs of genetically-confirmed dizygotic twins (188 participants). Overall, there are 457 different families in the study, as determined by genetic analysis. Our rich set of imaging, behavioral and genetic data - available through the Human Connectome database - will enable many types of analysis of brain circuitry, its relationship to behavior, and the contributions of genetic and environmental factors to brain circuits.

Link

dbGaP-study=phs001364

Keywords

Versions (1)
  1. 2/28/23 2/28/23 - Chiara Middel
Copyright Holder

David Van Essen, PhD, Washington University School of Medicine, St. Louis, MO, USA

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February 28, 2023

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Creative Commons BY 4.0
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    dbGaP phs001364 Mapping the Human Connectome: Structure, Function, and Heritability

    English

    Eligibility Criteria

    6 forms  
    Inclusion and exclusion criteria
    Description

    Inclusion and exclusion criteria

    Alias
    UMLS CUI [1,1]
    C1512693
    UMLS CUI [1,2]
    C0680251
    *HCP Inclusion Criteria*
    Description

    Elig.phs001364.v1.p1.1

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1512693
    UMLS CUI [1,2]
    C3494407
    Age 22 to 35 at the time of telephone diagnostic interview (SSAGA) *HCP exclusion Criteria*
    Description

    Elig.phs001364.v1.p1.2

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0001779
    UMLS CUI [1,2]
    C0011008
    UMLS CUI [1,3]
    C0039457
    UMLS CUI [1,4]
    C0348026
    UMLS CUI [1,5]
    C0021822
    Significant history of psychiatric disorder, substance abuse, neurological, or cardiovascular disease <ol type="a">
    Description

    Elig.phs001364.v1.p1.3

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0680251
    UMLS CUI [1,2]
    C3494407
    UMLS CUI [1,3]
    C0455498
    UMLS CUI [1,4]
    C1299544
    UMLS CUI [1,5]
    C0027765
    UMLS CUI [1,6]
    C0007222
    Participant report of diagnosis by a treating physician; or
    Description

    Elig.phs001364.v1.p1.4

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1710470
    UMLS CUI [1,2]
    C0700287
    UMLS CUI [1,3]
    C0011900
    Hospitalization for the condition for two days or longer; or
    Description

    Elig.phs001364.v1.p1.5

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0019993
    UMLS CUI [1,2]
    C0012634
    Pharmacologic or behavioral treatment by a cardiologist, psychiatrist, neurologist, or endocrinologist for a period of 12 months or longer, other than treatment for childhood-only ADHD.
    Description

    Elig.phs001364.v1.p1.6

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0013216
    UMLS CUI [1,2]
    C0004933
    UMLS CUI [1,3]
    C0175906
    UMLS CUI [1,4]
    C0033872
    UMLS CUI [1,5]
    C0237426
    UMLS CUI [1,6]
    C0259863
    UMLS CUI [1,7]
    C0040223
    UMLS CUI [2,1]
    C1298908
    UMLS CUI [2,2]
    C0680251
    UMLS CUI [2,3]
    C0013227
    UMLS CUI [2,4]
    C0449238
    UMLS CUI [2,5]
    C5203310
    UMLS CUI [2,6]
    C0231335
    Participant report of diagnosis by a treating physician; or
    Description

    Elig.phs001364.v1.p1.7

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1710470
    UMLS CUI [1,2]
    C0700287
    UMLS CUI [1,3]
    C0011900
    Hospitalization for the condition for two days or longer; or
    Description

    Elig.phs001364.v1.p1.8

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0019993
    UMLS CUI [1,2]
    C0012634
    Participant report of diagnosis by a treating physician; or
    Description

    Elig.phs001364.v1.p1.9

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1710470
    UMLS CUI [1,2]
    C0700287
    UMLS CUI [1,3]
    C0011900
    Hospitalization for the condition for two days or longer; or
    Description

    Elig.phs001364.v1.p1.10

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0019993
    UMLS CUI [1,2]
    C0012634
    Pharmacologic or behavioral treatment by a cardiologist, psychiatrist, neurologist, or endocrinologist for a period of 12 months or longer, other than treatment for childhood-only ADHD.
    Description

    Elig.phs001364.v1.p1.11

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0013216
    UMLS CUI [1,2]
    C0004933
    UMLS CUI [1,3]
    C0175906
    UMLS CUI [1,4]
    C0033872
    UMLS CUI [1,5]
    C0237426
    UMLS CUI [1,6]
    C0259863
    UMLS CUI [1,7]
    C0449238
    UMLS CUI [1,8]
    C0040223
    UMLS CUI [2,1]
    C1298908
    UMLS CUI [2,2]
    C0680251
    UMLS CUI [2,3]
    C0013227
    UMLS CUI [2,4]
    C5203310
    UMLS CUI [2,5]
    C0449238
    UMLS CUI [2,6]
    C0231335
    Two or more seizures after age 5 or a diagnosis of epilepsy
    Description

