ID

44969

Beschreibung

Principal Investigator: Pablo V. Gejman, MD, NorthShore University HealthSystem (NUH), Evanston, IL, USA MeSH: Schizophrenia https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000021 The goal of the study is to find susceptibility genes for schizophrenia. *Dataset versioning* - Version 1: European-American (EA) ancestry only - Version 2: Version 1 plus African-American (AA) ancestry *Consent groups and participant set* - General research use (GRU): 4591 cases and controls (1217 EA cases, 1442 EA controls, 953 AA cases, 979 AA controls) This consent group includes a subset of schizophrenia cases and all controls (which overlap with Bipolar study controls in Bipolar: GRU dataset). - Schizophrenia and related disorders (SARC): 475 cases (187 EA cases, 288 AA cases) This consent group includes a subset of schizophrenia cases.

Link

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000021

Stichworte

Versionen (2)
  1. 12.05.22 12.05.22 - Martin Dugas
  2. 20.05.22 20.05.22 - Dr. Christian Niklas
Rechteinhaber

Pablo V. Gejman, MD, NorthShore University HealthSystem (NUH), Evanston, IL, USA

Hochgeladen am

20. Mai 2022

DOI

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Lizenz

Creative Commons BY 4.0
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dbGaP phs000021 Genome-Wide Association Study of Schizophrenia

Englisch

Eligibility Criteria

9 Formulare  
Inclusion and exclusion criteria
Beschreibung

Inclusion and exclusion criteria

*Inclusion criteria*
Beschreibung

Elig.phs000021.v3.p2.1

Datentyp

boolean

All subjects must give signed, informed consent.
Beschreibung

Elig.phs000021.v3.p2.2

Datentyp

boolean

Probands must have a consensus best-estimate DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) diagnosis of SZ (schizophrenia) or of schizoaffective disorder with at least six months' duration of the "A" criteria for schizophrenia.
Beschreibung

Elig.phs000021.v3.p2.3

Datentyp

boolean

Subjects must be over 18 years of age at interview, male or female.
Beschreibung

Elig.phs000021.v3.p2.4

Datentyp

boolean

The informant should have known the subject for at least two years, be familiar with the psychiatric history, and have at least one hour of contact per week with the proband (close family members preferred). *Exclusion criteria*
Beschreibung

Elig.phs000021.v3.p2.5

Datentyp

boolean

Unable to give informed consent to all aspects of the study.
Beschreibung

Elig.phs000021.v3.p2.6

Datentyp

boolean

Unable to speak and be interviewed in English (to ensure validity of the interviews).
Beschreibung

Elig.phs000021.v3.p2.7

Datentyp

boolean

Psychosis is deemed secondary to substance use by the consensus diagnostic procedure because psychotic symptoms are limited to periods of likely intoxication or withdrawal, or there are persistent symptoms which are likely to be related to substance use (i.e., increasing paranoia after years of amphetamine use; symptoms limited to visual hallucinations after extensive hallucinogen use).
Beschreibung

Elig.phs000021.v3.p2.8

Datentyp

boolean

The psychotic disorder is deemed secondary to a neurological disorder such as epilepsy based on the nature and timing of symptoms. For example, non-specific, non-focal EEG abnormalities are common in SZ, but subjects with psychosis that emerged in the context of temporal lobe epilepsy would be excluded.
Beschreibung

Elig.phs000021.v3.p2.9

Datentyp

boolean

Subjects with severe mental retardation (MR). Subjects with mild MR (IQ is greater than or equal to 55 or based on clinical and educational history) will be included, if SZ symptoms and history can be clearly established.
Beschreibung

Elig.phs000021.v3.p2.10

Datentyp

boolean

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Ähnliche Modelle

Eligibility Criteria

9 Formulare
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Inclusion and exclusion criteria
Elig.phs000021.v3.p2.1
Item
*Inclusion criteria*
boolean
Elig.phs000021.v3.p2.2
Item
All subjects must give signed, informed consent.
boolean
Elig.phs000021.v3.p2.3
Item
Probands must have a consensus best-estimate DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) diagnosis of SZ (schizophrenia) or of schizoaffective disorder with at least six months' duration of the "A" criteria for schizophrenia.
boolean
Elig.phs000021.v3.p2.4
Item
Subjects must be over 18 years of age at interview, male or female.
boolean
Elig.phs000021.v3.p2.5
Item
The informant should have known the subject for at least two years, be familiar with the psychiatric history, and have at least one hour of contact per week with the proband (close family members preferred). *Exclusion criteria*
boolean
Elig.phs000021.v3.p2.6
Item
Unable to give informed consent to all aspects of the study.
boolean
Elig.phs000021.v3.p2.7
Item
Unable to speak and be interviewed in English (to ensure validity of the interviews).
boolean
Elig.phs000021.v3.p2.8
Item
Psychosis is deemed secondary to substance use by the consensus diagnostic procedure because psychotic symptoms are limited to periods of likely intoxication or withdrawal, or there are persistent symptoms which are likely to be related to substance use (i.e., increasing paranoia after years of amphetamine use; symptoms limited to visual hallucinations after extensive hallucinogen use).
boolean
Elig.phs000021.v3.p2.9
Item
The psychotic disorder is deemed secondary to a neurological disorder such as epilepsy based on the nature and timing of symptoms. For example, non-specific, non-focal EEG abnormalities are common in SZ, but subjects with psychosis that emerged in the context of temporal lobe epilepsy would be excluded.
boolean
Elig.phs000021.v3.p2.10
Item
Subjects with severe mental retardation (MR). Subjects with mild MR (IQ is greater than or equal to 55 or based on clinical and educational history) will be included, if SZ symptoms and history can be clearly established.
boolean
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