ID

45508

Beskrivning

Principal Investigator: Ronald M. Krauss, MD, University of California San Francisco, Oakland, CA, USA MeSH: Hypercholesterolemia,Cardiovascular Diseases,Hydroxymethylglutaryl-CoA Reductase Inhibitors https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000481 The Cholesterol and Pharmacogenetics Study was a 6-week open label, non-randomized study of 40mg/day simvastatin treatment in 335 black and 609 white (944 total) men and women. Plasma lipids and lipoproteins were measured on two occasions prior to treatment and at 4 and 6 weeks of treatment. The study was designed to test for genetic associations with baseline measurements and changes in response to simvastatin treatment. Whole genome genotyping was performed on 592 white CAP study participants in two stages. In Stage 1, 304 were genotyped for 314,621 SNPs to tag for common genomic variation. In Stage 2, 290 participants were genotyped, including 280 who were genotyped for 620,901 SNPs. Two samples were excluded due to gender discrepancies. More recently, CAP self-reported black participants were genotyped on Illumina Omni2.5Exome chips. PolyA-selected strand-specific RNA-seq libraries were generated in several batches from lymphoblastoid cell lines (LCLs) derived from 268 white and 165 black CAP participants. The LCLs were exposed to sham buffer (control) or 2 uM activated simvastatin for 24 hours, producing a total of 866 100/101 bp paired end RNA-seq libraries sequenced on Illumina HiSeq 2000 machines.

Länk

dbGap study = phs000481

Nyckelord

Versioner (2)
  1. 16/11/22 16/11/22 - Kristina Keller
  2. 13/12/22 13/12/22 - Kristina Keller
Rättsinnehavare

Ronald M. Krauss, MD, University of California San Francisco, Oakland, CA, USA

Uppladdad den

13 dicembre 2022

DOI

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Licens

Creative Commons BY 4.0
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dbGaP phs000481 Cholesterol and Pharmacogenetics (CAP) Study

Engelsk

Subject ID, genotyping platform, gender, race, age, BMI, smoking status, mean triglyceride level in blood, mean total cholesterol in blood, mean low-density lipoprotein cholesterol level in blood, mean low-density lipoprotein cholesterol level in blood, mean high-density lipoprotein cholesterol level in blood, enrollment visit placebo pill count compliance (%), visit 1, 2 and 3 simvastatin pill count compliance (%) of Subject ID, sample ID, and sample use variable obtained from participants involved in the "Cholesterol and Pharmacogenetics (CAP) Study" project.

6 Formulär  
pht002661
Beskrivning

pht002661

De-identified subject ID
Beskrivning

SUBJECT_ID

Datatyp

string

Alias
UMLS CUI [1,1]
C2348585
UMLS CUI [1,2]
C4684638
Illumina HumanHap genotyping platform HumanHap300k or HumanHap 610k-Quad
Beskrivning

GenoPlatform

Datatyp

string

Alias
UMLS CUI [1,1]
C1285573
UMLS CUI [1,2]
C1710360
Gender [Male or Female]
Beskrivning

Sex

Datatyp

string

Alias
UMLS CUI [1,1]
C0079399
UMLS CUI [1,2]
C0086582
UMLS CUI [1,3]
C0086287
Age
Beskrivning

Age

Datatyp

float

Måttenheter
  • years
Alias
UMLS CUI [1,1]
C0001779
years
Self-reported race (>=3 of 4 grandparents)
Beskrivning

Race

Datatyp

string

Alias
UMLS CUI [1,1]
C0034510
UMLS CUI [1,2]
C0681906
Body Mass Index
Beskrivning

BMI

Datatyp

float

Alias
UMLS CUI [1,1]
C1305855
Smoking status [non-smoker=0, smoker=1]
Beskrivning

