ID

42290

Description

Study Title: LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients https://leoss.net Study Indication: COVID-19 Date: 19.03.2021 Published with permission by Prof. Dr. med. J.-J. Vehreschild. LEOSS, a multi-center cohort study, has been created to get more in-depth knowledge about the epidemiology and clinical course of patients infected with SARS-CoV-2. Initiated by the ESCMID Emerging Infections Task Force (EITaF) and the German Infectious Disease Society, and supported by all German Centers for Health Research (DZG), LEOSS has developed into an international network of contributors. Via an integrative research approach with anonymous recruitment and collection of routine data in an open science context, LEOSS is building a uniform clinical dataset and providing real-time analyses. For more information feel free to explore https://leoss.net/. This document is for the liver cirrhosis sub-cohort. If a text field can't be filled out, note 'ND' (for not determined).

Link

https://leoss.net

Keywords

Versions (2)
  1. 11/1/20 11/1/20 -
  2. 5/6/21 5/6/21 -
Copyright Holder

LEOSS

Uploaded on

May 6, 2021

DOI

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License

Creative Commons BY 4.0
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LEOSS: Lean European Open Survey on SARS-CoV-2 Infected Patients

English

Liver cirrhosis sub-cohort

1 forms  
Etiology of liver cirrhosis
Description

Etiology of liver cirrhosis

Alias
UMLS CUI-1
C0023890
UMLS CUI-2
C1314792
Alcoholic liver cirrhosis
Description

Alcoholic liver cirrhosis

Data type

boolean

Alias
UMLS CUI [1]
C0023891
PBC (Primary biliary cholangitis))
Description

PBC

Data type

boolean

Alias
UMLS CUI [1]
C0008312
PSC (Primary sclerosing cholangitis)
Description

PSC

Data type

boolean

Alias
UMLS CUI [1]
C0566602
AIH (Autoimmune hepatitis)
Description

AIH

Data type

boolean

Alias
UMLS CUI [1]
C0241910
Viral hepatitis as reason for liver cirrhosis
Description

Etiology of liver cirrhosis: Viral hepatitis

Data type

boolean

Alias
UMLS CUI [1,1]
C0042721
UMLS CUI [1,2]
C0023890
UMLS CUI [1,3]
C1314792
Other etiology of liver cirrhosis
Description

Other etiology of liver cirrhosis

Data type

boolean

Alias
UMLS CUI [1,1]
C0023890
UMLS CUI [1,2]
C1314792
UMLS CUI [1,3]
C0205394
Indicate other etiology of cirrhosis
Description

Indicate other etiology of liver cirrhosis

Data type

text

Alias
UMLS CUI [1,1]
C1314792
UMLS CUI [1,2]
C0023890
UMLS CUI [1,3]
C0205394
UMLS CUI [1,4]
C1521902
Unknown
Description

Unknown etiology of liver cirrhosis

Data type

boolean

Alias
UMLS CUI [1,1]
C0439673
UMLS CUI [1,2]
C0023890
UMLS CUI [1,3]
C1314792
Decompensation of cirrhosis (Ascites, Variceal bleeding, Hepatic encephalopathy)
Description

Decompensation of cirrhosis (Ascites, Variceal bleeding, Hepatic encephalopathy)

Alias
UMLS CUI-1
C1394798
UMLS CUI-2
C0003962
UMLS CUI-3
C0333106
UMLS CUI-4
C0019151
Current status of cirrhosis (Ascites, Variceal bleeding, Hepatic encephalopathy)
Description

Hepatic decompensation (Ascites, Variceal bleeding, Hepatic encephalopathy)

Data type

integer

Alias
UMLS CUI [1]
C1394798
UMLS CUI [2]
C0003962
UMLS CUI [3]
C0333106
UMLS CUI [4]
C0019151
New or worsening ascites at Baseline
Description

New or worsening ascites at Baseline

Data type

boolean

Alias
UMLS CUI [1,1]
C1442488
UMLS CUI [1,2]
C0003962
UMLS CUI [1,3]
C0332271
UMLS CUI [2,1]
C1442488
UMLS CUI [2,2]
C0003962
UMLS CUI [2,3]
C0205314
Overt hepatic encephalopathy at Baseline
Description

