ID

18369

Beschrijving

A Randomized, Open-Label Study to Compare the Efficacy and Safety of AT1001 and Enzyme Replacement Therapy (ERT) in Patients With Fabry Disease and AT1001-Responsive GLA Mutations, Who Were Previously Treated With ERT Suicidality

Trefwoorden

Versies (2)
  1. 02-11-16 02-11-16 -
  2. 11-11-16 11-11-16 -
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2 november 2016

DOI

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Licentie

Creative Commons BY-NC 3.0
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Suicidality Galafold (migalastat) AT1001-012 NCT0121865

Engels

Suicidality Galafold (migalastat) AT1001-012 NCT0121865

1 Formulieren  
Additional Observations
Beschrijving

Additional Observations

Alias
UMLS CUI-1
C0700325
Reference date
Beschrijving

reference date

Datatype

date

Alias
UMLS CUI [1]
C1719096
Visit Type
Beschrijving

Visit

Datatype

text

Alias
UMLS CUI [1]
C0545082
electronic case report form
Beschrijving

eCRF

Datatype

text

Alias
UMLS CUI [1]
C1516308
Comment
Beschrijving

Comment

Datatype

text

Alias
UMLS CUI [1]
C0947611
Adverse Events
Beschrijving

Adverse Events

Alias
UMLS CUI-1
C0877248
Are there any adverse events to report?
Beschrijving

adverse events

Datatype

integer

Alias
UMLS CUI [1]
C0877248
Description of Event
Beschrijving

Please specify if an adverse event occurd

Datatype

text

Alias
UMLS CUI [1]
C0678257
Start date
Beschrijving

Please specify if an adverse event occurd

Datatype

date

Alias
UMLS CUI [1]
C0808070
Stop date
Beschrijving

Please specify if an adverse event occurd

Datatype

date

Alias
UMLS CUI [1]
C0806020
Seriousness of Adverse Event
Beschrijving

Please specify if an adverse event occurd

Datatype

integer

Alias
UMLS CUI [1]
C1710056
Severity of adverse event
Beschrijving

Please specify if an adverse event occurd

Datatype

integer

Alias
UMLS CUI [1]
C1710066
Relationship to study drug
Beschrijving

Please specify if an adverse event occurd

Datatype

integer

Alias
UMLS CUI [1]
C0013227
Outcome
Beschrijving

Please specify if an adverse event occurd

Datatype

integer

Alias
UMLS CUI [1]
C1705586
Action taken (other than with study drug)
Beschrijving

Please specify if an adverse event occurd

Datatype

integer

Alias
UMLS CUI [1]
C0441472
Action taken with study drug
Beschrijving

Please specify if an adverse event occurd

Datatype

integer

Alias
UMLS CUI [1,1]
C0877248
UMLS CUI [1,2]
C0441472
UMLS CUI [1,3]
C0013227
Suicidality
Beschrijving

Suicidality

Alias
UMLS CUI-1
C0438696
In the investigator's judgement, were there any possible suicidality-related adverse events?
Beschrijving

Suicidality

Datatype

integer

Alias
UMLS CUI [1]
C0438696
UMLS CUI [2]
C0877248
Please insert adverse event number
Beschrijving

Adverse Event number

Datatype

integer

Alias
UMLS CUI [1,1]
C0877248
UMLS CUI [1,2]
C0449788
Adverse Event date
Beschrijving

Adverse Event start date

Datatype

date

Alias
UMLS CUI [1]
C2697888
Provide a brief description of the possible suicidality-related adverse event
Beschrijving

Adverse Event Description

Datatype

text

Alias
UMLS CUI [1]
C2699044
Possible causes of possible suicidality-related adverse event: Disease under study
Beschrijving

Adverse Event Cause, Disease under study

Datatype

integer

Alias
UMLS CUI [1,1]
C1547657
UMLS CUI [1,2]
C0877248
UMLS CUI [2,1]
C0008976
UMLS CUI [2,2]
C0012634
Possible causes of possible suicidality-related adverse event: Concomitant medications
Beschrijving

Adverse Event Cause, Concomitant medications

Datatype

integer

Alias
UMLS CUI [1,1]
C1547657
UMLS CUI [1,2]
C0877248
UMLS CUI [2]
C2347852
Possible causes of possible suicidality-related adverse event: Comorbid psychiatric condition(s)
Beschrijving

Adverse Event Cause, Comorbid psychiatric condition(s)

Datatype

integer

Alias
UMLS CUI [1,1]
C1547657
UMLS CUI [1,2]
C0877248
UMLS CUI [2]
C0004936
Possible causes of possible suicidality-related adverse event: Medical condition(s)
Beschrijving

