ID

45240

Descrição

Principal Investigator: Glenn S. Gerhard, MD, Weis Center for Research, Geisinger Clinic, Danville, PA, USA MeSH: Type 2 Diabetes,Obesity,Bariatric Surgery https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000408 The Geisinger eMERGE Genome-Wide Association Studies of Obesity Project is a genetic study of a cohort of primarily Caucasian patients with extreme obesity who have undergone bariatric surgery. Roux-en-Y gastric bypass (RYGB) surgery, in which intestinal anatomy is altered, dramatically ameliorates and/or eliminates Type 2 diabetes mellitus (T2D) in 50-80% of patients within hours to days following surgery, well before significant weight loss, in contrast to other types of bariatric surgeries, such as gastric banding, that attenuate insulin resistance as a result of substantial weight loss that occurs over months to years. The molecular mechanism by which RYGB exerts this clinical phenomenon occurs is not known. The goal of this project was to conduct a genome-wide association study (GWAS) to identify genetic variants associated with amelioration in T2D defined by medication independence. Identifying genetic variants that influence the dramatic resolution of T2D from RYGB may identify novel targets for pharmacological T2D therapies and/or identify patients in whom RYGB may not be effective.

Link

dbGaP study = phs000408

Palavras-chave

Versões (2)
  1. 13/07/2022 13/07/2022 - Dr. Christian Niklas
  2. 12/10/2022 12/10/2022 - Adrian Schulz
Titular dos direitos

Glenn S. Gerhard, MD, Weis Center for Research, Geisinger Clinic, Danville, PA, USA

Transferido a

12 de outubro de 2022

DOI

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Licença

Creative Commons BY 4.0
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dbGaP phs000408 eMERGE Genome-Wide Association Studies of Obesity

Inglês

Eligibility Criteria

5 Formulários  
Inclusion and exclusion criteria
Descrição

Inclusion and exclusion criteria

**Inclusion criteria:** An individual was eligible for participation in this study if they were an adult meeting the following criteria:
Descrição

Inclusion criteria

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C1512693
Competent patients interested in Gastric Bypass Surgery
Descrição

Competent patients interested in Gastric Bypass Surgery

Tipo de dados

boolean

Alias
UMLS CUI [2,1]
C1512693
UMLS CUI [2,2]
C0543488
UMLS CUI [2,3]
C0017125
Patients who were eligible for Gastric Bypass Surgery based on NIH criteria
Descrição

Patients who were eligible for Gastric Bypass Surgery based on NIH criteria

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C1548635
UMLS CUI [1,3]
C0017125
UMLS CUI [1,4]
C0027468
UMLS CUI [1,5]
C0243161
**Exclusion criteria:**
Descrição

Exclusion criteria

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
Patients not interested in Gastric Bypass Surgery
Descrição

Patients not interested in Gastric Bypass Surgery

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C2984077
UMLS CUI [1,3]
C0543488
UMLS CUI [1,4]
C0017125
Patients who did not qualify for surgery based on medical contraindications
Descrição

Patients who did not qualify for surgery based on medical contraindications

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0543467
UMLS CUI [1,3]
C1301624
Patients with severe psychological contraindications
Descrição

Patients with severe psychological contraindications

Tipo de dados

boolean

Alias
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C1301624
UMLS CUI [2,3]
C0205486
UMLS CUI [2,4]
C0205082
Patients not willing to be compliant with pre-post surgical recommendations
Descrição

Patients not willing to be compliant with pre-post surgical recommendations

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0558080
UMLS CUI [1,3]
C1321605
UMLS CUI [1,4]
C0445204
UMLS CUI [1,5]
C0032790
UMLS CUI [1,6]
C0034866
Patients younger that 21 years of age
Descrição

Patients younger that 21 years of age

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0001779
Patients older than 70 years of age
Descrição

Patients older than 70 years of age

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0001779
Patients who were pregnant
Descrição

Patients who were pregnant

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [2,1]
C0032961
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Similar models

Eligibility Criteria

5 Formulários
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
Item Group
Inclusion and exclusion criteria
Inclusion criteria
Item
**Inclusion criteria:** An individual was eligible for participation in this study if they were an adult meeting the following criteria:
boolean
C1512693 (UMLS CUI [1,1])
Competent patients interested in Gastric Bypass Surgery
Item
Competent patients interested in Gastric Bypass Surgery
boolean
C1512693 (UMLS CUI [2,1])
C0543488 (UMLS CUI [2,2])
C0017125 (UMLS CUI [2,3])
Patients who were eligible for Gastric Bypass Surgery based on NIH criteria
Item
Patients who were eligible for Gastric Bypass Surgery based on NIH criteria
boolean
C1512693 (UMLS CUI [1,1])
C1548635 (UMLS CUI [1,2])
C0017125 (UMLS CUI [1,3])
C0027468 (UMLS CUI [1,4])
C0243161 (UMLS CUI [1,5])
Exclusion criteria
Item
**Exclusion criteria:**
boolean
C0680251 (UMLS CUI [1,1])
Patients not interested in Gastric Bypass Surgery
Item
Patients not interested in Gastric Bypass Surgery
boolean
C0680251 (UMLS CUI [1,1])
C2984077 (UMLS CUI [1,2])
C0543488 (UMLS CUI [1,3])
C0017125 (UMLS CUI [1,4])
Patients who did not qualify for surgery based on medical contraindications
Item
Patients who did not qualify for surgery based on medical contraindications
boolean
C0680251 (UMLS CUI [1,1])
C0543467 (UMLS CUI [1,2])
C1301624 (UMLS CUI [1,3])
Patients with severe psychological contraindications
Item
Patients with severe psychological contraindications
boolean
C0680251 (UMLS CUI [2,1])
C1301624 (UMLS CUI [2,2])
C0205486 (UMLS CUI [2,3])
C0205082 (UMLS CUI [2,4])
Patients not willing to be compliant with pre-post surgical recommendations
Item
Patients not willing to be compliant with pre-post surgical recommendations
boolean
C0680251 (UMLS CUI [1,1])
C0558080 (UMLS CUI [1,2])
C1321605 (UMLS CUI [1,3])
C0445204 (UMLS CUI [1,4])
C0032790 (UMLS CUI [1,5])
C0034866 (UMLS CUI [1,6])
Patients younger that 21 years of age
Item
Patients younger that 21 years of age
boolean
C0680251 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
Patients older than 70 years of age
Item
Patients older than 70 years of age
boolean
C0680251 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
Patients who were pregnant
Item
Patients who were pregnant
boolean
C0680251 (UMLS CUI [1,1])
C0032961 (UMLS CUI [2,1])
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