Hepatic encephalopathy at Baseline

Data type

boolean

Alias
UMLS CUI [1,1]
C0019151
UMLS CUI [1,2]
C1442488
Gastrointestinal bleeding at Baseline
Description

Gastrointestinal bleeding at Baseline

Data type

boolean

Alias
UMLS CUI [1,1]
C0017181
UMLS CUI [1,2]
C1442488
No decompensation at Baseline
Description

No hepatic decompensation at Baseline

Data type

boolean

Alias
UMLS CUI [1,1]
C0549184
UMLS CUI [1,2]
C1394798
UMLS CUI [1,3]
C1442488
Unknown decompensation status at Baseline
Description

Unknown decompensation status at Baseline

Data type

boolean

Alias
UMLS CUI [1,1]
C0439673
UMLS CUI [1,2]
C1394798
UMLS CUI [1,3]
C1442488
Reasons of consultation/ hospitalisation
Description

Reasons of consultation/ hospitalisation

Alias
UMLS CUI-1
C0566251
UMLS CUI-2
C0009818
UMLS CUI-3
C0019993
Consultation due to complications of cirrhosis
Description

Consultation / hospitalization due to complications of cirrhosis

Data type

boolean

Alias
UMLS CUI [1,1]
C0023890
UMLS CUI [1,2]
C0009566
UMLS CUI [1,3]
C0009818
UMLS CUI [1,4]
C0566251
UMLS CUI [2,1]
C0023890
UMLS CUI [2,2]
C0009566
UMLS CUI [2,3]
C0019993
UMLS CUI [2,4]
C0566251
Consultation due to gastrointestinal symptoms
Description

Consultation / hospitalization due to gastrointestinal symptoms

Data type

boolean

Alias
UMLS CUI [1,1]
C0426576
UMLS CUI [1,2]
C0009818
UMLS CUI [1,3]
C0566251
UMLS CUI [2,1]
C0426576
UMLS CUI [2,2]
C0019993
UMLS CUI [2,3]
C0566251
Consultation due to respiratory symptoms
Description

Consultation / hospitalization due to respiratory symptoms

Data type

boolean

Alias
UMLS CUI [1,1]
C0035237
UMLS CUI [1,2]
C1457887
UMLS CUI [1,3]
C0009818
UMLS CUI [1,4]
C0566251
UMLS CUI [2,1]
C0035237
UMLS CUI [2,2]
C1457887
UMLS CUI [2,3]
C0019993
UMLS CUI [2,4]
C0566251
Consultation due to other reasons
Description

Consultation / hospitalization due to other reasons

Data type

boolean

Alias
UMLS CUI [1,1]
C0009818
UMLS CUI [1,2]
C0566251
UMLS CUI [1,3]
C0205394
UMLS CUI [2,1]
C0019993
UMLS CUI [2,2]
C0566251
UMLS CUI [2,3]
C0205394
Indicate other reasons for consultation/ hospitalisation
Description

Indicate other reasons for consultation/ hospitalisation

Data type

text

Alias
UMLS CUI [1,1]
C0009818
UMLS CUI [1,2]
C0566251
UMLS CUI [1,3]
C0205394
UMLS CUI [1,4]
C1521902
UMLS CUI [2,1]
C0019993
UMLS CUI [2,2]
C0566251
UMLS CUI [2,3]
C0205394
UMLS CUI [2,4]
C1521902
Unknown reasons for consultation
Description

Unknown reasons for consultation / hospitalization

Data type

boolean

Alias
UMLS CUI [1,1]
C0009818
UMLS CUI [1,2]
C0566251
UMLS CUI [1,3]
C0439673
UMLS CUI [2,1]
C0019993
UMLS CUI [2,2]
C0566251
UMLS CUI [2,3]
C0439673
Current status on liver transplantation waiting list
Description

Current status on liver transplantation waiting list

Alias
UMLS CUI-1
C0422768
UMLS CUI-2
C0023911
Is the patient currently on the liver transplantation waiting list
Description

Liver transplantation waiting list

Data type

integer

Alias
UMLS CUI [1,1]
C0422768
UMLS CUI [1,2]
C0023911
Bacterial infections within the last 30 days
Description

