ID

46144

Description

Principal Investigator: Braxton D. Mitchell, PhD, University of Maryland, Baltimore, MD, USA MeSH: Stroke https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000292 The Genetics of Early Onset Stroke (GEOS) Study is a population-based case-control study designed to identify genes associated with early-onset ischemic stroke and to characterize interactions of identified stroke genes and/or SNPs with environmental risk factors such as smoking and oral contraceptive use. The GEOS study consists of 921 ischemic stroke cases with age of first stroke 16-50 years and a similar number of controls, identified from the Baltimore-Washington area. Cases and controls were recruited in 3 different time periods: Stroke Prevention in Young Women-1 (SPYW-1) conducted from 1992-1996, Stroke Prevention in Young Women-2 (SPYW-2) conducted from 2001-2003, and Stroke Prevention in Young Men (SPYM) conducted from 2003-2007. The overall GEOS sample includes 477 cases who self-reported their race as "white" and 396 cases who self-reported their race as "African American." Traditional stroke risk factors and other study variables, including age, ethnicity, and history of hypertension, diabetes, myocardial infarction (MI), current smoking status, and current oral contraceptive use (both defined as use within one month prior to event for cases and at a comparable reference time for controls), were also collected during standardized interview and were included as covariates in our analyses. This study is part of the Gene Environment Association Studies initiative (GENEVA, http://www.genevastudy.org) funded by the trans-NIH Genes, Environment, and Health Initiative (GEI). The overarching goal is to identify novel genetic factors that contribute to early-onset ischemic stroke through large-scale genome-wide association studies of cases and controls of European and African descent from the Baltimore-Washington area. Genotyping was performed at the Johns Hopkins University Center for Inherited Disease Research (CIDR). Data cleaning and harmonization were done at the GEI-funded GENEVA Coordinating Center at the University of Washington.

Link

dbGaP study=phs000292

Keywords

Versions (3)
  1. 6/23/22 6/23/22 - Dr. Christian Niklas
  2. 10/12/22 10/12/22 - Adrian Schulz
  3. 1/29/25 1/29/25 - Akane Nishihara
Copyright Holder

Braxton D. Mitchell, PhD, University of Maryland, Baltimore, MD, USA

Uploaded on

January 29, 2025

DOI

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License

Creative Commons BY 4.0
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dbGaP phs000292 GENEVA Genetics of Early Onset Stroke (GEOS) Study

English

Eligibility Criteria

5 forms  
Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

*Cases:* Inclusion: age at stroke 16-50 Exclusions: stroke occurring as an immediate consequence of trauma; stroke within 48 hours after a hospital procedure, stroke within 60 days after the onset of a non-traumatic subarachnoid hemorrhage, and cerebral venous thrombosis. Additional exclusions for these genetic analyses were known single-gene or mitochondrial disorder recognized by a distinctive phenotype (e.g., cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), homocystinuria, Fabry disease, or sickle cell anemia); mechanical aortic or mitral valve at the time of index stroke; untreated or actively treated bacterial endocarditis at the time of the index stroke; neurosyphilis or other CNS infections; neurosarcoidosis; severe sepsis with hypotension at the time of the index stroke; cerebral vasculitis by angiogram and clinical criteria; post-radiation arteriopathy; left atrial myxoma; major congenital heart disease; and cocaine use in the 48 hours prior to their stroke.
Description

Elig.phs000292.v1.p1.1

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C1706256
UMLS CUI [1,3]
C0038454
UMLS CUI [1,4]
C0001779
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C1706256
UMLS CUI [2,3]
C0332663
UMLS CUI [2,4]
C0038454
UMLS CUI [3,1]
C0680251
UMLS CUI [3,2]
C1706256
UMLS CUI [3,3]
C2036446
UMLS CUI [4,1]
C0680251
UMLS CUI [4,2]
C1706256
UMLS CUI [4,3]
C5230186
UMLS CUI [5,1]
C0680251
UMLS CUI [5,2]
C1706256
UMLS CUI [5,3]
C0151945
UMLS CUI [6,1]
C0680251
UMLS CUI [6,2]
C1706256
UMLS CUI [6,3]
C0518959
UMLS CUI [7,1]
C0680251
UMLS CUI [7,2]
C1706256
UMLS CUI [7,3]
C0152021
UMLS CUI [8,1]
C0680251
UMLS CUI [8,2]
C1706256
UMLS CUI [8,3]
C0239076
UMLS CUI [9,1]
C0680251
UMLS CUI [9,2]
C1706256
UMLS CUI [9,3]
C0162671
UMLS CUI [10,1]
C0680251
UMLS CUI [10,2]
C1706256
UMLS CUI [10,3]
C0396886
UMLS CUI [11,1]
C0680251
UMLS CUI [11,2]
C1706256
UMLS CUI [11,3]
C0396982
UMLS CUI [12,1]
C0680251
UMLS CUI [12,2]
C1706256
UMLS CUI [12,3]
C0475343
UMLS CUI [13,1]
C0680251
UMLS CUI [13,2]
C1706256
UMLS CUI [13,3]
C0751587
UMLS CUI [14,1]
C0680251
UMLS CUI [14,2]
C1706256
UMLS CUI [14,3]
C0014121
UMLS CUI [15,1]
C0680251
UMLS CUI [15,2]
C1706256
UMLS CUI [15,3]
C0007684
UMLS CUI [16,1]
C0680251
UMLS CUI [16,2]
C1706256
UMLS CUI [16,3]
C0393485
UMLS CUI [17,1]
C0680251
UMLS CUI [17,2]
C1706256
UMLS CUI [17,3]
C1719672
UMLS CUI [18,1]
C0680251
UMLS CUI [18,2]
C1706256
UMLS CUI [18,3]
C0238051
UMLS CUI [19,1]
C0680251
UMLS CUI [19,2]
C1706256
UMLS CUI [19,3]
C0034530
UMLS CUI [19,4]
C0852949
*Controls:* Exclusions: history of stroke
Description

