ID
42476
Beschrijving
Study Title: LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients https://leoss.net Study Indication: COVID-19 Date: 19.03.2021 Published with permission by Prof. Dr. med. J.-J. Vehreschild. LEOSS, a multi-center cohort study, has been created to get more in-depth knowledge about the epidemiology and clinical course of patients infected with SARS-CoV-2. Initiated by the ESCMID Emerging Infections Task Force (EITaF) and the German Infectious Disease Society, and supported by all German Centers for Health Research (DZG), LEOSS has developed into an international network of contributors. Via an integrative research approach with anonymous recruitment and collection of routine data in an open science context, LEOSS is building a uniform clinical dataset and providing real-time analyses. For more information feel free to explore https://leoss.net/. Please note that only cases with known outcome are collected! Baseline / diagnosis is defined as the day the sample of the first positive SARS-CoV-2 result was taken. Criteria of the Uncomplicated Phase: Asymptomatic OR Symptoms of upper respiratory tract infection and/or Nausea, emesis, diarrhea and/or Fever Remember: The Uncomplicated Phase ends, if a previously febrile patient has no fever anymore and has completed 14 days of follow-up without entering Complicated or Critical Phase; then move to Recovery Phase. Also, as soon as one of the criteria of the Complicated or Critical Phase are fulfilled, Uncomplicated Phase ends; move over to there. If the patient has died, the phase ends with the death of the patient. If the patient has died, do not report terminal values, e.g. those recorded after switching off life-support or heart rate "0" after death of the patient. Criteria of the Complicated Phase: * Need for oxygen supplementation (In patients with prior oxygen home therapy, clinically meaningful increase in need for oxygenation.) * paO2 at room air < 70 mmHg * SO2 at room air < 90 % * GOT or GPT > 5x ULN * New cardiac arrhythmia * New pericardial effusion >1cm * New heart failure with pulmonary edema, congestive hepatopathy or peripheral edema Remember: The Complicated Phase ends, if none of the criteria for the Complicated Phase is fulfilled anymore AND the patient is free of fever; then move to Recovery Phase. Also, as soon as one of the criteria of the Critical Phase are fulfilled, Complicated Phase ends; move over to Critical Phase. If the patient has died, the phase ends with the death of the patient. If the patient has died, do not report terminal values, e.g. those recorded after switching off life-support or heart rate "0" after death of the patient. Criteria of the Critical Phase: * Need for catecholamines * Life-threatening cardiac arrhythmia * Mechanical ventilation (invasive or non-invasive) * Liver failure with Quick< 50% * qSOFA >= 2 * Renal failure in need of dialysis Remember: The Critical Phase ends as soon as none of the criteria for the Critical Phase is fulfilled anymore AND the patient is free of fever. If the patient has died, it ends with the death of the patient. If the patient has died, do not report terminal values, i.e. those recorded after turning off life-support or heart rate "0" after death of the patient. Criteria of the Recovery Phase: *Improvement by at least one phase, i.e. Critical to Complicated or Complicated to Uncomplicated * Defervescence Remember: Uncomplicated asymptomatic patients enter recovery phase after 14 days of observation without disease progression No further progression or re-hospitalization If a text field can't be filled out, note 'ND' (for not determined).