    Elig.phs001364.v1.p1.12

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C3841879
    UMLS CUI [1,2]
    C0036572
    UMLS CUI [1,3]
    C0001779
    UMLS CUI [2,1]
    C0014544
    UMLS CUI [2,2]
    C0011900
    Any genetic disorder, such as cystic fibrosis or sickle cell disease
    Description

    Elig.phs001364.v1.p1.13

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0851352
    UMLS CUI [1,2]
    C0010674
    UMLS CUI [1,3]
    C0002895
    Multiple sclerosis, cerebral palsy, brain tumor or stroke
    Description

    Elig.phs001364.v1.p1.14

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0026769
    UMLS CUI [1,2]
    C0007789
    UMLS CUI [1,3]
    C0006118
    UMLS CUI [1,4]
    C0038454
    Any of the following head injuries <ol type="a">
    Description

    Elig.phs001364.v1.p1.15

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0332282
    UMLS CUI [1,2]
    C0018670
    UMLS CUI [1,3]
    C3263723
    Loss of consciousness for &#62; 30 minutes; or
    Description

    Elig.phs001364.v1.p1.16

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0449238
    UMLS CUI [1,2]
    C0234433
    Amnesia for &#62; 24 hours; or
    Description

    Elig.phs001364.v1.p1.17

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0002622
    UMLS CUI [1,2]
    C0449238
    Change in mental status for &#62; 24 hours; or
    Description

    Elig.phs001364.v1.p1.18

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0443172
    UMLS CUI [1,2]
    C0278060
    UMLS CUI [1,3]
    C0449238
    CT findings consistent with traumatic brain injury; or
    Description

    Elig.phs001364.v1.p1.19

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0332290
    UMLS CUI [1,2]
    C0040405
    UMLS CUI [1,3]
    C3263723
    UMLS CUI [1,4]
    C0006104
    Three or more concussive (mild) incidences of head injury
    Description

    Elig.phs001364.v1.p1.20

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1265611
    UMLS CUI [1,2]
    C2945599
    UMLS CUI [1,3]
    C0006107
    UMLS CUI [1,4]
    C0018674
    Premature birth (for twins, before 34 weeks; for non-twin siblings, before 37 weeks. If weeks unknown, less than 5 lbs. at birth for non-twins)
    Description

    Elig.phs001364.v1.p1.21

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0151526
    UMLS CUI [1,2]
    C0011900
    Currently on chemotherapy or immunomodulatory agents, or history of radiation or chemotherapy that could affect the brain.
    Description

    Elig.phs001364.v1.p1.22

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0392920
    UMLS CUI [1,2]
    C0021081
    UMLS CUI [2,1]
    C0279134
    UMLS CUI [2,2]
    C1514457
    Thyroid hormone treatment in the past month
    Description

    Elig.phs001364.v1.p1.23

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C2242640
    Treatment for diabetes in the past month (other than gestational or diet-controlled diabetes)
    Description

    Elig.phs001364.v1.p1.24

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0087111
    UMLS CUI [1,2]
    C0011849
    Use of daily prescription medications for migraines in the past month
    Description

    Elig.phs001364.v1.p1.25

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1524063
    UMLS CUI [1,2]
    C3843193
    UMLS CUI [1,3]
    C0149931
    A score of 25 or below on the Folstein Mini Mental State Exam on visit Day 1
    Description

    Elig.phs001364.v1.p1.26

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C2225229
    Moderate or severe claustrophobia
    Description

    Elig.phs001364.v1.p1.27

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205081
    UMLS CUI [1,2]
    C0205082
    UMLS CUI [1,3]
    C0008909
    Pregnancy
    Description

    Elig.phs001364.v1.p1.28

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0032961
    Unsafe metal in the body
    Description

    Elig.phs001364.v1.p1.29

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0237152
    UMLS CUI [1,2]
    C0025552
    UMLS CUI [1,3]
    C0460148
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    Similar models

