ID
41505
Beschrijving
DELCODE is conducted by DZNE, the German Center for Neurodegenerative Diseases within the Helmholtz Association. The following information was taken from https://www.dzne.de/en/research/studies/clinical-studies/delcode/. Background and aims: One of the important aims of research into Alzheimer's is to find ways of detecting the disease early – if at all possible, as soon as the first minor symptoms appear, or even before any symptoms at all have appeared. Such detection capabilities are the necessary basis for development of therapies that can be applied at such early stages in the disease. Recent research indicates that such therapies could be more effective than therapies initiated during the disease's later stages. Over a period of several years, the DELCODE study is studying persons in early stages of the disease, along with various risk groups. The research is aimed at the development of procedures for characterizing early stages of the disease, at improving prediction of the course of the disease and at identifying new markers for early diagnosis of Alzheimer's-related dementia. Overview: DELCODE is set up to run for an initial period of three years, and to include a total of 1,000 study participants, who will be examined on a yearly basis. The group of participants will include persons with no complaints (healthy control subjects), patients with slight memory impairment or mild dementia and first-degree relatives of patients with diagnosed Alzheimer's disease. The minimum age for participants is 60. Course of the study: The examinations in the framework of the study will include a comprehensive interview carried out by a study investigator, a detailed neuropsychological examination (testing of memory functions and other areas of cognitive performance), a blood test and a cranial MRI scan. Optionally, subject to the study participant's consent in each case, a lumbar puncture (collection of cerebrospinal fluid) will be carried out." For more information (e.g. principle investigator and study coordination), please visit the above link or https://www.dzne.de. This document contains information about the PET investigation. The PET investigation form is for patients eligible for the PET sub-study of DELCODE only. Two PET investigations are to be conducted: a baseline investigation once eligible and a follow-up investigation 24 months after the baseline PET.
Link
https://www.dzne.de/en/research/studies/clinical-studies/delcode/
Trefwoorden
Versies (1)
- 30-10-20 30-10-20 -
Houder van rechten
DZNE (German Center for Neurodegenerative Diseases)
Geüploaded op
30 oktober 2020
DOI
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Licentie
Creative Commons BY-NC 4.0
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DELCODE: DZNE – Longitudinal Cognitive Impairment and Dementia Study
PET Investigation
- StudyEvent: ODM
Beschrijving
FBB-PET-Untersuchung
Alias
- UMLS CUI-1
- C0032743
- UMLS CUI-2
- C3818757
Beschrijving
FBB-PET
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C3818757
- UMLS CUI [1,2]
- C0032743
Beschrijving
Date of investigation
Datatype
date
Alias
- UMLS CUI [1,1]
- C0011008
- UMLS CUI [1,2]
- C0032743
Beschrijving
Time of investigation
Datatype
text
Alias
- UMLS CUI [1,1]
- C1442880
- UMLS CUI [1,2]
- C0032743
Beschrijving
PET investigation successfully performed
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C3258067
- UMLS CUI [1,2]
- C0032743
Beschrijving