Bacterial infections within the last 30 days

Alias
UMLS CUI-1
C0004623
UMLS CUI-2
C0332185
Bacteremia within the last 30 days
Description

Recent bacteremia

Data type

integer

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0004610
Bacterial pneumonia within the last 30 days
Description

Recent bacterial pneumonia

Data type

integer

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0004626
Spontaneous bacterial peritonitis within the last 30 days
Description

Recent spontaneous bacterial peritonitis

Data type

integer

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0275551
Bacterial infections of skin and/or soft tissue within the last 30 days
Description

Recent bacterial infections of skin / soft tissue

Data type

integer

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0225317
UMLS CUI [1,3]
C0004623
UMLS CUI [2,1]
C0332185
UMLS CUI [2,2]
C1123023
UMLS CUI [2,3]
C0004623
Urinary tract infection within the last 30 days
Description

Recent urinary tract infection

Data type

integer

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0042029
UMLS CUI [1,3]
C0004623
Other bacterial infection within the last 30 days
Description

Other recent bacterial infection

Data type

integer

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0004623
UMLS CUI [1,3]
C0205394
Child-Pugh Score at Baseline
Description

Child-Pugh Score at Baseline

Alias
UMLS CUI-1
C4050412
UMLS CUI-2
C0011900
UMLS CUI-3
C1442488
Serum Bilirubin at Baseline
Description

Serum Bilirubin at Baseline

Data type

integer

Alias
UMLS CUI [1,1]
C1278039
UMLS CUI [1,2]
C1442488
Serum Albumin at Baseline
Description

Serum Albumin at Baseline

Data type

integer

Alias
UMLS CUI [1,1]
C0523465
UMLS CUI [1,2]
C1442488
INR at Baseline
Description

INR at Baseline

Data type

integer

Alias
UMLS CUI [1,1]
C0525032
UMLS CUI [1,2]
C1442488
Ascites at Baseline
Description

Ascites at Baseline

Data type

integer

Alias
UMLS CUI [1,1]
C0003962
UMLS CUI [1,2]
C1442488
Hepatic encephalopathy at Baseline
Description

Hepatic encephalopathy at Baseline

Data type

integer

Alias
UMLS CUI [1,1]
C0019151
UMLS CUI [1,2]
C1442488
MELD Score
Description

MELD Score

Alias
UMLS CUI-1
C1718072
Indicate the MELD Score within the last 30 days before Baseline
Description

Recent MELD Score before Baseline

Data type

integer

Alias
UMLS CUI [1,1]
C1718072
UMLS CUI [1,2]
C0332185
UMLS CUI [1,3]
C1442488
Indicate the MELD score at Baseline
Description

MELD score at Baseline

Data type

integer

Alias
UMLS CUI [1,1]
C1718072
UMLS CUI [1,2]
C1442488
Indicate the worst MELD score during the COVID-19 disease
Description

Worst MELD score during COVID-19 disease

Data type

integer

Alias
UMLS CUI [1,1]
C1718072
UMLS CUI [1,2]
C1522166
UMLS CUI [1,3]
C5203670
Acute-on-chronic liver failure at any point during the SARS-CoV-2 infection
Description

Acute-on-chronic liver failure at any point during the SARS-CoV-2 infection

Alias
UMLS CUI-1
C3850141
UMLS CUI-2
C1522166
UMLS CUI-3
C0040223
UMLS CUI-4
C3714514
UMLS CUI-5
C5203670
Liver: Total serum bilirubin ≥12 mg/dl (205 µmol/l)
Description

Indicate worst value at any point (Baseline or Phases) during infection.

Data type

integer

Alias
UMLS CUI [1]
C1278039
Kidney: Serum creatinin ≥2 mg/dl (177 µmol/l) or use of Terlipressin
Description

Indicate worst value at any point (Baseline or Phases) during infection.

Data type

integer

Alias
UMLS CUI [1]
C0201976
UMLS CUI [2]
C0145185
Brain: Overt hepatic encephalopathy stage III-IV (West-Haven)
Description

Indicate worst value at any point (Baseline or Phases) during infection.

Data type

integer

Alias
UMLS CUI [1]
C3890564
Coagulation: INR ≥2.5 or Platelets <20 /nl
Description

Indicate worst value at any point (Baseline or Phases) during infection.