Smoker

Datatyp

text

Alias
UMLS CUI [1,1]
C1519386
Mean triglyceride level in blood collected at screening and enrollment visits, mg/dL
Beskrivning

mTg_SVEV

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1,1]
C0542495
UMLS CUI [1,2]
C0220908
UMLS CUI [2,1]
C0542495
UMLS CUI [2,2]
C1516879
mg/dL
Mean triglyceride level in blood collected at visits 2 & 3 (on simvastatin), mg/dL
Beskrivning

mTg_V2V3

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1,1]
C0582824
UMLS CUI [1,2]
C0074554
mg/dL
Mean total cholesterol level in blood collected at screening and enrollment visits, mg/dL
Beskrivning

mTC_SVEV

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1,1]
C1445957
UMLS CUI [1,2]
C0220908
UMLS CUI [2,1]
C1445957
UMLS CUI [2,2]
C1516879
mg/dL
Mean total cholesterol level in blood collected at visits 2 & 3 (on simvastatin), mg/dL
Beskrivning

mTC_V2V3

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1,1]
C1445957
UMLS CUI [1,2]
C0074554
mg/dL
Mean low-density lipoprotein cholesterol level in blood collected at screening and enrollment visits, mg/dL
Beskrivning

mLDLC_SVEV

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1,1]
C0202117
UMLS CUI [1,2]
C0220908
UMLS CUI [2,1]
C1516879
UMLS CUI [2,2]
C0202117
mg/dL
Mean low-density lipoprotein cholesterol level in blood collected at visits 2 & 3 (on simvastatin), mg/dL
Beskrivning

mLDLC_V2V3

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1,1]
C0202117
UMLS CUI [1,2]
C0074554
mg/dL
Mean high-density lipoprotein cholesterol level in blood collected at screening and enrollment visits, mg/dL
Beskrivning

mHDLC_SVEV

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1,1]
C0392885
UMLS CUI [1,2]
C0220908
UMLS CUI [2,1]
C0392885
UMLS CUI [2,2]
C1516879
mg/dL
Mean high-density lipoprotein cholesterol level in blood collected at visits 2 & 3 (on simvastatin), mg/dL
Beskrivning

mHDLC_V2V3

Datatyp

float

Måttenheter
  • mg/dL
Alias
UMLS CUI [1,1]
C0392885
UMLS CUI [1,2]
C0074554
mg/dL
Enrollment visit placebo pill count compliance (%)
Beskrivning

compliance_EV

Datatyp

float

Måttenheter
  • %
Alias
UMLS CUI [1,1]
C1516879
UMLS CUI [1,2]
C1696465
UMLS CUI [1,3]
C1321605
UMLS CUI [1,4]
C5419043
%
Visit 1 (first 2 week period) simvastatin pill count compliance (%)
Beskrivning

compliance_V1

Datatyp

float

Måttenheter
  • %
Alias
UMLS CUI [1,1]
C1321605
UMLS CUI [1,2]
C5419043
UMLS CUI [1,3]
C0074554
UMLS CUI [1,4]
C0205435
UMLS CUI [1,5]
C0545082
%
Visit 2 (second 2 week period) simvastatin pill count compliance (%)
Beskrivning

compliance_V2

Datatyp

float

Måttenheter
  • %
Alias
UMLS CUI [1,1]
C1321605
UMLS CUI [1,2]
C5419043
UMLS CUI [1,3]
C0074554
UMLS CUI [1,4]
C0205436
UMLS CUI [1,5]
C0545082
%
Visit 3 (third 2 week period) simvastatin pill count compliance (%)
Beskrivning

compliance_V3

Datatyp

float

Måttenheter
  • %
Alias
UMLS CUI [1,1]
C1321605
UMLS CUI [1,2]
C5419043
UMLS CUI [1,3]
C0074554
UMLS CUI [1,4]
C0205437
UMLS CUI [1,5]
C0545082
%
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Similar models

Subject ID, genotyping platform, gender, race, age, BMI, smoking status, mean triglyceride level in blood, mean total cholesterol in blood, mean low-density lipoprotein cholesterol level in blood, mean low-density lipoprotein cholesterol level in blood, mean high-density lipoprotein cholesterol level in blood, enrollment visit placebo pill count compliance (%), visit 1, 2 and 3 simvastatin pill count compliance (%) of Subject ID, sample ID, and sample use variable obtained from participants involved in the "Cholesterol and Pharmacogenetics (CAP) Study" project.