Sick proband / Proband didn't appear
Datatype
boolean
Alias
- UMLS CUI [1]
- C2010702
- UMLS CUI [2]
- C1548414
Beschrijving
Informed Consent missing
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0021430
- UMLS CUI [1,2]
- C1705492
Beschrijving
Scanner or tracer not available
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C5208732
- UMLS CUI [1,2]
- C0686905
- UMLS CUI [2,1]
- C0182349
- UMLS CUI [2,2]
- C0686905
Beschrijving
Scanner malfunction after injection
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0182349
- UMLS CUI [1,2]
- C1881681
- UMLS CUI [1,3]
- C1548614
- UMLS CUI [1,4]
- C1272883
Beschrijving
Loss of data after scan
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C1880251
- UMLS CUI [1,2]
- C1548614
- UMLS CUI [1,3]
- C0032743
Beschrijving
Other reasons for failure
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C3840932
- UMLS CUI [1,2]
- C5200924
- UMLS CUI [1,3]
- C0032743
Beschrijving
Name reasons
Datatype
text
Alias
- UMLS CUI [1,1]
- C3840932
- UMLS CUI [1,2]
- C5200924
- UMLS CUI [1,3]
- C0032743
- UMLS CUI [1,4]
- C2348235
Beschrijving
Injection of radiopharmaceutical
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C1272883
- UMLS CUI [1,2]
- C0182638
Beschrijving
Informed consent signed
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0021430
- UMLS CUI [1,2]
- C0742766
Beschrijving
PET consent
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0032743
- UMLS CUI [1,2]
- C0021430
Beschrijving
PET - exclusion criteria examined daily
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0032743
- UMLS CUI [1,2]
- C0680251
- UMLS CUI [1,3]
- C0332128
- UMLS CUI [1,4]
- C0521116
Beschrijving
PET exclusion criteria
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0680251
- UMLS CUI [1,2]
- C0032743
Beschrijving
MRI exclusion criteria examined (only PET-MRI)
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C3641326
- UMLS CUI [1,2]
- C0680251
- UMLS CUI [1,3]
- C0332128
- UMLS CUI [1,4]
- C0521116
Beschrijving
MRI exclusion criteria
Datatype
integer
Alias
- UMLS CUI [1,1]
- C3641326
- UMLS CUI [1,2]
- C0680251
- UMLS CUI [1,3]
- C0332128
- UMLS CUI [1,4]
- C0521116
Beschrijving
Medication intake on investigation day
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0013227
- UMLS CUI [1,2]
- C1512806
- UMLS CUI [1,3]
- C2584899
Beschrijving
Pharmaceutical preparation
Datatype
text
Alias
- UMLS CUI [1]
- C0013227
Beschrijving
Bitte Werte vor und nach Injektion nicht einfach subtrahieren, sondern mit Dosisrechner den zwischenzeitlichen Verfall bis/seit Injektion korrigieren
Datatype
float
Maateenheden
- MBq
Alias
- UMLS CUI [1]
- C2986768
Beschrijving
Falls BfS-pflichtiger Proband
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C2986768
- UMLS CUI [1,2]
- C4296997
- UMLS CUI [1,3]
- C0752079
- UMLS CUI [1,4]
- C0032743
- UMLS CUI [1,5]
- C3818757
Beschrijving
<div>
Datatype
float
Maateenheden
- mGy*cm
Alias
- UMLS CUI [1,1]
- C0439810
- UMLS CUI [1,2]
- C3539930
- UMLS CUI [1,3]
- C1699633
Beschrijving
Medical abnormalities or other special incidents during or after the investigation
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0205476
- UMLS CUI [1,2]
- C1704258
- UMLS CUI [1,3]
- C1707834
- UMLS CUI [1,4]
- C4321457
- UMLS CUI [2,1]
- C0205555
- UMLS CUI [2,2]
- C1551358
- UMLS CUI [2,3]
- C1707834
- UMLS CUI [2,4]
- C4321457
Beschrijving
Medical abnormalities or other special incidents during or after the investigation - specification