Data type

integer

Alias
UMLS CUI [1]
C0032181
UMLS CUI [2]
C0525032
Circulatory: Vasopressor use
Description

Indicate worst value at any point (Baseline or Phases) during infection.

Data type

integer

Alias
UMLS CUI [1]
C0042397
Respiratory: paO2/FiO2 (Horowitz index) ≤200 mmHg
Description

Indicate worst value at any point (Baseline or Phases) during infection.

Data type

integer

Alias
UMLS CUI [1]
C1977592
Medication within the last 30 days
Description

Medication within the last 30 days

Alias
UMLS CUI-1
C0013227
UMLS CUI-2
C0332185
Beta-Blockers within the last 30 days
Description

Recent Beta-Blockers

Data type

integer

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0001645
Diuretics within the last 30 days
Description

Recent Diuretics

Data type

integer

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0012798
Norfloxacin within the last 30 days
Description

Recent Norfloxacin

Data type

integer

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0028365
Proton pump inhibitors within the last 30 days
Description

Recent PPI

Data type

integer

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0358591
Rifaximin within the last 30 days
Description

Recent Rifaximin

Data type

integer

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0073374
Statins within the last 30 days
Description

Recent Statins

Data type

integer

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0360714
Is data entry for this section finished?
Description

Is data entry for this section finished?

Alias
UMLS CUI-1
C4684556
UMLS CUI-2
C1828479
UMLS CUI-3
C0205197
Is data entry for this section finished?
Description

Is data entry for this section finished?

Data type

boolean

Alias
UMLS CUI [1,1]
C4684556
UMLS CUI [1,2]
C1828479
UMLS CUI [1,3]
C0205197
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Similar models