Link
Trefwoorden
Versies (3)
- 02-07-21 02-07-21 - Sarah Riepenhausen
- 15-07-21 15-07-21 - Sarah Riepenhausen
- 16-07-21 16-07-21 - Sarah Riepenhausen
Houder van rechten
LEOSS
Geüploaded op
16 juli 2021
DOI
10.21961/mdm:42476
Licentie
Creative Commons BY 4.0
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LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients
Liver cirrhosis sub-cohort
- StudyEvent: Baseline
- StudyEvent: Comorbidities and Pre-medication
- StudyEvent: Phases
- StudyEvent: Therapeutics
- StudyEvent: Diagnostics
Beschrijving
Decompensation of cirrhosis (Ascites, Variceal bleeding, Hepatic encephalopathy)
Alias
- UMLS CUI-1
- C1394798
- UMLS CUI-2
- C0003962
- UMLS CUI-3
- C0333106
- UMLS CUI-4
- C0019151
Beschrijving
Hepatic decompensation (Ascites, Variceal bleeding, Hepatic encephalopathy)
Datatype
integer
Alias
- UMLS CUI [1]
- C1394798
- UMLS CUI [2]
- C0003962
- UMLS CUI [3]
- C0333106
- UMLS CUI [4]
- C0019151
Beschrijving
New or worsening ascites at Baseline
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C1442488
- UMLS CUI [1,2]
- C0003962
- UMLS CUI [1,3]
- C0332271
- UMLS CUI [2,1]
- C1442488
- UMLS CUI [2,2]
- C0003962
- UMLS CUI [2,3]
- C0205314
Beschrijving
Hepatic encephalopathy at Baseline
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0019151
- UMLS CUI [1,2]
- C1442488
Beschrijving
Gastrointestinal bleeding at Baseline
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0017181
- UMLS CUI [1,2]
- C1442488
Beschrijving
No hepatic decompensation at Baseline
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0549184
- UMLS CUI [1,2]
- C1394798
- UMLS CUI [1,3]
- C1442488
Beschrijving
Unknown decompensation status at Baseline
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0439673
- UMLS CUI [1,2]
- C1394798
- UMLS CUI [1,3]
- C1442488
Beschrijving
Reasons of consultation/ hospitalisation
Alias
- UMLS CUI-1
- C0566251
- UMLS CUI-2
- C0009818
- UMLS CUI-3
- C0019993
Beschrijving
Consultation / hospitalization due to complications of cirrhosis
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0023890
- UMLS CUI [1,2]
- C0009566
- UMLS CUI [1,3]
- C0009818
- UMLS CUI [1,4]
- C0566251
- UMLS CUI [2,1]
- C0023890
- UMLS CUI [2,2]
- C0009566
- UMLS CUI [2,3]
- C0019993
- UMLS CUI [2,4]
- C0566251
Beschrijving
Consultation / hospitalization due to gastrointestinal symptoms
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0426576
- UMLS CUI [1,2]
- C0009818
- UMLS CUI [1,3]
- C0566251
- UMLS CUI [2,1]
- C0426576
- UMLS CUI [2,2]
- C0019993
- UMLS CUI [2,3]
- C0566251
Beschrijving
Consultation / hospitalization due to respiratory symptoms
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0035237
- UMLS CUI [1,2]
- C1457887
- UMLS CUI [1,3]
- C0009818
- UMLS CUI [1,4]
- C0566251
- UMLS CUI [2,1]
- C0035237
- UMLS CUI [2,2]
- C1457887
- UMLS CUI [2,3]
- C0019993
- UMLS CUI [2,4]
- C0566251
Beschrijving
Consultation / hospitalization due to other reasons
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0009818
- UMLS CUI [1,2]
- C0566251
- UMLS CUI [1,3]
- C0205394
- UMLS CUI [2,1]
- C0019993
- UMLS CUI [2,2]
- C0566251
- UMLS CUI [2,3]
- C0205394
Beschrijving
Indicate other reasons for consultation/ hospitalisation
Datatype
text
Alias
- UMLS CUI [1,1]
- C0009818
- UMLS CUI [1,2]
- C0566251
- UMLS CUI [1,3]
- C0205394
- UMLS CUI [1,4]
- C1521902
- UMLS CUI [2,1]
- C0019993
- UMLS CUI [2,2]
- C0566251
- UMLS CUI [2,3]
- C0205394
- UMLS CUI [2,4]
- C1521902
Beschrijving
Unknown reasons for consultation / hospitalization
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0009818
- UMLS CUI [1,2]
- C0566251
- UMLS CUI [1,3]
- C0439673
- UMLS CUI [2,1]
- C0019993
- UMLS CUI [2,2]
- C0566251
- UMLS CUI [2,3]
- C0439673
Beschrijving
Current status on liver transplantation waiting list
Alias
- UMLS CUI-1
- C0422768
- UMLS CUI-2
- C0023911
Beschrijving
Bacterial infections within the last 30 days
