ID
15787
Beschrijving
Principal Investigator: Luisa Klotz Collaborator: Novartis Information provided by (Responsible Party):University Hospital Muenster -Study to Assess Immune Function and MRI Disease Activity in RRMS Patients When Switching From Natalizumab to Gilenya (ToFingo2) Purpose A trial in patients with relapsing remitting multiple sclerosis (RRMS) Main objectives: •To evaluate changes in the reconstitution of immune surveillance over time upon switching from natalizumab to fingolimod assessed by a change in the expression of CD49d. •To evaluate changes in the migratory capacity of immune cells/peripheral blood mononuclear cells (PBMCs) upon switching from natalizumab to fingolimod in an in-vitro model of the blood-brain-barrier (BBB). •To evaluate changes in paraclinical disease activity over time upon switching from natalizumab to fingolimod assessed by MRI (changes in Gd+, T2w lesions and DTI). •To evaluate changes in T1w / FLAIR lesions upon switching from natalizumab to fingolimod. For further Information please visit https://clinicaltrials.gov/ct2/show/NCT02325440
Link
https://clinicaltrials.gov/ct2/show/NCT02325440
Trefwoorden
Versies (2)
- 01-06-16 01-06-16 -
- 13-06-16 13-06-16 -
Geüploaded op
13 juni 2016
DOI
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Licentie
Creative Commons BY 4.0
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ToFingo Screening V1 Previous and concomitant medication non drug therapies NCT02325440
ToFingo Screening V1 Previous and concomitant medication non drug therapies NCT02325440
Beschrijving
Previous and concomitant medication
Alias
- UMLS CUI-1
- C0033045
Beschrijving
Medication/non-drug therapy
Datatype
integer
Alias
- UMLS CUI [1]
- C0013227
Beschrijving
Start date of therapy
Datatype
date
Alias
- UMLS CUI [1]
- C1707481
Beschrijving
End date of therapy
Datatype
date
Alias
- UMLS CUI [1]
- C1707480
Beschrijving
Single dose/Unit
Datatype
float
Maateenheden
- mg
Alias
- UMLS CUI [1]
- C1960417
Beschrijving
Amount/Unit
Datatype
integer
Beschrijving
Frequency/Unit
Datatype
integer
Alias
- UMLS CUI [1]
- C3476109