Adverse Event Cause, Medical condition(s)

Datatype

integer

Alias
UMLS CUI [1,1]
C1547657
UMLS CUI [1,2]
C0877248
UMLS CUI [2]
C0009488
Possible causes of possible suicidality-related adverse event: Psycho-social stressors
Beschrijving

Psycho-social stressors

Datatype

integer

Alias
UMLS CUI [1,1]
C1547657
UMLS CUI [1,2]
C0877248
UMLS CUI [2]
C0748073
Possible causes of possible suicidality-related adverse event: Withdrawal of investigationalproduct(s)
Beschrijving

Withdrawal of investigational product

Datatype

integer

Alias
UMLS CUI [1,1]
C1547657
UMLS CUI [1,2]
C0877248
UMLS CUI [2,1]
C0304229
UMLS CUI [2,2]
C2349954
Possible causes of possible suicidality-related adverse event: Investigational product dose change
Beschrijving

Investigational product dose change

Datatype

integer

Alias
UMLS CUI [1,1]
C1547657
UMLS CUI [1,2]
C0877248
UMLS CUI [2,1]
C0304229
UMLS CUI [2,2]
C1707811
Possible causes of possible suicidality-related adverse event: Lack of efficacy
Beschrijving

Lack of efficacy

Datatype

integer

Alias
UMLS CUI [1,1]
C1547657
UMLS CUI [1,2]
C0877248
UMLS CUI [2]
C0235828
Possible causes of possible suicidality-related adverse event: Investigational product(s)
Beschrijving

Investigational product(s)

Datatype

integer

Alias
UMLS CUI [1,1]
C1547657
UMLS CUI [1,2]
C0877248
UMLS CUI [2]
C0304229
Possible causes of possible suicidality-related adverse event: Other, please specify
Beschrijving

undefined item

Datatype

text

Alias
UMLS CUI [1,1]
C1547657
UMLS CUI [1,2]
C0877248
Has the subject had any psychiatric conditions in the past (other than the one under study)?
Beschrijving

psychiatric conditions

Datatype

integer

Alias
UMLS CUI [1]
C0004936
Has the subject had any suicidal ideation, behaviour or self-harm in the past?
Beschrijving

Suicidal ideation

Datatype

integer

Alias
UMLS CUI [1]
C0424000
Subject's current use of llicit drugs?
Beschrijving

Illicit drugs

Datatype

integer

Alias
UMLS CUI [1]
C0086190
Subject's current use of alcohol?
Beschrijving

Alcohol consumption

Datatype

integer

Alias
UMLS CUI [1]
C0001948
Family history of suicidality?
Beschrijving

Family history of suicidality

Datatype

integer

Alias
UMLS CUI [1,1]
C0241889
UMLS CUI [1,2]
C0438696
Family history of psychiatric disorders?
Beschrijving

Family history of psychiatric disorders

Datatype

integer

Alias
UMLS CUI [1,1]
C0241889
UMLS CUI [1,2]
C0004936
Provide information on the subject's current psycho-social stressors
Beschrijving

psycho-social stressors

Datatype

text

Alias
UMLS CUI [1]
C0748073
Provide information on any relevant and/or recent suicidal ideation, not associated with suicidal behaviour, as assessed by the investigator, for this index event
Beschrijving

suicidal ideation

Datatype

text

Alias
UMLS CUI [1]
C0424000
Provide information on any suicidal behaviour present during the study, as assessed by the investigator, for this index event
Beschrijving

suicidal behaviour

Datatype

text

Alias
UMLS CUI [1]
C1760428
Provide any additional comments or explanation, including, but not limited to, both medical and psychiatric treatment, outcome and follow-up
Beschrijving

additional comments

Datatype

text

Alias
UMLS CUI [1]
C1830770
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Similar models

