ID

13739

Beschreibung

Background and Purpose: The purpose of the DESCRIBE study is to document the natural course of diseases in context of medical care of neurodegenerative disorders as well as cerebrovascular diseases and to perform phenotyping of the test persons. Disease-spanning analyses of the measured clincial data, the results of the imaging processes, results of the analysis of the biometerials including genetic analysis are planed. Principal Investigator: Prof. Klockgether, Dr. Spottke DZNE, Bonn. Source: DESCRIBE-Studie http://www.dzne.de/forschung/forschungsbereiche/klinische-forschung/studien/describe-bn006.html Participating Study Sites: Berlin, Bonn, Göttingen, Dresden, Köln, Magdeburg, München, Rostock/Greifswald, Tübingen

Link

http://www.dzne.de/forschung/forschungsbereiche/klinische-forschung/studien/describe-bn006.html

Stichworte

Versionen (14)
  1. 24.02.16 24.02.16 -
  2. 01.03.16 01.03.16 -
  3. 02.03.16 02.03.16 -
  4. 03.03.16 03.03.16 -
  5. 03.03.16 03.03.16 -
  6. 04.03.16 04.03.16 - Julian Varghese
  7. 07.03.16 07.03.16 -
  8. 09.03.16 09.03.16 -
  9. 09.03.16 09.03.16 -
  10. 09.03.16 09.03.16 -
  11. 10.03.16 10.03.16 -
  12. 10.03.16 10.03.16 -
  13. 13.04.21 13.04.21 - Dr. rer. medic Philipp Neuhaus
  14. 20.09.21 20.09.21 -
Hochgeladen am

1. März 2016

DOI

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Lizenz

Creative Commons BY-NC 3.0
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DESCRIBE (DZNE – Clinical Register Study of neurodegenerative Disorders) CRF Diagnostic Criteria

Englisch

CRF Diagnostic Criteria

1 Formulare  
Date of visit
Beschreibung

Date of visit

Alias
UMLS CUI-1
C1320303
Date of visit
Beschreibung

date of visit

Datentyp

date

Alias
UMLS CUI [1]
C1320303
Study-ID:
Beschreibung

study id

Datentyp

text

Alias
UMLS CUI [1]
C2826693
Visit:
Beschreibung

visit name

Datentyp

text

Alias
UMLS CUI [1]
C2826704
Mild cognitive impairment (MCI)
Beschreibung

Mild cognitive impairment (MCI)

Alias
UMLS CUI-1
C1270972
Is the patient currently diagnosed with a MCI according to Winblad & Petersen 2004?
Beschreibung

current MCI

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1270972
UMLS CUI [1,2]
C0150312
Cognitive Impairment 1. Subjective deterioration of cognition observed by the patient or an informant and/or...
Beschreibung

cognitive degration

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1270972
UMLS CUI [1,2]
C0854193
2. Evidence of degradation of cognition in time due to psychometric tests
Beschreibung

psychometric test proving cognitive degradation

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1270972
UMLS CUI [1,2]
C0033920
3. Ability to perform activities of everyday living/ minimal impairment of complex instrumental everyday functions
Beschreibung

everyday functioning

Datentyp

boolean

Alias
UMLS CUI [1]
C0562507
4. No signs of disturbed consciousness, of a delirium, of a dementia or of an amnesic aphasia that cannot be explained better by other psychotic illnesses (e.g. a disorder in connection with psychotropic substances or major depression).
Beschreibung

signs of disturbed consciousness

Datentyp

boolean

Alias
UMLS CUI [1]
C0234428
UMLS CUI [2]
C0011206
UMLS CUI [3]
C0497327
Operationalization 1. Wordlist - delayed word retrieval
Beschreibung

At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

Datentyp

boolean

Alias
UMLS CUI [1]
C0456660
2. Visuospatial ability - Drawing
Beschreibung

At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

Datentyp

boolean

Alias
UMLS CUI [1]
C0814069
UMLS CUI [2]
C0565772
3. Visuospatial ability - Delayed retrieval
Beschreibung