    Eligibility Criteria

    6 forms
    Name
    Type
    Description | Question | Decode (Coded Value)
    Data type
    Alias
    Item Group
    Inclusion and exclusion criteria
    C1512693 (UMLS CUI [1,1])
    C0680251 (UMLS CUI [1,2])
    Elig.phs001364.v1.p1.1
    Item
    *HCP Inclusion Criteria*
    boolean
    C1512693 (UMLS CUI [1,1])
    C3494407 (UMLS CUI [1,2])
    Elig.phs001364.v1.p1.2
    Item
    Age 22 to 35 at the time of telephone diagnostic interview (SSAGA) *HCP exclusion Criteria*
    boolean
    C0001779 (UMLS CUI [1,1])
    C0011008 (UMLS CUI [1,2])
    C0039457 (UMLS CUI [1,3])
    C0348026 (UMLS CUI [1,4])
    C0021822 (UMLS CUI [1,5])
    Elig.phs001364.v1.p1.3
    Item
    Significant history of psychiatric disorder, substance abuse, neurological, or cardiovascular disease <ol type="a">
    boolean
    C0680251 (UMLS CUI [1,1])
    C3494407 (UMLS CUI [1,2])
    C0455498 (UMLS CUI [1,3])
    C1299544 (UMLS CUI [1,4])
    C0027765 (UMLS CUI [1,5])
    C0007222 (UMLS CUI [1,6])
    Elig.phs001364.v1.p1.4
    Item
    Participant report of diagnosis by a treating physician; or
    boolean
    C1710470 (UMLS CUI [1,1])
    C0700287 (UMLS CUI [1,2])
    C0011900 (UMLS CUI [1,3])
    Elig.phs001364.v1.p1.5
    Item
    Hospitalization for the condition for two days or longer; or
    boolean
    C0019993 (UMLS CUI [1,1])
    C0012634 (UMLS CUI [1,2])
    Elig.phs001364.v1.p1.6
    Item
    Pharmacologic or behavioral treatment by a cardiologist, psychiatrist, neurologist, or endocrinologist for a period of 12 months or longer, other than treatment for childhood-only ADHD.
    boolean
    C0013216 (UMLS CUI [1,1])
    C0004933 (UMLS CUI [1,2])
    C0175906 (UMLS CUI [1,3])
    C0033872 (UMLS CUI [1,4])
    C0237426 (UMLS CUI [1,5])
    C0259863 (UMLS CUI [1,6])
    C0040223 (UMLS CUI [1,7])
    C1298908 (UMLS CUI [2,1])
    C0680251 (UMLS CUI [2,2])
    C0013227 (UMLS CUI [2,3])
    C0449238 (UMLS CUI [2,4])
    C5203310 (UMLS CUI [2,5])
    C0231335 (UMLS CUI [2,6])
    Elig.phs001364.v1.p1.7
    Item
    Participant report of diagnosis by a treating physician; or
    boolean
    C1710470 (UMLS CUI [1,1])
    C0700287 (UMLS CUI [1,2])
    C0011900 (UMLS CUI [1,3])
    Elig.phs001364.v1.p1.8
    Item
    Hospitalization for the condition for two days or longer; or
    boolean
    C0019993 (UMLS CUI [1,1])
    C0012634 (UMLS CUI [1,2])
    Elig.phs001364.v1.p1.9
    Item
    Participant report of diagnosis by a treating physician; or
    boolean
    C1710470 (UMLS CUI [1,1])
    C0700287 (UMLS CUI [1,2])
    C0011900 (UMLS CUI [1,3])
    Elig.phs001364.v1.p1.10
    Item
    Hospitalization for the condition for two days or longer; or
    boolean
    C0019993 (UMLS CUI [1,1])
    C0012634 (UMLS CUI [1,2])
    Elig.phs001364.v1.p1.11
    Item
    Pharmacologic or behavioral treatment by a cardiologist, psychiatrist, neurologist, or endocrinologist for a period of 12 months or longer, other than treatment for childhood-only ADHD.
    boolean
    C0013216 (UMLS CUI [1,1])
    C0004933 (UMLS CUI [1,2])
    C0175906 (UMLS CUI [1,3])
    C0033872 (UMLS CUI [1,4])
    C0237426 (UMLS CUI [1,5])
    C0259863 (UMLS CUI [1,6])
    C0449238 (UMLS CUI [1,7])
    C0040223 (UMLS CUI [1,8])
    C1298908 (UMLS CUI [2,1])
    C0680251 (UMLS CUI [2,2])
    C0013227 (UMLS CUI [2,3])
    C5203310 (UMLS CUI [2,4])
    C0449238 (UMLS CUI [2,5])
    C0231335 (UMLS CUI [2,6])
    Elig.phs001364.v1.p1.12
    Item
    Two or more seizures after age 5 or a diagnosis of epilepsy
