ID

45624

Beschreibung

Principal Investigator: David Van Essen, PhD, Washington University School of Medicine, St. Louis, MO, USA MeSH: Connectome,Magnetic Resonance Imaging,Behavioral Research,Magnetoencephalography,Healthy Volunteers https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001364 The Human Connectome Project (HCP) has acquired vast amounts of data about the pattern of long-distance connections (wiring) in the brains of large numbers of healthy participants aged 22-35 using cutting-edge MRI and MEG neuroimaging, and extensive behavioral testing. Types of MR data collected included diffusion MRI (dMRI), resting-state functional MRI (r-fMRI), and structural MRI at both 3T and 7T, and task-evoked functional MRI (t-fMRI) at 3T. Following an extensive period of development and optimization of data acquisition and analysis methods, at Washington University in St. Louis we studied 1,206 participants comprising twins and their non-twin siblings. A subset of 184 twins was scanned again at the University of Minnesota using a 7T scanner. A different subset of 95 twins was studied at St. Louis University using combined resting state and/or task-activated MEG. We were able to collect genetic data on 1142 of our 1206 participants, including 149 pairs of genetically-confirmed monozygotic twins (298 participants) and 94 pairs of genetically-confirmed dizygotic twins (188 participants). Overall, there are 457 different families in the study, as determined by genetic analysis. Our rich set of imaging, behavioral and genetic data - available through the Human Connectome database - will enable many types of analysis of brain circuitry, its relationship to behavior, and the contributions of genetic and environmental factors to brain circuits.

Link

dbGaP-study=phs001364

Stichworte

Versionen (1)
  1. 28.02.23 28.02.23 - Chiara Middel
Rechteinhaber

David Van Essen, PhD, Washington University School of Medicine, St. Louis, MO, USA

Hochgeladen am

28. Februar 2023

DOI

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Lizenz

Creative Commons BY 4.0
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dbGaP phs001364 Mapping the Human Connectome: Structure, Function, and Heritability

Englisch

Eligibility Criteria

6 Formulare  
Inclusion and exclusion criteria
Beschreibung

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
*HCP Inclusion Criteria*
Beschreibung

Elig.phs001364.v1.p1.1

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C3494407
Age 22 to 35 at the time of telephone diagnostic interview (SSAGA) *HCP exclusion Criteria*
Beschreibung

Elig.phs001364.v1.p1.2

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0011008
UMLS CUI [1,3]
C0039457
UMLS CUI [1,4]
C0348026
UMLS CUI [1,5]
C0021822
Significant history of psychiatric disorder, substance abuse, neurological, or cardiovascular disease <ol type="a">
Beschreibung

Elig.phs001364.v1.p1.3

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C3494407
UMLS CUI [1,3]
C0455498
UMLS CUI [1,4]
C1299544
UMLS CUI [1,5]
C0027765
UMLS CUI [1,6]
C0007222
Participant report of diagnosis by a treating physician; or
Beschreibung

Elig.phs001364.v1.p1.4

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1710470
UMLS CUI [1,2]
C0700287
UMLS CUI [1,3]
C0011900
Hospitalization for the condition for two days or longer; or
Beschreibung

Elig.phs001364.v1.p1.5

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0019993
UMLS CUI [1,2]
C0012634
Pharmacologic or behavioral treatment by a cardiologist, psychiatrist, neurologist, or endocrinologist for a period of 12 months or longer, other than treatment for childhood-only ADHD.
Beschreibung

Elig.phs001364.v1.p1.6

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0013216
UMLS CUI [1,2]
C0004933
UMLS CUI [1,3]
C0175906
UMLS CUI [1,4]
C0033872
UMLS CUI [1,5]
C0237426
UMLS CUI [1,6]
C0259863
UMLS CUI [1,7]
C0040223
UMLS CUI [2,1]
C1298908
UMLS CUI [2,2]
C0680251
UMLS CUI [2,3]
C0013227
UMLS CUI [2,4]
C0449238
UMLS CUI [2,5]
C5203310
UMLS CUI [2,6]
C0231335
Participant report of diagnosis by a treating physician; or
Beschreibung

Elig.phs001364.v1.p1.7

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1710470
UMLS CUI [1,2]
C0700287
UMLS CUI [1,3]
C0011900
Hospitalization for the condition for two days or longer; or
Beschreibung

Elig.phs001364.v1.p1.8

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0019993
UMLS CUI [1,2]
C0012634
Participant report of diagnosis by a treating physician; or
Beschreibung