At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

Datentyp

boolean

Alias
UMLS CUI [1]
C0814069
4. Trial making test A or B
Beschreibung

At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

Datentyp

boolean

Alias
UMLS CUI [1]
C0040604
5. Semantic or phonetic fluency
Beschreibung

At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

Datentyp

boolean

Alias
UMLS CUI [1]
C0233714
6. Object naming
Beschreibung

At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

Datentyp

boolean

Alias
UMLS CUI [1]
C0451342
7. No abnormal finding FAQ
Beschreibung

normal finding FAQ

Datentyp

boolean

Alias
UMLS CUI [1,1]
C3827007
UMLS CUI [1,2]
C0205307
Classification a. Amnesic MCI single domain (only memory)
Beschreibung

amnesic MCI single domain

Datentyp

boolean

Alias
UMLS CUI [1]
C1270972
b. Amnesic MCI multi domain (memory and one additional area)
Beschreibung

amnesic MCI multi domain

Datentyp

boolean

Alias
UMLS CUI [1]
C1270972
c. Non-amnesic MCI single domain (one area, except memory)
Beschreibung

non-amnesic MCI single domain

Datentyp

boolean

Alias
UMLS CUI [1]
C1270972
d. Non-amnesic MCI multi domain (several areas, except memory)
Beschreibung

non-amnesic MCI multi domain

Datentyp

boolean

Alias
UMLS CUI [1]
C1270972
Dementia in Alzheimer's Disease (AD)
Beschreibung

Dementia in Alzheimer's Disease (AD)

Alias
UMLS CUI-1
C3665464
Is the patient currently diagnosed with AD according to NINCDS/ADRDA-Criteria (McKhann et al. 1984)?
Beschreibung

NINCDS/ADRDA-Criteria AD diagnosis

Datentyp

boolean

Alias
UMLS CUI [1,1]
C3665464
UMLS CUI [1,2]
C2828081
I. Necessary requirements Evidence of dementia in a clinical examination including neuropsychological tests
Beschreibung

Clinical probable AD

Datentyp

boolean

Alias
UMLS CUI [1]
C0497327
UMLS CUI [2]
C0027902
Deficits in at least two cognitive areas
Beschreibung

cognitive deficits

Datentyp

boolean

Alias
UMLS CUI [1]
C0009241
Progressive disturbance of memory and other cognitive functions
Beschreibung

progressive disturbance of memory

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1864985
UMLS CUI [1,2]
C0025260
UMLS CUI [2,1]
C1864985
UMLS CUI [2,2]
C0392335
No consciousness disturbance
Beschreibung

no consciousness disturbance

Datentyp

boolean

Alias
UMLS CUI [1]
C0424525
Onset between age of 40 and 90, mostly 65 and older
Beschreibung

age at onset

Datentyp

boolean

Alias
UMLS CUI [1]
C0150907
No evidence of other system- or brain diseases as cause
Beschreibung

other system- or brain diseases

Datentyp

boolean

Alias
UMLS CUI [1]
C0442893
UMLS CUI [2]
C0006111
II. Subsidiary Findings Progressive deterioration of specific cognitive functions, e.g. of speech (aphasia), motor activity (apraxia) and perception (agnosia)
Beschreibung

progressive deterioration of specific cognitive functions

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0854193
UMLS CUI [1,2]
C0205329
Impairment of everyday activities and emerging of behavior modifications
Beschreibung

impairment of everyday activities and behavioral change

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0562507
UMLS CUI [1,2]
C0221099
UMLS CUI [2]
C0542299
Family history of similar disorders (especially if neurologically proven)
Beschreibung

family history of similar disorders

Datentyp

boolean

Alias
UMLS CUI [1]
C0241889
Results of additional examinations: Evidence of - progressively evolving in follow ups- cerebral atrophy due to imaging diagnostics
Beschreibung

cerebral atrophy

Datentyp

boolean

Alias
UMLS CUI [1]
C0235946
Normal finding or unspecific changes in EEG
Beschreibung

normal finding or unspecific changes in EEG

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0234550
UMLS CUI [1,2]
C0205307
UMLS CUI [2,1]
C0234550
UMLS CUI [2,2]
C0750540
Normal finding of cerebrospinal fluid
Beschreibung

normal finding of cerebrospinal fluid

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0007806
UMLS CUI [1,2]
C0205307
III. Matching with a probable diagnosis of Alzheimer's disease Temporal stagnation in course of disease
Beschreibung

diagnosis of Alzheimers disease

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1848980
UMLS CUI [1,2]
C0242656
Attendant symptoms like depression, insomnia, incontinence, illusion, hallucination, delusion, sudden aggressive outbreaks, sexual dysfunction and weight loss
Beschreibung