Datatype
text
Alias
- UMLS CUI [1,1]
- C0205476
- UMLS CUI [1,2]
- C1704258
- UMLS CUI [1,3]
- C1707834
- UMLS CUI [1,4]
- C4321457
- UMLS CUI [1,5]
- C2348235
- UMLS CUI [2,1]
- C0205555
- UMLS CUI [2,2]
- C1551358
- UMLS CUI [2,3]
- C1707834
- UMLS CUI [2,4]
- C4321457
- UMLS CUI [2,5]
- C2348235
Beschrijving
Falls zutreffend: Gemäß der Studienspezifischen Vorgaben
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C1519255
- UMLS CUI [1,2]
- C0205548
- UMLS CUI [1,3]
- C4319718
Beschrijving
Z.B. Verletzungen am Schädelknochen, Tumore oder Entzündungen
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0332120
- UMLS CUI [1,2]
- C0205210
- UMLS CUI [1,3]
- C1704258
- UMLS CUI [1,4]
- C2986746
- UMLS CUI [2,1]
- C0332120
- UMLS CUI [2,2]
- C0205210
- UMLS CUI [2,3]
- C1704258
- UMLS CUI [2,4]
- C2986834
Beschrijving
Evidence of not study-related clinical abnormalities in transmission or emission - specification
Datatype
text
Alias
- UMLS CUI [1,1]
- C0332120
- UMLS CUI [1,2]
- C0205210
- UMLS CUI [1,3]
- C1704258
- UMLS CUI [1,4]
- C2986746
- UMLS CUI [1,5]
- C2348235
- UMLS CUI [2,1]
- C0332120
- UMLS CUI [2,2]
- C0205210
- UMLS CUI [2,3]
- C1704258
- UMLS CUI [2,4]
- C2986834
- UMLS CUI [2,5]
- C2348235
Beschrijving
Notes
Datatype
text
Alias
- UMLS CUI [1]
- C0947611
Beschrijving
FDG-PET
Alias
- UMLS CUI-1
- C3641247
Beschrijving
FDG-PET
Datatype
boolean
Alias
- UMLS CUI [1]
- C3641247
Beschrijving
Date of investigation - FDG-PET
Datatype
date
Alias
- UMLS CUI [1,1]
- C3641247
- UMLS CUI [1,2]
- C0011008
Beschrijving
Point in time of investigation - FDG-PET
Datatype
text
Alias
- UMLS CUI [1,1]
- C3641247
- UMLS CUI [1,2]
- C1442880
Beschrijving
FDG-PET investigation successfully performed
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C3258067
- UMLS CUI [1,2]
- C3641247
Beschrijving
Sick proband / Proband didn't appear
Datatype
boolean
Alias
- UMLS CUI [1]
- C2010702
- UMLS CUI [2]
- C1548414
Beschrijving
Informed Consent missing
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0021430
- UMLS CUI [1,2]
- C1705492
Beschrijving
Scanner or Tracer not available
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C5208732
- UMLS CUI [1,2]
- C1706613
- UMLS CUI [2,1]
- C3641247
- UMLS CUI [2,2]
- C1706613
Beschrijving
Hyperglycemia
Datatype
boolean
Alias
- UMLS CUI [1]
- C0020456
Beschrijving
Scanner malfunction after injection
Datatype
text
Alias
- UMLS CUI [1,1]
- C3641247
- UMLS CUI [1,2]
- C1881681
- UMLS CUI [1,3]
- C1548614
- UMLS CUI [1,4]
- C1272883
Beschrijving
Loss of data after scan
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C1880251
- UMLS CUI [1,2]
- C1548614
- UMLS CUI [1,3]
- C3641247
Beschrijving
Other reasons for failure
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C3840932
- UMLS CUI [1,2]
- C5200924
- UMLS CUI [1,3]
- C3641247
Beschrijving
Name reasons
Datatype
text
Alias
- UMLS CUI [1,1]
- C3840932
- UMLS CUI [1,2]
- C5200924
- UMLS CUI [1,3]
- C0032743
- UMLS CUI [1,4]
- C2348235
Beschrijving
Injection of radiopharmaceutical
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C1272883
- UMLS CUI [1,2]
- C0182638
Beschrijving
Informed consent signed
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0021430
- UMLS CUI [1,2]
- C0742766
Beschrijving
PET consent
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0032743
- UMLS CUI [1,2]
- C0021430
Beschrijving
PET - exclusion criteria examined daily
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0032743
