0 Ratings

ID

45476

Description

Principal Investigator: Todd Lencz, PhD, Feinstein Institute for Medical Research, North Shore - LIJ Health System, Manhasset, NY, USA MeSH: Schizophrenia https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000448 Schizophrenia is characterized by high heritability (~80%), yet the identification of susceptibility genes has proven extremely challenging. The Ashkenazi Jewish population, derived from a limited number of founders, may be enriched for a subset of susceptibility alleles, which may also have higher odds ratios than those detected by previous studies. GWAS was conducted in a large Ashkenazi case-control cohort, derived from the Hebrew University Genetic Resource, using the Illumina HumanOmni1-Quad BeadChip.

Link

dbGap study = phs000448

Keywords

  1. 10/26/22 10/26/22 - Simon Heim
  2. 12/13/22 12/13/22 - Kristina Keller
Copyright Holder

Todd Lencz, PhD, Feinstein Institute for Medical Research, North Shore - LIJ Health System, Manhasset, NY, USA

Uploaded on

December 13, 2022

DOI

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License

Creative Commons BY 4.0

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    dbGaP phs000448 Genetics of Schizophrenia in an Ashkenazi Jewish Case-Control Cohort

    Eligibility Criteria

    Inclusion and exclusion criteria
    Description

    Inclusion and exclusion criteria

    Inclusion criteria for all subjects: self-identified 4 grandparents of Ashkenazi Jewish heritage Inclusion criteria for cases: hospitalized inpatients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder.
    Description

    Inclusion criteria for all subjects: self-identified 4 grandparents of Ashkenazi Jewish heritage Inclusion criteria for cases: hospitalized inpatients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder.

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1512693 (Inclusion)
    UMLS CUI [1,2]
    C0009932 (Control Groups)
    UMLS CUI [1,3]
    C1706256 (Clinical Study Case)
    UMLS CUI [1,4]
    C0337471 (grandparent)
    SNOMED
    38312007
    UMLS CUI [1,5]
    C2135555 (racial background: Ashkenazi Jewish)
    UMLS CUI [2,1]
    C1512693 (Inclusion)
    UMLS CUI [2,2]
    C1706256 (Clinical Study Case)
    UMLS CUI [2,3]
    C0220952 (DSM-IV)
    UMLS CUI [2,4]
    C0036341 (Schizophrenia)
    SNOMED
    58214004
    LOINC
    MTHU020814
    UMLS CUI [2,5]
    C0036337 (Schizoaffective Disorder)
    SNOMED
    191567000

    Similar models

    Eligibility Criteria

    Name
    Type
    Description | Question | Decode (Coded Value)
    Data type
    Alias
    Item Group
    Inclusion and exclusion criteria
    Inclusion criteria for all subjects: self-identified 4 grandparents of Ashkenazi Jewish heritage Inclusion criteria for cases: hospitalized inpatients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder.
    Item
    Inclusion criteria for all subjects: self-identified 4 grandparents of Ashkenazi Jewish heritage Inclusion criteria for cases: hospitalized inpatients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder.
    boolean
    C1512693 (UMLS CUI [1,1])
    C0009932 (UMLS CUI [1,2])
    C1706256 (UMLS CUI [1,3])
    C0337471 (UMLS CUI [1,4])
    C2135555 (UMLS CUI [1,5])
    C1512693 (UMLS CUI [2,1])
    C1706256 (UMLS CUI [2,2])
    C0220952 (UMLS CUI [2,3])
    C0036341 (UMLS CUI [2,4])
    C0036337 (UMLS CUI [2,5])

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