ID

42292

Description

Study Title: LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients https://leoss.net Study Indication: COVID-19 Date: 19.03.2021 Published with permission by Prof. Dr. med. J.-J. Vehreschild. LEOSS, a multi-center cohort study, has been created to get more in-depth knowledge about the epidemiology and clinical course of patients infected with SARS-CoV-2. Initiated by the ESCMID Emerging Infections Task Force (EITaF) and the German Infectious Disease Society, and supported by all German Centers for Health Research (DZG), LEOSS has developed into an international network of contributors. Via an integrative research approach with anonymous recruitment and collection of routine data in an open science context, LEOSS is building a uniform clinical dataset and providing real-time analyses. For more information feel free to explore https://leoss.net/. This document is for immunosuppressive premedication. If a text field can't be filled out, note 'ND'.

Link

https://leoss.net

Keywords

  1. 10/30/20 10/30/20 -
  2. 5/7/21 5/7/21 -
Copyright Holder

LEOSS

Uploaded on

May 7, 2021

DOI

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License

Creative Commons BY 4.0

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LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients

Immunosuppressive premedication

Antibodies: Anti-CD20
Description

Antibodies: Anti-CD20

Alias
UMLS CUI-1
C3891557
Obinutuzumab in the last 6 months
Description

Recent: Obinutuzumab

Data type

integer

Alias
UMLS CUI [1,1]
C2742503
UMLS CUI [1,2]
C0332185
Ocrelizumab in the last 6 months
Description

Recent: Ocrelizumab

Data type

integer

Alias
UMLS CUI [1,1]
C1882138
UMLS CUI [1,2]
C0332185
Ofatumumab in the last 3 months
Description

Recent: Ofatumumab

Data type

integer

Alias
UMLS CUI [1,1]
C1832027
UMLS CUI [1,2]
C0332185
Rituximab in the last 6 months
Description

Recent: Rituximab

Data type

integer

Alias
UMLS CUI [1,1]
C0393022
UMLS CUI [1,2]
C0332185
Antibodies: CD-22
Description

Antibodies: CD-22

Alias
UMLS CUI-1
C0003241
UMLS CUI-2
C0054947
Inotuzumab-Ozogamicin
Description

Inotuzumab-Ozogamicin

Data type

integer

Alias
UMLS CUI [1]
C1567130
Antibodies: CD-38
Description

Antibodies: CD-38

Alias
UMLS CUI-1
C0003241
UMLS CUI-2
C0075742
Daratumumab
Description

Daratumumab

Data type

integer

Alias
UMLS CUI [1]
C2346801
Antibodies: CD-52
Description

Antibodies: CD-52

Alias
UMLS CUI-1
C0003241
UMLS CUI-2
C1610534
Alemtuzumab in the last 12 months
Description

Recent: Alemtuzumab

Data type

integer

Alias
UMLS CUI [1,1]
C0383429
UMLS CUI [1,2]
C0332185
Antibodies: Anti-CD79b
Description

Antibodies: Anti-CD79b

Alias
UMLS CUI-1
C0104979
UMLS CUI-2
C0003241
Polatuzumab-Vedotin
Description

Polatuzumab-Vedotin

Data type

integer

Alias
UMLS CUI [1]
C4078806
Antibodies: B Lymphocyte stimulator-specific inhibitor (BLyS)
Description

Antibodies: B Lymphocyte stimulator-specific inhibitor (BLyS)

Alias
UMLS CUI-1
C0003241
UMLS CUI-2
C3160093
Belimumab in the last 6 months
Description

Recent: Belimumab

Data type

integer

Alias
UMLS CUI [1,1]
C1723401
UMLS CUI [1,2]
C0332185
Antibodies: CD19-BiTE
Description

Antibodies: CD19-BiTE

Alias
UMLS CUI-1
C0003241
UMLS CUI-2
C4727095
Blinatumomab
Description

Blinatumomab

Data type

integer

Alias
UMLS CUI [1]
C3853839
Antibodies: Complement inhibitors
Description

Antibodies: Complement inhibitors

Alias
UMLS CUI-1
C0003241
UMLS CUI-2
C1564892
Crovalimab
Description

Crovalimab

Data type

integer

Alias
UMLS CUI [1,1]
C1564892
UMLS CUI [1,2]
C3846158
Eculizumab
Description

Eculizumab

Data type

integer

Alias
UMLS CUI [1]
C1541483
Pegcetacoplan (APL-2)
Description

Pegcetacoplan (APL-2)