attendant symptoms

Datentyp

boolean

Alias
UMLS CUI [1]
C0011581
UMLS CUI [2]
C0917801
UMLS CUI [3]
C0021167
UMLS CUI [4]
C0020903
UMLS CUI [5]
C0018524
UMLS CUI [6]
C0011253
UMLS CUI [7]
C0001807
UMLS CUI [8]
C0549622
UMLS CUI [9]
C0936227
Neurological distinctive feature (particularly in case of advanced disease) like elevated muscle tonus, myoclonus or gait disturbance
Beschreibung

neurological distinctive feature

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1704258
UMLS CUI [1,2]
C0205494
UMLS CUI [2]
C0026841
UMLS CUI [3]
C0027066
UMLS CUI [4]
C1856566
Epileptic seizure (in case of advanced disease)
Beschreibung

epileptic seizure

Datentyp

boolean

Alias
UMLS CUI [1]
C1411824
CT commensurate with age
Beschreibung

CT commensurate with age

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0040405
UMLS CUI [1,2]
C0001783
IV. Exclusion Criteria Sudden, apoplectic onset
Beschreibung

sudden apoplectic onset

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1388315
UMLS CUI [1,2]
C1276802
Focal neurological signs like hemiparesis, sensorial failures, visual field defects or problems with coordination in early stage of disease
Beschreibung

focal neurological signs

Datentyp

boolean

Alias
UMLS CUI [1]
C0018989
UMLS CUI [2]
C0152027
UMLS CUI [3]
C0004134
UMLS CUI [4]
C3887875
Epileptic seizures or gait disturbance at onset or in early stage of disease
Beschreibung

epileptic seizures or gait disturbance

Datentyp

boolean

Alias
UMLS CUI [1]
C1411824
UMLS CUI [2]
C1856566
V. Clinical possible AD Dementia syndrome with atypical symptomatic with regard to onset, course and deficit profile, in absence of other neurological, psychiatric or internal disease that could cause the dementia syndrome
Beschreibung

dementia syndrome with atypical symptomatic

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0497327
UMLS CUI [1,2]
C0231220
Second systemic or brain disease that could cause dementia, but is commonly not regarded as a substantial cause
Beschreibung

second systemic or brain disease

Datentyp

boolean

Alias
UMLS CUI [1]
C0442893
UMLS CUI [2]
C0006111
Progressive severe cognitive deficit without notable different cause
Beschreibung

progressive severe cognitive deficit

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0009241
UMLS CUI [1,2]
C0205329
UMLS CUI [1,3]
C0205082
Posterior cortical atrophy (PCA)
Beschreibung

Posterior cortical atrophy (PCA)

Alias
UMLS CUI-1
C0235946
UMLS CUI-2
C0205095
Is the patient currently diagnosed with PCA according to the criteria of Mendez et.al. 2002?
Beschreibung

PCA diagnosis

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0235946
UMLS CUI [1,2]
C0205095
Main symptoms (all symptoms have to be present) A. Insidious onset and gradual progression
Beschreibung

insidious onset and gradual progression

Datentyp

boolean

Alias
UMLS CUI [1]
C1298634
UMLS CUI [2]
C1854645
B. Presentation with visual disorders while visual function intact
Beschreibung

visual disorders

Datentyp

boolean

Alias
UMLS CUI [1]
C0042790
C. Evidence of prominent complex visual deficits
Beschreibung

prominent complex visual deficits

Datentyp

boolean

Alias
UMLS CUI [1,1]
C3665347
UMLS CUI [1,2]
C0205402
UMLS CUI [1,3]
C0439855
Elements of Balint syndrome
Beschreibung

