ID
42476
Description
Study Title: LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients https://leoss.net Study Indication: COVID-19 Date: 19.03.2021 Published with permission by Prof. Dr. med. J.-J. Vehreschild. LEOSS, a multi-center cohort study, has been created to get more in-depth knowledge about the epidemiology and clinical course of patients infected with SARS-CoV-2. Initiated by the ESCMID Emerging Infections Task Force (EITaF) and the German Infectious Disease Society, and supported by all German Centers for Health Research (DZG), LEOSS has developed into an international network of contributors. Via an integrative research approach with anonymous recruitment and collection of routine data in an open science context, LEOSS is building a uniform clinical dataset and providing real-time analyses. For more information feel free to explore https://leoss.net/. Please note that only cases with known outcome are collected! Baseline / diagnosis is defined as the day the sample of the first positive SARS-CoV-2 result was taken. Criteria of the Uncomplicated Phase: Asymptomatic OR Symptoms of upper respiratory tract infection and/or Nausea, emesis, diarrhea and/or Fever Remember: The Uncomplicated Phase ends, if a previously febrile patient has no fever anymore and has completed 14 days of follow-up without entering Complicated or Critical Phase; then move to Recovery Phase. Also, as soon as one of the criteria of the Complicated or Critical Phase are fulfilled, Uncomplicated Phase ends; move over to there. If the patient has died, the phase ends with the death of the patient. If the patient has died, do not report terminal values, e.g. those recorded after switching off life-support or heart rate "0" after death of the patient. Criteria of the Complicated Phase: * Need for oxygen supplementation (In patients with prior oxygen home therapy, clinically meaningful increase in need for oxygenation.) * paO2 at room air < 70 mmHg * SO2 at room air < 90 % * GOT or GPT > 5x ULN * New cardiac arrhythmia * New pericardial effusion >1cm * New heart failure with pulmonary edema, congestive hepatopathy or peripheral edema Remember: The Complicated Phase ends, if none of the criteria for the Complicated Phase is fulfilled anymore AND the patient is free of fever; then move to Recovery Phase. Also, as soon as one of the criteria of the Critical Phase are fulfilled, Complicated Phase ends; move over to Critical Phase. If the patient has died, the phase ends with the death of the patient. If the patient has died, do not report terminal values, e.g. those recorded after switching off life-support or heart rate "0" after death of the patient. Criteria of the Critical Phase: * Need for catecholamines * Life-threatening cardiac arrhythmia * Mechanical ventilation (invasive or non-invasive) * Liver failure with Quick< 50% * qSOFA >= 2 * Renal failure in need of dialysis Remember: The Critical Phase ends as soon as none of the criteria for the Critical Phase is fulfilled anymore AND the patient is free of fever. If the patient has died, it ends with the death of the patient. If the patient has died, do not report terminal values, i.e. those recorded after turning off life-support or heart rate "0" after death of the patient. Criteria of the Recovery Phase: *Improvement by at least one phase, i.e. Critical to Complicated or Complicated to Uncomplicated * Defervescence Remember: Uncomplicated asymptomatic patients enter recovery phase after 14 days of observation without disease progression No further progression or re-hospitalization If a text field can't be filled out, note 'ND' (for not determined).