Elig.phs001364.v1.p1.9

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1710470
UMLS CUI [1,2]
C0700287
UMLS CUI [1,3]
C0011900
Hospitalization for the condition for two days or longer; or
Beschreibung

Elig.phs001364.v1.p1.10

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0019993
UMLS CUI [1,2]
C0012634
Pharmacologic or behavioral treatment by a cardiologist, psychiatrist, neurologist, or endocrinologist for a period of 12 months or longer, other than treatment for childhood-only ADHD.
Beschreibung

Elig.phs001364.v1.p1.11

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0013216
UMLS CUI [1,2]
C0004933
UMLS CUI [1,3]
C0175906
UMLS CUI [1,4]
C0033872
UMLS CUI [1,5]
C0237426
UMLS CUI [1,6]
C0259863
UMLS CUI [1,7]
C0449238
UMLS CUI [1,8]
C0040223
UMLS CUI [2,1]
C1298908
UMLS CUI [2,2]
C0680251
UMLS CUI [2,3]
C0013227
UMLS CUI [2,4]
C5203310
UMLS CUI [2,5]
C0449238
UMLS CUI [2,6]
C0231335
Two or more seizures after age 5 or a diagnosis of epilepsy
Beschreibung

Elig.phs001364.v1.p1.12

Datentyp

boolean

Alias
UMLS CUI [1,1]
C3841879
UMLS CUI [1,2]
C0036572
UMLS CUI [1,3]
C0001779
UMLS CUI [2,1]
C0014544
UMLS CUI [2,2]
C0011900
Any genetic disorder, such as cystic fibrosis or sickle cell disease
Beschreibung

Elig.phs001364.v1.p1.13

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0851352
UMLS CUI [1,2]
C0010674
UMLS CUI [1,3]
C0002895
Multiple sclerosis, cerebral palsy, brain tumor or stroke
Beschreibung

Elig.phs001364.v1.p1.14

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0026769
UMLS CUI [1,2]
C0007789
UMLS CUI [1,3]
C0006118
UMLS CUI [1,4]
C0038454
Any of the following head injuries <ol type="a">
Beschreibung

Elig.phs001364.v1.p1.15

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0332282
UMLS CUI [1,2]
C0018670
UMLS CUI [1,3]
C3263723
Loss of consciousness for &#62; 30 minutes; or
Beschreibung

Elig.phs001364.v1.p1.16

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0449238
UMLS CUI [1,2]
C0234433
Amnesia for &#62; 24 hours; or
Beschreibung

Elig.phs001364.v1.p1.17

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0002622
UMLS CUI [1,2]
C0449238
Change in mental status for &#62; 24 hours; or
Beschreibung

Elig.phs001364.v1.p1.18

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0443172
UMLS CUI [1,2]
C0278060
UMLS CUI [1,3]
C0449238
CT findings consistent with traumatic brain injury; or
Beschreibung

Elig.phs001364.v1.p1.19

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0332290
UMLS CUI [1,2]
C0040405
UMLS CUI [1,3]
C3263723
UMLS CUI [1,4]
C0006104
Three or more concussive (mild) incidences of head injury
Beschreibung

Elig.phs001364.v1.p1.20

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1265611
UMLS CUI [1,2]
C2945599
UMLS CUI [1,3]
C0006107
UMLS CUI [1,4]
C0018674
Premature birth (for twins, before 34 weeks; for non-twin siblings, before 37 weeks. If weeks unknown, less than 5 lbs. at birth for non-twins)
Beschreibung

Elig.phs001364.v1.p1.21

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0151526
UMLS CUI [1,2]
C0011900
Currently on chemotherapy or immunomodulatory agents, or history of radiation or chemotherapy that could affect the brain.
Beschreibung

Elig.phs001364.v1.p1.22

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0392920
UMLS CUI [1,2]
C0021081
UMLS CUI [2,1]
C0279134
UMLS CUI [2,2]
C1514457
Thyroid hormone treatment in the past month
Beschreibung

Elig.phs001364.v1.p1.23

Datentyp

boolean

Alias
UMLS CUI [1,1]
C2242640
Treatment for diabetes in the past month (other than gestational or diet-controlled diabetes)
Beschreibung

Elig.phs001364.v1.p1.24

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0087111
UMLS CUI [1,2]
C0011849
Use of daily prescription medications for migraines in the past month
Beschreibung