Balint syndrome

Datentyp

boolean

Alias
UMLS CUI [1]
C0270706
Visual agnosia
Beschreibung

visual agnosia

Datentyp

boolean

Alias
UMLS CUI [1]
C0234502
Dressing apraxis
Beschreibung

dressing apraxia

Datentyp

boolean

Alias
UMLS CUI [1]
C0234529
Topographic disorientation
Beschreibung

topographic disorientation

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0233407
UMLS CUI [1,2]
C1639223
D. Relatively small memory deficits and word fluency deficits
Beschreibung

relatively small deficits of memory and word fluency

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0233794
UMLS CUI [1,2]
C1843272
UMLS CUI [2,1]
C2018029
UMLS CUI [2,2]
C1843272
E. Relatively good awareness of disability with or without depression
Beschreibung

relatively good awareness of disability

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0424227
UMLS CUI [1,2]
C0205170
Subsidiary diagnosis A. Presenile onset
Beschreibung

presenile onset

Datentyp

boolean

Alias
UMLS CUI [1]
C0750901
B. Alexia
Beschreibung

alexia

Datentyp

boolean

Alias
UMLS CUI [1]
C0002018
C. Elements of Gerstmann syndrome
Beschreibung

Gerstmann syndrome

Datentyp

boolean

Alias
UMLS CUI [1]
C0017494
D. Ideomotor apraxia
Beschreibung

ideomotor apraxia

Datentyp

boolean

Alias
UMLS CUI [1]
C0234523
E. Physical examination within the norms
Beschreibung

physical examination

Datentyp

boolean

Alias
UMLS CUI [1]
C0031809
F. Neuropsychiatric: Prominent impairment of perceptual functions
Beschreibung

impairment of perceptual functions

Datentyp

boolean

Alias
UMLS CUI [1]
C0233746
Imaging: Prominent occipitoparietal abnormality (especially in functional imaging) with relative recess of frontal and mesiotemporal regions
Beschreibung

occipitoparietal abnormality

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1704258
UMLS CUI [1,2]
C1184145
UMLS CUI [1,3]
C0442030
Vascular dementia
Beschreibung

Vascular dementia

Alias
UMLS CUI-1
C0011269
Is the patient currently diagnosed with VD according to the criteria of NINDS/AIREN (Roman et al. 1993?)
Beschreibung

VD diagnoses

Datentyp

boolean

Alias
UMLS CUI [1]
C0011269
I. Dementia Cognitive impairment regarding previous higher functional status manifested by disturbance of memory
Beschreibung

cognitive impairment

Datentyp

boolean

Alias
UMLS CUI [1]
C0009241
UMLS CUI [2]
C0233794
Orientation
Beschreibung

and at least two of the following abilities

Datentyp

boolean

Alias
UMLS CUI [1]
C0029266
Attention
Beschreibung

attention

Datentyp

boolean

Alias
UMLS CUI [1]
C0004268
Speech
Beschreibung

speech

Datentyp

boolean

Alias
UMLS CUI [1]
C0037817
Spatial visualization ability
Beschreibung

spatial visualization ability

Datentyp

boolean

Alias
UMLS CUI [1]
C0679024
Ability to judge
Beschreibung

ability to judge

Datentyp

boolean

Alias
UMLS CUI [1]
C0022423
Action ability
Beschreibung

action ability

Datentyp

boolean

Alias
UMLS CUI [1]
C1820715
Abstraction ability
Beschreibung

abstraction ability

Datentyp

boolean

Alias
UMLS CUI [1]
C0679195
Motor control
Beschreibung

motor control

Datentyp

boolean

Alias
UMLS CUI [1]
C0517961
Praxia
Beschreibung

praxia

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0871470
UMLS CUI [1,2]
C0234621
Activities of daily living
Beschreibung

everyday activities

Datentyp

boolean

Alias
UMLS CUI [1]
C0001288
Exclusion criteria Disturbed consciousness
Beschreibung

disturbed consciousness

Datentyp

boolean

Alias
UMLS CUI [1]
C0549249
Delirium
Beschreibung

delirium

Datentyp

boolean

Alias
UMLS CUI [1]
C0011206
Psychosis
Beschreibung

psychosis

Datentyp

boolean

Alias
UMLS CUI [1]
C0033975
Severe aphasia
Beschreibung

severe aphasia

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0003537
UMLS CUI [1,2]
C0205082
Prominent sensomotoric disorder, which makes testing impossible
Beschreibung

sensomotoric disorder

Datentyp

boolean

Alias
UMLS CUI [1]
C0036675
Systemic or other brain diseases, that can cause cognitive disorders for their part
Beschreibung

systemic or other brain diseases

Datentyp

boolean

Alias
UMLS CUI [1]
C2874347
II. Cerebrovascular disease Central focal neurological signs with or without anamnestic stroke and signs of relevant cerebrovascular disease in CT/MRT
Beschreibung

cerebrovascular disease

Datentyp

boolean

Alias
UMLS CUI [1]
C1392298
UMLS CUI [2]
C0038454
UMLS CUI [3]
C0007820
A. cerebri anterior, bilateral
Beschreibung