6 Formulär
Name
Typ
Description | Question | Decode (Coded Value)
Datatyp
Alias
Item Group
pht002661
SUBJECT_ID
Item
De-identified subject ID
string
C2348585 (UMLS CUI [1,1])
C4684638 (UMLS CUI [1,2])
GenoPlatform
Item
Illumina HumanHap genotyping platform HumanHap300k or HumanHap 610k-Quad
string
C1285573 (UMLS CUI [1,1])
C1710360 (UMLS CUI [1,2])
Sex
Item
Gender [Male or Female]
string
C0079399 (UMLS CUI [1,1])
C0086582 (UMLS CUI [1,2])
C0086287 (UMLS CUI [1,3])
Age
Item
Age
float
C0001779 (UMLS CUI [1,1])
Race
Item
Self-reported race (>=3 of 4 grandparents)
string
C0034510 (UMLS CUI [1,1])
C0681906 (UMLS CUI [1,2])
BMI
Item
Body Mass Index
float
C1305855 (UMLS CUI [1,1])
Item
Smoking status [non-smoker=0, smoker=1]
text
C1519386 (UMLS CUI [1,1])
Smoker
Code List
Smoking status [non-smoker=0, smoker=1]
CL Item
Non-smoker (0)
CL Item
Smoker (1)
mTg_SVEV
Item
Mean triglyceride level in blood collected at screening and enrollment visits, mg/dL
float
C0542495 (UMLS CUI [1,1])
C0220908 (UMLS CUI [1,2])
C0542495 (UMLS CUI [2,1])
C1516879 (UMLS CUI [2,2])
mTg_V2V3
Item
Mean triglyceride level in blood collected at visits 2 & 3 (on simvastatin), mg/dL
float
C0582824 (UMLS CUI [1,1])
C0074554 (UMLS CUI [1,2])
mTC_SVEV
Item
Mean total cholesterol level in blood collected at screening and enrollment visits, mg/dL
float
C1445957 (UMLS CUI [1,1])
C0220908 (UMLS CUI [1,2])
C1445957 (UMLS CUI [2,1])
C1516879 (UMLS CUI [2,2])
mTC_V2V3
Item
Mean total cholesterol level in blood collected at visits 2 & 3 (on simvastatin), mg/dL
float
C1445957 (UMLS CUI [1,1])
C0074554 (UMLS CUI [1,2])
mLDLC_SVEV
Item
Mean low-density lipoprotein cholesterol level in blood collected at screening and enrollment visits, mg/dL
float
C0202117 (UMLS CUI [1,1])
C0220908 (UMLS CUI [1,2])
C1516879 (UMLS CUI [2,1])
C0202117 (UMLS CUI [2,2])
mLDLC_V2V3
Item
Mean low-density lipoprotein cholesterol level in blood collected at visits 2 & 3 (on simvastatin), mg/dL
float
C0202117 (UMLS CUI [1,1])
C0074554 (UMLS CUI [1,2])
mHDLC_SVEV
Item
Mean high-density lipoprotein cholesterol level in blood collected at screening and enrollment visits, mg/dL
float
C0392885 (UMLS CUI [1,1])
C0220908 (UMLS CUI [1,2])
C0392885 (UMLS CUI [2,1])
C1516879 (UMLS CUI [2,2])
mHDLC_V2V3
Item
Mean high-density lipoprotein cholesterol level in blood collected at visits 2 & 3 (on simvastatin), mg/dL
float
C0392885 (UMLS CUI [1,1])
C0074554 (UMLS CUI [1,2])
compliance_EV
Item
Enrollment visit placebo pill count compliance (%)
float
C1516879 (UMLS CUI [1,1])
C1696465 (UMLS CUI [1,2])
C1321605 (UMLS CUI [1,3])
C5419043 (UMLS CUI [1,4])
compliance_V1
Item
Visit 1 (first 2 week period) simvastatin pill count compliance (%)
float
C1321605 (UMLS CUI [1,1])
C5419043 (UMLS CUI [1,2])
C0074554 (UMLS CUI [1,3])
C0205435 (UMLS CUI [1,4])
C0545082 (UMLS CUI [1,5])
compliance_V2
Item
Visit 2 (second 2 week period) simvastatin pill count compliance (%)
float
C1321605 (UMLS CUI [1,1])
C5419043 (UMLS CUI [1,2])
C0074554 (UMLS CUI [1,3])
C0205436 (UMLS CUI [1,4])
C0545082 (UMLS CUI [1,5])
compliance_V3
Item
Visit 3 (third 2 week period) simvastatin pill count compliance (%)
float
C1321605 (UMLS CUI [1,1])
C5419043 (UMLS CUI [1,2])
C0074554 (UMLS CUI [1,3])
C0205437 (UMLS CUI [1,4])
C0545082 (UMLS CUI [1,5])
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