ID

25115

Descrição

GSK Study: Evaluation of safety and efficacy of VarilrixTM and of Combined Measles-Mumps-Rubella-Varicella Vaccine NCT00226499 - Diary Card Dose 2 Study ID: 100388 Clinical Study ID: 100388 Study Title: Study in Healthy Children (<2 Years) to Evaluate the Safety and Efficacy of GSK Biologicals' Live Attenuated Varicella Vaccine (VarilrixTM) and of GSK Biologicals' Combined Measles-Mumps-Rubella-Varicella Vaccine Patient Level Data: Study Listed on ClinicalStudyDataRequest.com Clinicaltrials.gov Identifier: NCT00226499 Sponsor: GlaxoSmithKline Collaborators: N/A Phase: phase 3 Study Recruitment Status: Completed Generic Name: Varicella Vaccine Trade Name: BIO OKAH; Varilrix Study Indication: Varicella

Palavras-chave

Versões (1)
  1. 26/08/2017 26/08/2017 -
Titular dos direitos

glaxoSmithKline

Transferido a

26 de agosto de 2017

DOI

Para um pedido faça login.

Licença

Creative Commons BY-NC 3.0
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GSK Study: Evaluation of safety and efficacy of VarilrixTM and of Combined Measles-Mumps-Rubella-Varicella Vaccine NCT00226499 - Diary Card Dose 2

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GSK Study: Evaluation of safety and efficacy of VarilrixTM and of Combined Measles-Mumps-Rubella-Varicella Vaccine NCT00226499 - Diary Card Dose 2

1 Formulários  
Solicited Symptoms
Descrição

Solicited Symptoms

Alias
UMLS CUI-1
C0683368
UMLS CUI-2
C1517001
Redness
Descrição

Administration site erythema

Tipo de dados

boolean

Alias
UMLS CUI [1]
C3805283
Size (of redness at administration site) Day 0
Descrição

Size of erythema at administration site Day 0

Tipo de dados

integer

Unidades de medida
  • mm
Alias
UMLS CUI [1,1]
C3805283
UMLS CUI [1,2]
C0456389
mm
Size (of redness at administration site) Day 1
Descrição

Size of erythema at administration site Day 1

Tipo de dados

integer

Unidades de medida
  • mm
Alias
UMLS CUI [1,1]
C3805283
UMLS CUI [1,2]
C0456389
mm
Size (of redness at administration site) Day 2
Descrição

Size of erythema at administration site Day 2

Tipo de dados

integer

Unidades de medida
  • mm
Alias
UMLS CUI [1,1]
C3805283
UMLS CUI [1,2]
C0456389
mm
Size (of redness at administration site) Day 3
Descrição

Size of erythema at administration site Day 3

Tipo de dados

integer

Unidades de medida
  • mm
Alias
UMLS CUI [1,1]
C3805283
UMLS CUI [1,2]
C0456389
mm
Ongoing after Day 3?
Descrição

Erythema ongoing after day 3

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C3805283
UMLS CUI [1,2]
C0549178
Date of last day of symptoms
Descrição

Date of last day of symptoms

Tipo de dados

date

Alias
UMLS CUI [1,1]
C0011008
UMLS CUI [1,2]
C0332575
UMLS CUI [1,3]
C2700396
Swelling
Descrição

Administration site swelling

Tipo de dados

boolean

Alias
UMLS CUI [1]
C3854415
Size (of swelling at administration site) Day 0
Descrição

Size of swelling at administration site Day 0

Tipo de dados

integer

Unidades de medida
  • mm
Alias
UMLS CUI [1,1]
C3854415
UMLS CUI [1,2]
C0456389
mm
Size (of swelling at administration site) Day 1
Descrição

Size of swelling at administration site Day 1

Tipo de dados

integer

Unidades de medida
  • mm
Alias
UMLS CUI [1,1]
C3854415
UMLS CUI [1,2]
C0456389
mm
Size (of swelling at administration site) Day 2
Descrição

Size of swelling at administration site Day 2

Tipo de dados

integer

Unidades de medida
  • mm
Alias
UMLS CUI [1,1]
C3854415
UMLS CUI [1,2]
C0456389
mm
Size (of swelling at administration site) Day 3
Descrição