Elig.phs001364.v1.p1.25

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1524063
UMLS CUI [1,2]
C3843193
UMLS CUI [1,3]
C0149931
A score of 25 or below on the Folstein Mini Mental State Exam on visit Day 1
Beschreibung

Elig.phs001364.v1.p1.26

Datentyp

boolean

Alias
UMLS CUI [1,1]
C2225229
Moderate or severe claustrophobia
Beschreibung

Elig.phs001364.v1.p1.27

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0205081
UMLS CUI [1,2]
C0205082
UMLS CUI [1,3]
C0008909
Pregnancy
Beschreibung

Elig.phs001364.v1.p1.28

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0032961
Unsafe metal in the body
Beschreibung

Elig.phs001364.v1.p1.29

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0237152
UMLS CUI [1,2]
C0025552
UMLS CUI [1,3]
C0460148
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Ähnliche Modelle

Eligibility Criteria

6 Formulare
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs001364.v1.p1.1
Item
*HCP Inclusion Criteria*
boolean
C1512693 (UMLS CUI [1,1])
C3494407 (UMLS CUI [1,2])
Elig.phs001364.v1.p1.2
Item
Age 22 to 35 at the time of telephone diagnostic interview (SSAGA) *HCP exclusion Criteria*
boolean
C0001779 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])
C0039457 (UMLS CUI [1,3])
C0348026 (UMLS CUI [1,4])
C0021822 (UMLS CUI [1,5])
Elig.phs001364.v1.p1.3
Item
Significant history of psychiatric disorder, substance abuse, neurological, or cardiovascular disease <ol type="a">
boolean
C0680251 (UMLS CUI [1,1])
C3494407 (UMLS CUI [1,2])
C0455498 (UMLS CUI [1,3])
C1299544 (UMLS CUI [1,4])
C0027765 (UMLS CUI [1,5])
C0007222 (UMLS CUI [1,6])
Elig.phs001364.v1.p1.4
Item
Participant report of diagnosis by a treating physician; or
boolean
C1710470 (UMLS CUI [1,1])
C0700287 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
Elig.phs001364.v1.p1.5
Item
Hospitalization for the condition for two days or longer; or
boolean
C0019993 (UMLS CUI [1,1])
C0012634 (UMLS CUI [1,2])
Elig.phs001364.v1.p1.6
Item
Pharmacologic or behavioral treatment by a cardiologist, psychiatrist, neurologist, or endocrinologist for a period of 12 months or longer, other than treatment for childhood-only ADHD.
boolean
C0013216 (UMLS CUI [1,1])
C0004933 (UMLS CUI [1,2])
C0175906 (UMLS CUI [1,3])
C0033872 (UMLS CUI [1,4])
C0237426 (UMLS CUI [1,5])
C0259863 (UMLS CUI [1,6])
C0040223 (UMLS CUI [1,7])
C1298908 (UMLS CUI [2,1])
C0680251 (UMLS CUI [2,2])
C0013227 (UMLS CUI [2,3])
C0449238 (UMLS CUI [2,4])
C5203310 (UMLS CUI [2,5])
C0231335 (UMLS CUI [2,6])
Elig.phs001364.v1.p1.7
Item
Participant report of diagnosis by a treating physician; or
boolean
C1710470 (UMLS CUI [1,1])
C0700287 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
Elig.phs001364.v1.p1.8
Item
Hospitalization for the condition for two days or longer; or
boolean
C0019993 (UMLS CUI [1,1])
C0012634 (UMLS CUI [1,2])
Elig.phs001364.v1.p1.9
Item
Participant report of diagnosis by a treating physician; or
boolean
C1710470 (UMLS CUI [1,1])
C0700287 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
Elig.phs001364.v1.p1.10
Item
Hospitalization for the condition for two days or longer; or
boolean
C0019993 (UMLS CUI [1,1])
C0012634 (UMLS CUI [1,2])
Elig.phs001364.v1.p1.11
Item
Pharmacologic or behavioral treatment by a cardiologist, psychiatrist, neurologist, or endocrinologist for a period of 12 months or longer, other than treatment for childhood-only ADHD.
boolean
C0013216 (UMLS CUI [1,1])
C0004933 (UMLS CUI [1,2])