Elig.phs000292.v1.p1.2

Data type

boolean

Alias
UMLS CUI [1,1]
C0009932
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C0559159
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Similar models

Eligibility Criteria

5 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
Elig.phs000292.v1.p1.1
Item
*Cases:* Inclusion: age at stroke 16-50 Exclusions: stroke occurring as an immediate consequence of trauma; stroke within 48 hours after a hospital procedure, stroke within 60 days after the onset of a non-traumatic subarachnoid hemorrhage, and cerebral venous thrombosis. Additional exclusions for these genetic analyses were known single-gene or mitochondrial disorder recognized by a distinctive phenotype (e.g., cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), homocystinuria, Fabry disease, or sickle cell anemia); mechanical aortic or mitral valve at the time of index stroke; untreated or actively treated bacterial endocarditis at the time of the index stroke; neurosyphilis or other CNS infections; neurosarcoidosis; severe sepsis with hypotension at the time of the index stroke; cerebral vasculitis by angiogram and clinical criteria; post-radiation arteriopathy; left atrial myxoma; major congenital heart disease; and cocaine use in the 48 hours prior to their stroke.
boolean
C1512693 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0038454 (UMLS CUI [1,3])
C0001779 (UMLS CUI [1,4])
C0680251 (UMLS CUI [2,1])
C1706256 (UMLS CUI [2,2])
C0332663 (UMLS CUI [2,3])
C0038454 (UMLS CUI [2,4])
C0680251 (UMLS CUI [3,1])
C1706256 (UMLS CUI [3,2])
C2036446 (UMLS CUI [3,3])
C0680251 (UMLS CUI [4,1])
C1706256 (UMLS CUI [4,2])
C5230186 (UMLS CUI [4,3])
C0680251 (UMLS CUI [5,1])
C1706256 (UMLS CUI [5,2])
C0151945 (UMLS CUI [5,3])
C0680251 (UMLS CUI [6,1])
C1706256 (UMLS CUI [6,2])
C0518959 (UMLS CUI [6,3])
C0680251 (UMLS CUI [7,1])
C1706256 (UMLS CUI [7,2])
C0152021 (UMLS CUI [7,3])
C0680251 (UMLS CUI [8,1])
C1706256 (UMLS CUI [8,2])
C0239076 (UMLS CUI [8,3])
C0680251 (UMLS CUI [9,1])
C1706256 (UMLS CUI [9,2])
C0162671 (UMLS CUI [9,3])
C0680251 (UMLS CUI [10,1])
C1706256 (UMLS CUI [10,2])
C0396886 (UMLS CUI [10,3])
C0680251 (UMLS CUI [11,1])
C1706256 (UMLS CUI [11,2])
C0396982 (UMLS CUI [11,3])
C0680251 (UMLS CUI [12,1])
C1706256 (UMLS CUI [12,2])
C0475343 (UMLS CUI [12,3])
C0680251 (UMLS CUI [13,1])
C1706256 (UMLS CUI [13,2])
C0751587 (UMLS CUI [13,3])
C0680251 (UMLS CUI [14,1])
C1706256 (UMLS CUI [14,2])
C0014121 (UMLS CUI [14,3])
C0680251 (UMLS CUI [15,1])
C1706256 (UMLS CUI [15,2])
C0007684 (UMLS CUI [15,3])
C0680251 (UMLS CUI [16,1])
C1706256 (UMLS CUI [16,2])
C0393485 (UMLS CUI [16,3])
C0680251 (UMLS CUI [17,1])
C1706256 (UMLS CUI [17,2])
C1719672 (UMLS CUI [17,3])
C0680251 (UMLS CUI [18,1])
C1706256 (UMLS CUI [18,2])
C0238051 (UMLS CUI [18,3])
C0680251 (UMLS CUI [19,1])
C1706256 (UMLS CUI [19,2])
C0034530 (UMLS CUI [19,3])
C0852949 (UMLS CUI [19,4])
Elig.phs000292.v1.p1.2
Item
*Controls:* Exclusions: history of stroke
boolean
C0009932 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0559159 (UMLS CUI [1,3])
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