Alias
- UMLS CUI-1
- C0004623
- UMLS CUI-2
- C0332185
Beschrijving
Recent bacteremia
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0004610
Beschrijving
Recent bacterial pneumonia
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0004626
Beschrijving
Recent spontaneous bacterial peritonitis
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0275551
Beschrijving
Recent bacterial infections of skin / soft tissue
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0225317
- UMLS CUI [1,3]
- C0004623
- UMLS CUI [2,1]
- C0332185
- UMLS CUI [2,2]
- C1123023
- UMLS CUI [2,3]
- C0004623
Beschrijving
Recent urinary tract infection
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0042029
- UMLS CUI [1,3]
- C0004623
Beschrijving
Other recent bacterial infection
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0004623
- UMLS CUI [1,3]
- C0205394
Beschrijving
Child-Pugh Score at Baseline
Alias
- UMLS CUI-1
- C4050412
- UMLS CUI-2
- C0011900
- UMLS CUI-3
- C1442488
Beschrijving
Serum Bilirubin at Baseline
Datatype
integer
Alias
- UMLS CUI [1,1]
- C1278039
- UMLS CUI [1,2]
- C1442488
Beschrijving
Serum Albumin at Baseline
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0523465
- UMLS CUI [1,2]
- C1442488
Beschrijving
INR at Baseline
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0525032
- UMLS CUI [1,2]
- C1442488
Beschrijving
Ascites at Baseline
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0003962
- UMLS CUI [1,2]
- C1442488
Beschrijving
Hepatic encephalopathy at Baseline
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0019151
- UMLS CUI [1,2]
- C1442488
Beschrijving
MELD Score
Alias
- UMLS CUI-1
- C1718072
Beschrijving
Recent MELD Score before Baseline
Datatype
integer
Alias
- UMLS CUI [1,1]
- C1718072
- UMLS CUI [1,2]
- C0332185
- UMLS CUI [1,3]
- C1442488
Beschrijving
MELD score at Baseline
Datatype
integer
Alias
- UMLS CUI [1,1]
- C1718072
- UMLS CUI [1,2]
- C1442488
Beschrijving
Worst MELD score during COVID-19 disease
Datatype
integer
Alias
- UMLS CUI [1,1]
- C1718072
- UMLS CUI [1,2]
- C1522166
- UMLS CUI [1,3]
- C5203670
Beschrijving
Acute-on-chronic liver failure at any point during the SARS-CoV-2 infection
Alias
- UMLS CUI-1
- C3850141
- UMLS CUI-2
- C1522166
- UMLS CUI-3
- C0040223
- UMLS CUI-4
- C3714514
- UMLS CUI-5
- C5203670
Beschrijving
Indicate worst value at any point (Baseline or Phases) during infection.
Datatype
integer
Alias
- UMLS CUI [1]
- C1278039
Beschrijving
Indicate worst value at any point (Baseline or Phases) during infection.
Datatype
integer
Alias
- UMLS CUI [1]
- C0201976
- UMLS CUI [2]
- C0145185
Beschrijving
Indicate worst value at any point (Baseline or Phases) during infection.
Datatype
integer
Alias
- UMLS CUI [1]
- C3890564
Beschrijving
Indicate worst value at any point (Baseline or Phases) during infection.
Datatype
integer
Alias
- UMLS CUI [1]
- C0032181
- UMLS CUI [2]
- C0525032
Beschrijving
Indicate worst value at any point (Baseline or Phases) during infection.
Datatype
integer
Alias
- UMLS CUI [1]
- C0042397
Beschrijving
Indicate worst value at any point (Baseline or Phases) during infection.
Datatype
integer
Alias
- UMLS CUI [1]
- C1977592
Beschrijving
Medication within the last 30 days
Alias
- UMLS CUI-1
- C0013227
- UMLS CUI-2
- C0332185
Beschrijving
Recent Beta-Blockers
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0001645
Beschrijving
Recent Diuretics
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0012798
Beschrijving
Recent Norfloxacin
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0028365
Beschrijving
Recent PPI
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0358591
Beschrijving
Recent Rifaximin
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0073374
Beschrijving
Recent Statins
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0332185
- UMLS CUI [1,2]
- C0360714
Beschrijving
Is data entry for this section finished?
