ID
42476
Beskrivning
Study Title: LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients https://leoss.net Study Indication: COVID-19 Date: 19.03.2021 Published with permission by Prof. Dr. med. J.-J. Vehreschild. LEOSS, a multi-center cohort study, has been created to get more in-depth knowledge about the epidemiology and clinical course of patients infected with SARS-CoV-2. Initiated by the ESCMID Emerging Infections Task Force (EITaF) and the German Infectious Disease Society, and supported by all German Centers for Health Research (DZG), LEOSS has developed into an international network of contributors. Via an integrative research approach with anonymous recruitment and collection of routine data in an open science context, LEOSS is building a uniform clinical dataset and providing real-time analyses. For more information feel free to explore https://leoss.net/. Please note that only cases with known outcome are collected! Baseline / diagnosis is defined as the day the sample of the first positive SARS-CoV-2 result was taken. Criteria of the Uncomplicated Phase: Asymptomatic OR Symptoms of upper respiratory tract infection and/or Nausea, emesis, diarrhea and/or Fever Remember: The Uncomplicated Phase ends, if a previously febrile patient has no fever anymore and has completed 14 days of follow-up without entering Complicated or Critical Phase; then move to Recovery Phase. Also, as soon as one of the criteria of the Complicated or Critical Phase are fulfilled, Uncomplicated Phase ends; move over to there. If the patient has died, the phase ends with the death of the patient. If the patient has died, do not report terminal values, e.g. those recorded after switching off life-support or heart rate "0" after death of the patient. Criteria of the Complicated Phase: * Need for oxygen supplementation (In patients with prior oxygen home therapy, clinically meaningful increase in need for oxygenation.) * paO2 at room air < 70 mmHg * SO2 at room air < 90 % * GOT or GPT > 5x ULN * New cardiac arrhythmia * New pericardial effusion >1cm * New heart failure with pulmonary edema, congestive hepatopathy or peripheral edema Remember: The Complicated Phase ends, if none of the criteria for the Complicated Phase is fulfilled anymore AND the patient is free of fever; then move to Recovery Phase. Also, as soon as one of the criteria of the Critical Phase are fulfilled, Complicated Phase ends; move over to Critical Phase. If the patient has died, the phase ends with the death of the patient. If the patient has died, do not report terminal values, e.g. those recorded after switching off life-support or heart rate "0" after death of the patient. Criteria of the Critical Phase: * Need for catecholamines * Life-threatening cardiac arrhythmia * Mechanical ventilation (invasive or non-invasive) * Liver failure with Quick< 50% * qSOFA >= 2 * Renal failure in need of dialysis Remember: The Critical Phase ends as soon as none of the criteria for the Critical Phase is fulfilled anymore AND the patient is free of fever. If the patient has died, it ends with the death of the patient. If the patient has died, do not report terminal values, i.e. those recorded after turning off life-support or heart rate "0" after death of the patient. Criteria of the Recovery Phase: *Improvement by at least one phase, i.e. Critical to Complicated or Complicated to Uncomplicated * Defervescence Remember: Uncomplicated asymptomatic patients enter recovery phase after 14 days of observation without disease progression No further progression or re-hospitalization If a text field can't be filled out, note 'ND' (for not determined).
