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Beschreibung
Background and Purpose: The purpose of the DESCRIBE study is to document the natural course of diseases in context of medical care of neurodegenerative disorders as well as cerebrovascular diseases and to perform phenotyping of the test persons. Disease-spanning analyses of the measured clincial data, the results of the imaging processes, results of the analysis of the biometerials including genetic analysis are planed. Principal Investigator: Prof. Klockgether, Dr. Spottke DZNE, Bonn. Source: DESCRIBE-Studie http://www.dzne.de/forschung/forschungsbereiche/klinische-forschung/studien/describe-bn006.html Participating Study Sites: Berlin, Bonn, Göttingen, Dresden, Köln, Magdeburg, München, Rostock/Greifswald, Tübingen
Link
http://www.dzne.de/forschung/forschungsbereiche/klinische-forschung/studien/describe-bn006.html
Stichworte
Versionen (14)
- 24.02.16 24.02.16 -
- 01.03.16 01.03.16 -
- 02.03.16 02.03.16 -
- 03.03.16 03.03.16 -
- 03.03.16 03.03.16 -
- 04.03.16 04.03.16 - Julian Varghese
- 07.03.16 07.03.16 -
- 09.03.16 09.03.16 -
- 09.03.16 09.03.16 -
- 09.03.16 09.03.16 -
- 10.03.16 10.03.16 -
- 10.03.16 10.03.16 -
- 13.04.21 13.04.21 - Dr. rer. medic Philipp Neuhaus
- 20.09.21 20.09.21 -
Hochgeladen am
13. April 2021
DOI
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Creative Commons BY-NC 3.0
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DESCRIBE (DZNE – Clinical Register Study of neurodegenerative Disorders) CRF Diagnostic Criteria
CRF Diagnostic Criteria
- StudyEvent: ODM
Ähnliche Modelle
CRF Diagnostic Criteria
- StudyEvent: ODM
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
date of visit
Item
Date of visit
date
C1320303 (UMLS CUI [1])
study id
Item
Study-ID:
text
C2826693 (UMLS CUI [1])
visit name
Item
Visit:
text
C2826704 (UMLS CUI [1])
current MCI
Item
Is the patient currently diagnosed with a MCI according to Winblad & Petersen 2004?
boolean
C1270972 (UMLS CUI [1,1])
C0150312 (UMLS CUI [1,2])
C0150312 (UMLS CUI [1,2])
cognitive degration
Item
Cognitive Impairment 1. Subjective deterioration of cognition observed by the patient or an informant and/or...
boolean
C1270972 (UMLS CUI [1,1])
C0854193 (UMLS CUI [1,2])
C0854193 (UMLS CUI [1,2])
psychometric test proving cognitive degradation
Item
2. Evidence of degradation of cognition in time due to psychometric tests
boolean
C1270972 (UMLS CUI [1,1])
C0033920 (UMLS CUI [1,2])
C0033920 (UMLS CUI [1,2])
everyday functioning
Item
3. Ability to perform activities of everyday living/ minimal impairment of complex instrumental everyday functions
boolean
C0562507 (UMLS CUI [1])
signs of disturbed consciousness
Item
4. No signs of disturbed consciousness, of a delirium, of a dementia or of an amnesic aphasia that cannot be explained better by other psychotic illnesses (e.g. a disorder in connection with psychotropic substances or major depression).
boolean
C0234428 (UMLS CUI [1])
C0011206 (UMLS CUI [2])
C0497327 (UMLS CUI [3])
C0011206 (UMLS CUI [2])
C0497327 (UMLS CUI [3])
wordlist
Item
Operationalization 1. Wordlist - delayed word retrieval
boolean
C0456660 (UMLS CUI [1])
visuospatial ability
Item
2. Visuospatial ability - Drawing
boolean
C0814069 (UMLS CUI [1])
C0565772 (UMLS CUI [2])
C0565772 (UMLS CUI [2])
visuospatial ability delayed
Item
3. Visuospatial ability - Delayed retrieval
boolean
C0814069 (UMLS CUI [1])
trail making test
Item
4. Trial making test A or B
boolean
C0040604 (UMLS CUI [1])
semantic or phonetic fluency
Item
5. Semantic or phonetic fluency
boolean
C0233714 (UMLS CUI [1])
object naming
Item
6. Object naming
boolean
C0451342 (UMLS CUI [1])
normal finding FAQ
Item
7. No abnormal finding FAQ
boolean
C3827007 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C0205307 (UMLS CUI [1,2])
amnesic MCI single domain
Item
Classification a. Amnesic MCI single domain (only memory)
boolean
C1270972 (UMLS CUI [1])
amnesic MCI multi domain
Item
b. Amnesic MCI multi domain (memory and one additional area)
boolean
C1270972 (UMLS CUI [1])
non-amnesic MCI single domain
Item
c. Non-amnesic MCI single domain (one area, except memory)
boolean
C1270972 (UMLS CUI [1])
non-amnesic MCI multi domain
Item
d. Non-amnesic MCI multi domain (several areas, except memory)
boolean
C1270972 (UMLS CUI [1])
Item Group
Dementia in Alzheimer's Disease (AD)
C3665464 (UMLS CUI-1)
NINCDS/ADRDA-Criteria AD diagnosis
Item
Is the patient currently diagnosed with AD according to NINCDS/ADRDA-Criteria (McKhann et al. 1984)?
boolean
C3665464 (UMLS CUI [1,1])
C2828081 (UMLS CUI [1,2])
C2828081 (UMLS CUI [1,2])
dementia
Item
I. Necessary requirements Evidence of dementia in a clinical examination including neuropsychological tests
boolean
C0497327 (UMLS CUI [1])
C0027902 (UMLS CUI [2])
C0027902 (UMLS CUI [2])
cognitive deficits
Item
Deficits in at least two cognitive areas
boolean
C0009241 (UMLS CUI [1])
progressive disturbance of memory
Item
Progressive disturbance of memory and other cognitive functions
boolean
C1864985 (UMLS CUI [1,1])
C0025260 (UMLS CUI [1,2])
C1864985 (UMLS CUI [2,1])
C0392335 (UMLS CUI [2,2])
C0025260 (UMLS CUI [1,2])
C1864985 (UMLS CUI [2,1])
C0392335 (UMLS CUI [2,2])
no consciousness disturbance
Item
No consciousness disturbance
boolean
C0424525 (UMLS CUI [1])
age at onset
Item
Onset between age of 40 and 90, mostly 65 and older
boolean
C0150907 (UMLS CUI [1])
other system- or brain diseases
Item
No evidence of other system- or brain diseases as cause
boolean
C0442893 (UMLS CUI [1])
C0006111 (UMLS CUI [2])
C0006111 (UMLS CUI [2])
progressive deterioration of specific cognitive functions
Item
II. Subsidiary Findings Progressive deterioration of specific cognitive functions, e.g. of speech (aphasia), motor activity (apraxia) and perception (agnosia)
boolean
C0854193 (UMLS CUI [1,1])
C0205329 (UMLS CUI [1,2])
C0205329 (UMLS CUI [1,2])
impairment of everyday activities and behavioral change
Item
Impairment of everyday activities and emerging of behavior modifications
boolean
C0562507 (UMLS CUI [1,1])
C0221099 (UMLS CUI [1,2])
C0542299 (UMLS CUI [2])
C0221099 (UMLS CUI [1,2])
C0542299 (UMLS CUI [2])
family history of similar disorders
Item
Family history of similar disorders (especially if neurologically proven)
boolean
C0241889 (UMLS CUI [1])
cerebral atrophy
Item
Results of additional examinations: Evidence of - progressively evolving in follow ups- cerebral atrophy due to imaging diagnostics
boolean
C0235946 (UMLS CUI [1])
normal finding or unspecific changes in EEG
Item
Normal finding or unspecific changes in EEG
boolean
C0234550 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C0234550 (UMLS CUI [2,1])
C0750540 (UMLS CUI [2,2])
C0205307 (UMLS CUI [1,2])
C0234550 (UMLS CUI [2,1])
C0750540 (UMLS CUI [2,2])
normal finding of cerebrospinal fluid
Item
Normal finding of cerebrospinal fluid
boolean
C0007806 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C0205307 (UMLS CUI [1,2])
diagnosis of Alzheimers disease
Item
III. Matching with a probable diagnosis of Alzheimer's disease Temporal stagnation in course of disease
boolean
C1848980 (UMLS CUI [1,1])
C0242656 (UMLS CUI [1,2])
C0242656 (UMLS CUI [1,2])
attendant symptoms
Item
Attendant symptoms like depression, insomnia, incontinence, illusion, hallucination, delusion, sudden aggressive outbreaks, sexual dysfunction and weight loss
boolean
C0011581 (UMLS CUI [1])
C0917801 (UMLS CUI [2])
C0021167 (UMLS CUI [3])
C0020903 (UMLS CUI [4])
C0018524 (UMLS CUI [5])
C0011253 (UMLS CUI [6])
C0001807 (UMLS CUI [7])
C0549622 (UMLS CUI [8])
C0936227 (UMLS CUI [9])
C0917801 (UMLS CUI [2])
C0021167 (UMLS CUI [3])
C0020903 (UMLS CUI [4])
C0018524 (UMLS CUI [5])
C0011253 (UMLS CUI [6])
C0001807 (UMLS CUI [7])
C0549622 (UMLS CUI [8])
C0936227 (UMLS CUI [9])
neurological distinctive feature
Item
Neurological distinctive feature (particularly in case of advanced disease) like elevated muscle tonus, myoclonus or gait disturbance
boolean
C1704258 (UMLS CUI [1,1])
C0205494 (UMLS CUI [1,2])
C0026841 (UMLS CUI [2])
C0027066 (UMLS CUI [3])
C1856566 (UMLS CUI [4])
C0205494 (UMLS CUI [1,2])
C0026841 (UMLS CUI [2])
C0027066 (UMLS CUI [3])
C1856566 (UMLS CUI [4])
epileptic seizure
Item
Epileptic seizure (in case of advanced disease)
boolean
C1411824 (UMLS CUI [1])
CT commensurate with age
Item
CT commensurate with age
boolean
C0040405 (UMLS CUI [1,1])
C0001783 (UMLS CUI [1,2])
C0001783 (UMLS CUI [1,2])
sudden apoplectic onset
Item
IV. Exclusion Criteria Sudden, apoplectic onset
boolean
C1388315 (UMLS CUI [1,1])
C1276802 (UMLS CUI [1,2])
C1276802 (UMLS CUI [1,2])
focal neurological signs
Item
Focal neurological signs like hemiparesis, sensorial failures, visual field defects or problems with coordination in early stage of disease
boolean
C0018989 (UMLS CUI [1])
C0152027 (UMLS CUI [2])
C0004134 (UMLS CUI [3])
C3887875 (UMLS CUI [4])
C0152027 (UMLS CUI [2])
C0004134 (UMLS CUI [3])
C3887875 (UMLS CUI [4])
epileptic seizures or gait disturbance
Item
Epileptic seizures or gait disturbance at onset or in early stage of disease
boolean
C1411824 (UMLS CUI [1])
C1856566 (UMLS CUI [2])
C1856566 (UMLS CUI [2])
dementia syndrome with atypical symptomatic
Item
V. Clinical possible AD Dementia syndrome with atypical symptomatic with regard to onset, course and deficit profile, in absence of other neurological, psychiatric or internal disease that could cause the dementia syndrome
boolean
C0497327 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C0231220 (UMLS CUI [1,2])
second systemic or brain disease
Item
Second systemic or brain disease that could cause dementia, but is commonly not regarded as a substantial cause
boolean
C0442893 (UMLS CUI [1])
C0006111 (UMLS CUI [2])
C0006111 (UMLS CUI [2])
progressive severe cognitive deficit
Item
Progressive severe cognitive deficit without notable different cause
boolean
C0009241 (UMLS CUI [1,1])
C0205329 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,3])
C0205329 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,3])
Item Group
Posterior cortical atrophy (PCA)
C0235946 (UMLS CUI-1)
C0205095 (UMLS CUI-2)
C0205095 (UMLS CUI-2)
PCA diagnosis
Item
Is the patient currently diagnosed with PCA according to the criteria of Mendez et.al. 2002?