Cerebrovascular lesions in radiologic finding considered relevant: Localization Strokes great vessel region:

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0149561
UMLS CUI [1,2]
C0238767
A. cerebri anterior
Beschreibung

Cerebrovascular lesions in radiologic finding considered relevant: Localization Strokes great vessel region:

Datentyp

boolean

Alias
UMLS CUI [1]
C0149561
Parietotemporal or temporoparietal association complex
Beschreibung

parietotemporal or temporoparietal association complex

Datentyp

boolean

Alias
UMLS CUI [1]
C3498498
UMLS CUI [2]
C3495412
Superiore frontale and parietal watershed zone
Beschreibung

watershed infarction

Datentyp

boolean

Alias
UMLS CUI [1]
C0333557
Disease of small vessels: Basal ganglia and frontal lacuna of white matter
Beschreibung

basal ganglia and frontal lacuna of white matter

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0152295
UMLS CUI [1,2]
C1459585
UMLS CUI [1,3]
C0004781
UMLS CUI [2,1]
C0152295
UMLS CUI [2,2]
C1459585
UMLS CUI [2,3]
C0016733
Broad periventricular white matter lesions
Beschreibung

periventricular white matter lesions

Datentyp

boolean

Alias
UMLS CUI [1,1]
C2675929
UMLS CUI [1,2]
C0228157
Bilateral thalamus lesions
Beschreibung

bilateral thalamus lesions

Datentyp

boolean

Alias
UMLS CUI [1,1]
C2026261
UMLS CUI [1,2]
C0238767
Severity: great vessel lesions in dominant hemisphere
Beschreibung

great vessel lesions

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0221198
UMLS CUI [1,2]
C3641002
UMLS CUI [1,3]
C0228465
UMLS CUI [1,4]
C1527180
Bilateral lesions of great vessel in hemisphere
Beschreibung

bilateral lesions of great vessel

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0221198
UMLS CUI [1,2]
C3641002
UMLS CUI [1,3]
C0228465
UMLS CUI [1,4]
C0238767
Leukoencephalopathy => 25% of white matter
Beschreibung

leukoencephalopathy

Datentyp

boolean

Alias
UMLS CUI [1]
C0023524
III. Combination of I. and II. Onset of dementia within three months after stroke
Beschreibung

onset of dementia

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0011269
UMLS CUI [1,2]
C0332162
Abrupt degeneration of cognitive functions
Beschreibung

abrupt degeneration of cognitive functions

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0338656
UMLS CUI [1,2]
C1276802
Fluctuating or gradual progression of cognitive deficits
Beschreibung

progression of cognitive deficits

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1854645
UMLS CUI [1,2]
C0338656
UMLS CUI [2,1]
C0338656
UMLS CUI [2,2]
C0231241
Supporting Symptoms: Early occuring gait disturbance
Beschreibung

gait disturbance

Datentyp

boolean

Alias
UMLS CUI [1,1]
C1856566
UMLS CUI [1,2]
C0596473
Motoric instability and frequent support
Beschreibung

motoric instability and frequent support

Datentyp

boolean

Alias
UMLS CUI [1]
C0260026
UMLS CUI [2]
C2197383
Bladder problem (frequent urge to urinate, not urological explainable)
Beschreibung

bladder problem

Datentyp

boolean

Alias
UMLS CUI [1]
C0579152
Pseudobulbar paralysis
Beschreibung

pseudobulbar paralysis

Datentyp

boolean

Alias
UMLS CUI [1]
C1390905
Personality disorder or mood alteration
Beschreibung

personality disorder or mood alteration

Datentyp

boolean

Alias
UMLS CUI [1]
C0031212
UMLS CUI [2]
C2939186
Abulia
Beschreibung

abulia

Datentyp

boolean

Alias
UMLS CUI [1]
C0919974
Depression
Beschreibung

depression

Datentyp

boolean

Alias
UMLS CUI [1]
C0011581
Emotional incontinence
Beschreibung

emotional incontinence

Datentyp

boolean

Alias
UMLS CUI [1]
C1142234
Other subcortical deficits
Beschreibung

other subcortical deficits

Datentyp

boolean

Alias
UMLS CUI [1,1]
C2987487
UMLS CUI [1,2]
C0815275
UMLS CUI [1,3]
C0205394
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CRF Diagnostic Criteria