Länk
Nyckelord
Versioner (3)
- 2021-07-02 2021-07-02 - Sarah Riepenhausen
- 2021-07-15 2021-07-15 - Sarah Riepenhausen
- 2021-07-16 2021-07-16 - Sarah Riepenhausen
Rättsinnehavare
LEOSS
Uppladdad den
16 juli 2021
DOI
10.21961/mdm:42476
Licens
Creative Commons BY 4.0
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LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients
Liver cirrhosis sub-cohort
- StudyEvent: Baseline
- StudyEvent: Comorbidities and Pre-medication
- StudyEvent: Phases
- StudyEvent: Therapeutics
- StudyEvent: Diagnostics
Beskrivning
Decompensation of cirrhosis (Ascites, Variceal bleeding, Hepatic encephalopathy)
Alias
- UMLS CUI-1
- C1394798
- UMLS CUI-2
- C0003962
- UMLS CUI-3
- C0333106
- UMLS CUI-4
- C0019151
Beskrivning
Hepatic decompensation (Ascites, Variceal bleeding, Hepatic encephalopathy)
Datatyp
integer
Alias
- UMLS CUI [1]
- C1394798
- UMLS CUI [2]
- C0003962
- UMLS CUI [3]
- C0333106
- UMLS CUI [4]
- C0019151
Beskrivning
New or worsening ascites at Baseline
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C1442488
- UMLS CUI [1,2]
- C0003962
- UMLS CUI [1,3]
- C0332271
- UMLS CUI [2,1]
- C1442488
- UMLS CUI [2,2]
- C0003962
- UMLS CUI [2,3]
- C0205314
Beskrivning
Hepatic encephalopathy at Baseline
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0019151
- UMLS CUI [1,2]
- C1442488
Beskrivning
Gastrointestinal bleeding at Baseline
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0017181
- UMLS CUI [1,2]
- C1442488
Beskrivning
No hepatic decompensation at Baseline
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0549184
- UMLS CUI [1,2]
- C1394798
- UMLS CUI [1,3]
- C1442488
Beskrivning
Unknown decompensation status at Baseline
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0439673
- UMLS CUI [1,2]
- C1394798
- UMLS CUI [1,3]
- C1442488
Beskrivning
Reasons of consultation/ hospitalisation
Alias
- UMLS CUI-1
- C0566251
- UMLS CUI-2
- C0009818
- UMLS CUI-3
- C0019993
Beskrivning
Consultation / hospitalization due to complications of cirrhosis
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0023890
- UMLS CUI [1,2]
- C0009566
- UMLS CUI [1,3]
- C0009818
- UMLS CUI [1,4]
- C0566251
- UMLS CUI [2,1]
- C0023890
- UMLS CUI [2,2]
- C0009566
- UMLS CUI [2,3]
- C0019993
- UMLS CUI [2,4]
- C0566251
Beskrivning
Consultation / hospitalization due to gastrointestinal symptoms
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0426576
- UMLS CUI [1,2]
- C0009818
- UMLS CUI [1,3]
- C0566251
- UMLS CUI [2,1]
- C0426576
- UMLS CUI [2,2]
- C0019993
- UMLS CUI [2,3]
- C0566251
Beskrivning
Consultation / hospitalization due to respiratory symptoms
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0035237
- UMLS CUI [1,2]
- C1457887
- UMLS CUI [1,3]
- C0009818
- UMLS CUI [1,4]
- C0566251
- UMLS CUI [2,1]
- C0035237
- UMLS CUI [2,2]
- C1457887
- UMLS CUI [2,3]
- C0019993
- UMLS CUI [2,4]
- C0566251
Beskrivning
Consultation / hospitalization due to other reasons
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0009818
- UMLS CUI [1,2]
- C0566251
- UMLS CUI [1,3]
- C0205394
- UMLS CUI [2,1]
- C0019993
- UMLS CUI [2,2]
- C0566251
- UMLS CUI [2,3]
- C0205394
Beskrivning
Indicate other reasons for consultation/ hospitalisation
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0009818
- UMLS CUI [1,2]
- C0566251
- UMLS CUI [1,3]
- C0205394
- UMLS CUI [1,4]
- C1521902
- UMLS CUI [2,1]
- C0019993
- UMLS CUI [2,2]
- C0566251
- UMLS CUI [2,3]
- C0205394
- UMLS CUI [2,4]
- C1521902
Beskrivning
Unknown reasons for consultation / hospitalization
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0009818
- UMLS CUI [1,2]
- C0566251
- UMLS CUI [1,3]
- C0439673
- UMLS CUI [2,1]
- C0019993
- UMLS CUI [2,2]
- C0566251
- UMLS CUI [2,3]
- C0439673
Beskrivning
Current status on liver transplantation waiting list
Alias
- UMLS CUI-1
- C0422768
- UMLS CUI-2
- C0023911
Beskrivning
Bacterial infections within the last 30 days