boolean
C0235946 (UMLS CUI [1,1])
C0205095 (UMLS CUI [1,2])
C0205095 (UMLS CUI [1,2])
insidious onset and gradual progression
Item
Main symptoms (all symptoms have to be present) A. Insidious onset and gradual progression
boolean
C1298634 (UMLS CUI [1])
C1854645 (UMLS CUI [2])
C1854645 (UMLS CUI [2])
visual disorders
Item
B. Presentation with visual disorders while visual function intact
boolean
C0042790 (UMLS CUI [1])
prominent complex visual deficits
Item
C. Evidence of prominent complex visual deficits
boolean
C3665347 (UMLS CUI [1,1])
C0205402 (UMLS CUI [1,2])
C0439855 (UMLS CUI [1,3])
C0205402 (UMLS CUI [1,2])
C0439855 (UMLS CUI [1,3])
Balint syndrome
Item
Elements of Balint syndrome
boolean
C0270706 (UMLS CUI [1])
visual agnosia
Item
Visual agnosia
boolean
C0234502 (UMLS CUI [1])
dressing apraxia
Item
Dressing apraxis
boolean
C0234529 (UMLS CUI [1])
topographic disorientation
Item
Topographic disorientation
boolean
C0233407 (UMLS CUI [1,1])
C1639223 (UMLS CUI [1,2])
C1639223 (UMLS CUI [1,2])
relatively small deficits of memory and word fluency
Item
D. Relatively small memory deficits and word fluency deficits
boolean
C0233794 (UMLS CUI [1,1])
C1843272 (UMLS CUI [1,2])
C2018029 (UMLS CUI [2,1])
C1843272 (UMLS CUI [2,2])
C1843272 (UMLS CUI [1,2])
C2018029 (UMLS CUI [2,1])
C1843272 (UMLS CUI [2,2])
relatively good awareness of disability
Item
E. Relatively good awareness of disability with or without depression
boolean
C0424227 (UMLS CUI [1,1])
C0205170 (UMLS CUI [1,2])
C0205170 (UMLS CUI [1,2])
presenile onset
Item
Subsidiary diagnosis A. Presenile onset
boolean
C0750901 (UMLS CUI [1])
alexia
Item
B. Alexia
boolean
C0002018 (UMLS CUI [1])
Gerstmann syndrome
Item
C. Elements of Gerstmann syndrome
boolean
C0017494 (UMLS CUI [1])
ideomotor apraxia
Item
D. Ideomotor apraxia
boolean
C0234523 (UMLS CUI [1])
physical examination
Item
E. Physical examination within the norms
boolean
C0031809 (UMLS CUI [1])
impairment of perceptual functions
Item
F. Neuropsychiatric: Prominent impairment of perceptual functions
boolean
C0233746 (UMLS CUI [1])
occipitoparietal abnormality
Item
Imaging: Prominent occipitoparietal abnormality (especially in functional imaging) with relative recess of frontal and mesiotemporal regions
boolean
C1704258 (UMLS CUI [1,1])
C1184145 (UMLS CUI [1,2])
C0442030 (UMLS CUI [1,3])
C1184145 (UMLS CUI [1,2])
C0442030 (UMLS CUI [1,3])
VD diagnoses
Item
Is the patient currently diagnosed with VD according to the criteria of NINDS/AIREN (Roman et al. 1993?)
boolean
C0011269 (UMLS CUI [1])
cognitive impairment
Item
I. Dementia Cognitive impairment regarding previous higher functional status manifested by disturbance of memory
boolean
C0009241 (UMLS CUI [1])
C0233794 (UMLS CUI [2])
C0233794 (UMLS CUI [2])
orientation
Item
Orientation
boolean
C0029266 (UMLS CUI [1])
attention
Item
Attention
boolean
C0004268 (UMLS CUI [1])
speech
Item
Speech
boolean
C0037817 (UMLS CUI [1])
spatial visualization ability
Item
Spatial visualization ability
boolean
C0679024 (UMLS CUI [1])
ability to judge
Item
Ability to judge
boolean
C0022423 (UMLS CUI [1])
action ability
Item
Action ability
boolean
C1820715 (UMLS CUI [1])
abstraction ability
Item
Abstraction ability
boolean
C0679195 (UMLS CUI [1])
motor control
Item
Motor control
boolean
C0517961 (UMLS CUI [1])
praxia
Item
Praxia
boolean
C0871470 (UMLS CUI [1,1])
C0234621 (UMLS CUI [1,2])
C0234621 (UMLS CUI [1,2])
everyday activities
Item
Activities of daily living
boolean
C0001288 (UMLS CUI [1])
disturbed consciousness
Item
Exclusion criteria Disturbed consciousness
boolean
C0549249 (UMLS CUI [1])
delirium
Item
Delirium
boolean
C0011206 (UMLS CUI [1])
psychosis
Item
Psychosis
boolean
C0033975 (UMLS CUI [1])
severe aphasia
Item
Severe aphasia
boolean
C0003537 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,2])
sensomotoric disorder
Item
Prominent sensomotoric disorder, which makes testing impossible
boolean
C0036675 (UMLS CUI [1])
systemic or other brain diseases
Item
Systemic or other brain diseases, that can cause cognitive disorders for their part
boolean
C2874347 (UMLS CUI [1])
cerebrovascular disease
Item
II. Cerebrovascular disease Central focal neurological signs with or without anamnestic stroke and signs of relevant cerebrovascular disease in CT/MRT
boolean
C1392298 (UMLS CUI [1])
C0038454 (UMLS CUI [2])
C0007820 (UMLS CUI [3])
C0038454 (UMLS CUI [2])
C0007820 (UMLS CUI [3])
bilateral artery cerebri anterior
Item
A. cerebri anterior, bilateral
boolean
C0149561 (UMLS CUI [1,1])
C0238767 (UMLS CUI [1,2])
C0238767 (UMLS CUI [1,2])
anterior cerebral artery
Item
A. cerebri anterior
boolean
C0149561 (UMLS CUI [1])
parietotemporal or temporoparietal association complex
Item
Parietotemporal or temporoparietal association complex
boolean
C3498498 (UMLS CUI [1])
C3495412 (UMLS CUI [2])
C3495412 (UMLS CUI [2])
watershed infarction
Item
Superiore frontale and parietal watershed zone
boolean
C0333557 (UMLS CUI [1])
basal ganglia and frontal lacuna of white matter
Item
Disease of small vessels: Basal ganglia and frontal lacuna of white matter
boolean
C0152295 (UMLS CUI [1,1])
C1459585 (UMLS CUI [1,2])
C0004781 (UMLS CUI [1,3])
C0152295 (UMLS CUI [2,1])
C1459585 (UMLS CUI [2,2])
C0016733 (UMLS CUI [2,3])
C1459585 (UMLS CUI [1,2])
C0004781 (UMLS CUI [1,3])
C0152295 (UMLS CUI [2,1])
C1459585 (UMLS CUI [2,2])
C0016733 (UMLS CUI [2,3])
periventricular white matter lesions
Item
Broad periventricular white matter lesions
boolean
C2675929 (UMLS CUI [1,1])
C0228157 (UMLS CUI [1,2])
C0228157 (UMLS CUI [1,2])
bilateral thalamus lesions
Item
Bilateral thalamus lesions
boolean
C2026261 (UMLS CUI [1,1])
C0238767 (UMLS CUI [1,2])
C0238767 (UMLS CUI [1,2])
great vessel lesions
Item
Severity: great vessel lesions in dominant hemisphere
boolean
C0221198 (UMLS CUI [1,1])
C3641002 (UMLS CUI [1,2])
C0228465 (UMLS CUI [1,3])
C1527180 (UMLS CUI [1,4])
C3641002 (UMLS CUI [1,2])
C0228465 (UMLS CUI [1,3])
C1527180 (UMLS CUI [1,4])
bilateral lesions of great vessel
Item
Bilateral lesions of great vessel in hemisphere
boolean
C0221198 (UMLS CUI [1,1])
C3641002 (UMLS CUI [1,2])
C0228465 (UMLS CUI [1,3])
C0238767 (UMLS CUI [1,4])
C3641002 (UMLS CUI [1,2])
C0228465 (UMLS CUI [1,3])
C0238767 (UMLS CUI [1,4])
leukoencephalopathy
Item
Leukoencephalopathy => 25% of white matter
boolean
C0023524 (UMLS CUI [1])
onset of dementia
Item
III. Combination of I. and II. Onset of dementia within three months after stroke
boolean
C0011269 (UMLS CUI [1,1])
C0332162 (UMLS CUI [1,2])
C0332162 (UMLS CUI [1,2])
abrupt degeneration of cognitive functions
Item
Abrupt degeneration of cognitive functions
boolean
C0338656 (UMLS CUI [1,1])
C1276802 (UMLS CUI [1,2])
C1276802 (UMLS CUI [1,2])
progression of cognitive deficits
Item
Fluctuating or gradual progression of cognitive deficits
boolean
C1854645 (UMLS CUI [1,1])
C0338656 (UMLS CUI [1,2])
C0338656 (UMLS CUI [2,1])
C0231241 (UMLS CUI [2,2])
C0338656 (UMLS CUI [1,2])
C0338656 (UMLS CUI [2,1])
C0231241 (UMLS CUI [2,2])
gait disturbance
Item
Supporting Symptoms: Early occuring gait disturbance
boolean
C1856566 (UMLS CUI [1,1])
C0596473 (UMLS CUI [1,2])
C0596473 (UMLS CUI [1,2])
motoric instability and frequent support
Item
Motoric instability and frequent support
boolean
C0260026 (UMLS CUI [1])
C2197383 (UMLS CUI [2])
C2197383 (UMLS CUI [2])
bladder problem
Item
Bladder problem (frequent urge to urinate, not urological explainable)
boolean
C0579152 (UMLS CUI [1])
pseudobulbar paralysis
Item
Pseudobulbar paralysis
boolean
C1390905 (UMLS CUI [1])
personality disorder or mood alteration
Item
Personality disorder or mood alteration
boolean
C0031212 (UMLS CUI [1])
C2939186 (UMLS CUI [2])
C2939186 (UMLS CUI [2])
abulia
Item
Abulia
boolean
C0919974 (UMLS CUI [1])
depression
Item
Depression
boolean
C0011581 (UMLS CUI [1])
emotional incontinence
Item
Emotional incontinence
boolean
C1142234 (UMLS CUI [1])
other subcortical deficits
Item
Other subcortical deficits
boolean
C2987487 (UMLS CUI [1,1])
C0815275 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0815275 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
Item Group
Frontotemporal dementia, behavioral variant
C4011788 (UMLS CUI-1)
bvFTD diagnosis
Item
Is the patient currently diagnosed with bvFTD according to the criteria of Raskovsky et. al. 2011?