1 Formulare
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Date of visit
C1320303 (UMLS CUI-1)
date of visit
Item
Date of visit
date
C1320303 (UMLS CUI [1])
study id
Item
Study-ID:
text
C2826693 (UMLS CUI [1])
visit name
Item
Visit:
text
C2826704 (UMLS CUI [1])
Item Group
Mild cognitive impairment (MCI)
C1270972 (UMLS CUI-1)
current MCI
Item
Is the patient currently diagnosed with a MCI according to Winblad & Petersen 2004?
boolean
C1270972 (UMLS CUI [1,1])
C0150312 (UMLS CUI [1,2])
cognitive degration
Item
Cognitive Impairment 1. Subjective deterioration of cognition observed by the patient or an informant and/or...
boolean
C1270972 (UMLS CUI [1,1])
C0854193 (UMLS CUI [1,2])
psychometric test proving cognitive degradation
Item
2. Evidence of degradation of cognition in time due to psychometric tests
boolean
C1270972 (UMLS CUI [1,1])
C0033920 (UMLS CUI [1,2])
everyday functioning
Item
3. Ability to perform activities of everyday living/ minimal impairment of complex instrumental everyday functions
boolean
C0562507 (UMLS CUI [1])
signs of disturbed consciousness
Item
4. No signs of disturbed consciousness, of a delirium, of a dementia or of an amnesic aphasia that cannot be explained better by other psychotic illnesses (e.g. a disorder in connection with psychotropic substances or major depression).
boolean
C0234428 (UMLS CUI [1])
C0011206 (UMLS CUI [2])
C0497327 (UMLS CUI [3])
wordlist
Item
Operationalization 1. Wordlist - delayed word retrieval
boolean
C0456660 (UMLS CUI [1])
visuospatial ability
Item
2. Visuospatial ability - Drawing
boolean
C0814069 (UMLS CUI [1])
C0565772 (UMLS CUI [2])
visuospatial ability delayed
Item
3. Visuospatial ability - Delayed retrieval
boolean
C0814069 (UMLS CUI [1])
trail making test
Item
4. Trial making test A or B
boolean
C0040604 (UMLS CUI [1])
semantic or phonetic fluency
Item
5. Semantic or phonetic fluency
boolean
C0233714 (UMLS CUI [1])
object naming
Item
6. Object naming
boolean
C0451342 (UMLS CUI [1])
normal finding FAQ
Item
7. No abnormal finding FAQ
boolean
C3827007 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
amnesic MCI single domain
Item
Classification a. Amnesic MCI single domain (only memory)
boolean
C1270972 (UMLS CUI [1])
amnesic MCI multi domain
Item
b. Amnesic MCI multi domain (memory and one additional area)
boolean
C1270972 (UMLS CUI [1])
non-amnesic MCI single domain
Item
c. Non-amnesic MCI single domain (one area, except memory)
boolean
C1270972 (UMLS CUI [1])
non-amnesic MCI multi domain
Item
d. Non-amnesic MCI multi domain (several areas, except memory)
boolean
C1270972 (UMLS CUI [1])
Item Group
Dementia in Alzheimer's Disease (AD)
C3665464 (UMLS CUI-1)
NINCDS/ADRDA-Criteria AD diagnosis
Item
Is the patient currently diagnosed with AD according to NINCDS/ADRDA-Criteria (McKhann et al. 1984)?
boolean
C3665464 (UMLS CUI [1,1])
C2828081 (UMLS CUI [1,2])
dementia
Item
I. Necessary requirements Evidence of dementia in a clinical examination including neuropsychological tests
boolean
C0497327 (UMLS CUI [1])
C0027902 (UMLS CUI [2])
cognitive deficits
Item
Deficits in at least two cognitive areas
boolean
C0009241 (UMLS CUI [1])
progressive disturbance of memory
Item
Progressive disturbance of memory and other cognitive functions
boolean
C1864985 (UMLS CUI [1,1])
C0025260 (UMLS CUI [1,2])
C1864985 (UMLS CUI [2,1])
C0392335 (UMLS CUI [2,2])
no consciousness disturbance
Item
No consciousness disturbance
boolean
C0424525 (UMLS CUI [1])
age at onset
Item
Onset between age of 40 and 90, mostly 65 and older
boolean