    boolean
    C3841879 (UMLS CUI [1,1])
    C0036572 (UMLS CUI [1,2])
    C0001779 (UMLS CUI [1,3])
    C0014544 (UMLS CUI [2,1])
    C0011900 (UMLS CUI [2,2])
    Elig.phs001364.v1.p1.13
    Item
    Any genetic disorder, such as cystic fibrosis or sickle cell disease
    boolean
    C0851352 (UMLS CUI [1,1])
    C0010674 (UMLS CUI [1,2])
    C0002895 (UMLS CUI [1,3])
    Elig.phs001364.v1.p1.14
    Item
    Multiple sclerosis, cerebral palsy, brain tumor or stroke
    boolean
    C0026769 (UMLS CUI [1,1])
    C0007789 (UMLS CUI [1,2])
    C0006118 (UMLS CUI [1,3])
    C0038454 (UMLS CUI [1,4])
    Elig.phs001364.v1.p1.15
    Item
    Any of the following head injuries <ol type="a">
    boolean
    C0332282 (UMLS CUI [1,1])
    C0018670 (UMLS CUI [1,2])
    C3263723 (UMLS CUI [1,3])
    Elig.phs001364.v1.p1.16
    Item
    Loss of consciousness for &#62; 30 minutes; or
    boolean
    C0449238 (UMLS CUI [1,1])
    C0234433 (UMLS CUI [1,2])
    Elig.phs001364.v1.p1.17
    Item
    Amnesia for &#62; 24 hours; or
    boolean
    C0002622 (UMLS CUI [1,1])
    C0449238 (UMLS CUI [1,2])
    Elig.phs001364.v1.p1.18
    Item
    Change in mental status for &#62; 24 hours; or
    boolean
    C0443172 (UMLS CUI [1,1])
    C0278060 (UMLS CUI [1,2])
    C0449238 (UMLS CUI [1,3])
    Elig.phs001364.v1.p1.19
    Item
    CT findings consistent with traumatic brain injury; or
    boolean
    C0332290 (UMLS CUI [1,1])
    C0040405 (UMLS CUI [1,2])
    C3263723 (UMLS CUI [1,3])
    C0006104 (UMLS CUI [1,4])
    Elig.phs001364.v1.p1.20
    Item
    Three or more concussive (mild) incidences of head injury
    boolean
    C1265611 (UMLS CUI [1,1])
    C2945599 (UMLS CUI [1,2])
    C0006107 (UMLS CUI [1,3])
    C0018674 (UMLS CUI [1,4])
    Elig.phs001364.v1.p1.21
    Item
    Premature birth (for twins, before 34 weeks; for non-twin siblings, before 37 weeks. If weeks unknown, less than 5 lbs. at birth for non-twins)
    boolean
    C0151526 (UMLS CUI [1,1])
    C0011900 (UMLS CUI [1,2])
    Elig.phs001364.v1.p1.22
    Item
    Currently on chemotherapy or immunomodulatory agents, or history of radiation or chemotherapy that could affect the brain.
    boolean
    C0392920 (UMLS CUI [1,1])
    C0021081 (UMLS CUI [1,2])
    C0279134 (UMLS CUI [2,1])
    C1514457 (UMLS CUI [2,2])
    Elig.phs001364.v1.p1.23
    Item
    Thyroid hormone treatment in the past month
    boolean
    C2242640 (UMLS CUI [1,1])
    Elig.phs001364.v1.p1.24
    Item
    Treatment for diabetes in the past month (other than gestational or diet-controlled diabetes)
    boolean
    C0087111 (UMLS CUI [1,1])
    C0011849 (UMLS CUI [1,2])
    Elig.phs001364.v1.p1.25
    Item
    Use of daily prescription medications for migraines in the past month
    boolean
    C1524063 (UMLS CUI [1,1])
    C3843193 (UMLS CUI [1,2])
    C0149931 (UMLS CUI [1,3])
    Elig.phs001364.v1.p1.26
    Item
    A score of 25 or below on the Folstein Mini Mental State Exam on visit Day 1
    boolean
    C2225229 (UMLS CUI [1,1])
    Elig.phs001364.v1.p1.27
    Item
    Moderate or severe claustrophobia
    boolean
    C0205081 (UMLS CUI [1,1])
    C0205082 (UMLS CUI [1,2])
    C0008909 (UMLS CUI [1,3])
    Elig.phs001364.v1.p1.28
    Item
    Pregnancy
    boolean
    C0032961 (UMLS CUI [1,1])
    Elig.phs001364.v1.p1.29
    Item
    Unsafe metal in the body
    boolean
    C0237152 (UMLS CUI [1,1])
    C0025552 (UMLS CUI [1,2])
    C0460148 (UMLS CUI [1,3])
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