ID

45610

Beschrijving

Principal Investigator: Bruce M. Psaty, MD, PhD, TOPMed Cardiovascular Health Study Project (TOPMed-CHS). University of Washington, Seattle, WA, USA MeSH: Cardiovascular Diseases,Myocardial Infarction,Stroke,Brain Ischemia,Intracranial Hemorrhage,Venous Thromboembolism,Venous Thrombosis,Pulmonary Embolism https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001368 Participants from the Cardiovascular Health Study (CHS), a large population-based longitudinal cohort study (phs000287), have been included in the TOPMed project. Whole genome sequencing will be performed to contribute to multiple analyses, including cardiovascular disease risk factors, subclinical disease measures, the occurrence of myocardial infarction (MI) and stroke, and analyses of venous thromboembolism (VTE).

Link

dbGaP-study=phs001368

Trefwoorden

Versies (1)
  1. 21/2/23 21/2/23 - Chiara Middel
Houder van rechten

Bruce M. Psaty, MD, PhD, TOPMed Cardiovascular Health Study Project (TOPMed-CHS). University of Washington, Seattle, WA, USA

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21 de febrero de 2023

DOI

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Licentie

Creative Commons BY 4.0
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dbGaP phs001368 NHLBI TOPMed: Trans-Omics for Precision Medicine (TOPMed) Whole Genome Sequencing Project: Cardiovascular Health Study

Engels

Eligibility Criteria

4 Formulieren  
Inclusion and exclusion criteria
Beschrijving

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
For TOPMed, CHS participants were initially included if they had appropriate consent, available DNA, and met any of the following criteria: <ol type="a"> had an adjudicated idiopathic VTE event during follow-up, were African American, had an incident MI or definite fatal coronary heart disease (CHD) event during follow-up, had a probable fatal CHD event during follow-up, had an incident stroke during follow-up, had a prevalent MI or stroke at baseline, or were part of a random sample of "healthy elderly" participants who survived free of an MI or stroke.
Beschrijving

Elig.phs001368.v3.p2.1

Datatype

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0021430
UMLS CUI [1,3]
C0470187
UMLS CUI [1,4]
C0012854
UMLS CUI [2,1]
C1861172
UMLS CUI [2,2]
C0441471
UMLS CUI [2,3]
C0347984
UMLS CUI [2,4]
C1522577
UMLS CUI [3,1]
C0085756
UMLS CUI [4,1]
C0027051
UMLS CUI [4,2]
C0441471
UMLS CUI [4,3]
C0347984
UMLS CUI [4,4]
C1522577
UMLS CUI [5,1]
C0439544
UMLS CUI [5,2]
C1302234
UMLS CUI [5,3]
C0010068
UMLS CUI [5,4]
C0441471
UMLS CUI [5,5]
C0347984
UMLS CUI [5,6]
C1522577
UMLS CUI [6,1]
C0332148
UMLS CUI [6,2]
C1302234
UMLS CUI [6,3]
C0010068
UMLS CUI [6,4]
C0441471
UMLS CUI [6,5]
C0347984
UMLS CUI [6,6]
C1522577
UMLS CUI [7,1]
C0038454
UMLS CUI [7,2]
C0441471
UMLS CUI [7,3]
C0347984
UMLS CUI [7,4]
C1522577
UMLS CUI [8,1]
C0027051
UMLS CUI [8,2]
C0038454
UMLS CUI [8,3]
C1442488
UMLS CUI [9,1]
C3274571
UMLS CUI [9,2]
C0038952
UMLS CUI [9,3]
C0332288
UMLS CUI [9,4]
C0027051
UMLS CUI [9,5]
C0038454
Selection of participants proceeded in a hierarchical manner from criteria a-g without replacement. Each participant was thus assigned to one, and only one, of the seven groups. Additional CHS participants were included in a second set if they had appropriate consent, had available DNA, and had no TOPMed sequencing. This second set of participants was assigned to an eighth &#8220;other&#8221; group. Follow-up for MI, stroke, and CHD events occurred from baseline in 1989-1990 or 1992-1993 through June 30, 2014. Follow-up for VTE events occurred from baseline (1989-1990 or 1992-1993) through December 31, 2001.
Beschrijving