Data type

integer

Alias
UMLS CUI [1]
C4053680
Ravulizumab
Description

Ravulizumab

Data type

integer

Alias
UMLS CUI [1]
C4550350
Antibodies: Integrin antagonists
Description

Antibodies: Integrin antagonists

Alias
UMLS CUI-1
C0003241
UMLS CUI-2
C2917367
Natalizumab
Description

Natalizumab

Data type

integer

Alias
UMLS CUI [1]
C1172734
Vedolizumab
Description

Vedolizumab

Data type

integer

Alias
UMLS CUI [1]
C2742797
Antibodies: Interleukin inhibitors
Description

Antibodies: Interleukin inhibitors

Alias
UMLS CUI-1
C3653320
UMLS CUI-2
C0003241
Basiliximab
Description

Basiliximab

Data type

integer

Alias
UMLS CUI [1]
C0676831
Canakinumab
Description

Canakinumab

Data type

integer

Alias
UMLS CUI [1]
C2718773
Ixekizumab
Description

Ixekizumab

Data type

integer

Alias
UMLS CUI [1]
C3489764
Sarilumab
Description

Sarilumab

Data type

integer

Alias
UMLS CUI [1]
C3885145
Secukinumab
Description

Secukinumab

Data type

integer

Alias
UMLS CUI [1]
C3179547
Tocilizumab
Description

Tocilizumab

Data type

integer

Alias
UMLS CUI [1]
C1609165
Ustekinumab
Description

Ustekinumab

Data type

integer

Alias
UMLS CUI [1]
C1608841
Antibodies: TNF-alpha inhibitors
Description

Antibodies: TNF-alpha inhibitors

Alias
UMLS CUI-1
C3653350
UMLS CUI-2
C0003241
Adalimumab
Description

Adalimumab

Data type

integer

Alias
UMLS CUI [1]
C1122087
Certolizumab
Description

Certolizumab

Data type

integer

Alias
UMLS CUI [1]
C1872109
Etanercept
Description

Etanercept

Data type

integer

Alias
UMLS CUI [1]
C0717758
Golimumab
Description

Golimumab

Data type

integer

Alias
UMLS CUI [1]
C2353893
Infliximab
Description

Infliximab

Data type

integer

Alias
UMLS CUI [1]
C0666743
Other Antibodies
Description

Other Antibodies

Alias
UMLS CUI-1
C0003241
UMLS CUI-2
C0205394
Other Antibodies
Description

Other Antibodies

Data type

integer

Alias
UMLS CUI [1,1]
C0003241
UMLS CUI [1,2]
C0205394
Indicate other Antibodies
Description

Indicate other Antibodies

Data type

text

Alias
UMLS CUI [1,1]
C0205394
UMLS CUI [1,2]
C1521902
UMLS CUI [1,3]
C0003241
Inhibitors: Co-stimulation inhibitors
Description

Inhibitors: Co-stimulation inhibitors

Alias
UMLS CUI-1
C0003241
UMLS CUI-2
C1622572
UMLS CUI-3
C1999216
Abatacept
Description

Abatacept

Data type

integer

Alias
UMLS CUI [1]
C1619966
Belatacept
Description

Belatacept

Data type

integer

Alias
UMLS CUI [1]
C1619962
Inhibitors: Calcineurin inhibitors
Description

Inhibitors: Calcineurin inhibitors

Alias
UMLS CUI-1
C1562036
Ciclosporin
Description

Ciclosporin

Data type

integer

Alias
UMLS CUI [1]
C0010592
Pimecrolimus
Description

Pimecrolimus

Data type

integer

Alias
UMLS CUI [1]
C1099414
Tacrolimus
Description

Tacrolimus

Data type

integer

Alias
UMLS CUI [1]
C0085149
Inhibitors: Interleukin inhibitor
Description

Inhibitors: Interleukin inhibitor

Alias
UMLS CUI-1
C3653320
Anakinra
Description

Anakinra

Data type

integer

Alias
UMLS CUI [1]
C0245109
Inhibitors: JAK inhibitors
Description

Inhibitors: JAK inhibitors

Alias
UMLS CUI-1
C3854325
Baricitinib
Description

Baricitinib

Data type

integer

Alias
UMLS CUI [1]
C4044947
Fedratinib
Description

Fedratinib

Data type

integer

Alias
UMLS CUI [1]
C3886623
Ruxolitinib
Description

Ruxolitinib

Data type

integer

Alias
UMLS CUI [1]
C2931926
Tofacitinib
Description

Tofacitinib

Data type

integer

Alias
UMLS CUI [1]
C2930696
Upadacitinib
Description

Upadacitinib

Data type

integer

Alias
UMLS CUI [1]
C4726929
Inhibitors: mTOR inhibitors
Description

Inhibitors: mTOR inhibitors

Alias
UMLS CUI-1
C2746052
Everolimus
Description

Everolimus

Data type

integer

Alias
UMLS CUI [1]
C0541315
Sirolimus
Description

Sirolimus

Data type

integer

Alias
UMLS CUI [1]
C0072980
Inhibitor: PDE-4-inhibitor
Description

Inhibitor: PDE-4-inhibitor

Alias
UMLS CUI-1
C2936609
Apremilast
Description

Apremilast

Data type

integer

Alias
UMLS CUI [1]
C1678805
Other Inhibitors
Description

Other Inhibitors

Alias
UMLS CUI-1
C0205394
UMLS CUI-2
C0243077
Other inhibitors
Description

Other inhibitors

Data type

integer

Alias
UMLS CUI [1,1]
C0205394
UMLS CUI [1,2]
C0243077
Indicate other inhibitors
Description

Indicate other inhibitors

Data type

text

Alias
UMLS CUI [1,1]
C0205394
UMLS CUI [1,2]
C1521902
UMLS CUI [1,3]
C0243077
Checkpoint inhibitors: last 3 months
Description

Checkpoint inhibitors: last 3 months

Alias
UMLS CUI-1
C0332185
UMLS CUI-2
C4733472
Nivolumab in the last 3 months
Description

In case of combination therapy please indicate all of the respective drugs.