Size of swelling at administration site Day 3

Tipo de dados

integer

Unidades de medida
  • mm
Alias
UMLS CUI [1,1]
C3854415
UMLS CUI [1,2]
C0456389
mm
Ongoing after day 3?
Descrição

Swelling ongoing after day 3

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C3854415
UMLS CUI [1,2]
C0549178
Date of last day of symptoms
Descrição

Date of last day of symptoms

Tipo de dados

date

Alias
UMLS CUI [1,1]
C0011008
UMLS CUI [1,2]
C0038999
UMLS CUI [1,3]
C2700396
Pain
Descrição

Administration site pain

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0521491
Intensity (of pain at administration site) Day 0
Descrição

Intensity of pain at administration site Day 0

Tipo de dados

integer

Alias
UMLS CUI [1,1]
C0521491
UMLS CUI [1,2]
C1320357
Intensity (of pain at administration site) Day 1
Descrição

Intensity of pain at administration site Day 1

Tipo de dados

integer

Alias
UMLS CUI [1,1]
C0521491
UMLS CUI [1,2]
C1320357
Intensity (of pain at administration site) Day 2
Descrição

Intensity of pain at administration site Day 2

Tipo de dados

integer

Alias
UMLS CUI [1,1]
C0521491
UMLS CUI [1,2]
C1320357
Intensity (of pain at administration site) Day 3
Descrição

Intensity of pain at administration site Day 3

Tipo de dados

integer

Alias
UMLS CUI [1,1]
C0521491
UMLS CUI [1,2]
C1320357
Unsolicited symptoms (day 0 - day 42)
Descrição

Unsolicited symptoms (day 0 - day 42)

Alias
UMLS CUI-1
C1457887
UMLS CUI-2
C4055646
Description - please specify side(s) and site(s)
Descrição

Description of unsolicited symptom

Tipo de dados

text

Alias
UMLS CUI [1,1]
C1457887
UMLS CUI [1,2]
C4055646
UMLS CUI [1,3]
C0678257
Intensity
Descrição

Intensity of unsolicited symptom

Tipo de dados

integer

Alias
UMLS CUI [1,1]
C0234687
UMLS CUI [1,2]
C1457887
UMLS CUI [1,3]
C4055646
Start Date
Descrição

Start date of unsolicited event

Tipo de dados

date

Alias
UMLS CUI [1,1]
C1457887
UMLS CUI [1,2]
C4055646
UMLS CUI [1,3]
C0808070
End Date
Descrição

End Date of unsolicited event

Tipo de dados

date

Alias
UMLS CUI [1,1]
C1457887
UMLS CUI [1,2]
C4055646
UMLS CUI [1,3]
C0806020
Unsolicited symptom is continuing
Descrição

Unsolicited symptom continuing

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C1457887
UMLS CUI [1,2]
C4055646
UMLS CUI [1,3]
C0549178
Temperature (day 0-day 14)
Descrição

Temperature (day 0-day 14)

Alias
UMLS CUI-1
C0039476
Fever
Descrição

Please record axillary / rectal temperature daily from day 0 to day 14 after vaccination at bedtime. Only one route of temperature measurement should be used consistently. If temperature has been taken more than once a day, please report the highest value for the day.

Tipo de dados

text

Alias
UMLS CUI [1]
C0015967
Temperature (day 0-day 14)
Descrição

Temperature (day 0-day 14)

Alias
UMLS CUI-1
C0039476
Episode No.
Descrição

Fever Episode Number

Tipo de dados

integer

Alias
UMLS CUI [1,1]
C0015967
UMLS CUI [1,2]
C0439228
Temperature
Descrição

Temperature

Tipo de dados

float

Unidades de medida
  • degree Celsius
Alias
UMLS CUI [1]
C0039476
degree Celsius
Medically attended Visit?
Descrição

Medically attended Visit

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0545082
UMLS CUI [1,2]
C1386497
UMLS CUI [1,3]
C0015967
Temperature (day 15-day 42)
Descrição

Temperature (day 15-day 42)

Alias
UMLS CUI-1
C0039476
Day
Descrição

Day 15-42 Please screen temperature daily from day 15 to 42 please use the temperature sensitive pad or thermometer. If fever is indicated, please take the childís temperature using a thermometer and report measurement below. If multiple measures, take the maximum value.