Elig.phs001368.v3.p2.2

Datatype

boolean

Alias
UMLS CUI [1,1]
C1516050
UMLS CUI [1,2]
C0441833
UMLS CUI [1,3]
C0205171
UMLS CUI [1,4]
C1515021
UMLS CUI [2,1]
C1516050
UMLS CUI [2,2]
C0439064
UMLS CUI [2,3]
C0441833
UMLS CUI [2,4]
C0021430
UMLS CUI [2,5]
C0470187
UMLS CUI [2,6]
C0012854
UMLS CUI [2,7]
C1298908
UMLS CUI [2,8]
C1561491
UMLS CUI [3,1]
C1516050
UMLS CUI [3,2]
C1524062
UMLS CUI [3,3]
C0205394
UMLS CUI [3,4]
C1515021
UMLS CUI [4,1]
C1522577
UMLS CUI [4,2]
C0027051
UMLS CUI [4,3]
C0038454
UMLS CUI [4,4]
C0010068
UMLS CUI [4,5]
C0449238
UMLS CUI [5,1]
C1522577
UMLS CUI [5,2]
C1861172
UMLS CUI [5,3]
C0449238
CHS publications describe the methods for prevalent (PMID: 8520708) and incident events (PMID: 26538580).
Beschrijving

Elig.phs001368.v3.p2.3

Datatype

boolean

Alias
UMLS CUI [1,1]
C0034036
UMLS CUI [1,2]
C0025663
UMLS CUI [1,3]
C5204628
UMLS CUI [1,4]
C0441471
UMLS CUI [2,1]
C0034036
UMLS CUI [2,2]
C0025663
UMLS CUI [2,3]
C1551358
UMLS CUI [2,4]
C0441471
VTE includes both deep vein thrombosis (DVT) in which a blood clot forms in a vein deep in the body, and pulmonary embolism (PE) where a blood clot travels to the lungs and blocks blood flow. The objectively diagnosed DVT and PE cases were confirmed by venous or pulmonary imaging, pathology examination of the thrombus removed at surgery, or by autopsy. In addition, many CHS participants have had other cardiovascular events, including atrial fibrillation (AF), angina, and heart failure (HF).
Beschrijving

Elig.phs001368.v3.p2.4

Datatype

boolean

Alias
UMLS CUI [1,1]
C1861172
UMLS CUI [1,2]
C0332257
UMLS CUI [1,3]
C0149871
UMLS CUI [1,4]
C0034065
UMLS CUI [2,1]
C0750484
UMLS CUI [2,2]
C0149871
UMLS CUI [2,3]
C0034065
UMLS CUI [2,4]
C0011923
UMLS CUI [2,5]
C0807321
UMLS CUI [2,6]
C0004398
UMLS CUI [3,1]
C0679646
UMLS CUI [3,2]
C0010068
UMLS CUI [3,3]
C1524062
UMLS CUI [3,4]
C1320716
UMLS CUI [3,5]
C0004238
UMLS CUI [3,6]
C0002962
UMLS CUI [3,7]
C0018801
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Similar models