Data type

boolean

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C3657270
Pembrolizumab in the last 3 months
Description

In case of combination therapy please indicate all of the respective drugs.

Data type

boolean

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C3658706
Ipilimumab in the last 3 months
Description

In case of combination therapy please indicate all of the respective drugs.

Data type

boolean

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C1367202
Other checkpoint inhibitor in the last 3 months
Description

In case of combination therapy please indicate all of the respective drugs.

Data type

boolean

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0205394
UMLS CUI [1,3]
C4733472
Indicate other checkpoint inhibitor in the last 3 months
Description

Indicate recent other checkpoint inhibitor

Data type

text

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0205394
UMLS CUI [1,3]
C4733472
UMLS CUI [1,4]
C1521902
No checkpoint inhibitor therapy in the last 3 months
Description

No recent checkpoint inhibitor therapy

Data type

boolean

Alias
UMLS CUI [1,1]
C1298908
UMLS CUI [1,2]
C0332185
UMLS CUI [1,3]
C4733472
Unknown
Description

Unknown Checkpoint inhibitor therapy

Data type

boolean

Alias
UMLS CUI [1,1]
C0439673
UMLS CUI [1,2]
C0332185
UMLS CUI [1,3]
C4733472
Chemotherapeutics: Antimetabolites
Description

Chemotherapeutics: Antimetabolites

Alias
UMLS CUI-1
C0003376
UMLS CUI-2
C0729502
6-Mercaptopurine
Description

6-Mercaptopurine

Data type

integer

Alias
UMLS CUI [1]
C0000618
Azathioprine
Description

Azathioprine

Data type

integer

Alias
UMLS CUI [1]
C0004482
Leflunomide
Description

Leflunomide

Data type

integer

Alias
UMLS CUI [1]
C0063041
Methotrexate
Description

Methotrexate

Data type

integer

Alias
UMLS CUI [1]
C0025677
Mycophenolate mofetil / Mycophenolic acid
Description

Mycophenolate mofetil / Mycophenolic acid

Data type

integer

Alias
UMLS CUI [1]
C0209368
UMLS CUI [2]
C0026933
Sulfasalazine
Description

Sulfasalazine

Data type

integer

Alias
UMLS CUI [1]
C0036078
Teriflunomide
Description

Teriflunomide

Data type

integer

Alias
UMLS CUI [1]
C1718383
Chemotherapeutics: Cytostatics
Description

Chemotherapeutics: Cytostatics

Alias
UMLS CUI-1
C0010858
UMLS CUI-2
C0729502
Cladribine (2-CDA) i.v./s.c. in the last 12 months
Description

Recent: Cladribine (2-CDA) i.v./s.c.

Data type

integer

Alias
UMLS CUI [1,1]
C0092801
UMLS CUI [1,2]
C0348016
UMLS CUI [1,3]
C0332185
UMLS CUI [2,1]
C0092801
UMLS CUI [2,2]
C0021499
UMLS CUI [2,3]
C0332185
Cladribine (2-CDA) p.o. in the last 12 months
Description

Recent: Cladribine (2-CDA) p.o.

Data type

integer

Alias
UMLS CUI [1,1]
C0092801
UMLS CUI [1,2]
C0001563
UMLS CUI [1,3]
C0332185
Cyclophosphamide i.v. in the last 3 months
Description

Recent: Cyclophosphamide i.v.

Data type

integer

Alias
UMLS CUI [1,1]
C0010583
UMLS CUI [1,2]
C0348016
UMLS CUI [1,3]
C0332185
Cyclophosphamide p.o. in the last 3 months
Description

Recent: Cyclophosphamide p.o.

Data type

integer

Alias
UMLS CUI [1,1]
C0010583
UMLS CUI [1,2]
C0001563
UMLS CUI [1,3]
C0332185
Mitoxantrone in the last 3 months
Description

Recent: Mitoxantrone

Data type

integer

Alias
UMLS CUI [1,1]
C0026259
UMLS CUI [1,2]
C0332185
Other Chemotherapeutics
Description

Other Chemotherapeutics

Alias
UMLS CUI-1
C0205394
UMLS CUI-2
C0729502
Other Chemotherapeutics
Description

Other Chemotherapeutics

Data type

integer

Alias
UMLS CUI [1,1]
C0205394
UMLS CUI [1,2]
C0729502
Indicate other Chemotherapeutics
Description

Indicate other Chemotherapeutics

Data type

text

Alias
UMLS CUI [1,1]
C0729502
UMLS CUI [1,2]
C0205394
UMLS CUI [1,3]
C1521902
Other immunosuppressive regimens: Corticosteroids
Description

