ID
41505
Beschreibung
DELCODE is conducted by DZNE, the German Center for Neurodegenerative Diseases within the Helmholtz Association. The following information was taken from https://www.dzne.de/en/research/studies/clinical-studies/delcode/. Background and aims: One of the important aims of research into Alzheimer's is to find ways of detecting the disease early – if at all possible, as soon as the first minor symptoms appear, or even before any symptoms at all have appeared. Such detection capabilities are the necessary basis for development of therapies that can be applied at such early stages in the disease. Recent research indicates that such therapies could be more effective than therapies initiated during the disease's later stages. Over a period of several years, the DELCODE study is studying persons in early stages of the disease, along with various risk groups. The research is aimed at the development of procedures for characterizing early stages of the disease, at improving prediction of the course of the disease and at identifying new markers for early diagnosis of Alzheimer's-related dementia. Overview: DELCODE is set up to run for an initial period of three years, and to include a total of 1,000 study participants, who will be examined on a yearly basis. The group of participants will include persons with no complaints (healthy control subjects), patients with slight memory impairment or mild dementia and first-degree relatives of patients with diagnosed Alzheimer's disease. The minimum age for participants is 60. Course of the study: The examinations in the framework of the study will include a comprehensive interview carried out by a study investigator, a detailed neuropsychological examination (testing of memory functions and other areas of cognitive performance), a blood test and a cranial MRI scan. Optionally, subject to the study participant's consent in each case, a lumbar puncture (collection of cerebrospinal fluid) will be carried out." For more information (e.g. principle investigator and study coordination), please visit the above link or https://www.dzne.de. This document contains information about the PET investigation. The PET investigation form is for patients eligible for the PET sub-study of DELCODE only. Two PET investigations are to be conducted: a baseline investigation once eligible and a follow-up investigation 24 months after the baseline PET.
Link
https://www.dzne.de/en/research/studies/clinical-studies/delcode/
Stichworte
Versionen (1)
- 30.10.20 30.10.20 -
Rechteinhaber
DZNE (German Center for Neurodegenerative Diseases)
Hochgeladen am
30. Oktober 2020
DOI
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Lizenz
Creative Commons BY-NC 4.0
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DELCODE: DZNE – Longitudinal Cognitive Impairment and Dementia Study
PET Investigation
- StudyEvent: ODM
Beschreibung
FBB-PET-Untersuchung
Alias
- UMLS CUI-1
- C0032743
- UMLS CUI-2
- C3818757
Beschreibung
FBB-PET
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C3818757
- UMLS CUI [1,2]
- C0032743
Beschreibung
Date of investigation
Datentyp
date
Alias
- UMLS CUI [1,1]
- C0011008
- UMLS CUI [1,2]
- C0032743
Beschreibung
Time of investigation
Datentyp
text
Alias
- UMLS CUI [1,1]
- C1442880
- UMLS CUI [1,2]
- C0032743
Beschreibung
PET investigation successfully performed
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C3258067
- UMLS CUI [1,2]
- C0032743
Beschreibung
