ID
44995
Descrição
Principal Investigator: Braxton D. Mitchell, PhD, University of Maryland, Baltimore, MD, USA MeSH: Stroke https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000292 The Genetics of Early Onset Stroke (GEOS) Study is a population-based case-control study designed to identify genes associated with early-onset ischemic stroke and to characterize interactions of identified stroke genes and/or SNPs with environmental risk factors such as smoking and oral contraceptive use. The GEOS study consists of 921 ischemic stroke cases with age of first stroke 16-50 years and a similar number of controls, identified from the Baltimore-Washington area. Cases and controls were recruited in 3 different time periods: Stroke Prevention in Young Women-1 (SPYW-1) conducted from 1992-1996, Stroke Prevention in Young Women-2 (SPYW-2) conducted from 2001-2003, and Stroke Prevention in Young Men (SPYM) conducted from 2003-2007. The overall GEOS sample includes 477 cases who self-reported their race as "white" and 396 cases who self-reported their race as "African American." Traditional stroke risk factors and other study variables, including age, ethnicity, and history of hypertension, diabetes, myocardial infarction (MI), current smoking status, and current oral contraceptive use (both defined as use within one month prior to event for cases and at a comparable reference time for controls), were also collected during standardized interview and were included as covariates in our analyses. This study is part of the Gene Environment Association Studies initiative (GENEVA, http://www.genevastudy.org) funded by the trans-NIH Genes, Environment, and Health Initiative (GEI). The overarching goal is to identify novel genetic factors that contribute to early-onset ischemic stroke through large-scale genome-wide association studies of cases and controls of European and African descent from the Baltimore-Washington area. Genotyping was performed at the Johns Hopkins University Center for Inherited Disease Research (CIDR). Data cleaning and harmonization were done at the GEI-funded GENEVA Coordinating Center at the University of Washington.
Link
https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000292
Palavras-chave
Versões (2)
- 23/06/2022 23/06/2022 - Dr. Christian Niklas
- 12/10/2022 12/10/2022 - Adrian Schulz
Titular dos direitos
Braxton D. Mitchell, PhD, University of Maryland, Baltimore, MD, USA
Transferido a
23 de junho de 2022
DOI
Para um pedido faça login.
Licença
Creative Commons BY 4.0
Comentários do modelo :
Aqui pode comentar o modelo. Pode comentá-lo especificamente através dos balões de texto nos grupos de itens e itens.
Comentários do grupo de itens para :
Comentários do item para :
Para descarregar formulários, precisa de ter uma sessão iniciada. Por favor faça login ou registe-se gratuitamente.
dbGaP phs000292 GENEVA Genetics of Early Onset Stroke (GEOS) Study
GEOS - Pedigree Information
- StudyEvent: SEV1
- Eligibility Criteria
- GEOS - Subject - Consent Information
- GEOS - Pedigree Information
- GEOS - Subject - Sample Mapping
- The data set provides general information about medical history associated with the occurrence of stroke (e.g. high blood pressure, diabetes, heart attack, use of oral contraceptives), sociodemographic factors (e.g. age, race) and smoking history.
Similar models
GEOS - Pedigree Information
- StudyEvent: SEV1
- Eligibility Criteria
- GEOS - Subject - Consent Information
- GEOS - Pedigree Information
- GEOS - Subject - Sample Mapping
- The data set provides general information about medical history associated with the occurrence of stroke (e.g. high blood pressure, diabetes, heart attack, use of oral contraceptives), sociodemographic factors (e.g. age, race) and smoking history.
C2348585 (UMLS CUI [1,2])