Tipo de dados

integer

Alias
UMLS CUI [1,1]
C0439228
UMLS CUI [1,2]
C0750480
UMLS CUI [1,3]
C0039476
Fever
Descrição

Fever

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0015967
Temperature
Descrição

Please screen temperature daily from day 15 to 42 please use the temperature sensitive pad or thermometer. If fever is indicated, please take the childís temperature using a thermometer and report measurement below. If multiple measures, take the maximum value.

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0039476
Medically attended visit
Descrição

Medically attended visit

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0545082
UMLS CUI [1,2]
C1386497
UMLS CUI [1,3]
C0332575
Rash / exanthema (day 0-day 42)
Descrição

Rash / exanthema (day 0-day 42)

Alias
UMLS CUI-1
C0015230
Episode No.
Descrição

rash number of episode

Tipo de dados

integer

Alias
UMLS CUI [1,1]
C0015230
UMLS CUI [1,2]
C0449788
Description
Descrição

Description of rash

Tipo de dados

text

Alias
UMLS CUI [1,1]
C0015230
UMLS CUI [1,2]
C0678257
Localisation of rash
Descrição

Localisation rash

Tipo de dados

integer

Alias
UMLS CUI [1,1]
C0015230
UMLS CUI [1,2]
C0475264
Date started
Descrição

Start Date of rash

Tipo de dados

date

Alias
UMLS CUI [1,1]
C0015230
UMLS CUI [1,2]
C0808070
Date stopped
Descrição

End Date of rash

Tipo de dados

date

Alias
UMLS CUI [1,1]
C0015230
UMLS CUI [1,2]
C0806020
Intensity
Descrição

Intensity of rash

Tipo de dados

integer

Alias
UMLS CUI [1,1]
C0015230
UMLS CUI [1,2]
C0518690
Did the subject seek medical advice?
Descrição

Medically attended visit

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0545082
UMLS CUI [1,2]
C1386497
UMLS CUI [1,3]
C0015230
Parotid / Salivary gland swelling events (day 0-day 42)
Descrição

Parotid / Salivary gland swelling events (day 0-day 42)

Alias
UMLS CUI-1
C0240925
UMLS CUI-2
C0240668
Parotid swelling No.
Descrição

Parotid Swelling number

Tipo de dados

integer

Alias
UMLS CUI [1,1]
C0240668
UMLS CUI [1,2]
C0449788
Description
Descrição

Description of parotid swelling

Tipo de dados

text

Alias
UMLS CUI [1,1]
C0240668
UMLS CUI [1,2]
C0678257
Date started
Descrição

Start date of parotid swelling

Tipo de dados

date

Alias
UMLS CUI [1,1]
C0240668
UMLS CUI [1,2]
C0808070
Date stopped
Descrição

End date of parotid swelling

Tipo de dados

date

Alias
UMLS CUI [1,1]
C0240668
UMLS CUI [1,2]
C0806020
Intensity
Descrição

Intensity of parotid swelling

Tipo de dados

integer

Alias
UMLS CUI [1,1]
C0240668
UMLS CUI [1,2]
C0518690
Did the subject seek medical advice?
Descrição

Medically attended visit

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0545082
UMLS CUI [1,2]
C1386497
UMLS CUI [1,3]
C1518404
Febrile convulsions - Suspected signs of meningism events
Descrição

Febrile convulsions - Suspected signs of meningism events

Alias
UMLS CUI-1
C0009952
UMLS CUI-2
C0025287
Febrile Convulsion No.
Descrição

Febrile convulsion number

Tipo de dados

integer

Alias
UMLS CUI [1,1]
C0009952
UMLS CUI [1,2]
C0449788
Description
Descrição

Description of febrile convulsion

Tipo de dados

text

Alias
UMLS CUI [1,1]
C0009952
UMLS CUI [1,2]
C0678257
Date started
Descrição

Start date of febrile convulsion

Tipo de dados

date

Alias
UMLS CUI [1,1]
C0009952
UMLS CUI [1,2]
C0808070
Date stopped
Descrição

End date of febrile convulsion

Tipo de dados

date

Alias
UMLS CUI [1,1]
C0009952
UMLS CUI [1,2]
C0806020
Did the subject seek medical advice?
Descrição