Alias
- UMLS CUI-1
- C4684556
- UMLS CUI-2
- C1828479
- UMLS CUI-3
- C0205197
Similar models
Liver cirrhosis sub-cohort
- StudyEvent: Baseline
- StudyEvent: Comorbidities and Pre-medication
- StudyEvent: Phases
- StudyEvent: Therapeutics
- StudyEvent: Diagnostics
C1314792 (UMLS CUI-2)
C0023890 (UMLS CUI [1,2])
C1314792 (UMLS CUI [1,3])
C1314792 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0023890 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C1521902 (UMLS CUI [1,4])
C0023890 (UMLS CUI [1,2])
C1314792 (UMLS CUI [1,3])
C0003962 (UMLS CUI-2)
C0333106 (UMLS CUI-3)
C0019151 (UMLS CUI-4)
C0003962 (UMLS CUI [2])
C0333106 (UMLS CUI [3])
C0019151 (UMLS CUI [4])
C0003962 (UMLS CUI [1,2])
C0332271 (UMLS CUI [1,3])
C1442488 (UMLS CUI [2,1])
C0003962 (UMLS CUI [2,2])
C0205314 (UMLS CUI [2,3])
C1442488 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,2])
C1394798 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
C1394798 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
C0009818 (UMLS CUI-2)
C0019993 (UMLS CUI-3)
C0009566 (UMLS CUI [1,2])
C0009818 (UMLS CUI [1,3])
C0566251 (UMLS CUI [1,4])
C0023890 (UMLS CUI [2,1])
C0009566 (UMLS CUI [2,2])
C0019993 (UMLS CUI [2,3])
C0566251 (UMLS CUI [2,4])
C0009818 (UMLS CUI [1,2])
C0566251 (UMLS CUI [1,3])
C0426576 (UMLS CUI [2,1])
C0019993 (UMLS CUI [2,2])
C0566251 (UMLS CUI [2,3])
C1457887 (UMLS CUI [1,2])
C0009818 (UMLS CUI [1,3])
C0566251 (UMLS CUI [1,4])
C0035237 (UMLS CUI [2,1])
C1457887 (UMLS CUI [2,2])
C0019993 (UMLS CUI [2,3])
C0566251 (UMLS CUI [2,4])
C0566251 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0019993 (UMLS CUI [2,1])
C0566251 (UMLS CUI [2,2])
C0205394 (UMLS CUI [2,3])
C0566251 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C1521902 (UMLS CUI [1,4])
C0019993 (UMLS CUI [2,1])
C0566251 (UMLS CUI [2,2])
C0205394 (UMLS CUI [2,3])
C1521902 (UMLS CUI [2,4])
C0566251 (UMLS CUI [1,2])
C0439673 (UMLS CUI [1,3])
C0019993 (UMLS CUI [2,1])
C0566251 (UMLS CUI [2,2])
C0439673 (UMLS CUI [2,3])
C0023911 (UMLS CUI-2)
C0023911 (UMLS CUI [1,2])
C0332185 (UMLS CUI-2)
C0004610 (UMLS CUI [1,2])
C0004626 (UMLS CUI [1,2])
C0275551 (UMLS CUI [1,2])
C0225317 (UMLS CUI [1,2])
C0004623 (UMLS CUI [1,3])
C0332185 (UMLS CUI [2,1])
C1123023 (UMLS CUI [2,2])
C0004623 (UMLS CUI [2,3])
C0042029 (UMLS CUI [1,2])
C0004623 (UMLS CUI [1,3])
C0004623 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0011900 (UMLS CUI-2)
C1442488 (UMLS CUI-3)
C1442488 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,2])
C0332185 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
C1442488 (UMLS CUI [1,2])
C1522166 (UMLS CUI [1,2])
C5203670 (UMLS CUI [1,3])
C1522166 (UMLS CUI-2)
C0040223 (UMLS CUI-3)
C3714514 (UMLS CUI-4)
C5203670 (UMLS CUI-5)
C0145185 (UMLS CUI [2])
C0525032 (UMLS CUI [2])
C0332185 (UMLS CUI-2)
C0001645 (UMLS CUI [1,2])
C0012798 (UMLS CUI [1,2])
C0028365 (UMLS CUI [1,2])
C0358591 (UMLS CUI [1,2])
C0073374 (UMLS CUI [1,2])
C0360714 (UMLS CUI [1,2])
C1828479 (UMLS CUI-2)
C0205197 (UMLS CUI-3)
C1828479 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,3])