Suicidality Galafold (migalastat) AT1001-012 NCT0121865

1 Formulieren
Name
Type
Description | Question | Decode (Coded Value)
Datatype
Alias
Item Group
Additional Observations
C0700325 (UMLS CUI-1)
reference date
Item
Reference date
date
C1719096 (UMLS CUI [1])
Visit
Item
Visit Type
text
C0545082 (UMLS CUI [1])
eCRF
Item
electronic case report form
text
C1516308 (UMLS CUI [1])
Comment
Item
Comment
text
C0947611 (UMLS CUI [1])
Item Group
Adverse Events
C0877248 (UMLS CUI-1)
Item
Are there any adverse events to report?
integer
C0877248 (UMLS CUI [1])
adverse events
Code List
Are there any adverse events to report?
CL Item
Yes (1)
CL Item
No (2)
Description of Event
Item
Description of Event
text
C0678257 (UMLS CUI [1])
Start date
Item
Start date
date
C0808070 (UMLS CUI [1])
Stop date
Item
Stop date
date
C0806020 (UMLS CUI [1])
Item
Seriousness of Adverse Event
integer
C1710056 (UMLS CUI [1])
Seriousness of Adverse Event
Code List
Seriousness of Adverse Event
CL Item
Yes, complete Serious Adverse Event Form (1)
CL Item
No (2)
Item
Severity of adverse event
integer
C1710066 (UMLS CUI [1])
Severity
Code List
Severity of adverse event
CL Item
Mild (1)
CL Item
Moderate (2)
CL Item
Severe (3)
Item
Relationship to study drug
integer
C0013227 (UMLS CUI [1])
Relationship to study drug
Code List
Relationship to study drug
CL Item
Definite (1)
CL Item
Probable (2)
CL Item
Possible (3)
CL Item
Unlikely (4)
CL Item
Unrelated (5)
Item
Outcome
integer
C1705586 (UMLS CUI [1])
Outcome
Code List
Outcome
CL Item
Resolved (1)
CL Item
Resolved with Sequelae (2)
CL Item
Ongoing (3)
CL Item
Fatal (4)
Item
Action taken (other than with study drug)
integer
C0441472 (UMLS CUI [1])
Action taken
Code List
Action taken (other than with study drug)
CL Item
None (1)
CL Item
Conmed, Complete Concomitant Medications Form (2)
CL Item
Non-Drug Therapy (3)
Item
Action taken with study drug
integer
C0877248 (UMLS CUI [1,1])
C0441472 (UMLS CUI [1,2])
C0013227 (UMLS CUI [1,3])
Action taken
Code List
Action taken with study drug
CL Item
None (1)
CL Item
Interrupted and later re-started (2)
CL Item
Dose Reduced (3)
CL Item
Stopped permanently (4)
Item Group
Suicidality
C0438696 (UMLS CUI-1)
Item
In the investigator's judgement, were there any possible suicidality-related adverse events?
integer
C0438696 (UMLS CUI [1])
C0877248 (UMLS CUI [2])
Suicidality
Code List
In the investigator's judgement, were there any possible suicidality-related adverse events?
CL Item
Yes; please fill out adverse events form (1)
CL Item
No (2)
Adverse Event number
Item
Please insert adverse event number
integer
C0877248 (UMLS CUI [1,1])
C0449788 (UMLS CUI [1,2])
Adverse Event start date
Item
Adverse Event date
date
C2697888 (UMLS CUI [1])
Adverse Event Description
Item
Provide a brief description of the possible suicidality-related adverse event
text
C2699044 (UMLS CUI [1])
Item
Possible causes of possible suicidality-related adverse event: Disease under study
integer
C1547657 (UMLS CUI [1,1])
C0877248 (UMLS CUI [1,2])
C0008976 (UMLS CUI [2,1])
C0012634 (UMLS CUI [2,2])
Adverse Event Cause
Code List
Possible causes of possible suicidality-related adverse event: Disease under study
CL Item
Yes (1)
CL Item
No (2)
Item
Possible causes of possible suicidality-related adverse event: Concomitant medications
integer
C1547657 (UMLS CUI [1,1])
C0877248 (UMLS CUI [1,2])
C2347852 (UMLS CUI [2])
undefined item
Code List
Possible causes of possible suicidality-related adverse event: Concomitant medications
CL Item
Yes (1)
CL Item
No (2)
Item
Possible causes of possible suicidality-related adverse event: Comorbid psychiatric condition(s)
integer
C1547657 (UMLS CUI [1,1])
C0877248 (UMLS CUI [1,2])
C0004936 (UMLS CUI [2])
undefined item
Code List
Possible causes of possible suicidality-related adverse event: Comorbid psychiatric condition(s)
CL Item
Yes (1)
CL Item
No (2)
Item
Possible causes of possible suicidality-related adverse event: Medical condition(s)
integer
C1547657 (UMLS CUI [1,1])
C0877248 (UMLS CUI [1,2])
C0009488 (UMLS CUI [2])
undefined item
Code List
Possible causes of possible suicidality-related adverse event: Medical condition(s)
CL Item
Yes (1)
CL Item
No (2)
Item