C0150907 (UMLS CUI [1])
other system- or brain diseases
Item
No evidence of other system- or brain diseases as cause
boolean
C0442893 (UMLS CUI [1])
C0006111 (UMLS CUI [2])
progressive deterioration of specific cognitive functions
Item
II. Subsidiary Findings Progressive deterioration of specific cognitive functions, e.g. of speech (aphasia), motor activity (apraxia) and perception (agnosia)
boolean
C0854193 (UMLS CUI [1,1])
C0205329 (UMLS CUI [1,2])
impairment of everyday activities and behavioral change
Item
Impairment of everyday activities and emerging of behavior modifications
boolean
C0562507 (UMLS CUI [1,1])
C0221099 (UMLS CUI [1,2])
C0542299 (UMLS CUI [2])
family history of similar disorders
Item
Family history of similar disorders (especially if neurologically proven)
boolean
C0241889 (UMLS CUI [1])
cerebral atrophy
Item
Results of additional examinations: Evidence of - progressively evolving in follow ups- cerebral atrophy due to imaging diagnostics
boolean
C0235946 (UMLS CUI [1])
normal finding or unspecific changes in EEG
Item
Normal finding or unspecific changes in EEG
boolean
C0234550 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C0234550 (UMLS CUI [2,1])
C0750540 (UMLS CUI [2,2])
normal finding of cerebrospinal fluid
Item
Normal finding of cerebrospinal fluid
boolean
C0007806 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
diagnosis of Alzheimers disease
Item
III. Matching with a probable diagnosis of Alzheimer's disease Temporal stagnation in course of disease
boolean
C1848980 (UMLS CUI [1,1])
C0242656 (UMLS CUI [1,2])
attendant symptoms
Item
Attendant symptoms like depression, insomnia, incontinence, illusion, hallucination, delusion, sudden aggressive outbreaks, sexual dysfunction and weight loss
boolean
C0011581 (UMLS CUI [1])
C0917801 (UMLS CUI [2])
C0021167 (UMLS CUI [3])
C0020903 (UMLS CUI [4])
C0018524 (UMLS CUI [5])
C0011253 (UMLS CUI [6])
C0001807 (UMLS CUI [7])
C0549622 (UMLS CUI [8])
C0936227 (UMLS CUI [9])
neurological distinctive feature
Item
Neurological distinctive feature (particularly in case of advanced disease) like elevated muscle tonus, myoclonus or gait disturbance
boolean
C1704258 (UMLS CUI [1,1])
C0205494 (UMLS CUI [1,2])
C0026841 (UMLS CUI [2])
C0027066 (UMLS CUI [3])
C1856566 (UMLS CUI [4])
epileptic seizure
Item
Epileptic seizure (in case of advanced disease)
boolean
C1411824 (UMLS CUI [1])
CT commensurate with age
Item
CT commensurate with age
boolean
C0040405 (UMLS CUI [1,1])
C0001783 (UMLS CUI [1,2])
sudden apoplectic onset
Item
IV. Exclusion Criteria Sudden, apoplectic onset
boolean
C1388315 (UMLS CUI [1,1])
C1276802 (UMLS CUI [1,2])
focal neurological signs
Item
Focal neurological signs like hemiparesis, sensorial failures, visual field defects or problems with coordination in early stage of disease
boolean
C0018989 (UMLS CUI [1])
C0152027 (UMLS CUI [2])
C0004134 (UMLS CUI [3])
C3887875 (UMLS CUI [4])
epileptic seizures or gait disturbance
Item
Epileptic seizures or gait disturbance at onset or in early stage of disease
boolean
C1411824 (UMLS CUI [1])
C1856566 (UMLS CUI [2])
dementia syndrome with atypical symptomatic
Item
V. Clinical possible AD Dementia syndrome with atypical symptomatic with regard to onset, course and deficit profile, in absence of other neurological, psychiatric or internal disease that could cause the dementia syndrome
boolean
C0497327 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
second systemic or brain disease
Item
Second systemic or brain disease that could cause dementia, but is commonly not regarded as a substantial cause