Sick proband / Proband didn't appear
Datentyp
boolean
Alias
- UMLS CUI [1]
- C2010702
- UMLS CUI [2]
- C1548414
Beschreibung
Informed Consent missing
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0021430
- UMLS CUI [1,2]
- C1705492
Beschreibung
Scanner or tracer not available
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C5208732
- UMLS CUI [1,2]
- C0686905
- UMLS CUI [2,1]
- C0182349
- UMLS CUI [2,2]
- C0686905
Beschreibung
Scanner malfunction after injection
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0182349
- UMLS CUI [1,2]
- C1881681
- UMLS CUI [1,3]
- C1548614
- UMLS CUI [1,4]
- C1272883
Beschreibung
Loss of data after scan
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C1880251
- UMLS CUI [1,2]
- C1548614
- UMLS CUI [1,3]
- C0032743
Beschreibung
Other reasons for failure
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C3840932
- UMLS CUI [1,2]
- C5200924
- UMLS CUI [1,3]
- C0032743
Beschreibung
Name reasons
Datentyp
text
Alias
- UMLS CUI [1,1]
- C3840932
- UMLS CUI [1,2]
- C5200924
- UMLS CUI [1,3]
- C0032743
- UMLS CUI [1,4]
- C2348235
Beschreibung
Injection of radiopharmaceutical
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C1272883
- UMLS CUI [1,2]
- C0182638
Beschreibung
Informed consent signed
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0021430
- UMLS CUI [1,2]
- C0742766
Beschreibung
PET consent
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0032743
- UMLS CUI [1,2]
- C0021430
Beschreibung
PET - exclusion criteria examined daily
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0032743
- UMLS CUI [1,2]
- C0680251
- UMLS CUI [1,3]
- C0332128
- UMLS CUI [1,4]
- C0521116
Beschreibung
PET exclusion criteria
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0680251
- UMLS CUI [1,2]
- C0032743
Beschreibung
MRI exclusion criteria examined (only PET-MRI)
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C3641326
- UMLS CUI [1,2]
- C0680251
- UMLS CUI [1,3]
- C0332128
- UMLS CUI [1,4]
- C0521116
Beschreibung
MRI exclusion criteria
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C3641326
- UMLS CUI [1,2]
- C0680251
- UMLS CUI [1,3]
- C0332128
- UMLS CUI [1,4]
- C0521116
Beschreibung
Medication intake on investigation day
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0013227
- UMLS CUI [1,2]
- C1512806
- UMLS CUI [1,3]
- C2584899
Beschreibung
Pharmaceutical preparation
Datentyp
text
Alias
- UMLS CUI [1]
- C0013227
Beschreibung
Bitte Werte vor und nach Injektion nicht einfach subtrahieren, sondern mit Dosisrechner den zwischenzeitlichen Verfall bis/seit Injektion korrigieren
Datentyp
float
Maßeinheiten
- MBq
Alias
- UMLS CUI [1]
- C2986768
Beschreibung
Falls BfS-pflichtiger Proband
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C2986768
- UMLS CUI [1,2]
- C4296997
- UMLS CUI [1,3]
- C0752079
- UMLS CUI [1,4]
- C0032743
- UMLS CUI [1,5]
- C3818757
Beschreibung
<div>
Datentyp
float
Maßeinheiten
- mGy*cm
Alias
- UMLS CUI [1,1]
- C0439810
- UMLS CUI [1,2]
- C3539930
- UMLS CUI [1,3]
- C1699633
Beschreibung
Medical abnormalities or other special incidents during or after the investigation
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0205476
- UMLS CUI [1,2]
- C1704258
- UMLS CUI [1,3]
- C1707834
- UMLS CUI [1,4]
- C4321457
- UMLS CUI [2,1]
- C0205555
- UMLS CUI [2,2]
- C1551358
- UMLS CUI [2,3]
- C1707834
- UMLS CUI [2,4]
- C4321457
Beschreibung
Medical abnormalities or other special incidents during or after the investigation - specification