Eligibility Criteria

4 Formulieren
Name
Type
Description | Question | Decode (Coded Value)
Datatype
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs001368.v3.p2.1
Item
For TOPMed, CHS participants were initially included if they had appropriate consent, available DNA, and met any of the following criteria: <ol type="a"> had an adjudicated idiopathic VTE event during follow-up, were African American, had an incident MI or definite fatal coronary heart disease (CHD) event during follow-up, had a probable fatal CHD event during follow-up, had an incident stroke during follow-up, had a prevalent MI or stroke at baseline, or were part of a random sample of "healthy elderly" participants who survived free of an MI or stroke.
boolean
C1512693 (UMLS CUI [1,1])
C0021430 (UMLS CUI [1,2])
C0470187 (UMLS CUI [1,3])
C0012854 (UMLS CUI [1,4])
C1861172 (UMLS CUI [2,1])
C0441471 (UMLS CUI [2,2])
C0347984 (UMLS CUI [2,3])
C1522577 (UMLS CUI [2,4])
C0085756 (UMLS CUI [3,1])
C0027051 (UMLS CUI [4,1])
C0441471 (UMLS CUI [4,2])
C0347984 (UMLS CUI [4,3])
C1522577 (UMLS CUI [4,4])
C0439544 (UMLS CUI [5,1])
C1302234 (UMLS CUI [5,2])
C0010068 (UMLS CUI [5,3])
C0441471 (UMLS CUI [5,4])
C0347984 (UMLS CUI [5,5])
C1522577 (UMLS CUI [5,6])
C0332148 (UMLS CUI [6,1])
C1302234 (UMLS CUI [6,2])
C0010068 (UMLS CUI [6,3])
C0441471 (UMLS CUI [6,4])
C0347984 (UMLS CUI [6,5])
C1522577 (UMLS CUI [6,6])
C0038454 (UMLS CUI [7,1])
C0441471 (UMLS CUI [7,2])
C0347984 (UMLS CUI [7,3])
C1522577 (UMLS CUI [7,4])
C0027051 (UMLS CUI [8,1])
C0038454 (UMLS CUI [8,2])
C1442488 (UMLS CUI [8,3])
C3274571 (UMLS CUI [9,1])
C0038952 (UMLS CUI [9,2])
C0332288 (UMLS CUI [9,3])
C0027051 (UMLS CUI [9,4])
C0038454 (UMLS CUI [9,5])
Elig.phs001368.v3.p2.2
Item
Selection of participants proceeded in a hierarchical manner from criteria a-g without replacement. Each participant was thus assigned to one, and only one, of the seven groups. Additional CHS participants were included in a second set if they had appropriate consent, had available DNA, and had no TOPMed sequencing. This second set of participants was assigned to an eighth &#8220;other&#8221; group. Follow-up for MI, stroke, and CHD events occurred from baseline in 1989-1990 or 1992-1993 through June 30, 2014. Follow-up for VTE events occurred from baseline (1989-1990 or 1992-1993) through December 31, 2001.
boolean
C1516050 (UMLS CUI [1,1])
C0441833 (UMLS CUI [1,2])
C0205171 (UMLS CUI [1,3])
C1515021 (UMLS CUI [1,4])
C1516050 (UMLS CUI [2,1])
C0439064 (UMLS CUI [2,2])
C0441833 (UMLS CUI [2,3])
C0021430 (UMLS CUI [2,4])
C0470187 (UMLS CUI [2,5])
C0012854 (UMLS CUI [2,6])
C1298908 (UMLS CUI [2,7])
C1561491 (UMLS CUI [2,8])
C1516050 (UMLS CUI [3,1])
C1524062 (UMLS CUI [3,2])
C0205394 (UMLS CUI [3,3])
C1515021 (UMLS CUI [3,4])
C1522577 (UMLS CUI [4,1])
C0027051 (UMLS CUI [4,2])
C0038454 (UMLS CUI [4,3])
C0010068 (UMLS CUI [4,4])
C0449238 (UMLS CUI [4,5])
C1522577 (UMLS CUI [5,1])
C1861172 (UMLS CUI [5,2])
C0449238 (UMLS CUI [5,3])
Elig.phs001368.v3.p2.3
Item
CHS publications describe the methods for prevalent (PMID: 8520708) and incident events (PMID: 26538580).
boolean
C0034036 (UMLS CUI [1,1])
C0025663 (UMLS CUI [1,2])
C5204628 (UMLS CUI [1,3])
C0441471 (UMLS CUI [1,4])
C0034036 (UMLS CUI [2,1])
C0025663 (UMLS CUI [2,2])
C1551358 (UMLS CUI [2,3])
C0441471 (UMLS CUI [2,4])
Elig.phs001368.v3.p2.4
Item
VTE includes both deep vein thrombosis (DVT) in which a blood clot forms in a vein deep in the body, and pulmonary embolism (PE) where a blood clot travels to the lungs and blocks blood flow. The objectively diagnosed DVT and PE cases were confirmed by venous or pulmonary imaging, pathology examination of the thrombus removed at surgery, or by autopsy. In addition, many CHS participants have had other cardiovascular events, including atrial fibrillation (AF), angina, and heart failure (HF).
boolean
C1861172 (UMLS CUI [1,1])
C0332257 (UMLS CUI [1,2])
C0149871 (UMLS CUI [1,3])
C0034065 (UMLS CUI [1,4])
C0750484 (UMLS CUI [2,1])
C0149871 (UMLS CUI [2,2])
C0034065 (UMLS CUI [2,3])
C0011923 (UMLS CUI [2,4])
C0807321 (UMLS CUI [2,5])
C0004398 (UMLS CUI [2,6])
C0679646 (UMLS CUI [3,1])
C0010068 (UMLS CUI [3,2])
C1524062 (UMLS CUI [3,3])
C1320716 (UMLS CUI [3,4])
C0004238 (UMLS CUI [3,5])
C0002962 (UMLS CUI [3,6])
C0018801 (UMLS CUI [3,7])
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