Liver cirrhosis sub-cohort

1 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Etiology of liver cirrhosis
C0023890 (UMLS CUI-1)
C1314792 (UMLS CUI-2)
Alcoholic liver cirrhosis
Item
Alcoholic liver cirrhosis
boolean
C0023891 (UMLS CUI [1])
PBC
Item
PBC (Primary biliary cholangitis))
boolean
C0008312 (UMLS CUI [1])
PSC
Item
PSC (Primary sclerosing cholangitis)
boolean
C0566602 (UMLS CUI [1])
AIH
Item
AIH (Autoimmune hepatitis)
boolean
C0241910 (UMLS CUI [1])
Etiology of liver cirrhosis: Viral hepatitis
Item
Viral hepatitis as reason for liver cirrhosis
boolean
C0042721 (UMLS CUI [1,1])
C0023890 (UMLS CUI [1,2])
C1314792 (UMLS CUI [1,3])
Other etiology of liver cirrhosis
Item
Other etiology of liver cirrhosis
boolean
C0023890 (UMLS CUI [1,1])
C1314792 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
Indicate other etiology of liver cirrhosis
Item
Indicate other etiology of cirrhosis
text
C1314792 (UMLS CUI [1,1])
C0023890 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C1521902 (UMLS CUI [1,4])
Unknown etiology of liver cirrhosis
Item
Unknown
boolean
C0439673 (UMLS CUI [1,1])
C0023890 (UMLS CUI [1,2])
C1314792 (UMLS CUI [1,3])
Item Group
Decompensation of cirrhosis (Ascites, Variceal bleeding, Hepatic encephalopathy)
C1394798 (UMLS CUI-1)
C0003962 (UMLS CUI-2)
C0333106 (UMLS CUI-3)
C0019151 (UMLS CUI-4)
Item
Current status of cirrhosis (Ascites, Variceal bleeding, Hepatic encephalopathy)
integer
C1394798 (UMLS CUI [1])
C0003962 (UMLS CUI [2])
C0333106 (UMLS CUI [3])
C0019151 (UMLS CUI [4])
Decompensation of Cirrhosis (Ascites, Variceal bleeding, Hepatic encephalopathy)
Code List
Current status of cirrhosis (Ascites, Variceal bleeding, Hepatic encephalopathy)
CL Item
Currently compensated, but decompensated in the past (1)
CL Item
Acute decompensation within the last 30 days (New or worsening ascites, acute hepatic encephalopathy, gastrointestinal bleeding) (2)
CL Item
Chronic decompensated state (Refractory ascites, chronic hepatic encephalopathy) (3)
CL Item
Never decompensated (4)
CL Item
Unknown (5)
New or worsening ascites at Baseline
Item
New or worsening ascites at Baseline
boolean
C1442488 (UMLS CUI [1,1])
C0003962 (UMLS CUI [1,2])
C0332271 (UMLS CUI [1,3])
C1442488 (UMLS CUI [2,1])
C0003962 (UMLS CUI [2,2])
C0205314 (UMLS CUI [2,3])
Hepatic encephalopathy at Baseline
Item
Overt hepatic encephalopathy at Baseline
boolean
C0019151 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
Gastrointestinal bleeding at Baseline
Item
Gastrointestinal bleeding at Baseline
boolean
C0017181 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
No hepatic decompensation at Baseline
Item
No decompensation at Baseline
boolean
C0549184 (UMLS CUI [1,1])
C1394798 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
Unknown decompensation status at Baseline
Item
Unknown decompensation status at Baseline
boolean
C0439673 (UMLS CUI [1,1])
C1394798 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
Item Group
Reasons of consultation/ hospitalisation
C0566251 (UMLS CUI-1)
C0009818 (UMLS CUI-2)
C0019993 (UMLS CUI-3)
Consultation / hospitalization due to complications of cirrhosis
Item
Consultation due to complications of cirrhosis
boolean
C0023890 (UMLS CUI [1,1])
C0009566 (UMLS CUI [1,2])
C0009818 (UMLS CUI [1,3])
C0566251 (UMLS CUI [1,4])
C0023890 (UMLS CUI [2,1])
C0009566 (UMLS CUI [2,2])
C0019993 (UMLS CUI [2,3])
C0566251 (UMLS CUI [2,4])
Consultation / hospitalization due to gastrointestinal symptoms
Item
Consultation due to gastrointestinal symptoms
boolean
C0426576 (UMLS CUI [1,1])
C0009818 (UMLS CUI [1,2])
C0566251 (UMLS CUI [1,3])
C0426576 (UMLS CUI [2,1])
C0019993 (UMLS CUI [2,2])
C0566251 (UMLS CUI [2,3])
Consultation / hospitalization due to respiratory symptoms
Item
Consultation due to respiratory symptoms
boolean
C0035237 (UMLS CUI [1,1])
C1457887 (UMLS CUI [1,2])
C0009818 (UMLS CUI [1,3])
C0566251 (UMLS CUI [1,4])
C0035237 (UMLS CUI [2,1])
C1457887 (UMLS CUI [2,2])
C0019993 (UMLS CUI [2,3])
C0566251 (UMLS CUI [2,4])
Consultation / hospitalization due to other reasons
Item
Consultation due to other reasons
boolean
C0009818 (UMLS CUI [1,1])
C0566251 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0019993 (UMLS CUI [2,1])
C0566251 (UMLS CUI [2,2])
C0205394 (UMLS CUI [2,3])
