Informações:
Falhas:
ID
14004
Descrição
Idarubicin Overcomes MDR1 Induced Chemoresistance With Higher Induction Remission Rate and Quality Than Daunorubicin in Acute Myeloid Leukemia Patients; ODM derived from: https://clinicaltrials.gov/show/NCT01889407
Link
https://clinicaltrials.gov/show/NCT01889407
Palavras-chave
Versões (1)
- 21/03/2016 21/03/2016 -
Transferido a
21 de março de 2016
DOI
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Licença
Creative Commons BY 4.0
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Eligibility Acute Myeloid Leukemia NCT01889407
Eligibility Acute Myeloid Leukemia NCT01889407
- StudyEvent: Eligibility
Similar models
Eligibility Acute Myeloid Leukemia NCT01889407
- StudyEvent: Eligibility
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
AML
Item
Diagnosis of aml (who classification definition of >/= 20% blasts).
boolean
C0023467 (UMLS CUI [1])
Age
Item
Patients aged 16 to 60 years are eligible. patients must be chemo-naïve, i.e. not have received any prior chemotherapy (except hydrea) for aml. they could have received transfusion, hematopoietic growth factors or vitamins. temporary measures such as pheresis or hydrea (0.5 to 5g daily or more for up to 3 days) are allowed.
boolean
C0001779 (UMLS CUI [1])
ABCB1 gene
Item
the relative expression level of mdr1 mrna (mdr1/gapdh ratio using the quantitative real-time pcr) in pre-treated bone marrow samples should over 0.016 (cut-off point from our results of preliminary experiment data)
boolean
C0376622 (UMLS CUI [1])
ECOG performance status
Item
ECOG performance status of 0, 1, 2 at screening
boolean
C1520224 (UMLS CUI [1])
Creatinine
Item
Serum biochemical values with the following limits: - creatinine </= 2.0 mg/dl -
boolean
C0010294 (UMLS CUI [1])
Bilirubin
Item
Total bilirubin </= 2.0 mg/dl, unless increase is due to hemolysis -
boolean
C0005437 (UMLS CUI [1])
Transaminases
Item
Transaminases (sg pt) </= 3x uln
boolean
C0002594 (UMLS CUI [1])
Informed Consent
Item
Ability to understand and provide signed informed consent.
boolean
C0021430 (UMLS CUI [1])
Acute Promyelocytic Leukemia
Item
Subjects with acute promyelocytic leukemia (apl)
boolean
C0023487 (UMLS CUI [1])
Systemic infection
Item
Presence of active systemic infection
boolean
C0243026 (UMLS CUI [1])
Medical condition
Item
Any coexisting medical condition that in the judgment of the treating physician is likely to interfere with study procedures or results.
boolean
C0525058 (UMLS CUI [1,1])
C0009488 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,2])
Positive urine pregnancy test
Item
Nursing women, women of childbearing potential with positive urine pregnancy test, or women of childbearing potential who are not willing to maintain adequate contraception (such as birth control pills, iud, diaphragm, abstinence, or condoms by their partner) over the entire course of the study.
boolean
C0430059 (UMLS CUI [1])