Other immunosuppressive regimens: Corticosteroids

Alias
UMLS CUI-1
C0021081
UMLS CUI-2
C0205394
UMLS CUI-3
C0001617
< 10 mg / d prednisolone equivalent
Description

low dose prednisolone equivalent

Data type

integer

Alias
UMLS CUI [1,1]
C0445550
UMLS CUI [1,2]
C0038317
10 - 100 mg / d prednisolone equivalent
Description

medium dose prednisolone equivalent

Data type

integer

Alias
UMLS CUI [1,1]
C0439536
UMLS CUI [1,2]
C0178602
UMLS CUI [1,3]
C0038317
> 100 mg / d prednisolone equivalent
Description

high dose prednisolone equivalent

Data type

integer

Alias
UMLS CUI [1,1]
C0038317
UMLS CUI [1,2]
C0444956
Other immunosuppressive regimens: Fumarate
Description

Other immunosuppressive regimens: Fumarate

Alias
UMLS CUI-1
C0021081
UMLS CUI-2
C0205394
UMLS CUI-3
C0220833
Dimethyl fumarate
Description

Dimethyl fumarate

Data type

integer

Alias
UMLS CUI [1]
C0058218
Dimethyl fumarate / ethyl hydrogen fumarate
Description

Dimethyl fumarate/ethyl hydrogen fumarate (Fumaderm)

Data type

integer

Alias
UMLS CUI [1,1]
C0058218
UMLS CUI [1,2]
C0059764
UMLS CUI [2]
C0633802
Other immunosuppressive regimens: Immunoglobulines
Description

Other immunosuppressive regimens: Immunoglobulines

Alias
UMLS CUI-1
C1963758
UMLS CUI-2
C0205394
UMLS CUI-3
C0021081
Immunoglobulins i.v.
Description

Immunoglobulins i.v.

Data type

integer

Alias
UMLS CUI [1,1]
C0021027
UMLS CUI [1,2]
C0348016
Immunoglobulins s.c.
Description

Immunoglobulins s.c.

Data type

integer

Alias
UMLS CUI [1,1]
C0021027
UMLS CUI [1,2]
C0021499
Other immunosuppressive regimens: Interferon
Description

Other immunosuppressive regimens: Interferon

Alias
UMLS CUI-1
C0021081
UMLS CUI-2
C0205394
UMLS CUI-3
C3652465
Interferon-alpha
Description

Interferon-alpha

Data type

integer

Alias
UMLS CUI [1]
C0002199
Interferon-beta
Description

Interferon-beta

Data type

integer

Alias
UMLS CUI [1]
C0015980
Other immunosuppressive regimens: Other Multiple Sclerosis drugs
Description

Other immunosuppressive regimens: Other Multiple Sclerosis drugs

Alias
UMLS CUI-1
C0021081
UMLS CUI-2
C0205394
UMLS CUI-3
C0013227
UMLS CUI-4
C0026769
Glatirameracetat
Description

Glatirameracetat

Data type

integer

Alias
UMLS CUI [1]
C0289884
Fingolimod
Description

Fingolimod

Data type

integer

Alias
UMLS CUI [1]
C1699926
Siponimod
Description

Siponimod

Data type

integer

Alias
UMLS CUI [1]
C3657824
Other immunosuppressive regimens
Description

Other immunosuppressive regimens

Alias
UMLS CUI-1
C0205394
UMLS CUI-2
C0021081
Other immunosuppressive drugs
Description

Other immunosuppressive drugs

Data type

integer

Alias
UMLS CUI [1,1]
C0021081
UMLS CUI [1,2]
C0205394
Indicate other immunosuppressive drugs
Description

Indicate other immunosuppressive drugs

Data type

text

Alias
UMLS CUI [1,1]
C0021081
UMLS CUI [1,2]
C0205394
UMLS CUI [1,3]
C1521902
Immunosuppressive drugs: Underlying disease
Description

Immunosuppressive drugs: Underlying disease

Alias
UMLS CUI-1
C0021081
UMLS CUI-2
C3146298
Multiple Sclerosis
Description

Please indicate the underlying disease which has lead to the use of the indicated treatments. E.g. a patient might has suffered from breast cancer but the immunosuppressive treatment is due to a rheumatic disease with a lower dosis than it would be used in case of anticancer treatment. In this case only rheumatic disease should be indicated.

Data type

boolean

Alias
UMLS CUI [1,1]
C0021081
UMLS CUI [1,2]
C3146298
UMLS CUI [1,3]
C0026769
Other neurological autoimmune diseases
Description

Please indicate the underlying disease which has lead to the use of the indicated treatments. E.g. a patient might has suffered from breast cancer but the immunosuppressive treatment is due to a rheumatic disease with a lower dosis than it would be used in case of anticancer treatment. In this case only rheumatic disease should be indicated.

Data type

boolean

Alias
UMLS CUI [1,1]
C0021081
UMLS CUI [1,2]
C3146298
UMLS CUI [1,3]
C0205494
UMLS CUI [1,4]
C0004364
UMLS CUI [1,5]
C0205394
Oncology
Description

Please indicate the underlying disease which has lead to the use of the indicated treatments. E.g. a patient might has suffered from breast cancer but the immunosuppressive treatment is due to a rheumatic disease with a lower dosis than it would be used in case of anticancer treatment. In this case only rheumatic disease should be indicated.

