Eligibility Lymphoma NCT00299182

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StudyEvent: Eligibility
1. Eligibility Lymphoma NCT00299182

Name

Tipo

Description | Question | Decode (Coded Value)

Tipo de dados

Alias

Inclusion Criteria

Item Group

C1512693 (UMLS CUI)

Aggressive non-hodgkin's lymphoma, therapy with r-hypercvad and r-ara-c/mtx, contraindication to rituximab, switch to (r)hyper-CVAD

Item

1. patients with a diagnosis of previously untreated aggressive non-hodgkin's lymphoma, including patients with mantle cell lymphoma, who will be or are receiving treatment with r-hypercvad and r-ara-c/mtx. patients in whom rituximab is not used, due to contraindication, will be eligible. patients whose therapy was switched to (r)hyper-cvad after initial treatment with (r)chop, because of aggressive disease will also be eligible for the study.

boolean

C1332225 (UMLS CUI [1])
C1881081 (UMLS CUI [2])
C0393022 (UMLS CUI [3,1])
C0522473 (UMLS CUI [3,2])
C1742845 (UMLS CUI [4,1])
C0392747 (UMLS CUI [4,2])

Age

Item

2. patients age >/= 18 years.

boolean

C0001779 (UMLS CUI [1])

Karnofsky performance scale

Item

3. karnofsky performance scale >/= 70.

boolean

C0206065 (UMLS CUI [1])

ANC, platelet count, hemoglobin measurement, creatinine measurement, total bilirubin, sgpt

Item

4. adequate hematologic (anc >/= 1000/mm(3), platelet count >/= 100,000/mm(3) and hgb >/= 8gm/dl), renal (serum creatinine < 2mg/dl), and hepatic functions (total bilirubin </= 2 times, serum glutamate pyruvate transaminase (sgpt) or serum glutamate oxaloacetate transaminase (sgot) </= 3 times the upper limit of the respective normal range).

boolean

C0948762 (UMLS CUI [1])
C0005821 (UMLS CUI [2])
C0019046 (UMLS CUI [3])
C0201976 (UMLS CUI [4])
C0201913 (UMLS CUI [5])
C0201836 (UMLS CUI [6])
C0201899 (UMLS CUI [7])

Contraceptive method

Item

5. patients (male and female) with childbearing potential (defined as not post-menopausal for 12 months or no previous surgical sterilization) must use adequate birth control.

boolean

C0700589 (UMLS CUI [1])

Informed consent

Item

6. institutional review board (irb)-approved signed informed consent.

boolean

C0021430 (UMLS CUI [1])

Exclusion Criteria

Item Group

C0680251 (UMLS CUI)

Gynaecological status

Item

1. pregnant or lactating women.

boolean

C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])

CNS involvement

Item

2. history of central nervous system (cns) involvement.

boolean

C0449389 (UMLS CUI [1])

Comorbidity

Item

3. co-morbid medical or psychiatric illnesses that preclude treatment with intense dose chemotherapy.

boolean

C0009488 (UMLS CUI [1])

Deep vein thrombosis or pulmonary embolus

Item

4. patients with history of deep vein thrombosis (dvt) or pulmonary embolus.

boolean

C0149871 (UMLS CUI [1])
C0034065 (UMLS CUI [2])

Platelet or bleeding disorders

Item

5. history of any platelet disorders including idiopathic thrombocytopenic purpura (itp), thrombotic thrombocytopenic purpura (ttp) or bleeding disorders.

boolean

C0005818 (UMLS CUI [1])
C0005779 (UMLS CUI [2])

Prior Surgery or Radiation

Item

6. prior surgery or radiation therapy (rt) within 2 weeks of study entry.

boolean

C0744961 (UMLS CUI [1])
C0279134 (UMLS CUI [2])

NYHA, arrhythmia, myocardial ischemia, cerebrovascular accident

Item

7. patients with significant cardiac disease (new york heart association (nyha) class iii or iv), dysrrhythmia, or recent history of myocardial ischemia (mi) or ischemia, transient ischemic attack or cerebrovascular accident (cva) within the previous 6 months of study entry.

boolean

C1275491 (UMLS CUI [1])
C0003811 (UMLS CUI [2])
C0027051 (UMLS CUI [3])
C0038454 (UMLS CUI [4])

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Eligibility Lymphoma NCT00299182