Medically attended visit

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0545082
UMLS CUI [1,2]
C1386497
UMLS CUI [1,3]
C1518404
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GSK Study: Evaluation of safety and efficacy of VarilrixTM and of Combined Measles-Mumps-Rubella-Varicella Vaccine NCT00226499 - Diary Card Dose 2

1 Formulários
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
Item Group
Solicited Symptoms
C0683368 (UMLS CUI-1)
C1517001 (UMLS CUI-2)
Administration site erythema
Item
Redness
boolean
C3805283 (UMLS CUI [1])
Size of erythema at administration site Day 0
Item
Size (of redness at administration site) Day 0
integer
C3805283 (UMLS CUI [1,1])
C0456389 (UMLS CUI [1,2])
Size of erythema at administration site Day 1
Item
Size (of redness at administration site) Day 1
integer
C3805283 (UMLS CUI [1,1])
C0456389 (UMLS CUI [1,2])
Size of erythema at administration site Day 2
Item
Size (of redness at administration site) Day 2
integer
C3805283 (UMLS CUI [1,1])
C0456389 (UMLS CUI [1,2])
Size of erythema at administration site Day 3
Item
Size (of redness at administration site) Day 3
integer
C3805283 (UMLS CUI [1,1])
C0456389 (UMLS CUI [1,2])
Erythema ongoing after day 3
Item
Ongoing after Day 3?
boolean
C3805283 (UMLS CUI [1,1])
C0549178 (UMLS CUI [1,2])
Date of last day of symptoms
Item
Date of last day of symptoms
date
C0011008 (UMLS CUI [1,1])
C0332575 (UMLS CUI [1,2])
C2700396 (UMLS CUI [1,3])
Administration site swelling
Item
Swelling
boolean
C3854415 (UMLS CUI [1])
Size of swelling at administration site Day 0
Item
Size (of swelling at administration site) Day 0
integer
C3854415 (UMLS CUI [1,1])
C0456389 (UMLS CUI [1,2])
Size of swelling at administration site Day 1
Item
Size (of swelling at administration site) Day 1
integer
C3854415 (UMLS CUI [1,1])
C0456389 (UMLS CUI [1,2])
Size of swelling at administration site Day 2
Item
Size (of swelling at administration site) Day 2
integer
C3854415 (UMLS CUI [1,1])
C0456389 (UMLS CUI [1,2])
Size of swelling at administration site Day 3
Item
Size (of swelling at administration site) Day 3
integer
C3854415 (UMLS CUI [1,1])
C0456389 (UMLS CUI [1,2])
Swelling ongoing after day 3
Item
Ongoing after day 3?
boolean
C3854415 (UMLS CUI [1,1])
C0549178 (UMLS CUI [1,2])
Date of last day of symptoms
Item
Date of last day of symptoms
date
C0011008 (UMLS CUI [1,1])
C0038999 (UMLS CUI [1,2])
C2700396 (UMLS CUI [1,3])
Administration site pain
Item
Pain
boolean
C0521491 (UMLS CUI [1])
Item
Intensity (of pain at administration site) Day 0
integer
C0521491 (UMLS CUI [1,1])
C1320357 (UMLS CUI [1,2])
Intensity of pain at administration site Day 0
Code List
Intensity (of pain at administration site) Day 0
CL Item
Absent (0)
CL Item
Minor reaction to touch (1)
CL Item
Cries/protests on touch (2)
CL Item
Cries when limb is moved / spontaneously painful (3)
Item
Intensity (of pain at administration site) Day 1
integer
C0521491 (UMLS CUI [1,1])
C1320357 (UMLS CUI [1,2])
Intensity of pain at administration site Day 1
Code List
Intensity (of pain at administration site) Day 1
CL Item
Absent (0)
CL Item
Minor reaction to touch (1)
CL Item