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Mots-clés
Versions (3)
- 02/07/2021 02/07/2021 - Sarah Riepenhausen
- 15/07/2021 15/07/2021 - Sarah Riepenhausen
- 16/07/2021 16/07/2021 - Sarah Riepenhausen
Détendeur de droits
LEOSS
Téléchargé le
16 juillet 2021
DOI
10.21961/mdm:42476
Licence
Creative Commons BY 4.0
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LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients
Oncological Sub-cohort
- StudyEvent: Baseline
- StudyEvent: Comorbidities and Pre-medication
- StudyEvent: Phases
- StudyEvent: Therapeutics
- StudyEvent: Diagnostics
Description
Underlying disease: Solid tumors
Alias
- UMLS CUI-1
- C0277554
- UMLS CUI-2
- C0280100
- UMLS CUI-3
- C0205394
Description
Gastrointestinal cancer
Type de données
boolean
Alias
- UMLS CUI [1]
- C0685938
Description
Lung cancer
Type de données
boolean
Alias
- UMLS CUI [1]
- C0242379
Description
Head/Neck cancer
Type de données
boolean
Alias
- UMLS CUI [1]
- C0278996
Description
Prostate cancer
Type de données
boolean
Alias
- UMLS CUI [1]
- C0600139
Description
Bladder cancer
Type de données
boolean
Alias
- UMLS CUI [1]
- C0005684
Description
Breast cancer
Type de données
boolean
Alias
- UMLS CUI [1]
- C0678222
Description
Other gynecological cancer
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C1707251
- UMLS CUI [1,2]
- C0018417
Description
Malignant melanoma
Type de données
boolean
Alias
- UMLS CUI [1]
- C0025202
Description
Underlying disease: Other underlying diseases
Alias
- UMLS CUI-1
- C0277554
- UMLS CUI-2
- C0205394
Description
Other underlying diseases
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0205394
- UMLS CUI [1,2]
- C0277554
Description
Other underlying diseases_text
Type de données
text
Alias
- UMLS CUI [1,1]
- C0205394
- UMLS CUI [1,2]
- C0277554
- UMLS CUI [1,3]
- C1521902
Description
Unknown underlying diseases
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0439673
- UMLS CUI [1,2]
- C0277554
Description
Please specify the underlying NHL
Alias
- UMLS CUI-1
- C0277554
- UMLS CUI-2
- C0024305
- UMLS CUI-3
- C1521902
Description
If several NHLs have been diagnosed, please indicate all types.
Type de données
boolean
Alias
- UMLS CUI [1]
- C1332225
Description
If several NHLs have been diagnosed, please indicate all types.
Type de données
boolean
Alias
- UMLS CUI [1]
- C0026764
Description
If several NHLs have been diagnosed, please indicate all types.
Type de données
boolean
Alias
- UMLS CUI [1]
- C0023434
Description
If several NHLs have been diagnosed, please indicate all types.
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C1334170
- UMLS CUI [1,2]
- C0205394
Description
If several NHLs have been diagnosed, please indicate all types.
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0439673
- UMLS CUI [1,2]
- C0024305
Description
If several NHLs have been diagnosed, please indicate all types.
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C1298908
- UMLS CUI [1,2]
- C0024305
Description
Diagnosis date of hematological / oncological disease
Alias
- UMLS CUI-1
- C0018939
- UMLS CUI-2
- C2316983
- UMLS CUI-3
- C0027651
- UMLS CUI-4
- C2316983
Description
Please indicate how much time has passed since the patient was first diagnosed.
Type de données
integer
Alias
- UMLS CUI [1,1]
- C0018939
- UMLS CUI [1,2]
- C2316983
- UMLS CUI [2,1]
- C0027651
- UMLS CUI [2,2]
- C2316983
Description
Status at Baseline
Alias
- UMLS CUI-1
- C0699749
- UMLS CUI-2
- C1175175
- UMLS CUI-3
- C1511790
Description
BL (ECOG)
Type de données
integer
Alias
- UMLS CUI [1,1]
- C1512162
- UMLS CUI [1,2]
- C1442488
Description
Active disease
Type de données
integer
Alias
- UMLS CUI [1]
- C2707252
Description
Chemotherapy
Type de données
integer
Alias
- UMLS CUI [1]
- C3665472
Description
High dose steroids
Type de données
integer
Alias
- UMLS CUI [1,1]
- C0038317
- UMLS CUI [1,2]
- C0444956
Description
Targeted therapy
Type de données
integer
Alias
- UMLS CUI [1]
- C2985566
Description
Other immunosuppressive medication
Type de données
integer
Alias
- UMLS CUI [1,1]
- C0205394
- UMLS CUI [1,2]
- C0021081
Description
Remission
Type de données
integer
Alias
- UMLS CUI [1]
- C0544452
Description
Anti-cancer therapy
Alias
- UMLS CUI-1
- C0920425
Description
Systemic anti-cancer last month
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C1515119
- UMLS CUI [1,2]
- C2360065
- UMLS CUI [1,3]
- C4331910
Description
Indicate the name of the drug/regimen and specify the time frame.
Type de données
text
Alias
- UMLS CUI [1,1]
- C1515119
- UMLS CUI [1,2]
- C2360065
- UMLS CUI [1,3]
- C4331910
Description
Systemic anti-cancer last 3 months
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C1515119
- UMLS CUI [1,2]
- C2360065
- UMLS CUI [1,3]
- C3887294
Description
Indicate the name of the regimen and specify the time frame.
