ID
15787
Descripción
Principal Investigator: Luisa Klotz Collaborator: Novartis Information provided by (Responsible Party):University Hospital Muenster -Study to Assess Immune Function and MRI Disease Activity in RRMS Patients When Switching From Natalizumab to Gilenya (ToFingo2) Purpose A trial in patients with relapsing remitting multiple sclerosis (RRMS) Main objectives: •To evaluate changes in the reconstitution of immune surveillance over time upon switching from natalizumab to fingolimod assessed by a change in the expression of CD49d. •To evaluate changes in the migratory capacity of immune cells/peripheral blood mononuclear cells (PBMCs) upon switching from natalizumab to fingolimod in an in-vitro model of the blood-brain-barrier (BBB). •To evaluate changes in paraclinical disease activity over time upon switching from natalizumab to fingolimod assessed by MRI (changes in Gd+, T2w lesions and DTI). •To evaluate changes in T1w / FLAIR lesions upon switching from natalizumab to fingolimod. For further Information please visit https://clinicaltrials.gov/ct2/show/NCT02325440
Link
https://clinicaltrials.gov/ct2/show/NCT02325440
Palabras clave
Versiones (2)
- 1/6/16 1/6/16 -
- 13/6/16 13/6/16 -
Subido en
13 de junio de 2016
DOI
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Licencia
Creative Commons BY 4.0
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ToFingo Screening V1 Previous and concomitant medication non drug therapies NCT02325440
ToFingo Screening V1 Previous and concomitant medication non drug therapies NCT02325440
Descripción
Previous and concomitant medication
Alias
- UMLS CUI-1
- C0033045
Descripción
Medication/non-drug therapy
Tipo de datos
integer
Alias
- UMLS CUI [1]
- C0013227
Descripción
Start date of therapy
Tipo de datos
date
Alias
- UMLS CUI [1]
- C1707481
Descripción
End date of therapy
Tipo de datos
date
Alias
- UMLS CUI [1]
- C1707480
Descripción
Single dose/Unit
Tipo de datos
float
Unidades de medida
- mg
Alias
- UMLS CUI [1]
- C1960417
Descripción
Amount/Unit
Tipo de datos
integer
Descripción
Frequency/Unit
Tipo de datos
integer
Alias
- UMLS CUI [1]
- C3476109