Possible causes of possible suicidality-related adverse event: Psycho-social stressors
integer
C1547657 (UMLS CUI [1,1])
C0877248 (UMLS CUI [1,2])
C0748073 (UMLS CUI [2])
undefined item
Code List
Possible causes of possible suicidality-related adverse event: Psycho-social stressors
CL Item
Yes (1)
CL Item
No (2)
Item
Possible causes of possible suicidality-related adverse event: Withdrawal of investigationalproduct(s)
integer
C1547657 (UMLS CUI [1,1])
C0877248 (UMLS CUI [1,2])
C0304229 (UMLS CUI [2,1])
C2349954 (UMLS CUI [2,2])
undefined item
Code List
Possible causes of possible suicidality-related adverse event: Withdrawal of investigationalproduct(s)
CL Item
Yes (1)
CL Item
No (2)
Item
Possible causes of possible suicidality-related adverse event: Investigational product dose change
integer
C1547657 (UMLS CUI [1,1])
C0877248 (UMLS CUI [1,2])
C0304229 (UMLS CUI [2,1])
C1707811 (UMLS CUI [2,2])
undefined item
Code List
Possible causes of possible suicidality-related adverse event: Investigational product dose change
CL Item
Yes (1)
CL Item
No (2)
Item
Possible causes of possible suicidality-related adverse event: Lack of efficacy
integer
C1547657 (UMLS CUI [1,1])
C0877248 (UMLS CUI [1,2])
C0235828 (UMLS CUI [2])
undefined item
Code List
Possible causes of possible suicidality-related adverse event: Lack of efficacy
CL Item
Yes (1)
CL Item
No (2)
Item
Possible causes of possible suicidality-related adverse event: Investigational product(s)
integer
C1547657 (UMLS CUI [1,1])
C0877248 (UMLS CUI [1,2])
C0304229 (UMLS CUI [2])
undefined item
Code List
Possible causes of possible suicidality-related adverse event: Investigational product(s)
CL Item
Yes (1)
CL Item
No (2)
undefined item
Item
Possible causes of possible suicidality-related adverse event: Other, please specify
text
C1547657 (UMLS CUI [1,1])
C0877248 (UMLS CUI [1,2])
Item
Has the subject had any psychiatric conditions in the past (other than the one under study)?
integer
C0004936 (UMLS CUI [1])
psychiatric conditions
Code List
Has the subject had any psychiatric conditions in the past (other than the one under study)?
CL Item
Yes, provide Information (1)
CL Item
No (2)
Item
Has the subject had any suicidal ideation, behaviour or self-harm in the past?
integer
C0424000 (UMLS CUI [1])
Suicidal ideation
Code List
Has the subject had any suicidal ideation, behaviour or self-harm in the past?
CL Item
Yes, provide information (1)
CL Item
No (2)
Item
Subject's current use of llicit drugs?
integer
C0086190 (UMLS CUI [1])
Illicit drugs
Code List
Subject's current use of llicit drugs?
CL Item
Yes, provide information, including results of a drug screen test if one has been obtained (1)
CL Item
No (2)
Item
Subject's current use of alcohol?
integer
C0001948 (UMLS CUI [1])
Alcohol consumption
Code List
Subject's current use of alcohol?
CL Item
Yes, provide information, including test results of an alcohol level test if one has been obtained (1)
CL Item
No (2)
Item
Family history of suicidality?
integer
C0241889 (UMLS CUI [1,1])
C0438696 (UMLS CUI [1,2])
Family history of suicidality
Code List
Family history of suicidality?
CL Item
Yes, provide information (1)
CL Item
No (2)
CL Item
Unknown (3)
Item
Family history of psychiatric disorders?
integer
C0241889 (UMLS CUI [1,1])
C0004936 (UMLS CUI [1,2])
Family history of psychiatric disorders
Code List
Family history of psychiatric disorders?
CL Item
Yes, provide information (1)
CL Item
No (2)
CL Item
Unknown (3)
psycho-social stressors
Item
Provide information on the subject's current psycho-social stressors
text
C0748073 (UMLS CUI [1])
suicidal ideation
Item
Provide information on any relevant and/or recent suicidal ideation, not associated with suicidal behaviour, as assessed by the investigator, for this index event
text
C0424000 (UMLS CUI [1])
suicidal behaviour
Item
Provide information on any suicidal behaviour present during the study, as assessed by the investigator, for this index event
text
C1760428 (UMLS CUI [1])
additional comments
Item
Provide any additional comments or explanation, including, but not limited to, both medical and psychiatric treatment, outcome and follow-up
text
C1830770 (UMLS CUI [1])
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