boolean
C4011788 (UMLS CUI [1])
slowly progressing disturbance of behavior or of cognition
Item
I. Signs of neurodegenerative disease: Slowly progressing disturbance of behavior or of cognition in order to distinguish it from acute beginning or stable disturbance for a long time, which is typical for psychiatric disease
boolean
C0149623 (UMLS CUI [1])
C0338656 (UMLS CUI [2])
C0338656 (UMLS CUI [2])
socially inappropriate behavior
Item
II. "Possible" bvFTD Three of the symptoms listed in A to F have to be fulfilled. It should be ensured that these symptoms are prominent and persistent and are not rare or even nonrecurring clinical pictures. A. Early onset of behavior disturbance with the symptom "disinhibition" A.1.Socially inappropriate behavior
boolean
C2220010 (UMLS CUI [1])
loss of manners and decency
Item
A.2. Loss of manners and decency
boolean
C0564122 (UMLS CUI [1])
impulsive or reckless behavior
Item
A.3. Impulsive, unreflected or reckless behavior
boolean
C0021125 (UMLS CUI [1])
C0683304 (UMLS CUI [2])
C0683304 (UMLS CUI [2])
apathy
Item
B. Early onset of symptoms of apathy or inactivity B.1. Apathy
boolean
C0085632 (UMLS CUI [1])
inactivity
Item
B.2. Inactivity
boolean
C3890554 (UMLS CUI [1])
reduced sympathy
Item
C. Early loss of sympathy or empathy (one symptom has to be present) C.1. Reduced sympathy for needs and feelings or other human beings
boolean
C0683287 (UMLS CUI [1,1])
C0392756 (UMLS CUI [1,2])
C0392756 (UMLS CUI [1,2])
reduced interest in social contacts or human affection
Item
C.2. Reduced interest in social contacts or human affection
boolean
C0237170 (UMLS CUI [1])
C0424091 (UMLS CUI [2,1])
C0562561 (UMLS CUI [2,2])
C0424091 (UMLS CUI [2,1])
C0562561 (UMLS CUI [2,2])
repetitive movements
Item
D. Early onset of perservative, stereotypic or compulsive, ritualized behaviour patterns (one of the symptoms has to be present) D.1. Simple repetitive movements
boolean
C3806732 (UMLS CUI [1])
compulsive or ritualized behaviour patterns
Item
D.2. Complex, compulsive executed or ritualized behaviour patterns
boolean
C0600104 (UMLS CUI [1])
C2266670 (UMLS CUI [2])
C2266670 (UMLS CUI [2])
stereotypes in language
Item
D.3. Stereotypes in language
boolean
C0038271 (UMLS CUI [1,1])
C0037817 (UMLS CUI [1,2])
C0037817 (UMLS CUI [1,2])
disturbed preference in choice of food
Item
E. Hyperorality or changes in eating behavior (one of the symptoms has to be present) E.1. Disturbed preference in choice of food
boolean
C2699787 (UMLS CUI [1,1])
C0016483 (UMLS CUI [1,2])
C0016483 (UMLS CUI [1,2])
eating orgy or increased consumption of alcohol or cigarettes
Item
E.2. Eating orgy, increased consumption of alcohol or cigarettes
boolean
C1843777 (UMLS CUI [1])
C2169567 (UMLS CUI [2])
C0037369 (UMLS CUI [3,1])
C0205217 (UMLS CUI [3,2])
C2169567 (UMLS CUI [2])
C0037369 (UMLS CUI [3,1])
C0205217 (UMLS CUI [3,2])
hyperorality
Item
E.3. Oral exposure behavior or even oral consumption of uneatable objects
boolean
C1838320 (UMLS CUI [1])
disturbance in executive functions
Item
F. Typical neuropsychological profile: Disturbance of executive functions along with relatively intact memory and intact visuoconstructive skills (all symptoms must be present) F.1. Disturbance in executive functions, including complex cognitive functions like working memory, planing, generalization of rules and abstracting of rules, problem solution and mental flexibility
boolean
C2678119 (UMLS CUI [1])
performance of episodic memory
Item
F.2. Relatively intact performance of episodic memory
boolean
C0561843 (UMLS CUI [1])
visuocontructive functions
Item
F.3. Relatively intact performance testing visuocontructive functions
boolean
C3852968 (UMLS CUI [1])
FTD diagnosis
Item
III. "Probable" bvFTD All of the following criteria(A-C) have to be fulfilled for a diagnosis of a probable bvFTD A. Diagnosis criteria of a probable FTD have to be fulfilled
boolean
C0338451 (UMLS CUI [1,1])
C0332148 (UMLS CUI [1,2])
C0332148 (UMLS CUI [1,2])
everyday functioning
Item
B. The amount of disturbance causes disturbance in everyday functioning
boolean
C0562507 (UMLS CUI [1])
anterior temporal atrophy
Item
C. Imaging is compatible with the behavioral variant of FTD (one of the two attributes has to be present) C.1. CT or MRI imaging show a frontal and/or anterior temporal atrophy
boolean
C3281302 (UMLS CUI [1])
C0011923 (UMLS CUI [2])
C0011923 (UMLS CUI [2])
frontal or temporal hypo-perfusion
Item
C.2. PET or SPECT examinations showing frontal and/or temporal hypo-perfusion/hypo-metabolism
boolean
C0442856 (UMLS CUI [1])
C0347938 (UMLS CUI [2])
C1699633 (UMLS CUI [3])
C0183126 (UMLS CUI [4])
C0347938 (UMLS CUI [2])
C1699633 (UMLS CUI [3])
C0183126 (UMLS CUI [4])
FTD criteria fulfilled
Item
IV. bvFTD with ensured FTD-pathology (criterion A and one additional criterion (B or C) have to be fulfilled) A. Criteria of possible or probable FTD fulfilled
boolean
C0338451 (UMLS CUI [1])
histopathological evidence
Item
B. Histopathological evidence for the disease (by biopsy or post mortem)
boolean
C0428093 (UMLS CUI [1])
mutation causing the behavioural variant of FTD
Item
C. Presence of a known mutation which causes the behavioural variant of FTD
boolean
C0596611 (UMLS CUI [1,1])
C0678227 (UMLS CUI [1,2])
C4011788 (UMLS CUI [1,3])
C0678227 (UMLS CUI [1,2])
C4011788 (UMLS CUI [1,3])
disease pattern better explained by another disease
Item
V. Exclusion criteria for bvFTD A. The pattern of disturbance can be better explained by another (neurodegenerative) disease
boolean
C0449782 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0524851 (UMLS CUI [1,3])
C0205394 (UMLS CUI [1,4])
C0678226 (UMLS CUI [1,2])
C0524851 (UMLS CUI [1,3])
C0205394 (UMLS CUI [1,4])
behavioral disturbances explained by a psychiatric disease
Item
B. The behavioral disturbances can be better explained by a psychiatric disease
boolean
C0233514 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0004936 (UMLS CUI [1,3])
C0678226 (UMLS CUI [1,2])
C0004936 (UMLS CUI [1,3])
biomarkers emphasize Alzheimers disease or another neurodegenarative disease
Item
C. Biomarkers emphasize Alzheimer's disease or another neurodegenarative disease
boolean
C0005516 (UMLS CUI [1])
C0002395 (UMLS CUI [2,1])
C0524851 (UMLS CUI [2,2])
C0205394 (UMLS CUI [2,3])
C0002395 (UMLS CUI [2,1])
C0524851 (UMLS CUI [2,2])
C0205394 (UMLS CUI [2,3])
Item Group
Primary progressive aphasia (PPA)
C0282513 (UMLS CUI-1)
PPA diagnosis
Item
Is the patient currently diagnosed with PPA according to the criteria of Mesulam et. al. 2001?
boolean
C0282513 (UMLS CUI [1])
impairment of speech characteristics
Item
1. Gradually starting and slowly progressing impairment in word formation, object naming, syntax or word comprehension in conversation or applying a well-established neuropsychologic speech tests.
boolean
C0233715 (UMLS CUI [1])
C0566058 (UMLS CUI [2])
C0027902 (UMLS CUI [3])
C0513762 (UMLS CUI [4])
C0566058 (UMLS CUI [2])
C0027902 (UMLS CUI [3])
C0513762 (UMLS CUI [4])
restrictions in everylife due to speech impairment
Item
2. All restrictions in everyday life in the first two years after onset of symptoms can be attributed to impairment of speech.
boolean
C0562507 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0678226 (UMLS CUI [1,3])
C0233715 (UMLS CUI [1,4])
C0439801 (UMLS CUI [1,2])
C0678226 (UMLS CUI [1,3])
C0233715 (UMLS CUI [1,4])
intact premobid function of speech
Item
3. The premobid function of speech is intact (a dyslexia during development is possible).
boolean
C0037817 (UMLS CUI [1,1])
C0871122 (UMLS CUI [1,2])
C0205266 (UMLS CUI [1,3])
C0871122 (UMLS CUI [1,2])
C0205266 (UMLS CUI [1,3])
symtoms missing in first two years
Item
4. A prominent apathy, disinhibition, disturbance of short-term memory, visuo-spatial disturbances, disability of visual recognition and sensomotoric deficits are missing in the first two years of disease in consideration of anamnesis, everyday activities or neuropsychologic results, so that the participant fulfills no diagnostic criteria of another dementia.
boolean
C0085632 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0234410 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C2363813 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C2676705 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
C0030709 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
C0221163 (UMLS CUI [6,1])
C0332197 (UMLS CUI [6,2])
C0332197 (UMLS CUI [1,2])
C0234410 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C2363813 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C2676705 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
C0030709 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
C0221163 (UMLS CUI [6,1])
C0332197 (UMLS CUI [6,2])
dyscalculia, ideomotoric apraxia and problems tracing
Item
5. Dyscalculia, ideomotoric apraxia and problems tracing can be present in the first two years of disease. However these are not developed so that everyday activities are influenced.
boolean
C0869474 (UMLS CUI [1])
C0234523 (UMLS CUI [2])
C0565772 (UMLS CUI [3])
C0234523 (UMLS CUI [2])
C0565772 (UMLS CUI [3])
other cognitive functions
Item
6. Other cognitive functions can be affected after the first two years after disease, but speech remains the strongest impaired function during the whole course of disease and declines faster than every other function.
boolean
C0392335 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0037817 (UMLS CUI [2,1])
C0242656 (UMLS CUI [2,2])
C1838681 (UMLS CUI [2,3])
C0205394 (UMLS CUI [1,2])
C0037817 (UMLS CUI [2,1])
C0242656 (UMLS CUI [2,2])
C1838681 (UMLS CUI [2,3])
other reasons for aphasia excluded
Item
7. Other reasons for aphasia like stroke or tumor are excluded by imaging.
boolean
C2828389 (UMLS CUI [1,1])
C0015127 (UMLS CUI [1,2])
C0003537 (UMLS CUI [1,3])
C0015127 (UMLS CUI [1,2])
C0003537 (UMLS CUI [1,3])
Item Group
Progressive nonfluent aphasia (PNFA)
C0751706 (UMLS CUI-1)
PNFA diagnosis
Item
Is the patient currently diagnosed with PNFA according to the criteria of Gorno-Tempini et. al. 2011?
boolean
C0751706 (UMLS CUI [1])
agrammatism
Item
I. Clinical diagnosis of PNFA At least one of the diagnostic main criteria has to be fulfilled: 1. Speech with agrammatism
boolean
C0242186 (UMLS CUI [1])
speech apraxia
Item
2. Labored, haltingly speech with inconsistent prosody and speech attitudes (speech apraxia)
boolean
C0264611 (UMLS CUI [1])
speech intelligibility disturbances
Item
At least two of the following features have to be fulfilled: 1. Speech intelligibility disturbances formulating sentences with complex syntax
boolean
C0037824 (UMLS CUI [1,1])
C0221099 (UMLS CUI [1,2])
C0221099 (UMLS CUI [1,2])
speech intelligibility
Item
2. Maintained speech intelligibility of single words
boolean
C0037824 (UMLS CUI [1])
object knowledge
Item
3. Maintained object knowledge
boolean
C0599621 (UMLS CUI [1])
clinical diagnosis of PNFA
Item
II. Imaging results supporting diagnosis of PNFA Both criteria have to be fulfilled 1. Clinical diagnosis of PNFA
boolean
C0332140 (UMLS CUI [1,1])
C0751706 (UMLS CUI [1,2])
C0751706 (UMLS CUI [1,2])
atrophy in posterior part of frontal lobe in MRI
Item
2. Imaging diagnostics have to show one of the following findings: 2a. MRI: Emphasized atrophy in posterior part of frontal lobe/island region of left hemisphere
boolean
C0016733 (UMLS CUI [1,1])
C0205095 (UMLS CUI [1,2])
C0228176 (UMLS CUI [2,1])
C3496404 (UMLS CUI [2,2])
C0024485 (UMLS CUI [3])
C0333641 (UMLS CUI [4])
C0205095 (UMLS CUI [1,2])
C0228176 (UMLS CUI [2,1])
C3496404 (UMLS CUI [2,2])
C0024485 (UMLS CUI [3])
C0333641 (UMLS CUI [4])
hypoperfusion and hypometabolism in posterior part of frontal lobe
Item
2b. SPECT/PET: Emphasized hypoperfusion and hypometabolism in posterior part of frontal lobe/insular region of left hemisphere
boolean
C0442856 (UMLS CUI [1])
C0347938 (UMLS CUI [2])
C1699633 (UMLS CUI [3])
C0183126 (UMLS CUI [4])
C0016733 (UMLS CUI [5,1])
C0205095 (UMLS CUI [5,2])
C0228176 (UMLS CUI [6,1])
C3496404 (UMLS CUI [6,2])
C0347938 (UMLS CUI [2])
C1699633 (UMLS CUI [3])
C0183126 (UMLS CUI [4])
C0016733 (UMLS CUI [5,1])
C0205095 (UMLS CUI [5,2])
C0228176 (UMLS CUI [6,1])
C3496404 (UMLS CUI [6,2])
clinical diagnosis PNFA
Item
III. Diagnostic criteria for PNFA and clear histopathologic finding The clinical diagnosis (criterion 1) an criterion 2 or criterion 3 have to be fulfilled: 1. Clinical diagnosis of PNFA
boolean
C0332140 (UMLS CUI [1,1])
C0751706 (UMLS CUI [1,2])
C0751706 (UMLS CUI [1,2])
neurodegenarative pathology
Item
2. Histopathological evidence of a specific neurodegenerative pathology (e.g. FTD-tau, FTD-TDP, AD or another specific pathology)
boolean
C0524851 (UMLS CUI [1,1])
C0243140 (UMLS CUI [1,2])
C0243140 (UMLS CUI [1,2])
mutation
Item
3. Evidence of a common mutation
boolean
C0026882 (UMLS CUI [1])
Item Group
Logopenic progressive aphasia (LPA)
C0282513 (UMLS CUI-1)
C0037825 (UMLS CUI-2)
C0037825 (UMLS CUI-2)
diagnosis of LPA
Item
Is the patient currently diagnosed with LPA according to the criteria of Gorno-Tempini et. al. 2011 and Raskovsky et. al. 2011?