Data type

boolean

Alias
UMLS CUI [1,1]
C0021081
UMLS CUI [1,2]
C3146298
UMLS CUI [1,3]
C0205478
Organ transplantation
Description

Please indicate the underlying disease which has lead to the use of the indicated treatments. E.g. a patient might has suffered from breast cancer but the immunosuppressive treatment is due to a rheumatic disease with a lower dosis than it would be used in case of anticancer treatment. In this case only rheumatic disease should be indicated.

Data type

boolean

Alias
UMLS CUI [1,1]
C0021081
UMLS CUI [1,2]
C3146298
UMLS CUI [1,3]
C0029216
Rheumatic diseases
Description

Please indicate the underlying disease which has lead to the use of the indicated treatments. E.g. a patient might has suffered from breast cancer but the immunosuppressive treatment is due to a rheumatic disease with a lower dosis than it would be used in case of anticancer treatment. In this case only rheumatic disease should be indicated.

Data type

boolean

Alias
UMLS CUI [1,1]
C0021081
UMLS CUI [1,2]
C3146298
UMLS CUI [1,3]
C3495832
Other Underlying disease
Description

Please indicate the underlying disease which has lead to the use of the indicated treatments. E.g. a patient might has suffered from breast cancer but the immunosuppressive treatment is due to a rheumatic disease with a lower dosis than it would be used in case of anticancer treatment. In this case only rheumatic disease should be indicated.

Data type

boolean

Alias
UMLS CUI [1,1]
C0021081
UMLS CUI [1,2]
C3146298
UMLS CUI [1,3]
C0277554
UMLS CUI [1,4]
C0205394
Indicate other Underlying disease
Description

Please indicate the underlying disease which has lead to the use of the indicated treatments. E.g. a patient might has suffered from breast cancer but the immunosuppressive treatment is due to a rheumatic disease with a lower dosis than it would be used in case of anticancer treatment. In this case only rheumatic disease should be indicated.

Data type

boolean

Alias
UMLS CUI [1,1]
C0021081
UMLS CUI [1,2]
C3146298
UMLS CUI [1,3]
C0277554
UMLS CUI [1,4]
C0205394
UMLS CUI [1,5]
C1521902
Unknown
Description

Indication for immunosuppressive drugs: Unknown underlying disease

Data type

boolean

Alias
UMLS CUI [1,1]
C0021081
UMLS CUI [1,2]
C3146298
UMLS CUI [1,3]
C0439673
UMLS CUI [1,4]
C0277554
Is data entry for this section finished?
Description

Is data entry for this section finished?

Alias
UMLS CUI-1
C4684556
UMLS CUI-2
C1828479
UMLS CUI-3
C0205197
Is data entry for this section finished?
Description

Is data entry for this section finished?