- UMLS CUI [1,2]
- C0680251
- UMLS CUI [1,3]
- C0332128
- UMLS CUI [1,4]
- C0521116
Beschrijving
PET exclusion criteria
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0680251
- UMLS CUI [1,2]
- C0032743
Beschrijving
MRI exclusion criteria examined (only PET-MRI)
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C3641326
- UMLS CUI [1,2]
- C0680251
- UMLS CUI [1,3]
- C0332128
- UMLS CUI [1,4]
- C0521116
Beschrijving
MRI exclusion criteria
Datatype
integer
Alias
- UMLS CUI [1,1]
- C3641326
- UMLS CUI [1,2]
- C0680251
- UMLS CUI [1,3]
- C0332128
- UMLS CUI [1,4]
- C0521116
Beschrijving
Medication intake on investigation day
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0013227
- UMLS CUI [1,2]
- C2584899
Beschrijving
Pharmaceutical preparation
Datatype
text
Alias
- UMLS CUI [1]
- C0013227
Beschrijving
Bitte Werte vor und nach Injektion nicht einfach subtrahieren, sondern mit Dosisrechner den zwischenzeitlichen Verfall bis/seit Injektion korrigieren
Datatype
float
Maateenheden
- MBq
Alias
- UMLS CUI [1]
- C2986768
Beschrijving
Falls BfS-pflichtiger Proband
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C2986768
- UMLS CUI [1,2]
- C4296997
- UMLS CUI [1,3]
- C0752079
- UMLS CUI [1,4]
- C0032743
- UMLS CUI [1,5]
- C3818757
Beschrijving
<div>
Datatype
float
Maateenheden
- mGy*cm
Alias
- UMLS CUI [1,1]
- C0439810
- UMLS CUI [1,2]
- C3539930
- UMLS CUI [1,3]
- C1699633
Beschrijving
Medical abnormalities or other special incidents during or after the investigation
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0205476
- UMLS CUI [1,2]
- C1704258
- UMLS CUI [1,3]
- C1707834
- UMLS CUI [1,4]
- C4321457
- UMLS CUI [2,1]
- C0205555
- UMLS CUI [2,2]
- C1551358
- UMLS CUI [2,3]
- C1707834
- UMLS CUI [2,4]
- C4321457
Beschrijving
Medical abnormalities or other special incidents during or after the investigation - specification
Datatype
text
Alias
- UMLS CUI [1,1]
- C0205476
- UMLS CUI [1,2]
- C1704258
- UMLS CUI [1,3]
- C1707834
- UMLS CUI [1,4]
- C4321457
- UMLS CUI [1,5]
- C2348235
- UMLS CUI [2,1]
- C0205555
- UMLS CUI [2,2]
- C1551358
- UMLS CUI [2,3]
- C1707834
- UMLS CUI [2,4]
- C4321457
- UMLS CUI [2,5]
- C2348235
Beschrijving
Z.B. Verletzungen am Schädelknochen, Tumore oder Entzündungen
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0332120
- UMLS CUI [1,2]
- C0205210
- UMLS CUI [1,3]
- C1704258
- UMLS CUI [1,4]
- C2986746
- UMLS CUI [2,1]
- C0332120
- UMLS CUI [2,2]
- C0205210
- UMLS CUI [2,3]
- C1704258
- UMLS CUI [2,4]
- C2986834
Beschrijving
Evidence of not study-related clinical abnormalities in transmission or emission - specification
Datatype
text
Alias
- UMLS CUI [1,1]
- C0332120
- UMLS CUI [1,2]
- C0205210
- UMLS CUI [1,3]
- C1704258
- UMLS CUI [1,4]
- C2986746
- UMLS CUI [1,5]
- C2348235
- UMLS CUI [2,1]
- C0332120
- UMLS CUI [2,2]
- C0205210
- UMLS CUI [2,3]
- C1704258
- UMLS CUI [2,4]
- C2986834
- UMLS CUI [2,5]
- C2348235
Beschrijving
Notes
Datatype
text
Alias
- UMLS CUI [1]
- C0947611
Similar models
PET Investigation
- StudyEvent: ODM
C0032743 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,2])
C1548414 (UMLS CUI [2])
C1705492 (UMLS CUI [1,2])
C0686905 (UMLS CUI [1,2])
C0182349 (UMLS CUI [2,1])
C0686905 (UMLS CUI [2,2])
C1881681 (UMLS CUI [1,2])
C1548614 (UMLS CUI [1,3])
C1272883 (UMLS CUI [1,4])
C1548614 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,3])
C5200924 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,3])