boolean
C0282513 (UMLS CUI [1,1])
C0037825 (UMLS CUI [1,2])
C0037825 (UMLS CUI [1,2])
disturbed sponteneous speech
Item
I. Clinical diagnosis of LPA: Both diagnostic main criteria have to be fulfilled: 1. Disturbed ability to fetch words in sponteneous speech and in naming
boolean
C0855217 (UMLS CUI [1])
disturbed repetition of sentences
Item
2. Repeating of sentences and sentence elements disturbed
boolean
C0233741 (UMLS CUI [1,1])
C0221099 (UMLS CUI [1,2])
C0233740 (UMLS CUI [2,1])
C0221099 (UMLS CUI [2,2])
C0221099 (UMLS CUI [1,2])
C0233740 (UMLS CUI [2,1])
C0221099 (UMLS CUI [2,2])
phonologic paraphrasia
Item
At least 3 of the following characteristics have to be fulfilled: 1. Phonologic paraphrasia in spontaneous speech and naming
boolean
C0233722 (UMLS CUI [1])
C0454640 (UMLS CUI [2])
C0454640 (UMLS CUI [2])
speech intelligibility and object knowledge
Item
2. Maintained speech intelligibility of single words and object knowledge
boolean
C0037824 (UMLS CUI [1])
C0599621 (UMLS CUI [2])
C0599621 (UMLS CUI [2])
motor speech
Item
3. Maintained motor speech (no speech apraxia)
boolean
C4035655 (UMLS CUI [1])
no distinctive agrammatism
Item
4. No distinctive agrammatism
boolean
C0242186 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,2])
clinical diagnosis of LPA
Item
I. Diagnosis of LPA supported by imaging Both of the following criteria have to be fulfilled 1. Clinical diagnosis of LPA
boolean
C0332140 (UMLS CUI [1,1])
C0282513 (UMLS CUI [1,2])
C0037825 (UMLS CUI [1,3])
C0282513 (UMLS CUI [1,2])
C0037825 (UMLS CUI [1,3])
atrophy in posterior sections of perisylvian area or parietal atrophy
Item
2. Imaging diagnostics have to show one or several of the following findings: 2a. MRI: Emphasized atrophy in posterior sections of perisylvian area or parietal atrophy
boolean
C0333641 (UMLS CUI [1,1])
C3495412 (UMLS CUI [1,2])
C4023041 (UMLS CUI [2])
C0024485 (UMLS CUI [3])
C3495412 (UMLS CUI [1,2])
C4023041 (UMLS CUI [2])
C0024485 (UMLS CUI [3])
hypoperfusion and hypometabolism in a section of perisylvian area or parietal lobe
Item
2b. SPECT/PET: Emphasized hypoperfusion and hypometabolism in a section of perisylvian area or parietal lobe
boolean
C0442856 (UMLS CUI [1])
C0347938 (UMLS CUI [2])
C1699633 (UMLS CUI [3])
C0347938 (UMLS CUI [2])
C1699633 (UMLS CUI [3])
clinical diagnosis LPA
Item
II. Diagnostic criteria for LPA and clear histopathologic finding The clinical diagnosis (criterion 1) and criterion 2 or criterion 3 have to be fulfilled: 1. Clinical diagnosis of LPA
boolean
C0332140 (UMLS CUI [1,1])
C0282513 (UMLS CUI [1,2])
C0037825 (UMLS CUI [1,3])
C0282513 (UMLS CUI [1,2])
C0037825 (UMLS CUI [1,3])
histopathological evidence of a specific neurodegenerative pathology
Item
2. Histopathological evidence of a specific neurodegenerative pathology (e.g. FTD-tau, FTD-TDP, AD or another specific pathology)
boolean
C0524851 (UMLS CUI [1,1])
C0243140 (UMLS CUI [1,2])
C0243140 (UMLS CUI [1,2])
evidence of mutation
Item
3. Evidence of a common mutation
boolean
C0026882 (UMLS CUI [1])
diagnosis of SemD
Item
Is the patient currently diagnosed with SemD according to the criteria of Gorno-Tempini et. al. 2011?
boolean
C0338462 (UMLS CUI [1])
anomia
Item
I. Clinical diagnosis of SemD: Both diagnostic main criteria have to be fulfilled: 1. Disturbed behavior (anomia)
boolean
C0003113 (UMLS CUI [1])
disturbed speech intelligibility
Item
2. Disturbed speech intelligibility of single words
boolean
C0037824 (UMLS CUI [1,1])
C0221099 (UMLS CUI [1,2])
C0221099 (UMLS CUI [1,2])
disturbed object knowledge
Item
At least three of the following characteristics have to be fulfilled: 1. Disturbed object knowledge, especially of words which are rarely used or have a lower familiarity
boolean
C0599621 (UMLS CUI [1,1])
C0221099 (UMLS CUI [1,2])
C0221099 (UMLS CUI [1,2])
dyslexia or agraphia
Item
2. Dyslexia or agraphia
boolean
C0476254 (UMLS CUI [1])
C0001825 (UMLS CUI [2])
C0001825 (UMLS CUI [2])
undisturbed repetition
Item
3. Undisturbed repetition
boolean
C0589243 (UMLS CUI [1])
fluent production of speech
Item
4. Maintained fluent production of speech (grammatically correct and without apraxic disorders)
boolean
C0564240 (UMLS CUI [1])
clinical diagnosis of SemD
Item
II. Imaging results supporting diagnosis of SemD: Both of the following criteria have to be fulfilled 1. Clinical diagnosis of SemD
boolean
C0332140 (UMLS CUI [1,1])
C0338462 (UMLS CUI [1,2])
C0338462 (UMLS CUI [1,2])
atrophy in anterior part of frontal lobe
Item
2. Imaging diagnostics have to show one of the following findings: 2a. MRI: Emphasized atrophy in anterior part of frontal lobe
boolean
C0333641 (UMLS CUI [1,1])
C0016733 (UMLS CUI [1,2])
C0205094 (UMLS CUI [1,3])
C0024485 (UMLS CUI [2])
C0016733 (UMLS CUI [1,2])
C0205094 (UMLS CUI [1,3])
C0024485 (UMLS CUI [2])
hypoperfusion and hypometabolism in anterior part of frontal lope
Item
2b. SPECT/PET: Emphasized hypoperfusion and hypometabolism in anterior part of frontal lope
boolean
C0442856 (UMLS CUI [1])
C0347938 (UMLS CUI [2])
C1699633 (UMLS CUI [3])
C0016733 (UMLS CUI [4,1])
C0205094 (UMLS CUI [4,2])
C0347938 (UMLS CUI [2])
C1699633 (UMLS CUI [3])
C0016733 (UMLS CUI [4,1])
C0205094 (UMLS CUI [4,2])
clinical diagnosis SemD
Item
III. Diagnostic criteria for SemD and clear histopathologic finding 1. Clinical diagnosis of SemD
boolean
C0332140 (UMLS CUI [1,1])
C0338462 (UMLS CUI [1,2])
C0338462 (UMLS CUI [1,2])
neurodegenarative pathology
Item
2. Histopathological evidence of a specific neurodegenerative pathology (e.g. FTD-tau, FTD-TDP, AD or another specific pathology)
boolean
C0524851 (UMLS CUI [1,1])
C0243140 (UMLS CUI [1,2])
C0243140 (UMLS CUI [1,2])
mutation
Item
3. Evidence of a common mutation
boolean
C0026882 (UMLS CUI [1])
Item Group
Idiopathic Parkinson's disease (IPS)
C0030567 (UMLS CUI-1)
IPS diagnosis
Item
Is the patient currently diagnosed with IPS according to the UKBB criteria (Litvan et. al. 2003)?
boolean
C0030567 (UMLS CUI [1])
hypo-bradykinesia
Item
Hypo-bradykinesia
boolean
C3176307 (UMLS CUI [1])
resting tremor
Item
Resting tremor
boolean
C0234379 (UMLS CUI [1])
rigor
Item
Rigor
boolean
C0026837 (UMLS CUI [1])
postural instability
Item
Postural instability
boolean
C1843921 (UMLS CUI [1])
unilateral onset
Item
Unilateral onset
boolean
C0332162 (UMLS CUI [1,1])
C0205092 (UMLS CUI [1,2])
C0205092 (UMLS CUI [1,2])
resting tremor manifest
Item
Resting tremor manifest
boolean
C0234379 (UMLS CUI [1,1])
C0205319 (UMLS CUI [1,2])
C0205319 (UMLS CUI [1,2])
progressive course of disease
Item
Progressive course of disease
boolean
C0242656 (UMLS CUI [1,1])
C0205329 (UMLS CUI [1,2])
C0205329 (UMLS CUI [1,2])
laterality
Item
Laterality
boolean
C0332304 (UMLS CUI [1])
response to L-Dopa
Item
Excellent response to L-Dopa (70-100%)
boolean
C3280274 (UMLS CUI [1])
L-Dopa induced chorea
Item
L-Dopa induced chorea
boolean
C0008489 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0023570 (UMLS CUI [1,3])
C0678226 (UMLS CUI [1,2])
C0023570 (UMLS CUI [1,3])
response to L-Dopa over 5 years
Item
Response to L-Dopa over 5 years
boolean
C3280274 (UMLS CUI [1])
response to L-Dopa over 10 years
Item
Response to L-Dopa over 10 years
boolean
C3280274 (UMLS CUI [1])
medical history of brain damage
Item
Medical history of brain damage (e.g. stroke, craniocerebral trauma)
boolean
C0262926 (UMLS CUI [1,1])
C0270611 (UMLS CUI [1,2])
C0270611 (UMLS CUI [1,2])
medical history of encephalitis
Item
Medical history of encephalitis
boolean
C0014038 (UMLS CUI [1])
oculogyric crisis
Item
Oculogyric crisis
boolean
C0085637 (UMLS CUI [1])
neuroleptic drugs at onset of disease
Item
Therapy using neuroleptic drugs at onset of disease
boolean
C0040615 (UMLS CUI [1,1])
C0277793 (UMLS CUI [1,2])
C0277793 (UMLS CUI [1,2])
remission of disease
Item
Remission of disease
boolean
C0544452 (UMLS CUI [1])
unilateral motor impairment
Item
Unilateral motor impairment after 3 years of disease
boolean
C0221163 (UMLS CUI [1,1])
C0205092 (UMLS CUI [1,2])
C0205092 (UMLS CUI [1,2])
supranuclear palsy
Item
Supranuclear palsy
boolean
C1720037 (UMLS CUI [1])
cerebellar signs
Item
Cerebellar signs
boolean
C0742038 (UMLS CUI [1])
severe autonomous dysfunction
Item
Severe autonomous dysfunction (e.g. urinary incontinence, cardiovascular system problem)
boolean
C1397846 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,2])
early development of dementia
Item
Early development of dementia (within first year of disease) with special impairment of memory, speech and in practice
boolean
C1833334 (UMLS CUI [1,1])
C0497327 (UMLS CUI [1,2])
C0497327 (UMLS CUI [1,2])
babinski sign
Item
Babinski sign
boolean
C0034935 (UMLS CUI [1])
poor response to L-Dopa
Item
Poor response to L-Dopa
boolean
C2751071 (UMLS CUI [1])
MTPT exposition
Item
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MTPT) exposition
boolean
C0046312 (UMLS CUI [1])
Item Group
Morbus parkinson along with MCI (PD-MCI)
C0030567 (UMLS CUI-1)
C1270972 (UMLS CUI-3)
C1270972 (UMLS CUI-3)
PD-MCI diagnosis
Item
Is the patient currently diagnosed with PD-MCI according to the criteria Litvan et. al. 2012?