Data type

boolean

Alias
UMLS CUI [1,1]
C4684556
UMLS CUI [1,2]
C1828479
UMLS CUI [1,3]
C0205197

Similar models

Immunosuppressive premedication

Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Antibodies: Anti-CD20
C3891557 (UMLS CUI-1)
Item
Obinutuzumab in the last 6 months
integer
C2742503 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
Code List
Obinutuzumab in the last 6 months
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Ocrelizumab in the last 6 months
integer
C1882138 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
Code List
Ocrelizumab in the last 6 months
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Ofatumumab in the last 3 months
integer
C1832027 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
Code List
Ofatumumab in the last 3 months
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Rituximab in the last 6 months
integer
C0393022 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
Code List
Rituximab in the last 6 months
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Antibodies: CD-22
C0003241 (UMLS CUI-1)
C0054947 (UMLS CUI-2)
Item
Inotuzumab-Ozogamicin
integer
C1567130 (UMLS CUI [1])
Code List
Inotuzumab-Ozogamicin
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Antibodies: CD-38
C0003241 (UMLS CUI-1)
C0075742 (UMLS CUI-2)
Item
Daratumumab
integer
C2346801 (UMLS CUI [1])
Code List
Daratumumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Antibodies: CD-52
C0003241 (UMLS CUI-1)
C1610534 (UMLS CUI-2)
Item
Alemtuzumab in the last 12 months
integer
C0383429 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
Code List
Alemtuzumab in the last 12 months
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Antibodies: Anti-CD79b
C0104979 (UMLS CUI-1)
C0003241 (UMLS CUI-2)
Item
Polatuzumab-Vedotin
integer
C4078806 (UMLS CUI [1])
Code List
Polatuzumab-Vedotin
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Antibodies: B Lymphocyte stimulator-specific inhibitor (BLyS)
C0003241 (UMLS CUI-1)
C3160093 (UMLS CUI-2)
Item
Belimumab in the last 6 months
integer
C1723401 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
Code List
Belimumab in the last 6 months
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Antibodies: CD19-BiTE
C0003241 (UMLS CUI-1)
C4727095 (UMLS CUI-2)
Item
Blinatumomab
integer
C3853839 (UMLS CUI [1])
Code List
Blinatumomab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Antibodies: Complement inhibitors
C0003241 (UMLS CUI-1)
C1564892 (UMLS CUI-2)
Item
Crovalimab
integer
C1564892 (UMLS CUI [1,1])
C3846158 (UMLS CUI [1,2])
Code List
Crovalimab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Eculizumab
integer
C1541483 (UMLS CUI [1])
Code List
Eculizumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Pegcetacoplan (APL-2)
integer
C4053680 (UMLS CUI [1])
Code List
Pegcetacoplan (APL-2)
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Ravulizumab
integer
C4550350 (UMLS CUI [1])
Code List
Ravulizumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Antibodies: Integrin antagonists
C0003241 (UMLS CUI-1)
C2917367 (UMLS CUI-2)
Item
Natalizumab
integer
C1172734 (UMLS CUI [1])
Code List
Natalizumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Vedolizumab
integer
C2742797 (UMLS CUI [1])
Code List
Vedolizumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Antibodies: Interleukin inhibitors
C3653320 (UMLS CUI-1)
C0003241 (UMLS CUI-2)
Item
Basiliximab
integer
C0676831 (UMLS CUI [1])
Code List
Basiliximab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Canakinumab
integer
C2718773 (UMLS CUI [1])
Code List
Canakinumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Ixekizumab
integer
C3489764 (UMLS CUI [1])
Code List
Ixekizumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Sarilumab
integer
C3885145 (UMLS CUI [1])
Code List
Sarilumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Secukinumab
integer
C3179547 (UMLS CUI [1])
Code List
Secukinumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Tocilizumab
integer
C1609165 (UMLS CUI [1])
Code List
Tocilizumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Ustekinumab
integer
C1608841 (UMLS CUI [1])
Code List
Ustekinumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Antibodies: TNF-alpha inhibitors
C3653350 (UMLS CUI-1)
C0003241 (UMLS CUI-2)
Item
Adalimumab
integer
C1122087 (UMLS CUI [1])
Code List
Adalimumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Certolizumab
integer
C1872109 (UMLS CUI [1])
Code List
Certolizumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Etanercept
integer
C0717758 (UMLS CUI [1])
Code List
Etanercept
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Golimumab
integer
C2353893 (UMLS CUI [1])
Code List
Golimumab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Infliximab
integer
C0666743 (UMLS CUI [1])
Code List
Infliximab
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Other Antibodies
C0003241 (UMLS CUI-1)
C0205394 (UMLS CUI-2)
Item
Other Antibodies
integer
C0003241 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
Code List
Other Antibodies
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Indicate other Antibodies
Item
Indicate other Antibodies
text
C0205394 (UMLS CUI [1,1])
C1521902 (UMLS CUI [1,2])
C0003241 (UMLS CUI [1,3])
Item Group
Inhibitors: Co-stimulation inhibitors
C0003241 (UMLS CUI-1)
C1622572 (UMLS CUI-2)
C1999216 (UMLS CUI-3)
Item
Abatacept
integer
C1619966 (UMLS CUI [1])
Code List
Abatacept
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Belatacept
integer
C1619962 (UMLS CUI [1])
Code List
Belatacept