Datentyp
text
Alias
- UMLS CUI [1,1]
- C0205476
- UMLS CUI [1,2]
- C1704258
- UMLS CUI [1,3]
- C1707834
- UMLS CUI [1,4]
- C4321457
- UMLS CUI [1,5]
- C2348235
- UMLS CUI [2,1]
- C0205555
- UMLS CUI [2,2]
- C1551358
- UMLS CUI [2,3]
- C1707834
- UMLS CUI [2,4]
- C4321457
- UMLS CUI [2,5]
- C2348235
Beschreibung
Falls zutreffend: Gemäß der Studienspezifischen Vorgaben
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C1519255
- UMLS CUI [1,2]
- C0205548
- UMLS CUI [1,3]
- C4319718
Beschreibung
Z.B. Verletzungen am Schädelknochen, Tumore oder Entzündungen
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0332120
- UMLS CUI [1,2]
- C0205210
- UMLS CUI [1,3]
- C1704258
- UMLS CUI [1,4]
- C2986746
- UMLS CUI [2,1]
- C0332120
- UMLS CUI [2,2]
- C0205210
- UMLS CUI [2,3]
- C1704258
- UMLS CUI [2,4]
- C2986834
Beschreibung
Evidence of not study-related clinical abnormalities in transmission or emission - specification
Datentyp
text
Alias
- UMLS CUI [1,1]
- C0332120
- UMLS CUI [1,2]
- C0205210
- UMLS CUI [1,3]
- C1704258
- UMLS CUI [1,4]
- C2986746
- UMLS CUI [1,5]
- C2348235
- UMLS CUI [2,1]
- C0332120
- UMLS CUI [2,2]
- C0205210
- UMLS CUI [2,3]
- C1704258
- UMLS CUI [2,4]
- C2986834
- UMLS CUI [2,5]
- C2348235
Beschreibung
Notes
Datentyp
text
Alias
- UMLS CUI [1]
- C0947611
Beschreibung
FDG-PET
Alias
- UMLS CUI-1
- C3641247
Beschreibung
FDG-PET
Datentyp
boolean
Alias
- UMLS CUI [1]
- C3641247
Beschreibung
Date of investigation - FDG-PET
Datentyp
date
Alias
- UMLS CUI [1,1]
- C3641247
- UMLS CUI [1,2]
- C0011008
Beschreibung
Point in time of investigation - FDG-PET
Datentyp
text
Alias
- UMLS CUI [1,1]
- C3641247
- UMLS CUI [1,2]
- C1442880
Beschreibung
FDG-PET investigation successfully performed
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C3258067
- UMLS CUI [1,2]
- C3641247
Beschreibung
Sick proband / Proband didn't appear
Datentyp
boolean
Alias
- UMLS CUI [1]
- C2010702
- UMLS CUI [2]
- C1548414
Beschreibung
Informed Consent missing
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0021430
- UMLS CUI [1,2]
- C1705492
Beschreibung
Scanner or Tracer not available
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C5208732
- UMLS CUI [1,2]
- C1706613
- UMLS CUI [2,1]
- C3641247
- UMLS CUI [2,2]
- C1706613
Beschreibung
Hyperglycemia
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0020456
Beschreibung
Scanner malfunction after injection
Datentyp
text
Alias
- UMLS CUI [1,1]
- C3641247
- UMLS CUI [1,2]
- C1881681
- UMLS CUI [1,3]
- C1548614
- UMLS CUI [1,4]
- C1272883
Beschreibung
Loss of data after scan
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C1880251
- UMLS CUI [1,2]
- C1548614
- UMLS CUI [1,3]
- C3641247
Beschreibung
Other reasons for failure
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C3840932
- UMLS CUI [1,2]
- C5200924
- UMLS CUI [1,3]
- C3641247
Beschreibung
Name reasons
Datentyp
text
Alias
- UMLS CUI [1,1]
- C3840932
- UMLS CUI [1,2]
- C5200924
- UMLS CUI [1,3]
- C0032743
- UMLS CUI [1,4]
- C2348235
Beschreibung
Injection of radiopharmaceutical
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C1272883
- UMLS CUI [1,2]
- C0182638
Beschreibung
Informed consent signed
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0021430
- UMLS CUI [1,2]
- C0742766
Beschreibung
PET consent
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0032743
- UMLS CUI [1,2]
- C0021430
Beschreibung
PET - exclusion criteria examined daily