C5200924 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,3])
C2348235 (UMLS CUI [1,4])
C0182638 (UMLS CUI [1,2])
C0742766 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,2])
C0332128 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
C0032743 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,2])
C0332128 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
C0680251 (UMLS CUI [1,2])
C0332128 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
C1512806 (UMLS CUI [1,2])
C2584899 (UMLS CUI [1,3])
C4296997 (UMLS CUI [1,2])
C0752079 (UMLS CUI [1,3])
C0032743 (UMLS CUI [1,4])
C3818757 (UMLS CUI [1,5])
C3539930 (UMLS CUI [1,2])
C1699633 (UMLS CUI [1,3])
C1704258 (UMLS CUI [1,2])
C1707834 (UMLS CUI [1,3])
C4321457 (UMLS CUI [1,4])
C0205555 (UMLS CUI [2,1])
C1551358 (UMLS CUI [2,2])
C1707834 (UMLS CUI [2,3])
C4321457 (UMLS CUI [2,4])
C1704258 (UMLS CUI [1,2])
C1707834 (UMLS CUI [1,3])
C4321457 (UMLS CUI [1,4])
C2348235 (UMLS CUI [1,5])
C0205555 (UMLS CUI [2,1])
C1551358 (UMLS CUI [2,2])
C1707834 (UMLS CUI [2,3])
C4321457 (UMLS CUI [2,4])
C2348235 (UMLS CUI [2,5])
C0205548 (UMLS CUI [1,2])
C4319718 (UMLS CUI [1,3])
C0205210 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,3])
C2986746 (UMLS CUI [1,4])
C0332120 (UMLS CUI [2,1])
C0205210 (UMLS CUI [2,2])
C1704258 (UMLS CUI [2,3])
C2986834 (UMLS CUI [2,4])
C0205210 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,3])
C2986746 (UMLS CUI [1,4])
C2348235 (UMLS CUI [1,5])
C0332120 (UMLS CUI [2,1])
C0205210 (UMLS CUI [2,2])
C1704258 (UMLS CUI [2,3])
C2986834 (UMLS CUI [2,4])
C2348235 (UMLS CUI [2,5])
C0011008 (UMLS CUI [1,2])
C1442880 (UMLS CUI [1,2])
C3641247 (UMLS CUI [1,2])
C1548414 (UMLS CUI [2])
C1705492 (UMLS CUI [1,2])
C1706613 (UMLS CUI [1,2])
C3641247 (UMLS CUI [2,1])
C1706613 (UMLS CUI [2,2])
C1881681 (UMLS CUI [1,2])
C1548614 (UMLS CUI [1,3])
C1272883 (UMLS CUI [1,4])
C1548614 (UMLS CUI [1,2])
C3641247 (UMLS CUI [1,3])
C5200924 (UMLS CUI [1,2])
C3641247 (UMLS CUI [1,3])
C5200924 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,3])
C2348235 (UMLS CUI [1,4])
C0182638 (UMLS CUI [1,2])
C0742766 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,2])
C0332128 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
C0032743 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,2])
C0332128 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
C0680251 (UMLS CUI [1,2])
C0332128 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
C2584899 (UMLS CUI [1,2])
C4296997 (UMLS CUI [1,2])
C0752079 (UMLS CUI [1,3])
C0032743 (UMLS CUI [1,4])
C3818757 (UMLS CUI [1,5])
C3539930 (UMLS CUI [1,2])
C1699633 (UMLS CUI [1,3])
C1704258 (UMLS CUI [1,2])
C1707834 (UMLS CUI [1,3])
C4321457 (UMLS CUI [1,4])
C0205555 (UMLS CUI [2,1])
C1551358 (UMLS CUI [2,2])
C1707834 (UMLS CUI [2,3])
C4321457 (UMLS CUI [2,4])
C1704258 (UMLS CUI [1,2])
C1707834 (UMLS CUI [1,3])
C4321457 (UMLS CUI [1,4])
C2348235 (UMLS CUI [1,5])
C0205555 (UMLS CUI [2,1])
C1551358 (UMLS CUI [2,2])
C1707834 (UMLS CUI [2,3])
C4321457 (UMLS CUI [2,4])
C2348235 (UMLS CUI [2,5])
C0205210 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,3])
C2986746 (UMLS CUI [1,4])
C0332120 (UMLS CUI [2,1])
C0205210 (UMLS CUI [2,2])
C1704258 (UMLS CUI [2,3])
C2986834 (UMLS CUI [2,4])
C0205210 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,3])
C2986746 (UMLS CUI [1,4])
C2348235 (UMLS CUI [1,5])
C0332120 (UMLS CUI [2,1])
C0205210 (UMLS CUI [2,2])
C1704258 (UMLS CUI [2,3])
C2986834 (UMLS CUI [2,4])
C2348235 (UMLS CUI [2,5])