Alias
- UMLS CUI-1
- C0004623
- UMLS CUI-2
- C0332185
Beskrivning
Recent bacteremia
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0004610
Beskrivning
Recent bacterial pneumonia
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0004626
Beskrivning
Recent spontaneous bacterial peritonitis
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0275551
Beskrivning
Recent bacterial infections of skin / soft tissue
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0225317
- UMLS CUI [1,3]
- C0004623
- UMLS CUI [2,1]
- C0332185
- UMLS CUI [2,2]
- C1123023
- UMLS CUI [2,3]
- C0004623
Beskrivning
Recent urinary tract infection
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0042029
- UMLS CUI [1,3]
- C0004623
Beskrivning
Other recent bacterial infection
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0004623
- UMLS CUI [1,3]
- C0205394
Beskrivning
Child-Pugh Score at Baseline
Alias
- UMLS CUI-1
- C4050412
- UMLS CUI-2
- C0011900
- UMLS CUI-3
- C1442488
Beskrivning
Serum Bilirubin at Baseline
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C1278039
- UMLS CUI [1,2]
- C1442488
Beskrivning
Serum Albumin at Baseline
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0523465
- UMLS CUI [1,2]
- C1442488
Beskrivning
INR at Baseline
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0525032
- UMLS CUI [1,2]
- C1442488
Beskrivning
Ascites at Baseline
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0003962
- UMLS CUI [1,2]
- C1442488
Beskrivning
Hepatic encephalopathy at Baseline
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0019151
- UMLS CUI [1,2]
- C1442488
Beskrivning
MELD Score
Alias
- UMLS CUI-1
- C1718072
Beskrivning
Recent MELD Score before Baseline
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C1718072
- UMLS CUI [1,2]
- C0332185
- UMLS CUI [1,3]
- C1442488
Beskrivning
MELD score at Baseline
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C1718072
- UMLS CUI [1,2]
- C1442488
Beskrivning
Worst MELD score during COVID-19 disease
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C1718072
- UMLS CUI [1,2]
- C1522166
- UMLS CUI [1,3]
- C5203670
Beskrivning
Acute-on-chronic liver failure at any point during the SARS-CoV-2 infection
Alias
- UMLS CUI-1
- C3850141
- UMLS CUI-2
- C1522166
- UMLS CUI-3
- C0040223
- UMLS CUI-4
- C3714514
- UMLS CUI-5
- C5203670
Beskrivning
Indicate worst value at any point (Baseline or Phases) during infection.
Datatyp
integer
Alias
- UMLS CUI [1]
- C1278039
Beskrivning
Indicate worst value at any point (Baseline or Phases) during infection.
Datatyp
integer
Alias
- UMLS CUI [1]
- C0201976
- UMLS CUI [2]
- C0145185
Beskrivning
Indicate worst value at any point (Baseline or Phases) during infection.
Datatyp
integer
Alias
- UMLS CUI [1]
- C3890564
Beskrivning
Indicate worst value at any point (Baseline or Phases) during infection.
Datatyp
integer
Alias
- UMLS CUI [1]
- C0032181
- UMLS CUI [2]
- C0525032
Beskrivning
Indicate worst value at any point (Baseline or Phases) during infection.
Datatyp
integer
Alias
- UMLS CUI [1]
- C0042397
Beskrivning
Indicate worst value at any point (Baseline or Phases) during infection.
Datatyp
integer
Alias
- UMLS CUI [1]
- C1977592
Beskrivning
Medication within the last 30 days
Alias
- UMLS CUI-1
- C0013227
- UMLS CUI-2
- C0332185
Beskrivning
Recent Beta-Blockers
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0001645
Beskrivning
Recent Diuretics
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0012798
Beskrivning
Recent Norfloxacin
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0028365
Beskrivning
Recent PPI
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0358591
Beskrivning
Recent Rifaximin
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0073374
Beskrivning
Recent Statins
Datatyp
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0360714
Beskrivning
Is data entry for this section finished?