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0032743
- UMLS CUI [1,2]
- C0680251
- UMLS CUI [1,3]
- C0332128
- UMLS CUI [1,4]
- C0521116
Beschreibung
PET exclusion criteria
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0680251
- UMLS CUI [1,2]
- C0032743
Beschreibung
MRI exclusion criteria examined (only PET-MRI)
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C3641326
- UMLS CUI [1,2]
- C0680251
- UMLS CUI [1,3]
- C0332128
- UMLS CUI [1,4]
- C0521116
Beschreibung
MRI exclusion criteria
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C3641326
- UMLS CUI [1,2]
- C0680251
- UMLS CUI [1,3]
- C0332128
- UMLS CUI [1,4]
- C0521116
Beschreibung
Medication intake on investigation day
Datentyp
integer
Alias
- UMLS CUI [1,1]
- C0013227
- UMLS CUI [1,2]
- C2584899
Beschreibung
Pharmaceutical preparation
Datentyp
text
Alias
- UMLS CUI [1]
- C0013227
Beschreibung
Bitte Werte vor und nach Injektion nicht einfach subtrahieren, sondern mit Dosisrechner den zwischenzeitlichen Verfall bis/seit Injektion korrigieren
Datentyp
float
Maßeinheiten
- MBq
Alias
- UMLS CUI [1]
- C2986768
Beschreibung
Falls BfS-pflichtiger Proband
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C2986768
- UMLS CUI [1,2]
- C4296997
- UMLS CUI [1,3]
- C0752079
- UMLS CUI [1,4]
- C0032743
- UMLS CUI [1,5]
- C3818757
Beschreibung
<div>
Datentyp
float
Maßeinheiten
- mGy*cm
Alias
- UMLS CUI [1,1]
- C0439810
- UMLS CUI [1,2]
- C3539930
- UMLS CUI [1,3]
- C1699633
Beschreibung
Medical abnormalities or other special incidents during or after the investigation
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0205476
- UMLS CUI [1,2]
- C1704258
- UMLS CUI [1,3]
- C1707834
- UMLS CUI [1,4]
- C4321457
- UMLS CUI [2,1]
- C0205555
- UMLS CUI [2,2]
- C1551358
- UMLS CUI [2,3]
- C1707834
- UMLS CUI [2,4]
- C4321457
Beschreibung
Medical abnormalities or other special incidents during or after the investigation - specification
Datentyp
text
Alias
- UMLS CUI [1,1]
- C0205476
- UMLS CUI [1,2]
- C1704258
- UMLS CUI [1,3]
- C1707834
- UMLS CUI [1,4]
- C4321457
- UMLS CUI [1,5]
- C2348235
- UMLS CUI [2,1]
- C0205555
- UMLS CUI [2,2]
- C1551358
- UMLS CUI [2,3]
- C1707834
- UMLS CUI [2,4]
- C4321457
- UMLS CUI [2,5]
- C2348235
Beschreibung
Z.B. Verletzungen am Schädelknochen, Tumore oder Entzündungen
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0332120
- UMLS CUI [1,2]
- C0205210
- UMLS CUI [1,3]
- C1704258
- UMLS CUI [1,4]
- C2986746
- UMLS CUI [2,1]
- C0332120
- UMLS CUI [2,2]
- C0205210
- UMLS CUI [2,3]
- C1704258
- UMLS CUI [2,4]
- C2986834
Beschreibung
Evidence of not study-related clinical abnormalities in transmission or emission - specification
Datentyp
text
Alias
- UMLS CUI [1,1]
- C0332120
- UMLS CUI [1,2]
- C0205210
- UMLS CUI [1,3]
- C1704258
- UMLS CUI [1,4]
- C2986746
- UMLS CUI [1,5]
- C2348235
- UMLS CUI [2,1]
- C0332120
- UMLS CUI [2,2]
- C0205210
- UMLS CUI [2,3]
- C1704258
- UMLS CUI [2,4]
- C2986834
- UMLS CUI [2,5]
- C2348235
Beschreibung
Notes
Datentyp
text
Alias
- UMLS CUI [1]
- C0947611
Ähnliche Modelle
PET Investigation
- StudyEvent: ODM
C0032743 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,2])
C1548414 (UMLS CUI [2])
C1705492 (UMLS CUI [1,2])
C0686905 (UMLS CUI [1,2])
C0182349 (UMLS CUI [2,1])
C0686905 (UMLS CUI [2,2])
C1881681 (UMLS CUI [1,2])
C1548614 (UMLS CUI [1,3])
C1272883 (UMLS CUI [1,4])
C1548614 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,3])
C5200924 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,3])