Cries/protests on touch (2)
CL Item
Cries when limb is moved / spontaneously painful (3)
Item
Intensity (of pain at administration site) Day 2
integer
C0521491 (UMLS CUI [1,1])
C1320357 (UMLS CUI [1,2])
Intensity of pain at administration site Day 2
Code List
Intensity (of pain at administration site) Day 2
CL Item
Absent (0)
CL Item
Minor reaction to touch (1)
CL Item
Cries/protests on touch (2)
CL Item
Cries when limb is moved / spontaneously painful (3)
Item
Intensity (of pain at administration site) Day 3
integer
C0521491 (UMLS CUI [1,1])
C1320357 (UMLS CUI [1,2])
Intensity of pain at administration site Day 3
Code List
Intensity (of pain at administration site) Day 3
CL Item
Absent (0)
CL Item
Minor reaction to touch (1)
CL Item
Cries/protests on touch (2)
CL Item
Cries when limb is moved / spontaneously painful (3)
Item Group
Unsolicited symptoms (day 0 - day 42)
C1457887 (UMLS CUI-1)
C4055646 (UMLS CUI-2)
Description of unsolicited symptom
Item
Description - please specify side(s) and site(s)
text
C1457887 (UMLS CUI [1,1])
C4055646 (UMLS CUI [1,2])
C0678257 (UMLS CUI [1,3])
Item
Intensity
integer
C0234687 (UMLS CUI [1,1])
C1457887 (UMLS CUI [1,2])
C4055646 (UMLS CUI [1,3])
Intensity of unsolicited symptom
Code List
Intensity
CL Item
Mild: An adverse event which is easily tolerated by the subject, causing minimal discomfort and not (1)
CL Item
Moderate: An adverse event which is sufficiently discomforting to interfere with normal every day activities. (2)
CL Item
Moderate: An adverse event which is sufficiently discomforting to interfere with normal every day activities. (2)
CL Item
Severe: An adverse event which prevents normal, everyday activities. (In a young child, such an adverse event would, for example, prevent attendance at school/kindergarten/a day-care center and would cause the parents/guardians to seek medical advice) (3)
Start date of unsolicited event
Item
Start Date
date
C1457887 (UMLS CUI [1,1])
C4055646 (UMLS CUI [1,2])
C0808070 (UMLS CUI [1,3])
End Date of unsolicited event
Item
End Date
date
C1457887 (UMLS CUI [1,1])
C4055646 (UMLS CUI [1,2])
C0806020 (UMLS CUI [1,3])
Unsolicited symptom continuing
Item
Unsolicited symptom is continuing
boolean
C1457887 (UMLS CUI [1,1])
C4055646 (UMLS CUI [1,2])
C0549178 (UMLS CUI [1,3])
Item Group
Temperature (day 0-day 14)
C0039476 (UMLS CUI-1)
Item
Fever
text
C0015967 (UMLS CUI [1])
Fever
Code List
Fever
CL Item
Axillary (A)
CL Item
Rectal (R)
Item Group
Temperature (day 0-day 14)
C0039476 (UMLS CUI-1)
Item
Episode No.
integer
C0015967 (UMLS CUI [1,1])
C0439228 (UMLS CUI [1,2])
Fever Episode Number
Code List
Episode No.
CL Item
Day 1 (01)
CL Item
Day 2 (02)
CL Item
Day 3 (03)
CL Item
Day 4 (04)
CL Item
Day 5 (05)
CL Item
Day 6 (06)
CL Item
Day 7 (07)
CL Item
Day 8 (08)
CL Item
Day 9 (09)
CL Item
Day 10 (10)
CL Item
Day 11 (11)
CL Item
Day 12 (12)
CL Item
Day 13 (13)
CL Item
Day 14 (14)
Temperature
Item
Temperature
float
C0039476 (UMLS CUI [1])
Medically attended Visit
Item
Medically attended Visit?
boolean
C0545082 (UMLS CUI [1,1])
C1386497 (UMLS CUI [1,2])
C0015967 (UMLS CUI [1,3])
Item Group
Temperature (day 15-day 42)