C0175906 (UMLS CUI [1,3])
C0033872 (UMLS CUI [1,4])
C0237426 (UMLS CUI [1,5])
C0259863 (UMLS CUI [1,6])
C0449238 (UMLS CUI [1,7])
C0040223 (UMLS CUI [1,8])
C1298908 (UMLS CUI [2,1])
C0680251 (UMLS CUI [2,2])
C0013227 (UMLS CUI [2,3])
C5203310 (UMLS CUI [2,4])
C0449238 (UMLS CUI [2,5])
C0231335 (UMLS CUI [2,6])
Elig.phs001364.v1.p1.12
Item
Two or more seizures after age 5 or a diagnosis of epilepsy
boolean
C3841879 (UMLS CUI [1,1])
C0036572 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0014544 (UMLS CUI [2,1])
C0011900 (UMLS CUI [2,2])
Elig.phs001364.v1.p1.13
Item
Any genetic disorder, such as cystic fibrosis or sickle cell disease
boolean
C0851352 (UMLS CUI [1,1])
C0010674 (UMLS CUI [1,2])
C0002895 (UMLS CUI [1,3])
Elig.phs001364.v1.p1.14
Item
Multiple sclerosis, cerebral palsy, brain tumor or stroke
boolean
C0026769 (UMLS CUI [1,1])
C0007789 (UMLS CUI [1,2])
C0006118 (UMLS CUI [1,3])
C0038454 (UMLS CUI [1,4])
Elig.phs001364.v1.p1.15
Item
Any of the following head injuries <ol type="a">
boolean
C0332282 (UMLS CUI [1,1])
C0018670 (UMLS CUI [1,2])
C3263723 (UMLS CUI [1,3])
Elig.phs001364.v1.p1.16
Item
Loss of consciousness for &#62; 30 minutes; or
boolean
C0449238 (UMLS CUI [1,1])
C0234433 (UMLS CUI [1,2])
Elig.phs001364.v1.p1.17
Item
Amnesia for &#62; 24 hours; or
boolean
C0002622 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
Elig.phs001364.v1.p1.18
Item
Change in mental status for &#62; 24 hours; or
boolean
C0443172 (UMLS CUI [1,1])
C0278060 (UMLS CUI [1,2])
C0449238 (UMLS CUI [1,3])
Elig.phs001364.v1.p1.19
Item
CT findings consistent with traumatic brain injury; or
boolean
C0332290 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
C3263723 (UMLS CUI [1,3])
C0006104 (UMLS CUI [1,4])
Elig.phs001364.v1.p1.20
Item
Three or more concussive (mild) incidences of head injury
boolean
C1265611 (UMLS CUI [1,1])
C2945599 (UMLS CUI [1,2])
C0006107 (UMLS CUI [1,3])
C0018674 (UMLS CUI [1,4])
Elig.phs001364.v1.p1.21
Item
Premature birth (for twins, before 34 weeks; for non-twin siblings, before 37 weeks. If weeks unknown, less than 5 lbs. at birth for non-twins)
boolean
C0151526 (UMLS CUI [1,1])
C0011900 (UMLS CUI [1,2])
Elig.phs001364.v1.p1.22
Item
Currently on chemotherapy or immunomodulatory agents, or history of radiation or chemotherapy that could affect the brain.
boolean
C0392920 (UMLS CUI [1,1])
C0021081 (UMLS CUI [1,2])
C0279134 (UMLS CUI [2,1])
C1514457 (UMLS CUI [2,2])
Elig.phs001364.v1.p1.23
Item
Thyroid hormone treatment in the past month
boolean
C2242640 (UMLS CUI [1,1])
Elig.phs001364.v1.p1.24
Item
Treatment for diabetes in the past month (other than gestational or diet-controlled diabetes)
boolean
C0087111 (UMLS CUI [1,1])
C0011849 (UMLS CUI [1,2])
Elig.phs001364.v1.p1.25
Item
Use of daily prescription medications for migraines in the past month
boolean
C1524063 (UMLS CUI [1,1])
C3843193 (UMLS CUI [1,2])
C0149931 (UMLS CUI [1,3])
Elig.phs001364.v1.p1.26
Item
A score of 25 or below on the Folstein Mini Mental State Exam on visit Day 1
boolean
C2225229 (UMLS CUI [1,1])
Elig.phs001364.v1.p1.27
Item
Moderate or severe claustrophobia
boolean
C0205081 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0008909 (UMLS CUI [1,3])
Elig.phs001364.v1.p1.28
Item
Pregnancy
boolean
C0032961 (UMLS CUI [1,1])
Elig.phs001364.v1.p1.29
Item
Unsafe metal in the body
boolean
C0237152 (UMLS CUI [1,1])
C0025552 (UMLS CUI [1,2])
C0460148 (UMLS CUI [1,3])
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