boolean
C0030567 (UMLS CUI [1])
C1270972 (UMLS CUI [2])
C1270972 (UMLS CUI [2])
Parkinson disease according to UKPD BB criteria
Item
Diagnosis of Parkinson disease according to UKPD BB criteria
boolean
C0030567 (UMLS CUI [1,1])
C0679228 (UMLS CUI [1,2])
C0679228 (UMLS CUI [1,2])
insidious onset and progressive course of disease of cognitive dysfunction
Item
Insidious onset and progressive course of disease of cognitive dysfunction under PD disease reported by participant, relatives and treating physician
boolean
C0338656 (UMLS CUI [1,1])
C1298634 (UMLS CUI [1,2])
C0338656 (UMLS CUI [1,3])
C0242656 (UMLS CUI [1,4])
C0205329 (UMLS CUI [1,5])
C1298634 (UMLS CUI [1,2])
C0338656 (UMLS CUI [1,3])
C0242656 (UMLS CUI [1,4])
C0205329 (UMLS CUI [1,5])
loss of power
Item
Loss of power (<=1.5 times standard deviation below the mean value of reference group) in (A) two assessments of a domain or (B) in each assessment of two different domains. Following domains can be affected: -attention & working memory -executive functions -visuo-constructive/visuospatial performance -memory -speech
boolean
C0548863 (UMLS CUI [1])
cognitive deficits do not interfere everyday activities
Item
Cognitive deficits do not interfere with lost of independence regarding everyday activities, although mild impairment may occur performing complex tasks
boolean
C0009241 (UMLS CUI [1,1])
C0521103 (UMLS CUI [1,2])
C0001288 (UMLS CUI [1,3])
C0521103 (UMLS CUI [1,2])
C0001288 (UMLS CUI [1,3])
Dementia in Parkinson disease
Item
Parkinson disease with dementia according to criteria of Movement Disorder Society Task Force
boolean
C0349081 (UMLS CUI [1])
diseases that can explain cognitive impairment
Item
Diseases that can explain cognitive impairment primarily (e.g. delir, stroke, traumatic brain injury, metabolic disorder, side effects of medication, severe depressive episode)
boolean
C0009241 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
C0678226 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
comorbidities influence on test performance
Item
Other PD associated comorbidities like severe motor impairment, high anxiety, depression,increasing daytime sleepiness, psychosis, which have a significant influence on test performance according to a clinician's opinion.
boolean
C0009488 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0679605 (UMLS CUI [1,3])
C0521102 (UMLS CUI [1,2])
C0679605 (UMLS CUI [1,3])
PDD diagnosis
Item
Is the patient currently diagnosed with PDD according to the criteria Emre et. al. 2007?
boolean
C0349081 (UMLS CUI [1])
diagnostic criteria for PD
Item
I. Main criteria of PDD Diagnosis of Parkonson disease according to UKPD BB criteria
boolean
C0030567 (UMLS CUI [1,1])
C0679228 (UMLS CUI [1,2])
C0679228 (UMLS CUI [1,2])
course of disease of dementia
Item
Dementia syndrome with insidious onset and progressive course of disease with respect to Parkinson's disease (onset of dementia > 1 year after diagnosis of Parkinson's disease
boolean
C0497327 (UMLS CUI [1,1])
C1298634 (UMLS CUI [1,2])
C0349081 (UMLS CUI [2])
C1298634 (UMLS CUI [1,2])
C0349081 (UMLS CUI [2])
loss of power
Item
Loss of power (<=1.5 times standard deviation below mean of reference group/normal population) affecting more than one cognitive domain and represent an impairment in contrast to the premobid level of performance
boolean
C0548863 (UMLS CUI [1])
interference with everyday living activities
Item
Cognitive deficits interfer with loss of independence in everyday activities (concerning social, occupational or personal aspects of life). These limitations of activities in everyday living should be primarily caused by cognitive factors and not by motor impairment or an autonomous functional disorder.
boolean
C0009241 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0001288 (UMLS CUI [1,3])
C0521102 (UMLS CUI [1,2])
C0001288 (UMLS CUI [1,3])
affected domains
Item
II. Additional criteria a) Following domains can be affected: -attention & working memory -executive functions -visuo-constructive/visuospatial performance -memory -speech
boolean
C0004268 (UMLS CUI [1])
C0025265 (UMLS CUI [2])
C0935584 (UMLS CUI [3,1])
C2370887 (UMLS CUI [3,2])
C0025260 (UMLS CUI [4])
C0037817 (UMLS CUI [5])
C0025265 (UMLS CUI [2])
C0935584 (UMLS CUI [3,1])
C2370887 (UMLS CUI [3,2])
C0025260 (UMLS CUI [4])
C0037817 (UMLS CUI [5])
behavior changes
Item
b) The following behavior changes can occur: -apathy (reduced spontaneity, loss of motivation, interest and performance) -change of personality like depressive or anxious symptomatic -hallucinations (at most visual, complex visions of humans, animals or objects) -delusions (at most of paranoid nature like cheating of the partner or foreign persons living in the household) -increased sleepiness at daytime or doziness at daytime
boolean
C0542299 (UMLS CUI [1])
disease also causing cognitive impairment
Item
III. Findings, which make PDD diagnosis less probable Diseases that can also cause cognitive impairment as a result (e.g. vascular distinctive feature in MRI), but cannot be considered primary cause of dementia
boolean
C0009488 (UMLS CUI [1,1])
C0678227 (UMLS CUI [1,2])
C0009241 (UMLS CUI [1,3])
C0678227 (UMLS CUI [1,2])
C0009241 (UMLS CUI [1,3])
time interval between onset of cognitive and motor symptoms unknown
Item
Time interval between onset of cognitive and motor symptoms unknown
boolean
C0872291 (UMLS CUI [1,1])
C0332162 (UMLS CUI [1,2])
C0426980 (UMLS CUI [1,3])
C0392335 (UMLS CUI [1,4])
C0332162 (UMLS CUI [1,2])
C0426980 (UMLS CUI [1,3])
C0392335 (UMLS CUI [1,4])
symptoms exclusive due to comorbidity
Item
IV. Exclusion criteria of PDD Cognitive symptomes or behavioral disorders occor exclusively as part of another disease or concomitants, like e.g. delir caused by a systemic disease or as consequence of a certain medication or a severe depressive episode
boolean
C0011206 (UMLS CUI [1])
C0442893 (UMLS CUI [2])
C2364092 (UMLS CUI [3])
C0442893 (UMLS CUI [2])
C2364092 (UMLS CUI [3])
probable vascular dementia
Item
Prevalence of a probable vascular dementia according to NINDS-AIREN-criteria
boolean
C0011269 (UMLS CUI [1,1])
C0033204 (UMLS CUI [1,2])
C0033204 (UMLS CUI [1,2])
probable PDD
Item
Probable PDD -All criteria in section I have to be fulfilled -Typical profile of cognitive impairment along with distinctive features in more than one cognitive domain (IIa), especially deficits of attention, a dysexecutive syndrome, an impaired visuospatial perception, limitations regarding direct recall of memory performance with improvement after provided assistance in recall. -presence of at least one behavior disorder (IIb) -no criteria mentioned in section III and IV must be present
boolean
C0349081 (UMLS CUI [1,1])
C0033204 (UMLS CUI [1,2])
C0033204 (UMLS CUI [1,2])
possible PDD
Item
Possible PDD -atypical profile of cognitive impairment with abnormalities in more than one cognitive domain (IIa) like fluent aphasia or memory impairment or attention deficit -behavior disorders (IIb) can be present but do not have to be present -one or more criteria in III may be present -no criterion mentioned in section IV must be present
boolean
C0349081 (UMLS CUI [1,1])
C0332149 (UMLS CUI [1,2])
C0332149 (UMLS CUI [1,2])
DLB diagnosis
Item
Is the patient currently diagnosed with DLB according to the criteria Mc Keith et. al. 2005?
boolean
C0752347 (UMLS CUI [1])
dementia causing loss of independence
Item
Central Criterion 1. Dementia, defined as progressive loss, which causes loss of independence in everyday living activities (concerning social, occupational or personal life aspects)
boolean
C0497327 (UMLS CUI [1])
C0085862 (UMLS CUI [2,1])
C0001288 (UMLS CUI [2,2])
C1517945 (UMLS CUI [2,3])
C0085862 (UMLS CUI [2,1])
C0001288 (UMLS CUI [2,2])
C1517945 (UMLS CUI [2,3])
fluctuation in cognition
Item
Main criteria 2. Fluctuations in cognition, especially attention performance
boolean
C0853574 (UMLS CUI [1,1])
C0009240 (UMLS CUI [1,2])
C0009240 (UMLS CUI [1,2])
recurrent visual hallucinations
Item
3. Recurrent visual hallucinations, that typically consists of figures and are detailed.
boolean
C0233763 (UMLS CUI [1,1])
C2945760 (UMLS CUI [1,2])
C2945760 (UMLS CUI [1,2])
spontaneous Parkinson symptomatic
Item
Spontaneous Parkinson symptomatic
boolean
C0030569 (UMLS CUI [1,1])
C0205359 (UMLS CUI [1,2])
C0205359 (UMLS CUI [1,2])
REM sleep behavior disorder
Item
Additional criteria 5. REM sleep behavior disorder
boolean
C0751772 (UMLS CUI [1])
severe side effects due to neuroleptic medication
Item
6. Severe side effects due to neuroleptic medication
boolean
C0041755 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0040615 (UMLS CUI [1,3])
C0205082 (UMLS CUI [1,2])
C0040615 (UMLS CUI [1,3])
dopamine transporter ligand storage in basal ganglia
Item
Reduced dopamine transporter ligand storage in basal ganglia (SPECT/PET)
boolean
C0114838 (UMLS CUI [1,1])
C0392756 (UMLS CUI [1,2])
C0004781 (UMLS CUI [1,3])
C3828509 (UMLS CUI [2])
C0392756 (UMLS CUI [1,2])
C0004781 (UMLS CUI [1,3])
C3828509 (UMLS CUI [2])