C0039476 (UMLS CUI-1)
Day
Item
Day
integer
C0439228 (UMLS CUI [1,1])
C0750480 (UMLS CUI [1,2])
C0039476 (UMLS CUI [1,3])
Fever
Item
Fever
boolean
C0015967 (UMLS CUI [1])
Temperature
Item
Temperature
boolean
C0039476 (UMLS CUI [1])
Medically attended visit
Item
Medically attended visit
boolean
C0545082 (UMLS CUI [1,1])
C1386497 (UMLS CUI [1,2])
C0332575 (UMLS CUI [1,3])
Item Group
Rash / exanthema (day 0-day 42)
C0015230 (UMLS CUI-1)
rash number of episode
Item
Episode No.
integer
C0015230 (UMLS CUI [1,1])
C0449788 (UMLS CUI [1,2])
Description of rash
Item
Description
text
C0015230 (UMLS CUI [1,1])
C0678257 (UMLS CUI [1,2])
Item
Localisation of rash
integer
C0015230 (UMLS CUI [1,1])
C0475264 (UMLS CUI [1,2])
Localisation rash
Code List
Localisation of rash
CL Item
Administration site (1)
CL Item
Non-Administration site (2)
Start Date of rash
Item
Date started
date
C0015230 (UMLS CUI [1,1])
C0808070 (UMLS CUI [1,2])
End Date of rash
Item
Date stopped
date
C0015230 (UMLS CUI [1,1])
C0806020 (UMLS CUI [1,2])
Item
Intensity
integer
C0015230 (UMLS CUI [1,1])
C0518690 (UMLS CUI [1,2])
Intensity of rash
Code List
Intensity
CL Item
1-50 lesions (1)
CL Item
51-100 lesions (2)
CL Item
101-500 lesions (3)
CL Item
>500 lesions (4)
Medically attended visit
Item
Did the subject seek medical advice?
boolean
C0545082 (UMLS CUI [1,1])
C1386497 (UMLS CUI [1,2])
C0015230 (UMLS CUI [1,3])
Item Group
Parotid / Salivary gland swelling events (day 0-day 42)
C0240925 (UMLS CUI-1)
C0240668 (UMLS CUI-2)
Parotid Swelling number
Item
Parotid swelling No.
integer
C0240668 (UMLS CUI [1,1])
C0449788 (UMLS CUI [1,2])
Description of parotid swelling
Item
Description
text
C0240668 (UMLS CUI [1,1])
C0678257 (UMLS CUI [1,2])
Start date of parotid swelling
Item
Date started
date
C0240668 (UMLS CUI [1,1])
C0808070 (UMLS CUI [1,2])
End date of parotid swelling
Item
Date stopped
date
C0240668 (UMLS CUI [1,1])
C0806020 (UMLS CUI [1,2])
Item
Intensity
integer
C0240668 (UMLS CUI [1,1])
C0518690 (UMLS CUI [1,2])
Intensity of parotid swelling
Code List
Intensity
CL Item
Swelling without difficulties to move the jaw. (1)
CL Item
Swelling with difficulties to move the jaw. (2)
CL Item
Swelling and additional general symptoms. (3)
Medically attended visit
Item
Did the subject seek medical advice?
boolean
C0545082 (UMLS CUI [1,1])
C1386497 (UMLS CUI [1,2])
C1518404 (UMLS CUI [1,3])
Item Group
Febrile convulsions - Suspected signs of meningism events
C0009952 (UMLS CUI-1)
C0025287 (UMLS CUI-2)
Febrile convulsion number
Item
Febrile Convulsion No.
integer
C0009952 (UMLS CUI [1,1])
C0449788 (UMLS CUI [1,2])
Description of febrile convulsion
Item
Description
text
C0009952 (UMLS CUI [1,1])
C0678257 (UMLS CUI [1,2])
Start date of febrile convulsion
Item
Date started
date
C0009952 (UMLS CUI [1,1])
C0808070 (UMLS CUI [1,2])
End date of febrile convulsion
Item
Date stopped
date
C0009952 (UMLS CUI [1,1])
C0806020 (UMLS CUI [1,2])
Medically attended visit
Item
Did the subject seek medical advice?
boolean
C0545082 (UMLS CUI [1,1])
C1386497 (UMLS CUI [1,2])
C1518404 (UMLS CUI [1,3])
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