Indicate other reasons for consultation/ hospitalisation
Item
Indicate other reasons for consultation/ hospitalisation
text
C0009818 (UMLS CUI [1,1])
C0566251 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C1521902 (UMLS CUI [1,4])
C0019993 (UMLS CUI [2,1])
C0566251 (UMLS CUI [2,2])
C0205394 (UMLS CUI [2,3])
C1521902 (UMLS CUI [2,4])
Unknown reasons for consultation / hospitalization
Item
Unknown reasons for consultation
boolean
C0009818 (UMLS CUI [1,1])
C0566251 (UMLS CUI [1,2])
C0439673 (UMLS CUI [1,3])
C0019993 (UMLS CUI [2,1])
C0566251 (UMLS CUI [2,2])
C0439673 (UMLS CUI [2,3])
Item Group
Current status on liver transplantation waiting list
C0422768 (UMLS CUI-1)
C0023911 (UMLS CUI-2)
Item
Is the patient currently on the liver transplantation waiting list
integer
C0422768 (UMLS CUI [1,1])
C0023911 (UMLS CUI [1,2])
Patient currently on the liver transplantation waiting list
Code List
Is the patient currently on the liver transplantation waiting list
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Bacterial infections within the last 30 days
C0004623 (UMLS CUI-1)
C0332185 (UMLS CUI-2)
Item
Bacteremia within the last 30 days
integer
C0332185 (UMLS CUI [1,1])
C0004610 (UMLS CUI [1,2])
Bacteremia
Code List
Bacteremia within the last 30 days
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Bacterial pneumonia within the last 30 days
integer
C0332185 (UMLS CUI [1,1])
C0004626 (UMLS CUI [1,2])
Bacterial Pneumonia
Code List
Bacterial pneumonia within the last 30 days
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Spontaneous bacterial peritonitis within the last 30 days
integer
C0332185 (UMLS CUI [1,1])
C0275551 (UMLS CUI [1,2])
Spontaneous bacterial peritonitis
Code List
Spontaneous bacterial peritonitis within the last 30 days
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Bacterial infections of skin and/or soft tissue within the last 30 days
integer
C0332185 (UMLS CUI [1,1])
C0225317 (UMLS CUI [1,2])
C0004623 (UMLS CUI [1,3])
C0332185 (UMLS CUI [2,1])
C1123023 (UMLS CUI [2,2])
C0004623 (UMLS CUI [2,3])
Skin / Soft Tissue
Code List
Bacterial infections of skin and/or soft tissue within the last 30 days
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Urinary tract infection within the last 30 days
integer
C0332185 (UMLS CUI [1,1])
C0042029 (UMLS CUI [1,2])
C0004623 (UMLS CUI [1,3])
Urinary Tract Infection
Code List
Urinary tract infection within the last 30 days
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Other bacterial infection within the last 30 days
integer
C0332185 (UMLS CUI [1,1])
C0004623 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
Other bacterial Infection
Code List
Other bacterial infection within the last 30 days
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Child-Pugh Score at Baseline
C4050412 (UMLS CUI-1)
C0011900 (UMLS CUI-2)
C1442488 (UMLS CUI-3)
Item
Serum Bilirubin at Baseline
integer
C1278039 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
Serum Bilirubin
Code List
Serum Bilirubin at Baseline
CL Item
<2 mg/dl (1)
CL Item
2-3 mg/dl (2)
CL Item
>3 mg/dl (3)
CL Item
Not done (4)
CL Item
Unknown (6)
Item
Serum Albumin at Baseline
integer
C0523465 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
Serum Albumin
Code List
Serum Albumin at Baseline
CL Item
>3.5 g/dl (1)
CL Item
2.8-3.5 g/dl (2)
CL Item
<2.8 g/dl (3)
CL Item
Not done (4)
CL Item
Unknown (5)
Item
INR at Baseline
integer
C0525032 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
INR
Code List
INR at Baseline
CL Item
<1.7 (1)
CL Item
1.7-2.2 (2)
CL Item
>2.2 (3)
CL Item
Not done (4)
CL Item
Unknown (5)
Item
Ascites at Baseline
integer
C0003962 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
Ascites
Code List
Ascites at Baseline
CL Item
Mild to moderate (1)
CL Item
Severe (2)
CL Item
None (3)
CL Item
Unknown (4)
Item
Hepatic encephalopathy at Baseline
integer
C0019151 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
Hepatic encephalopathy
Code List
Hepatic encephalopathy at Baseline
CL Item
Mild to moderate (Stage I-II West Haven) (1)
CL Item
Severe (grade III or IV) (2)
CL Item
None (3)
CL Item
Unknown (4)
Item Group
MELD Score
C1718072 (UMLS CUI-1)
Item
Indicate the MELD Score within the last 30 days before Baseline
integer
C1718072 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