Alias
- UMLS CUI-1
- C4684556
- UMLS CUI-2
- C1828479
- UMLS CUI-3
- C0205197
Similar models
Liver cirrhosis sub-cohort
- StudyEvent: Baseline
- StudyEvent: Comorbidities and Pre-medication
- StudyEvent: Phases
- StudyEvent: Therapeutics
- StudyEvent: Diagnostics
C1314792 (UMLS CUI-2)
C0023890 (UMLS CUI [1,2])
C1314792 (UMLS CUI [1,3])
C1314792 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0023890 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C1521902 (UMLS CUI [1,4])
C0023890 (UMLS CUI [1,2])
C1314792 (UMLS CUI [1,3])
C0003962 (UMLS CUI-2)
C0333106 (UMLS CUI-3)
C0019151 (UMLS CUI-4)
C0003962 (UMLS CUI [2])
C0333106 (UMLS CUI [3])
C0019151 (UMLS CUI [4])
C0003962 (UMLS CUI [1,2])
C0332271 (UMLS CUI [1,3])
C1442488 (UMLS CUI [2,1])
C0003962 (UMLS CUI [2,2])
C0205314 (UMLS CUI [2,3])
C1442488 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,2])
C1394798 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
C1394798 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
C0009818 (UMLS CUI-2)
C0019993 (UMLS CUI-3)
C0009566 (UMLS CUI [1,2])
C0009818 (UMLS CUI [1,3])
C0566251 (UMLS CUI [1,4])
C0023890 (UMLS CUI [2,1])
C0009566 (UMLS CUI [2,2])
C0019993 (UMLS CUI [2,3])
C0566251 (UMLS CUI [2,4])
C0009818 (UMLS CUI [1,2])
C0566251 (UMLS CUI [1,3])
C0426576 (UMLS CUI [2,1])
C0019993 (UMLS CUI [2,2])
C0566251 (UMLS CUI [2,3])
C1457887 (UMLS CUI [1,2])
C0009818 (UMLS CUI [1,3])
C0566251 (UMLS CUI [1,4])
C0035237 (UMLS CUI [2,1])
C1457887 (UMLS CUI [2,2])
C0019993 (UMLS CUI [2,3])
C0566251 (UMLS CUI [2,4])
C0566251 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0019993 (UMLS CUI [2,1])
C0566251 (UMLS CUI [2,2])
C0205394 (UMLS CUI [2,3])
C0566251 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C1521902 (UMLS CUI [1,4])
C0019993 (UMLS CUI [2,1])
C0566251 (UMLS CUI [2,2])
C0205394 (UMLS CUI [2,3])
C1521902 (UMLS CUI [2,4])
C0566251 (UMLS CUI [1,2])
C0439673 (UMLS CUI [1,3])
C0019993 (UMLS CUI [2,1])
C0566251 (UMLS CUI [2,2])
C0439673 (UMLS CUI [2,3])
C0023911 (UMLS CUI-2)
C0023911 (UMLS CUI [1,2])
C0332185 (UMLS CUI-2)
C0004610 (UMLS CUI [1,2])
C0004626 (UMLS CUI [1,2])
C0275551 (UMLS CUI [1,2])
C0225317 (UMLS CUI [1,2])
C0004623 (UMLS CUI [1,3])
C0332185 (UMLS CUI [2,1])
C1123023 (UMLS CUI [2,2])
C0004623 (UMLS CUI [2,3])
C0042029 (UMLS CUI [1,2])
C0004623 (UMLS CUI [1,3])
C0004623 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0011900 (UMLS CUI-2)
C1442488 (UMLS CUI-3)
C1442488 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,2])
C0332185 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
C1442488 (UMLS CUI [1,2])
C1522166 (UMLS CUI [1,2])
C5203670 (UMLS CUI [1,3])
C1522166 (UMLS CUI-2)
C0040223 (UMLS CUI-3)
C3714514 (UMLS CUI-4)
C5203670 (UMLS CUI-5)
C0145185 (UMLS CUI [2])
C0525032 (UMLS CUI [2])
C0332185 (UMLS CUI-2)
C0001645 (UMLS CUI [1,2])
C0012798 (UMLS CUI [1,2])
C0028365 (UMLS CUI [1,2])
C0358591 (UMLS CUI [1,2])
C0073374 (UMLS CUI [1,2])
C0360714 (UMLS CUI [1,2])
C1828479 (UMLS CUI-2)
C0205197 (UMLS CUI-3)
C1828479 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,3])