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Inhibitors: Calcineurin inhibitors
C1562036 (UMLS CUI-1)
Item
Ciclosporin
integer
C0010592 (UMLS CUI [1])
Code List
Ciclosporin
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Pimecrolimus
integer
C1099414 (UMLS CUI [1])
Code List
Pimecrolimus
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Tacrolimus
integer
C0085149 (UMLS CUI [1])
Code List
Tacrolimus
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Inhibitors: Interleukin inhibitor
C3653320 (UMLS CUI-1)
Item
Anakinra
integer
C0245109 (UMLS CUI [1])
Code List
Anakinra
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Inhibitors: JAK inhibitors
C3854325 (UMLS CUI-1)
Item
Baricitinib
integer
C4044947 (UMLS CUI [1])
Code List
Baricitinib
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Fedratinib
integer
C3886623 (UMLS CUI [1])
Code List
Fedratinib
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Ruxolitinib
integer
C2931926 (UMLS CUI [1])
Code List
Ruxolitinib
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Tofacitinib
integer
C2930696 (UMLS CUI [1])
Code List
Tofacitinib
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Upadacitinib
integer
C4726929 (UMLS CUI [1])
Code List
Upadacitinib
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Inhibitors: mTOR inhibitors
C2746052 (UMLS CUI-1)
Item
Everolimus
integer
C0541315 (UMLS CUI [1])
Code List
Everolimus
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Sirolimus
integer
C0072980 (UMLS CUI [1])
Code List
Sirolimus
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Inhibitor: PDE-4-inhibitor
C2936609 (UMLS CUI-1)
Item
Apremilast
integer
C1678805 (UMLS CUI [1])
Code List
Apremilast
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Other Inhibitors
C0205394 (UMLS CUI-1)
C0243077 (UMLS CUI-2)
Item
Other inhibitors
integer
C0205394 (UMLS CUI [1,1])
C0243077 (UMLS CUI [1,2])
Code List
Other inhibitors
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Indicate other inhibitors
Item
Indicate other inhibitors
text
C0205394 (UMLS CUI [1,1])
C1521902 (UMLS CUI [1,2])
C0243077 (UMLS CUI [1,3])
Item Group
Checkpoint inhibitors: last 3 months
C0332185 (UMLS CUI-1)
C4733472 (UMLS CUI-2)
Recent: Nivolumab
Item
Nivolumab in the last 3 months
boolean
C0332185 (UMLS CUI [1,1])
C3657270 (UMLS CUI [1,2])
Recent: Pembrolizumab
Item
Pembrolizumab in the last 3 months
boolean
C0332185 (UMLS CUI [1,1])
C3658706 (UMLS CUI [1,2])
Recent: Ipilimumab
Item
Ipilimumab in the last 3 months
boolean
C0332185 (UMLS CUI [1,1])
C1367202 (UMLS CUI [1,2])
Recent: Other checkpoint inhibitor
Item
Other checkpoint inhibitor in the last 3 months
boolean
C0332185 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C4733472 (UMLS CUI [1,3])
Indicate recent other checkpoint inhibitor
Item
Indicate other checkpoint inhibitor in the last 3 months
text
C0332185 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C4733472 (UMLS CUI [1,3])
C1521902 (UMLS CUI [1,4])
No recent checkpoint inhibitor therapy
Item
No checkpoint inhibitor therapy in the last 3 months
boolean
C1298908 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
C4733472 (UMLS CUI [1,3])
Unknown Checkpoint inhibitor therapy
Item
Unknown
boolean
C0439673 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
C4733472 (UMLS CUI [1,3])
Item Group
Chemotherapeutics: Antimetabolites
C0003376 (UMLS CUI-1)
C0729502 (UMLS CUI-2)
Item
6-Mercaptopurine
integer
C0000618 (UMLS CUI [1])
Code List
6-Mercaptopurine
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Azathioprine
integer
C0004482 (UMLS CUI [1])
Code List
Azathioprine
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Leflunomide
integer
C0063041 (UMLS CUI [1])
Code List
Leflunomide
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Methotrexate
integer
C0025677 (UMLS CUI [1])
Code List
Methotrexate
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Mycophenolate mofetil / Mycophenolic acid
integer
C0209368 (UMLS CUI [1])
C0026933 (UMLS CUI [2])
Code List
Mycophenolate mofetil / Mycophenolic acid
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Sulfasalazine
integer
C0036078 (UMLS CUI [1])
Code List
Sulfasalazine
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Teriflunomide
integer
C1718383 (UMLS CUI [1])
Code List
Teriflunomide
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Chemotherapeutics: Cytostatics
C0010858 (UMLS CUI-1)
C0729502 (UMLS CUI-2)
Item
Cladribine (2-CDA) i.v./s.c. in the last 12 months
integer
C0092801 (UMLS CUI [1,1])
C0348016 (UMLS CUI [1,2])
C0332185 (UMLS CUI [1,3])
C0092801 (UMLS CUI [2,1])
C0021499 (UMLS CUI [2,2])
C0332185 (UMLS CUI [2,3])
Code List
Cladribine (2-CDA) i.v./s.c. in the last 12 months
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Cladribine (2-CDA) p.o. in the last 12 months
integer
C0092801 (UMLS CUI [1,1])
C0001563 (UMLS CUI [1,2])
C0332185 (UMLS CUI [1,3])
Code List
Cladribine (2-CDA) p.o. in the last 12 months
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Cyclophosphamide i.v. in the last 3 months
integer
C0010583 (UMLS CUI [1,1])
C0348016 (UMLS CUI [1,2])
C0332185 (UMLS CUI [1,3])
Code List
Cyclophosphamide i.v. in the last 3 months
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Cyclophosphamide p.o. in the last 3 months
integer
C0010583 (UMLS CUI [1,1])
C0001563 (UMLS CUI [1,2])
C0332185 (UMLS CUI [1,3])
Code List
Cyclophosphamide p.o. in the last 3 months
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Mitoxantrone in the last 3 months
integer
C0026259 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
Code List