MELD Score within the last 30 days before diagnosis
Code List
Indicate the MELD Score within the last 30 days before Baseline
CL Item
>=25 (1)
CL Item
19 - 24 (2)
CL Item
11 - 18 (3)
CL Item
<=10 (4)
CL Item
Unknown (5)
Item
Indicate the MELD score at Baseline
integer
C1718072 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
MELD score at diagnosis
Code List
Indicate the MELD score at Baseline
CL Item
>=25 (1)
CL Item
19 - 24 (2)
CL Item
11 - 18 (3)
CL Item
<=10 (4)
CL Item
Unknown (5)
Item
Indicate the worst MELD score during the COVID-19 disease
integer
C1718072 (UMLS CUI [1,1])
C1522166 (UMLS CUI [1,2])
C5203670 (UMLS CUI [1,3])
MELD score at diagnosis
Code List
Indicate the worst MELD score during the COVID-19 disease
CL Item
>=25 (1)
CL Item
19 - 24 (2)
CL Item
11 - 18 (3)
CL Item
<=10 (4)
CL Item
Unknown (5)
Item Group
Acute-on-chronic liver failure at any point during the SARS-CoV-2 infection
C3850141 (UMLS CUI-1)
C1522166 (UMLS CUI-2)
C0040223 (UMLS CUI-3)
C3714514 (UMLS CUI-4)
C5203670 (UMLS CUI-5)
Item
Liver: Total serum bilirubin ≥12 mg/dl (205 µmol/l)
integer
C1278039 (UMLS CUI [1])
Liver: Total serum bilirubin ≥12 mg/dl (205 µmol/l)
Code List
Liver: Total serum bilirubin ≥12 mg/dl (205 µmol/l)
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Kidney: Serum creatinin ≥2 mg/dl (177 µmol/l) or use of Terlipressin
integer
C0201976 (UMLS CUI [1])
C0145185 (UMLS CUI [2])
Kidney: Serum creatinin ≥2 mg/dl (177 µmol/l) or use of Terlipressin
Code List
Kidney: Serum creatinin ≥2 mg/dl (177 µmol/l) or use of Terlipressin
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Brain: Overt hepatic encephalopathy stage III-IV (West-Haven)
integer
C3890564 (UMLS CUI [1])
Brain: Overt hepatic encephalopathy stage III-IV (West-Haven)
Code List
Brain: Overt hepatic encephalopathy stage III-IV (West-Haven)
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Coagulation: INR ≥2.5 or Platelets <20 /nl
integer
C0032181 (UMLS CUI [1])
C0525032 (UMLS CUI [2])
Coagulation: INR ≥2.5 or Platelets <20 /nl
Code List
Coagulation: INR ≥2.5 or Platelets <20 /nl
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Circulatory: Vasopressor use
integer
C0042397 (UMLS CUI [1])
Circulatory: Vasopressor use
Code List
Circulatory: Vasopressor use
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Respiratory: paO2/FiO2 (Horowitz index) ≤200 mmHg
integer
C1977592 (UMLS CUI [1])
Respiratory: paO2/FiO2 (Horowitz index) ≤200 mmHg
Code List
Respiratory: paO2/FiO2 (Horowitz index) ≤200 mmHg
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Medication within the last 30 days
C0013227 (UMLS CUI-1)
C0332185 (UMLS CUI-2)
Item
Beta-Blockers within the last 30 days
integer
C0332185 (UMLS CUI [1,1])
C0001645 (UMLS CUI [1,2])
Beta-Blockers
Code List
Beta-Blockers within the last 30 days
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Diuretics within the last 30 days
integer
C0332185 (UMLS CUI [1,1])
C0012798 (UMLS CUI [1,2])
Diuretics
Code List
Diuretics within the last 30 days
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Norfloxacin within the last 30 days
integer
C0332185 (UMLS CUI [1,1])
C0028365 (UMLS CUI [1,2])
Norfloxacin
Code List
Norfloxacin within the last 30 days
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Proton pump inhibitors within the last 30 days
integer
C0332185 (UMLS CUI [1,1])
C0358591 (UMLS CUI [1,2])
Proton pump inhibitors
Code List
Proton pump inhibitors within the last 30 days
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Rifaximin within the last 30 days
integer
C0332185 (UMLS CUI [1,1])
C0073374 (UMLS CUI [1,2])
Rifaximin
Code List
Rifaximin within the last 30 days
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Statins within the last 30 days
integer
C0332185 (UMLS CUI [1,1])
C0360714 (UMLS CUI [1,2])
Statins
Code List
Statins within the last 30 days
CL Item
Yes (1)
CL Item
No (2)
CL Item
Unknown (3)
Item Group
Is data entry for this section finished?
C4684556 (UMLS CUI-1)
C1828479 (UMLS CUI-2)
C0205197 (UMLS CUI-3)
Is data entry for this section finished?
Item
Is data entry for this section finished?
boolean
C4684556 (UMLS CUI [1,1])
C1828479 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,3])
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