ID

45017

Descrizione

Principal Investigator: Glenn S. Gerhard, MD, Weis Center for Research, Geisinger Clinic, Danville, PA, USA MeSH: Type 2 Diabetes,Obesity,Bariatric Surgery https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000408 The Geisinger eMERGE Genome-Wide Association Studies of Obesity Project is a genetic study of a cohort of primarily Caucasian patients with extreme obesity who have undergone bariatric surgery. Roux-en-Y gastric bypass (RYGB) surgery, in which intestinal anatomy is altered, dramatically ameliorates and/or eliminates Type 2 diabetes mellitus (T2D) in 50-80% of patients within hours to days following surgery, well before significant weight loss, in contrast to other types of bariatric surgeries, such as gastric banding, that attenuate insulin resistance as a result of substantial weight loss that occurs over months to years. The molecular mechanism by which RYGB exerts this clinical phenomenon occurs is not known. The goal of this project was to conduct a genome-wide association study (GWAS) to identify genetic variants associated with amelioration in T2D defined by medication independence. Identifying genetic variants that influence the dramatic resolution of T2D from RYGB may identify novel targets for pharmacological T2D therapies and/or identify patients in whom RYGB may not be effective.

collegamento

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000408

Keywords

versioni (2)
  1. 13/07/22 13/07/22 - Dr. Christian Niklas
  2. 12/10/22 12/10/22 - Adrian Schulz
Titolare del copyright

Glenn S. Gerhard, MD, Weis Center for Research, Geisinger Clinic, Danville, PA, USA

Caricato su

13 luglio 2022

DOI

Per favore, per richiedere un accesso.

Licenza

Creative Commons BY 4.0
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dbGaP phs000408 eMERGE Genome-Wide Association Studies of Obesity

Inglese

Eligibility Criteria

5 moduli  
Inclusion and exclusion criteria
Descrizione

Inclusion and exclusion criteria

**Inclusion criteria:** An individual was eligible for participation in this study if they were an adult meeting the following criteria:
Descrizione

Inclusion criteria

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C1512693
Competent patients interested in Gastric Bypass Surgery
Descrizione

Competent patients interested in Gastric Bypass Surgery

Tipo di dati

boolean

Alias
UMLS CUI [2,1]
C1512693
UMLS CUI [2,2]
C0543488
UMLS CUI [2,3]
C0017125
Patients who were eligible for Gastric Bypass Surgery based on NIH criteria
Descrizione

Patients who were eligible for Gastric Bypass Surgery based on NIH criteria

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C1548635
UMLS CUI [1,3]
C0017125
UMLS CUI [1,4]
C0027468
UMLS CUI [1,5]
C0243161
**Exclusion criteria:**
Descrizione

Exclusion criteria

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0680251
Patients not interested in Gastric Bypass Surgery
Descrizione

Patients not interested in Gastric Bypass Surgery

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C2984077
UMLS CUI [1,3]
C0543488
UMLS CUI [1,4]
C0017125
Patients who did not qualify for surgery based on medical contraindications
Descrizione

Patients who did not qualify for surgery based on medical contraindications

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0543467
UMLS CUI [1,3]
C1301624
Patients with severe psychological contraindications
Descrizione

Patients with severe psychological contraindications

Tipo di dati

boolean

Alias
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C1301624
UMLS CUI [2,3]
C0205486
UMLS CUI [2,4]
C0205082
Patients not willing to be compliant with pre-post surgical recommendations
Descrizione

Patients not willing to be compliant with pre-post surgical recommendations

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0558080
UMLS CUI [1,3]
C1321605
UMLS CUI [1,4]
C0445204
UMLS CUI [1,5]
C0032790
UMLS CUI [1,6]
C0034866
Patients younger that 21 years of age
Descrizione

Patients younger that 21 years of age

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0001779
Patients older than 70 years of age
Descrizione

Patients older than 70 years of age

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0001779
Patients who were pregnant
Descrizione

Patients who were pregnant

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [2,1]
C0032961
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Similar models

Eligibility Criteria

5 moduli
Name
genere
Description | Question | Decode (Coded Value)
Tipo di dati
Alias
Item Group
Inclusion and exclusion criteria
Inclusion criteria
Item
**Inclusion criteria:** An individual was eligible for participation in this study if they were an adult meeting the following criteria:
boolean
C1512693 (UMLS CUI [1,1])
Competent patients interested in Gastric Bypass Surgery
Item
Competent patients interested in Gastric Bypass Surgery
boolean
C1512693 (UMLS CUI [2,1])
C0543488 (UMLS CUI [2,2])
C0017125 (UMLS CUI [2,3])
Patients who were eligible for Gastric Bypass Surgery based on NIH criteria
Item
Patients who were eligible for Gastric Bypass Surgery based on NIH criteria
boolean
C1512693 (UMLS CUI [1,1])
C1548635 (UMLS CUI [1,2])
C0017125 (UMLS CUI [1,3])
C0027468 (UMLS CUI [1,4])
C0243161 (UMLS CUI [1,5])
Exclusion criteria
Item
**Exclusion criteria:**
boolean
C0680251 (UMLS CUI [1,1])
Patients not interested in Gastric Bypass Surgery
Item
Patients not interested in Gastric Bypass Surgery
boolean
C0680251 (UMLS CUI [1,1])
C2984077 (UMLS CUI [1,2])
C0543488 (UMLS CUI [1,3])
C0017125 (UMLS CUI [1,4])
Patients who did not qualify for surgery based on medical contraindications
Item
Patients who did not qualify for surgery based on medical contraindications
boolean
C0680251 (UMLS CUI [1,1])
C0543467 (UMLS CUI [1,2])
C1301624 (UMLS CUI [1,3])
Patients with severe psychological contraindications
Item
Patients with severe psychological contraindications
boolean
C0680251 (UMLS CUI [2,1])
C1301624 (UMLS CUI [2,2])
C0205486 (UMLS CUI [2,3])
C0205082 (UMLS CUI [2,4])
Patients not willing to be compliant with pre-post surgical recommendations
Item
Patients not willing to be compliant with pre-post surgical recommendations
boolean
C0680251 (UMLS CUI [1,1])
C0558080 (UMLS CUI [1,2])
C1321605 (UMLS CUI [1,3])
C0445204 (UMLS CUI [1,4])
C0032790 (UMLS CUI [1,5])
C0034866 (UMLS CUI [1,6])
Patients younger that 21 years of age
Item
Patients younger that 21 years of age
boolean
C0680251 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
Patients older than 70 years of age
Item
Patients older than 70 years of age
boolean
C0680251 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
Patients who were pregnant
Item
Patients who were pregnant
boolean
C0680251 (UMLS CUI [1,1])
C0032961 (UMLS CUI [2,1])
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