C5200924 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,3])
C2348235 (UMLS CUI [1,4])
C0182638 (UMLS CUI [1,2])
C0742766 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,2])
C0332128 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
C0032743 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,2])
C0332128 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
C0680251 (UMLS CUI [1,2])
C0332128 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
C1512806 (UMLS CUI [1,2])
C2584899 (UMLS CUI [1,3])
C4296997 (UMLS CUI [1,2])
C0752079 (UMLS CUI [1,3])
C0032743 (UMLS CUI [1,4])
C3818757 (UMLS CUI [1,5])
C3539930 (UMLS CUI [1,2])
C1699633 (UMLS CUI [1,3])
C1704258 (UMLS CUI [1,2])
C1707834 (UMLS CUI [1,3])
C4321457 (UMLS CUI [1,4])
C0205555 (UMLS CUI [2,1])
C1551358 (UMLS CUI [2,2])
C1707834 (UMLS CUI [2,3])
C4321457 (UMLS CUI [2,4])
C1704258 (UMLS CUI [1,2])
C1707834 (UMLS CUI [1,3])
C4321457 (UMLS CUI [1,4])
C2348235 (UMLS CUI [1,5])
C0205555 (UMLS CUI [2,1])
C1551358 (UMLS CUI [2,2])
C1707834 (UMLS CUI [2,3])
C4321457 (UMLS CUI [2,4])
C2348235 (UMLS CUI [2,5])
C0205548 (UMLS CUI [1,2])
C4319718 (UMLS CUI [1,3])
C0205210 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,3])
C2986746 (UMLS CUI [1,4])
C0332120 (UMLS CUI [2,1])
C0205210 (UMLS CUI [2,2])
C1704258 (UMLS CUI [2,3])
C2986834 (UMLS CUI [2,4])
C0205210 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,3])
C2986746 (UMLS CUI [1,4])
C2348235 (UMLS CUI [1,5])
C0332120 (UMLS CUI [2,1])
C0205210 (UMLS CUI [2,2])
C1704258 (UMLS CUI [2,3])
C2986834 (UMLS CUI [2,4])
C2348235 (UMLS CUI [2,5])
C0011008 (UMLS CUI [1,2])
C1442880 (UMLS CUI [1,2])
C3641247 (UMLS CUI [1,2])
C1548414 (UMLS CUI [2])
C1705492 (UMLS CUI [1,2])
C1706613 (UMLS CUI [1,2])
C3641247 (UMLS CUI [2,1])
C1706613 (UMLS CUI [2,2])
C1881681 (UMLS CUI [1,2])
C1548614 (UMLS CUI [1,3])
C1272883 (UMLS CUI [1,4])
C1548614 (UMLS CUI [1,2])
C3641247 (UMLS CUI [1,3])
C5200924 (UMLS CUI [1,2])
C3641247 (UMLS CUI [1,3])
C5200924 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,3])
C2348235 (UMLS CUI [1,4])
C0182638 (UMLS CUI [1,2])
C0742766 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,2])
C0332128 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
C0032743 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,2])
C0332128 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
C0680251 (UMLS CUI [1,2])
C0332128 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
C2584899 (UMLS CUI [1,2])
C4296997 (UMLS CUI [1,2])
C0752079 (UMLS CUI [1,3])
C0032743 (UMLS CUI [1,4])
C3818757 (UMLS CUI [1,5])
C3539930 (UMLS CUI [1,2])
C1699633 (UMLS CUI [1,3])
C1704258 (UMLS CUI [1,2])
C1707834 (UMLS CUI [1,3])
C4321457 (UMLS CUI [1,4])
C0205555 (UMLS CUI [2,1])
C1551358 (UMLS CUI [2,2])
C1707834 (UMLS CUI [2,3])
C4321457 (UMLS CUI [2,4])
C1704258 (UMLS CUI [1,2])
C1707834 (UMLS CUI [1,3])
C4321457 (UMLS CUI [1,4])
C2348235 (UMLS CUI [1,5])
C0205555 (UMLS CUI [2,1])
C1551358 (UMLS CUI [2,2])
C1707834 (UMLS CUI [2,3])
C4321457 (UMLS CUI [2,4])
C2348235 (UMLS CUI [2,5])
C0205210 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,3])
C2986746 (UMLS CUI [1,4])
C0332120 (UMLS CUI [2,1])
C0205210 (UMLS CUI [2,2])
C1704258 (UMLS CUI [2,3])
C2986834 (UMLS CUI [2,4])
C0205210 (UMLS CUI [1,2])
C1704258 (UMLS CUI [1,3])
C2986746 (UMLS CUI [1,4])
C2348235 (UMLS CUI [1,5])
C0332120 (UMLS CUI [2,1])
C0205210 (UMLS CUI [2,2])
C1704258 (UMLS CUI [2,3])
C2986834 (UMLS CUI [2,4])
C2348235 (UMLS CUI [2,5])