dementia occurred about the same time
Item
8. Dementia occurred before or at the same time (resp. within first year) symptoms of Parkinson's disease did?
boolean
C0683368 (UMLS CUI [1,1])
C0497327 (UMLS CUI [1,2])
C3843404 (UMLS CUI [1,3])
C0497327 (UMLS CUI [1,2])
C3843404 (UMLS CUI [1,3])
probable DLB
Item
Probable DLB (item 1 and at least one feature in 2-4 and at least one feature 5-7 applies, item 8 is fulfilled)
boolean
C0752347 (UMLS CUI [1,1])
C0332148 (UMLS CUI [1,2])
C0332148 (UMLS CUI [1,2])
possible DLB
Item
Possible DLB (item 1 and at least one feature in 5-7 apply; item 8 is fulfilled)
boolean
C0752347 (UMLS CUI [1,1])
C0332149 (UMLS CUI [1,2])
C0332149 (UMLS CUI [1,2])
frequent falls or syncopes
Item
Supportive Symptoms without diagnostic specifity Frequent falls or syncopes
boolean
C0850703 (UMLS CUI [1])
C0039070 (UMLS CUI [2])
C0039070 (UMLS CUI [2])
transient loss of consciousness
Item
Transient loss of consciousness
boolean
C0041657 (UMLS CUI [1])
severe autonomous functional disorder
Item
Severe autonomous dysfunction
boolean
C1397846 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,2])
hallucinations in other modalities
Item
Hallucinations in other modalities
boolean
C0018524 (UMLS CUI [1,1])
C0695347 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0695347 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
delusion
Item
Delusions
boolean
C0011253 (UMLS CUI [1])
depression
Item
Depression
boolean
C0011581 (UMLS CUI [1])
medial temporal lobe
Item
Medial temporal lobe slightly changed in MRI
boolean
C0039485 (UMLS CUI [1,1])
C0205098 (UMLS CUI [1,2])
C0871641 (UMLS CUI [1,3])
C0750482 (UMLS CUI [1,4])
C0024485 (UMLS CUI [2])
C0205098 (UMLS CUI [1,2])
C0871641 (UMLS CUI [1,3])
C0750482 (UMLS CUI [1,4])
C0024485 (UMLS CUI [2])
SPECT/PET perfusion scan at reduced occipital activity
Item
Light take in SPECT/PET perfusion scan at reduced occipital activity
boolean
C2094594 (UMLS CUI [1])
C0443158 (UMLS CUI [2,1])
C1184145 (UMLS CUI [2,2])
C0443158 (UMLS CUI [2,1])
C1184145 (UMLS CUI [2,2])
abnormally light take in MIBG myocardial scintiscan
Item
Abnormally light take in MIBG myocardial scintiscan
boolean
C1704258 (UMLS CUI [1,1])
C2229074 (UMLS CUI [1,2])
C2229074 (UMLS CUI [1,2])
slow-wave-activity in EEG with temporal transient shape waves
Item
Prominent slow-wave-activity in EEG with temporal transient shape waves
boolean
C2206519 (UMLS CUI [1])
C2678116 (UMLS CUI [2])
C2678116 (UMLS CUI [2])
medical history of brain injury
Item
Findings making diagnosis less probable medical history of brain injury (e.g. stroke, traumatic brain injury)
boolean
C0262926 (UMLS CUI [1,1])
C0270611 (UMLS CUI [1,2])
C0270611 (UMLS CUI [1,2])
presence of another medical or neurological condition explaining deficits
Item
Presence of another medical or neurological condition explaining deficits
boolean
C0009488 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C2987487 (UMLS CUI [1,3])
C0678226 (UMLS CUI [1,2])
C2987487 (UMLS CUI [1,3])
first occurrence of symptoms of Parkinsons disease
Item
Symptoms of Parkinson's disease occur in a severe stadium of dementia for the first time
boolean
C0030567 (UMLS CUI [1,1])
C0205435 (UMLS CUI [1,2])
C0497327 (UMLS CUI [2,1])
C0699749 (UMLS CUI [2,2])
C0205082 (UMLS CUI [2,3])
C0205435 (UMLS CUI [1,2])
C0497327 (UMLS CUI [2,1])
C0699749 (UMLS CUI [2,2])
C0205082 (UMLS CUI [2,3])
PSP diagnosis
Item
Is the patient currently diagnosed with PSP according to the criteria NINDS-PSP-criteria (Litvan et. al. 1996)?
boolean
C0038868 (UMLS CUI [1])
gradual progressive disease
Item
Conditions Gradual progressive disease with onset of disease at age of at least 40
boolean
C1335499 (UMLS CUI [1,1])
C0439833 (UMLS CUI [1,2])
C0206132 (UMLS CUI [2])
C0439833 (UMLS CUI [1,2])
C0206132 (UMLS CUI [2])
vertical gaze palsy
Item
Main criteria 1. Vertical palsy (up or down)
boolean
C0339652 (UMLS CUI [1])
slowing of vertical saccades
Item
2. Slowing of vertical saccades
boolean
C4011795 (UMLS CUI [1])
postural instability with falls
Item
3. Postural instability with falls < 1 year after onset of disease
boolean
C1843921 (UMLS CUI [1])
C0085639 (UMLS CUI [2])
C0085639 (UMLS CUI [2])
probable PSP
Item
Probable PSP (item 1 and item 3 have to be answered with 'Yes'
boolean
C0038868 (UMLS CUI [1,1])
C0033204 (UMLS CUI [1,2])
C0033204 (UMLS CUI [1,2])
possible PSP
Item
Possible PSP (item 1 or 2 und item 3 have to be answered with 'Yes')
boolean
C0038868 (UMLS CUI [1,1])
C0332149 (UMLS CUI [1,2])
C0332149 (UMLS CUI [1,2])
symmetric akinesia or rigor,
Item
Supportive symptoms Symmetric akinesia or rigor, proximal more than distal
boolean
C0085623 (UMLS CUI [1,1])
C0332516 (UMLS CUI [1,2])
C0026837 (UMLS CUI [2])
C0332516 (UMLS CUI [1,2])
C0026837 (UMLS CUI [2])
abnormal head posture especially retrocollis
Item
Abnormal head posture especially retrocollis
boolean
C1536116 (UMLS CUI [1])
C3887667 (UMLS CUI [2])
C3887667 (UMLS CUI [2])
poor response to L-Dopa
Item
Poor or low response to L-Dopa
boolean
C2751071 (UMLS CUI [1])
dysphagia or dysarthria
Item
Earlier dysphagia or dysarthria
boolean
C0011168 (UMLS CUI [1])
C0013362 (UMLS CUI [2])
C0013362 (UMLS CUI [2])
symptoms of cognitive impairment
Item
Earlier onset of a cognitive impairment along with presence at least two of the following symptoms: Apathy, impairment of abstract thinking, reduced verbal fluency, tool use behavior, imitation and frontal lobe syndrome
boolean
C0085632 (UMLS CUI [1])
C0233642 (UMLS CUI [2])
C0751514 (UMLS CUI [3])
C1720915 (UMLS CUI [4])
C3826143 (UMLS CUI [5])
C0549117 (UMLS CUI [6])
C0233642 (UMLS CUI [2])
C0751514 (UMLS CUI [3])
C1720915 (UMLS CUI [4])
C3826143 (UMLS CUI [5])
C0549117 (UMLS CUI [6])
medical history of brain injury
Item
Exclusion criteria Medical history of brain injury (e.g. encephalitis)
boolean
C0262926 (UMLS CUI [1,1])
C0270611 (UMLS CUI [1,2])
C0270611 (UMLS CUI [1,2])
presence of another medical or neurological condition explaining deficits
Item
Presence of another medical or neurological condition explaining deficits
boolean
C0009488 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C2987487 (UMLS CUI [1,3])
C0678226 (UMLS CUI [1,2])
C2987487 (UMLS CUI [1,3])
presence of alien limb syndrome
Item
Presence of alien limb syndrome
boolean
C3160753 (UMLS CUI [1])
cortical perception disorder
Item
Presence of a cortical perception disorder
boolean
C0030975 (UMLS CUI [1])
focal frontal or temporal-parietal atrophy
Item
Evidence of focal frontal or temporal-parietal atrophy
boolean
C2674464 (UMLS CUI [1])
hallucinations and delusions
Item
Occurrence of hallucinations and delusions independently of a dopaminergic therapy
boolean
C0018524 (UMLS CUI [1])
C0011253 (UMLS CUI [2])
C0011253 (UMLS CUI [2])
cerebellar diseases
Item
Prominent early signs of cerebellar diseases
boolean
C0007760 (UMLS CUI [1])
severe autonomous functional disorder
Item
Evidence of severe autonomous functional disorder with unknown cause
boolean
C0277785 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,2])
severe asymmetric Parkinson syndrome
Item
Severe asymmetric signs of Parkinson's syndrome
boolean
C0030567 (UMLS CUI [1,1])
C0332514 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,3])
C0332514 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,3])
evidence of relevant structural abnormalities
Item
Neuroradiological evidence of relevant structural abnormalities
boolean
C1866933 (UMLS CUI [1])
Morbus Whipple
Item
Evidence of Morbus Whipple
boolean
C0023788 (UMLS CUI [1])
CBD diagnosis
Item
Is the patient currently diagnosed with CBD according to the criteria of Boeve et. al. 1996?
boolean
C0393570 (UMLS CUI [1])
insidious onset and progressive course of disease
Item
Main criteria 1. Insidious onset and progressive course of disease
boolean
C0814125 (UMLS CUI [1])
C0242656 (UMLS CUI [2,1])
C0205329 (UMLS CUI [2,2])
C0242656 (UMLS CUI [2,1])
C0205329 (UMLS CUI [2,2])
no other medical or neurological disease can explain the deficits
Item
2. No other medical or neurological disease can explain the deficits
boolean
C0009488 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C2987487 (UMLS CUI [1,3])
C0678226 (UMLS CUI [1,2])
C2987487 (UMLS CUI [1,3])
ideomotor apraxia
Item
3. Cortical dysfunction with at least one of the following symptoms: 3a. Focal or asymmetric ideomotor apraxia
boolean
C0234523 (UMLS CUI [1])
alien limb syndrome
Item
3b. Alien limb syndrome
boolean
C3160753 (UMLS CUI [1])
cortical sensibility loss
Item
3c. Cortical sensibility loss
boolean
C0030975 (UMLS CUI [1])
visual or sensorial hemineglect
Item
3d. Visual or sensorial hemineglect
boolean
C0751418 (UMLS CUI [1])
constructional apraxia
Item
3e. Constructional apraxia
boolean
C2243023 (UMLS CUI [1])
myoclonus
Item
3e. Focal or asymmetric myoclonus
boolean
C0027066 (UMLS CUI [1])
speech apraxia or non-fluent aphasia
Item
3g. Speech apraxia/ non-fluent aphasia
boolean
C0264611 (UMLS CUI [1])
C0349390 (UMLS CUI [2])
C0349390 (UMLS CUI [2])
rigor of extremities without clear reponse to L-Dopa
Item
4. Extrapyramidal dysfunction with at least one of the following symptomes: 4a. Focal or asymmetrical rigor of extremities without clear reponse to L-Dopa
boolean
C0026837 (UMLS CUI [1,1])
C0278454 (UMLS CUI [1,2])
C3806728 (UMLS CUI [2])
C0278454 (UMLS CUI [1,2])
C3806728 (UMLS CUI [2])
focal or asymmetrical dystonia
Item
4b. Focal or asymmetrical dystonia of extremity muscles
boolean
C0743332 (UMLS CUI [1])
C0332514 (UMLS CUI [2])
C0332514 (UMLS CUI [2])
diagnosis of CBD
Item
Diagnosis of CBD If item 1,2 and at least one item in 3a-3g and at least one in item 4a, item 4b is fulfilled
boolean
C0393570 (UMLS CUI [1,1])
C0679228 (UMLS CUI [1,2])
C0679228 (UMLS CUI [1,2])
neuropsychological showing cognitive impairment
Item
Supportive symptoms Neuropsychological testing: Evidenz of focal or lateralised cognitive impairment with relatively maintained learning and memory function
boolean
C0027902 (UMLS CUI [1])
C0338656 (UMLS CUI [2])
C0233832 (UMLS CUI [3])
C0025260 (UMLS CUI [4])
C0338656 (UMLS CUI [2])
C0233832 (UMLS CUI [3])
C0025260 (UMLS CUI [4])
atrophy showing in MRI or CT
Item
Evidence in MRI/ CT of focal or asymmetric atrophy, typically manifesting in frontoparietal cortex
boolean
C2674464 (UMLS CUI [1])
C0011923 (UMLS CUI [2])
C0011923 (UMLS CUI [2])
focal or asymmetrical hypoperfusion showing in SPECT or PET
Item
Evidence in SPECT or PET of focal or asymmetrical hypoperfusion, typically manifested in frontoparietal cortex at maximum, with or without involvement of basal ganglia resp. the thalamus
boolean
C1695782 (UMLS CUI [1])
C0183126 (UMLS CUI [2])
C0032743 (UMLS CUI [3])
C0183126 (UMLS CUI [2])
C0032743 (UMLS CUI [3])
MSA diagnosis
Item
Is the patient currently diagnosed with MSA according to the criteria of Gilman et. al. 2008?