Type de données
text
Alias
- UMLS CUI [1,1]
- C1515119
- UMLS CUI [1,2]
- C2360065
- UMLS CUI [1,3]
- C3887294
Description
Surgery last 3 months
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0543467
- UMLS CUI [1,2]
- C3887294
Description
Radiotherapy last 3 months
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C1522449
- UMLS CUI [1,2]
- C3887294
Description
No anti-cancer therapy
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0920425
- UMLS CUI [1,2]
- C0549184
Description
Unknown anti-cancer therapy
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C0439673
- UMLS CUI [1,2]
- C0920425
Description
Stem cell transplantation
Alias
- UMLS CUI-1
- C1504389
Description
Allogenic SCT
Type de données
boolean
Alias
- UMLS CUI [1]
- C2242529
Description
Please provide the number of months that have passed since the stem cell transplantation.
Type de données
text
Unités de mesure
- months
Alias
- UMLS CUI [1,1]
- C2242529
- UMLS CUI [1,2]
- C1272706
Description
Autologous SCT
Type de données
boolean
Alias
- UMLS CUI [1]
- C1831743
Description
Please provide the number of months that have passed since the stem cell transplantation.
Type de données
text
Unités de mesure
- months
Alias
- UMLS CUI [1,1]
- C1831743
- UMLS CUI [1,2]
- C1272706
Description
Unknown SCT
Type de données
boolean
Alias
- UMLS CUI [1,1]
- C1504389
- UMLS CUI [1,2]
- C0439673
Description
Specific hypogammaglobuliaemia: IgG
Alias
- UMLS CUI-1
- C0086438
- UMLS CUI-2
- C0020852
Description
Is data entry for this section finished?
Alias
- UMLS CUI-1
- C4684556
- UMLS CUI-2
- C1828479
- UMLS CUI-3
- C0205197
Similar models
Oncological Sub-cohort
- StudyEvent: Baseline
- StudyEvent: Comorbidities and Pre-medication
- StudyEvent: Phases
- StudyEvent: Therapeutics
- StudyEvent: Diagnostics
C0018939 (UMLS CUI-2)
C0205183 (UMLS CUI [1,2])
C0376545 (UMLS CUI [1,2])
C0032463 (UMLS CUI [2])
C0040028 (UMLS CUI [3])
C0280100 (UMLS CUI-2)
C0205394 (UMLS CUI-3)
C0018417 (UMLS CUI [1,2])
C0205394 (UMLS CUI-2)
C0277554 (UMLS CUI [1,2])
C0277554 (UMLS CUI [1,2])
C1521902 (UMLS CUI [1,3])
C0277554 (UMLS CUI [1,2])
C0024305 (UMLS CUI-2)
C1521902 (UMLS CUI-3)
C0205394 (UMLS CUI [1,2])
C0024305 (UMLS CUI [1,2])
C0024305 (UMLS CUI [1,2])
C2316983 (UMLS CUI-2)
C0027651 (UMLS CUI-3)
C2316983 (UMLS CUI-4)
C2316983 (UMLS CUI [1,2])
C0027651 (UMLS CUI [2,1])
C2316983 (UMLS CUI [2,2])
C1175175 (UMLS CUI-2)
C1511790 (UMLS CUI-3)
C1442488 (UMLS CUI [1,2])
C0444956 (UMLS CUI [1,2])
C0021081 (UMLS CUI [1,2])
C2360065 (UMLS CUI [1,2])
C4331910 (UMLS CUI [1,3])
C2360065 (UMLS CUI [1,2])
C4331910 (UMLS CUI [1,3])
C2360065 (UMLS CUI [1,2])
C3887294 (UMLS CUI [1,3])
C2360065 (UMLS CUI [1,2])
C3887294 (UMLS CUI [1,3])
C3887294 (UMLS CUI [1,2])
C3887294 (UMLS CUI [1,2])
C0549184 (UMLS CUI [1,2])
C0920425 (UMLS CUI [1,2])
C1272706 (UMLS CUI [1,2])
C1272706 (UMLS CUI [1,2])
C0439673 (UMLS CUI [1,2])
C0020852 (UMLS CUI-2)
C0020852 (UMLS CUI [1,2])
C1828479 (UMLS CUI-2)
C0205197 (UMLS CUI-3)
C1828479 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,3])