Mitoxantrone in the last 3 months
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Other Chemotherapeutics
C0205394 (UMLS CUI-1)
C0729502 (UMLS CUI-2)
Item
Other Chemotherapeutics
integer
C0205394 (UMLS CUI [1,1])
C0729502 (UMLS CUI [1,2])
Code List
Other Chemotherapeutics
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Indicate other Chemotherapeutics
Item
Indicate other Chemotherapeutics
text
C0729502 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C1521902 (UMLS CUI [1,3])
Item Group
Other immunosuppressive regimens: Corticosteroids
C0021081 (UMLS CUI-1)
C0205394 (UMLS CUI-2)
C0001617 (UMLS CUI-3)
Item
< 10 mg / d prednisolone equivalent
integer
C0445550 (UMLS CUI [1,1])
C0038317 (UMLS CUI [1,2])
Code List
< 10 mg / d prednisolone equivalent
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
10 - 100 mg / d prednisolone equivalent
integer
C0439536 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0038317 (UMLS CUI [1,3])
Code List
10 - 100 mg / d prednisolone equivalent
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
> 100 mg / d prednisolone equivalent
integer
C0038317 (UMLS CUI [1,1])
C0444956 (UMLS CUI [1,2])
Code List
> 100 mg / d prednisolone equivalent
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Other immunosuppressive regimens: Fumarate
C0021081 (UMLS CUI-1)
C0205394 (UMLS CUI-2)
C0220833 (UMLS CUI-3)
Item
Dimethyl fumarate
integer
C0058218 (UMLS CUI [1])
Code List
Dimethyl fumarate
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Dimethyl fumarate / ethyl hydrogen fumarate
integer
C0058218 (UMLS CUI [1,1])
C0059764 (UMLS CUI [1,2])
C0633802 (UMLS CUI [2])
Code List
Dimethyl fumarate / ethyl hydrogen fumarate
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Other immunosuppressive regimens: Immunoglobulines
C1963758 (UMLS CUI-1)
C0205394 (UMLS CUI-2)
C0021081 (UMLS CUI-3)
Item
Immunoglobulins i.v.
integer
C0021027 (UMLS CUI [1,1])
C0348016 (UMLS CUI [1,2])
Code List
Immunoglobulins i.v.
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Immunoglobulins s.c.
integer
C0021027 (UMLS CUI [1,1])
C0021499 (UMLS CUI [1,2])
Code List
Immunoglobulins s.c.
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Other immunosuppressive regimens: Interferon
C0021081 (UMLS CUI-1)
C0205394 (UMLS CUI-2)
C3652465 (UMLS CUI-3)
Item
Interferon-alpha
integer
C0002199 (UMLS CUI [1])
Code List
Interferon-alpha
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Interferon-beta
integer
C0015980 (UMLS CUI [1])
Code List
Interferon-beta
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Other immunosuppressive regimens: Other Multiple Sclerosis drugs
C0021081 (UMLS CUI-1)
C0205394 (UMLS CUI-2)
C0013227 (UMLS CUI-3)
C0026769 (UMLS CUI-4)
Item
Glatirameracetat
integer
C0289884 (UMLS CUI [1])
Code List
Glatirameracetat
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Fingolimod
integer
C1699926 (UMLS CUI [1])
Code List
Fingolimod
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Siponimod
integer
C3657824 (UMLS CUI [1])
Code List
Siponimod
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Other immunosuppressive regimens
C0205394 (UMLS CUI-1)
C0021081 (UMLS CUI-2)
Item
Other immunosuppressive drugs
integer
C0021081 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
Code List
Other immunosuppressive drugs
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Indicate other immunosuppressive drugs
Item
Indicate other immunosuppressive drugs
text
C0021081 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C1521902 (UMLS CUI [1,3])
Item Group
Immunosuppressive drugs: Underlying disease
C0021081 (UMLS CUI-1)
C3146298 (UMLS CUI-2)
Indication for immunosuppressive drugs: Multiple Sclerosis
Item
Multiple Sclerosis
boolean
C0021081 (UMLS CUI [1,1])
C3146298 (UMLS CUI [1,2])
C0026769 (UMLS CUI [1,3])
Indication for immunosuppressive drugs: Other neurological autoimmune diseases
Item
Other neurological autoimmune diseases
boolean
C0021081 (UMLS CUI [1,1])
C3146298 (UMLS CUI [1,2])
C0205494 (UMLS CUI [1,3])
C0004364 (UMLS CUI [1,4])
C0205394 (UMLS CUI [1,5])
Indication for immunosuppressive drugs: Oncology
Item
Oncology
boolean
C0021081 (UMLS CUI [1,1])
C3146298 (UMLS CUI [1,2])
C0205478 (UMLS CUI [1,3])
Indication for immunosuppressive drugs: Organ transplantation
Item
Organ transplantation
boolean
C0021081 (UMLS CUI [1,1])
C3146298 (UMLS CUI [1,2])
C0029216 (UMLS CUI [1,3])
Indication for immunosuppressive drugs: Rheumatic diseases
Item
Rheumatic diseases
boolean
C0021081 (UMLS CUI [1,1])
C3146298 (UMLS CUI [1,2])
C3495832 (UMLS CUI [1,3])
Indication for immunosuppressive drugs: Other Underlying disease
Item
Other Underlying disease
boolean
C0021081 (UMLS CUI [1,1])
C3146298 (UMLS CUI [1,2])
C0277554 (UMLS CUI [1,3])
C0205394 (UMLS CUI [1,4])
Indication for immunosuppressive drugs: Indicate other Underlying disease
Item
Indicate other Underlying disease
boolean
C0021081 (UMLS CUI [1,1])
C3146298 (UMLS CUI [1,2])
C0277554 (UMLS CUI [1,3])
C0205394 (UMLS CUI [1,4])
C1521902 (UMLS CUI [1,5])
Indication for immunosuppressive drugs: Unknown underlying disease
Item
Unknown
boolean
C0021081 (UMLS CUI [1,1])
C3146298 (UMLS CUI [1,2])
C0439673 (UMLS CUI [1,3])
C0277554 (UMLS CUI [1,4])
Item Group
Is data entry for this section finished?
C4684556 (UMLS CUI-1)
C1828479 (UMLS CUI-2)
C0205197 (UMLS CUI-3)
Is data entry for this section finished?
Item
Is data entry for this section finished?
boolean
C4684556 (UMLS CUI [1,1])
C1828479 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,3])

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