boolean
C0393571 (UMLS CUI [1])
episodic progressive disease
Item
Conditions Episodic, progressive disease with onset of symptoms after age of 30
boolean
C1335499 (UMLS CUI [1,1])
C1455761 (UMLS CUI [1,2])
C0150907 (UMLS CUI [2])
C1455761 (UMLS CUI [1,2])
C0150907 (UMLS CUI [2])
episodic progressive disease
Item
Conditions Episodic, progressive disease with onset of symptoms after age of 30
boolean
C1335499 (UMLS CUI [1,1])
C1455761 (UMLS CUI [1,2])
C0150907 (UMLS CUI [2])
C1455761 (UMLS CUI [1,2])
C0150907 (UMLS CUI [2])
Parkinsons disease
Item
1. Parkinson's disease (bradykinesia with rigor, tremor or postural instability)
boolean
C0030567 (UMLS CUI [1])
cerebellar syndrome
Item
Or a cerebellar syndrome (gait ataxia with cerebellar dysarthria, limb ataxia or cerebellar oculomotor disturbance)
boolean
C0231691 (UMLS CUI [1])
C0454599 (UMLS CUI [2])
C0231691 (UMLS CUI [3])
C1411869 (UMLS CUI [4])
C0454599 (UMLS CUI [2])
C0231691 (UMLS CUI [3])
C1411869 (UMLS CUI [4])
signs of autonomous dysfunction
Item
2. At least one sign suggesting autonomous dysfunction: -bladder incontinence that cannot be explained by another disease -incomplete urination -erectile dysfunction -significant decrease of orthostatic blood pressure without fulfilling criteria of a probable MSA
boolean
C0042024 (UMLS CUI [1])
C0426373 (UMLS CUI [2])
C0242350 (UMLS CUI [3])
C1095974 (UMLS CUI [4])
C0426373 (UMLS CUI [2])
C0242350 (UMLS CUI [3])
C1095974 (UMLS CUI [4])
additional sign
Item
3. At least one additional sign have to be fulfilled
boolean
C0679228 (UMLS CUI [1])
possible MSA
Item
Possible MSA (items 1-3 apply)
boolean
C0393571 (UMLS CUI [1,1])
C0332149 (UMLS CUI [1,2])
C0332149 (UMLS CUI [1,2])
autonomous dysfunction
Item
Signs of a probable multiple system atrophy 4. Autonomous disorder -with bladder incontinence (inability to control urination along with erectile dysfunction among men) -orthostatic decrease of blood pressure standing for 3 minutes of >30mmHg systolic or >15mmHg
boolean
C0042024 (UMLS CUI [1])
C0242350 (UMLS CUI [2])
C1095974 (UMLS CUI [3])
C0242350 (UMLS CUI [2])
C1095974 (UMLS CUI [3])
parkinsons syndrome
Item
5. Parkinson's syndrome (bradykinesia with rigor, tremor or postural instability) with poor response to Levodopa
boolean
C0030567 (UMLS CUI [1])
C2751071 (UMLS CUI [2])
C2751071 (UMLS CUI [2])
cerebellar syndrome
Item
Or a cerebellar syndrome (gait ataxia with cerebellar dysarthria, limb ataxia or cerebellar oculomotor disturbance)
boolean
C0231691 (UMLS CUI [1])
C0454599 (UMLS CUI [2])
C0231691 (UMLS CUI [3])
C1411869 (UMLS CUI [4])
C0454599 (UMLS CUI [2])
C0231691 (UMLS CUI [3])
C1411869 (UMLS CUI [4])
probable MSA
Item
Probable MSA (item 4-5 apply)
boolean
C0393571 (UMLS CUI [1,1])
C0033204 (UMLS CUI [1,2])
C0033204 (UMLS CUI [1,2])
additional signs of MSA-P or MSA-C
Item
boolean
C2732311 (UMLS CUI [1])
C2733447 (UMLS CUI [2])
C2733447 (UMLS CUI [2])
Babinski sign with increased reflex
Item
Babinski sign with increased reflex
boolean
C0034935 (UMLS CUI [1])
C0151889 (UMLS CUI [2])
C0151889 (UMLS CUI [2])
stridor
Item
Stridor
boolean
C0038450 (UMLS CUI [1])
rapid progression of Parkinsons syndrome
Item
Rapid progression of Parkinson's syndrome
boolean
C1834700 (UMLS CUI [1])
poor response to L-Dopa
Item
Poor response to L-Dopa
boolean
C2751071 (UMLS CUI [1])
postural instability
Item
Postural instability within three years after first motor symptomes
boolean
C1843921 (UMLS CUI [1])
cerebellar disorders
Item
Gait ataxia, cerebellar dysarthria, ataxia of extremities or cerebellar occulomotor disorder
boolean
C0751837 (UMLS CUI [1])
C0454599 (UMLS CUI [2])
C4015302 (UMLS CUI [3])
C1411869 (UMLS CUI [4])
C0454599 (UMLS CUI [2])
C4015302 (UMLS CUI [3])
C1411869 (UMLS CUI [4])
dysphagia
Item
Dysphagia within 5 years after onset of motor disease
boolean
C0011168 (UMLS CUI [1])
atrophy of putamen, cerebellar peduncle, pons or cerebellum
Item
Atrophy of putamen, cerebellar peduncle, pons or cerebellum proven in MRI
boolean
C1860217 (UMLS CUI [1])
C0228515 (UMLS CUI [2,1])
C0333641 (UMLS CUI [2,2])
C3552972 (UMLS CUI [3])
C0740279 (UMLS CUI [4])
C0228515 (UMLS CUI [2,1])
C0333641 (UMLS CUI [2,2])
C3552972 (UMLS CUI [3])
C0740279 (UMLS CUI [4])
hypometabolism
Item
Hypometabolism in putamen, brain stem or cerebellum proven in FDG-PET
boolean
C0347938 (UMLS CUI [1])
C3641247 (UMLS CUI [2])
C3641247 (UMLS CUI [2])
Parkinsons syndrome
Item
Parkinson's syndrome (bradykinesia and rigor)
boolean
C0030567 (UMLS CUI [1])
C0233565 (UMLS CUI [2])
C0026837 (UMLS CUI [3])
C0233565 (UMLS CUI [2])
C0026837 (UMLS CUI [3])
atrophies
Item
Putamen atrophy, middling cerebellar peduncle atrophy or pons atrophy proven in MRI
boolean
C1860217 (UMLS CUI [1])
C0228515 (UMLS CUI [2,1])
C0333641 (UMLS CUI [2,2])
C3552972 (UMLS CUI [3])
C0228515 (UMLS CUI [2,1])
C0333641 (UMLS CUI [2,2])
C3552972 (UMLS CUI [3])
presynaptic striatonigral dopaminergic denervation
Item
Presynaptic striatonigral dopaminergic denervation
boolean
C0011307 (UMLS CUI [1,1])
C0206129 (UMLS CUI [1,2])
C3498773 (UMLS CUI [1,3])
C0034798 (UMLS CUI [1,4])
C0206129 (UMLS CUI [1,2])
C3498773 (UMLS CUI [1,3])
C0034798 (UMLS CUI [1,4])
orofacial dystonia
Item
Orofacial dystonia
boolean
C1395979 (UMLS CUI [1])
antecollis
Item
Unproportional antecollis
boolean
C1698476 (UMLS CUI [1])
camptocormia
Item
Camptocormia
boolean
C0264162 (UMLS CUI [1])
contractions of hands and feet
Item
Contractions of hands and feet
boolean
C1140999 (UMLS CUI [1,1])
C0018563 (UMLS CUI [1,2])
C1140999 (UMLS CUI [2,1])
C0016504 (UMLS CUI [2,2])
C0018563 (UMLS CUI [1,2])
C1140999 (UMLS CUI [2,1])
C0016504 (UMLS CUI [2,2])
inspiratory sighs
Item
Inspiratory sighs
boolean
C0425481 (UMLS CUI [1])
severe dysphonia
Item
Severe dysphonia
boolean
C1527344 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,2])
severe dysarthria
Item
Severe dysarthria
boolean
C0013362 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,2])
incipient snoring
Item
Incipient snoring
boolean
C0037384 (UMLS CUI [1,1])
C0205256 (UMLS CUI [1,2])
C0205256 (UMLS CUI [1,2])
cold hand or feet
Item
Cold hand or feet
boolean
C0857073 (UMLS CUI [1])
pathological laughter or crying
Item
Pathological laughter or crying
boolean
C0424304 (UMLS CUI [1])
C0860609 (UMLS CUI [2])
C0860609 (UMLS CUI [2])
resting or action tremor
Item
Jerky, myoclonic resting or action tremor
boolean
C0234379 (UMLS CUI [1])
C0234376 (UMLS CUI [2])
C0234376 (UMLS CUI [2])
pill rolling tremor
Item
Classic pill rolling tremor
boolean
C0751564 (UMLS CUI [1])
clinically significant neuropathy
Item
Clinically significant neuropathy
boolean
C0442874 (UMLS CUI [1,1])
C2985739 (UMLS CUI [1,2])
C2985739 (UMLS CUI [1,2])
hallucinations
Item
Hallucinations which are not induced by medication
boolean
C0018524 (UMLS CUI [1])
age at onset of disease
Item
Onset of disease after age of 75
boolean
C0150907 (UMLS CUI [1])
family history of ataxia or parkinsonism
Item
Positive family history of ataxia or parkinsonism
boolean
C2939151 (UMLS CUI [1])
C0004134 (UMLS CUI [2,1])
C0241889 (UMLS CUI [2,2])
C0004134 (UMLS CUI [2,1])
C0241889 (UMLS CUI [2,2])
dementia diagnosis
Item
Dementia diagnosis
boolean
C0497327 (UMLS CUI [1])
lesions of white substance in MRI hinting for diagnosis of multiple sclerosis
Item
Lesions of white substance in MRI hinting for diagnosis of multiple sclerosis
boolean
C0682708 (UMLS CUI [1,1])
C0221198 (UMLS CUI [1,2])
C0026769 (UMLS CUI [2])
C0221198 (UMLS CUI [1,2])
C0026769 (UMLS CUI [2])
ET diagnosis
Item
Is the patient currently diagnosed with ET according to the criteria of Deutschi et. al. 1998?
boolean
C0270736 (UMLS CUI [1])
family genesis of tremor
Item
Known family genesis of tremor?
boolean
C0241889 (UMLS CUI [1,1])
C0270736 (UMLS CUI [1,2])
C0270736 (UMLS CUI [1,2])
bilateral permanent resting or action tremor
Item
I. Signs of a definite essential tremor 1. Bilateral , at most symmetric resting or action tremor, concerning hands and forearms, that is persistent and visible (Persistent tremor in other body regions can occur in addition; bilateral tremor can have different severity grades; tremor is described by participant as permanent continuous, but amplitude of the tremor can vary; tremor can cause disabilities in everyday living, but do not have to.
boolean
C0234379 (UMLS CUI [1,1])
C0238767 (UMLS CUI [1,2])
C0205355 (UMLS CUI [1,3])
C0234376 (UMLS CUI [2,1])
C0238767 (UMLS CUI [2,2])
C0205355 (UMLS CUI [2,3])
C0238767 (UMLS CUI [1,2])
C0205355 (UMLS CUI [1,3])
C0234376 (UMLS CUI [2,1])
C0238767 (UMLS CUI [2,2])
C0205355 (UMLS CUI [2,3])
duration of illness
Item
2. Duration of illness > 5 years
boolean
C3176590 (UMLS CUI [1])
other abnormal neurological symptoms
Item
II. Exclusion criteria of definite essential tremor 3. Presence of other abnormal neurological symptoms
boolean
C1533281 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,2])
indications of tremor
Item
4. Presence of indications or known reasons for occurrence of physiologic tremor
boolean
C0040822 (UMLS CUI [1,1])
C0392360 (UMLS CUI [1,2])
C0392360 (UMLS CUI [1,2])
intake of psychotics
Item
5. Current or earlier intake of psychogenic substances that can cause tremor or the current withdrawal symptoms
boolean
C0458006 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
C0678227 (UMLS CUI [1,3])
C0040822 (UMLS CUI [1,4])
C0013227 (UMLS CUI [1,2])
C0678227 (UMLS CUI [1,3])
C0040822 (UMLS CUI [1,4])
other disease causing tremor
Item
6. Other medical or neurological diseases, that can explain the tremor (especially brain injury, peripheral injury or trauma, 3 months before onset of tremor.
boolean
C0009488 (UMLS CUI [1,1])
C0678227 (UMLS CUI [1,2])
C0040822 (UMLS CUI [1,3])
C0678227 (UMLS CUI [1,2])
C0040822 (UMLS CUI [1,3])
evidence for psychosomatic tremor
Item
7. Anamnestic indication or clinical evidence for psychosomatic tremor
boolean
C0040822 (UMLS CUI [1,1])
C1537048 (UMLS CUI [1,2])
C1537048 (UMLS CUI [1,2])
indication for acute onset
Item
8. Indication for acute onset or stepped course of disease
boolean
C0242656 (UMLS CUI [1,1])
C1276802 (UMLS CUI [1,2])
C1276802 (UMLS CUI [1,2])
signs of probable essential tremor
Item
III. Signs of probable essential tremor III1. Bilateral, mainly symmetric resting or action tremor, which concerns hands and forearms but other body parts as well like head or legs, visible and persistent (bilateral tremor can be asymmetric; tremor is described by participant as permanent continuous, but amplitude of the tremor can vary; tremor can cause disabilities in everyday living, but do not have to)
boolean
C0234379 (UMLS CUI [1,1])
C0238767 (UMLS CUI [1,2])
C0205355 (UMLS CUI [1,3])
C0234376 (UMLS CUI [2,1])
C0238767 (UMLS CUI [2,2])
C0205355 (UMLS CUI [2,3])
C0238767 (UMLS CUI [1,2])
C0205355 (UMLS CUI [1,3])
C0234376 (UMLS CUI [2,1])
C0238767 (UMLS CUI [2,2])
C0205355 (UMLS CUI [2,3])
duration of disease
Item
III2. Duration of disease > 3 years
boolean
C3176590 (UMLS CUI [1])
diagnostic exclusion criteria
Item
III Exclusion criteria for possible essential tremor III.3 At least one exclusion criterion mentioned in I3-I8 is true.
boolean
C0679228 (UMLS CUI [1])
primary orthostatic tremor
Item
III4. Presence of primary orthostatic tremor
boolean
C0878578 (UMLS CUI [1])
isolated tremor of the voice
Item
III5. Presence of isolated tremor of the voice
boolean
C0234808 (UMLS CUI [1,1])
C0205409 (UMLS CUI [1,2])
C0205409 (UMLS CUI [1,2])
tremor specific to position and tasks
Item
III6. Presence of isolated tremor specific to position and tasks, including action-specific tremor or a primary writing tremor
boolean
C0040822 (UMLS CUI [1,1])
C1262869 (UMLS CUI [1,2])
C0205409 (UMLS CUI [1,3])
C1262869 (UMLS CUI [1,2])
C0205409 (UMLS CUI [1,3])
isolated tongue or chin tremor
Item
III7. Presence of isolated tongue or chin tremor
boolean
C0241446 (UMLS CUI [1,1])
C0205409 (UMLS CUI [1,2])
C3809829 (UMLS CUI [2,1])
C0205409 (UMLS CUI [2,2])
C0205409 (UMLS CUI [1,2])
C3809829 (UMLS CUI [2,1])
C0205409 (UMLS CUI [2,2])
type I essential tremor
Item
III. Signs of possible tremor Type I: Persons fulfilling criteria of definite or probable essential tremor but suffering from another neurological disease like parkinsonism, a dystonia, a peripheral neuropathology or restless leg syndrome. Persons fulfilling criteria of definite or probable essential tremor but suffering from other neurological symptoms that are not sufficient enough to make the diagnosis of another neurological illness. These symptoms concern for example minimal extra pyramidal signs like hypomimia, reduced arm drive or mild bradykinesia.
boolean
C3278729 (UMLS CUI [1])
type II essential tremor
Item
Mono-symptomatic and isolated tremor with uncertain relation to essential tremor, like for example isolated tremor specific to position and task, including action-specific tremor or a primary writing tremor, a primary orthostatic tremor, an isolated voice tremor, an isolated leg tremor or a unilateral resting tremor of the hand.
boolean
C1865810 (UMLS CUI [1])
exclusion criteria possible essential tremor
Item
III. Exclusion criteria for possible essential tremor At least one exclusion criterion mentioning in I4-I6 is true
boolean
C0679228 (UMLS CUI [1,1])
C0270736 (UMLS CUI [1,2])
C0332149 (UMLS CUI [1,3])
C0270736 (UMLS CUI [1,2])
C0332149 (UMLS CUI [1,3])
Item Group
Amyotrophic lateral sclerosis (ALS)
C0002736 (UMLS CUI-1)
ALS diagnosis
Item
Is the patient currently diagnosed with ALS according to the criteria of El-Escorial (revised 1998)?
boolean
C0002736 (UMLS CUI [1])
lesion of first motor neuron
Item
Symptoms that have to be present: Signs of lesion of 1. motor neuron
boolean
C0235834 (UMLS CUI [1])
lesion of second motor neuron
Item
Signs of lesion of 2. motor neuron (including EMG changes in clinically not affected muscles)
boolean
C0221198 (UMLS CUI [1,1])
C0524459 (UMLS CUI [1,2])
C0524459 (UMLS CUI [1,2])
progression
Item
Progression
boolean
C0449258 (UMLS CUI [1])
emotional disorder
Item
Symptoms, excluding a diagnosis of ALS emotional disorder
boolean
C0233459 (UMLS CUI [1])
sphincter disturbance
Item
boolean
C1409894 (UMLS CUI [1,1])
C2699787 (UMLS CUI [1,2])
C2699787 (UMLS CUI [1,2])
vision disorders
Item
Vision disorder
boolean
C0042790 (UMLS CUI [1])
autonomous dysfunctions
Item
Autonomous dysfunctions (e.g. urinary incontinence, cerebrovascular circulation)
boolean
C1397846 (UMLS CUI [1])
alzheimers disease
Item
Alzheimer's disease
boolean
C0002395 (UMLS CUI [1])
syndromes similar to ALS
Item
Syndromes similar to ALS
boolean
C0039082 (UMLS CUI [1,1])
C2348205 (UMLS CUI [1,2])
C0002736 (UMLS CUI [1,3])
C2348205 (UMLS CUI [1,2])
C0002736 (UMLS CUI [1,3])
fasciculations
Item
Supportive symptoms Fasciculations in one or several region
boolean
C0015644 (UMLS CUI [1])
neurogenic change in EMG
Item
Neurogenic change in EMG
boolean
C1843506 (UMLS CUI [1])
nerve conduction study
Item
Normal motor and sensory nerve conduction study
boolean
C0200125 (UMLS CUI [1])
missing nerve conduction block
Item
Missing nerve conduction block
boolean
C4012631 (UMLS CUI [1,1])
C1705492 (UMLS CUI [1,2])
C1705492 (UMLS CUI [1,2])
damage of 1. and 2. motor neuron
Item
Definite ALS Signs of damage of 1. and 2. motor neuron in 3 of 4 regions (bulbar, cervical, thoracic, lumbosacral)
boolean
C0026609 (UMLS CUI [1,1])
C1883709 (UMLS CUI [1,2])
C1883709 (UMLS CUI [1,2])
signs of probable ALS
Item
Probable ALS Signs of damage of 1. and 2. motor neuron in 2 of 4 regions, where the damage signs of 2. motor neuron has to be in position rostral of the damage of the 2. motor neuron
boolean
C0026609 (UMLS CUI [1,1])
C1883709 (UMLS CUI [1,2])
C1883709 (UMLS CUI [1,2])
damage of 1. and 2. motor neuron in 1 of 4 regions
Item
Probable, laboratory supported symptoms Signs of damage of 1. and 2. motor neuron in 1 of 4 regions (or only one region of 1. motor neuron) and signs of degeneration in EMG in at least two extremities
boolean
C0026609 (UMLS CUI [1,1])
C1883709 (UMLS CUI [1,2])
C1883709 (UMLS CUI [1,2])
signs of possible ALS
Item
Possible ALS Signs of damage of 1. and 2. motor neuron in one of 4 regions
boolean
C0026609 (UMLS CUI [1,1])
C1883709 (UMLS CUI [1,2])
C1883709 (UMLS CUI [1,2])
depression diagnosis
Item
Is the patient currently diagnosed with an episode of major depression according to the criteria of DSM-IV?
boolean
C0011581 (UMLS CUI [1])
symptoms of episode of major depression
Item
Key syndrome: Episode of major depression Five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. 1 depressed mood most of the day, nearly every day, as indicated by either subjective report (e.g., feels sad or empty) or observation made by others (e.g., appears tearful). 2 markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day (as indicated by either subjective account or observation made by others) 3 significant weight loss when not dieting or weight gain (e.g., a change of more than 5% of body weight in a month), or decrease or increase in appetite nearly every day. 4 insomnia or hypersomnia nearly every day 5 psychomotor agitation or retardation nearly every day (observable by others, not merely subjective feelings of restlessness or being slowed down) 6 fatigue or loss of energy nearly every day 7 feelings of worthlessness or excessive or inappropriate guilt (which may be delusional) nearly every day (not merely self-reproach or guilt about being sick) 8 diminished ability to think or concentrate, or indecisiveness, nearly every day (either by subjective account or as observed by others) 9 recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide
boolean
C0024517 (UMLS CUI [1])
no symptoms of mixed episode
Item
B The symptoms do not meet criteria for a Mixed Episode
boolean
C2874862 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,2])
clinically significant distress
Item
C. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning
boolean
C0700361 (UMLS CUI [1])
C0679477 (UMLS CUI [2])
C0679477 (UMLS CUI [2])
symtoms not caused by substances or a general medical condition
Item
D. The symptoms are not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication) or a general medical condition (e.g., hypothyroidism).
boolean
C0728866 (UMLS CUI [1])
C0236747 (UMLS CUI [2])
C0236747 (UMLS CUI [2])
symptoms are not better accounted for by bereavement
Item
E. The symptoms are not better accounted for by bereavement, i.e., after the loss of a loved one, the symptoms persist for longer than 2 months or are characterized by marked functional impairment, morbid preoc-cupation with worthlessness, suicidal ideation, psychotic symptoms, or psychomotor retardation.
boolean
C0005119 (UMLS CUI [1,1])
C0683368 (UMLS CUI [1,2])
C0683368 (UMLS CUI [1,2])
presence of a single Major Depressive Episode
Item
A. Presence of a single Major Depressive Episode
boolean
C0024517 (UMLS CUI [1])
major depressive episode is not better accounted for by schizoaffective disorder
Item
B. The Major Depressive Episode is not better accounted for by Schizoaffective Disorder and is not superimposed on Schizophrenia, Schizophreniform Disorder, Delusional Disorder, or Psychotic disorder not otherwise specified.
boolean
C0036337 (UMLS CUI [1,1])
C0683368 (UMLS CUI [1,2])
C0683368 (UMLS CUI [1,2])
never manic mixed or hypomanic episode
Item
C. There has never been a Manic Episode, a Mixed Episode, or a Hypomanic Episode.
boolean
C0349208 (UMLS CUI [1,1])
C2003901 (UMLS CUI [1,2])
C1608433 (UMLS CUI [2,1])
C2003901 (UMLS CUI [2,2])
C1396834 (UMLS CUI [3,1])
C2003901 (UMLS CUI [3,2])
C2003901 (UMLS CUI [1,2])
C1608433 (UMLS CUI [2,1])
C2003901 (UMLS CUI [2,2])
C1396834 (UMLS CUI [3,1])
C2003901 (UMLS CUI [3,2])
two or more major depressive episodes
Item
Major depression, recurrent A. Presence of two or more Major Depressive Episodes. (To be considered separate episodes, there must be an interval of at least 2 consecutive months in which criteria are not met for a Major Depressive Episode)
boolean
C0154409 (UMLS CUI [1])
episodes are not better accounted for by schizoaffective disorder
Item
B. The Major Depressive Episodes are not better accounted for by Schizoaffective Disorder and are not superimposed on Schizophrenia, Schizophreniform Disorder, Delusional Disorder, or Psychotic Disorder Not Otherwise Specified.
boolean
C0036337 (UMLS CUI [1,1])
C0686906 (UMLS CUI [1,2])
C0686906 (UMLS CUI [1,2])
no earlier manic mixed or hypomanic episode
Item
There has never been a Manic Episode, a Mixed Episode, or a Hypomanic Episode. (This exclusion does not apply if all of the manic-like, mixed-like, or hypomanic-like episodes are substance or treatment induced or are due to the direct physiological effects of a general medical condition.)
boolean
C0349208 (UMLS CUI [1,1])
C2003901 (UMLS CUI [1,2])
C1608433 (UMLS CUI [2,1])
C2003901 (UMLS CUI [2,2])
C1396834 (UMLS CUI [3,1])
C2003901 (UMLS CUI [3,2])
C2003901 (UMLS CUI [1,2])
C1608433 (UMLS CUI [2,1])
C2003901 (UMLS CUI [2,2])
C1396834 (UMLS CUI [3,1])
C2003901 (UMLS CUI [3,2])
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