boolean
C0442893 (UMLS CUI [1])
C0006111 (UMLS CUI [2])
progressive severe cognitive deficit
Item
Progressive severe cognitive deficit without notable different cause
boolean
C0009241 (UMLS CUI [1,1])
C0205329 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,3])
Item Group
Posterior cortical atrophy (PCA)
C0235946 (UMLS CUI-1)
C0205095 (UMLS CUI-2)
PCA diagnosis
Item
Is the patient currently diagnosed with PCA according to the criteria of Mendez et.al. 2002?
boolean
C0235946 (UMLS CUI [1,1])
C0205095 (UMLS CUI [1,2])
insidious onset and gradual progression
Item
Main symptoms (all symptoms have to be present) A. Insidious onset and gradual progression
boolean
C1298634 (UMLS CUI [1])
C1854645 (UMLS CUI [2])
visual disorders
Item
B. Presentation with visual disorders while visual function intact
boolean
C0042790 (UMLS CUI [1])
prominent complex visual deficits
Item
C. Evidence of prominent complex visual deficits
boolean
C3665347 (UMLS CUI [1,1])
C0205402 (UMLS CUI [1,2])
C0439855 (UMLS CUI [1,3])
Balint syndrome
Item
Elements of Balint syndrome
boolean
C0270706 (UMLS CUI [1])
visual agnosia
Item
Visual agnosia
boolean
C0234502 (UMLS CUI [1])
dressing apraxia
Item
Dressing apraxis
boolean
C0234529 (UMLS CUI [1])
topographic disorientation
Item
Topographic disorientation
boolean
C0233407 (UMLS CUI [1,1])
C1639223 (UMLS CUI [1,2])
relatively small deficits of memory and word fluency
Item
D. Relatively small memory deficits and word fluency deficits
boolean
C0233794 (UMLS CUI [1,1])
C1843272 (UMLS CUI [1,2])
C2018029 (UMLS CUI [2,1])
C1843272 (UMLS CUI [2,2])
relatively good awareness of disability
Item
E. Relatively good awareness of disability with or without depression
boolean
C0424227 (UMLS CUI [1,1])
C0205170 (UMLS CUI [1,2])
presenile onset
Item
Subsidiary diagnosis A. Presenile onset
boolean
C0750901 (UMLS CUI [1])
alexia
Item
B. Alexia
boolean
C0002018 (UMLS CUI [1])
Gerstmann syndrome
Item
C. Elements of Gerstmann syndrome
boolean
C0017494 (UMLS CUI [1])
ideomotor apraxia
Item
D. Ideomotor apraxia
boolean
C0234523 (UMLS CUI [1])
physical examination
Item
E. Physical examination within the norms
boolean
C0031809 (UMLS CUI [1])
impairment of perceptual functions
Item
F. Neuropsychiatric: Prominent impairment of perceptual functions
boolean
C0233746 (UMLS CUI [1])
occipitoparietal abnormality
Item
Imaging: Prominent occipitoparietal abnormality (especially in functional imaging) with relative recess of frontal and mesiotemporal regions
boolean
C1704258 (UMLS CUI [1,1])
C1184145 (UMLS CUI [1,2])
C0442030 (UMLS CUI [1,3])
Item Group
Vascular dementia
C0011269 (UMLS CUI-1)
VD diagnoses
Item
Is the patient currently diagnosed with VD according to the criteria of NINDS/AIREN (Roman et al. 1993?)
boolean
C0011269 (UMLS CUI [1])
cognitive impairment
Item
I. Dementia Cognitive impairment regarding previous higher functional status manifested by disturbance of memory
boolean
C0009241 (UMLS CUI [1])
C0233794 (UMLS CUI [2])
orientation
Item
Orientation
boolean
C0029266 (UMLS CUI [1])
attention
Item
Attention
boolean
C0004268 (UMLS CUI [1])
speech
Item
Speech
boolean
C0037817 (UMLS CUI [1])
spatial visualization ability
Item
Spatial visualization ability
boolean
C0679024 (UMLS CUI [1])
ability to judge
Item
Ability to judge
boolean
C0022423 (UMLS CUI [1])
action ability
Item
Action ability
boolean
C1820715 (UMLS CUI [1])
abstraction ability
Item
Abstraction ability
boolean
C0679195 (UMLS CUI [1])
motor control
Item
Motor control
boolean
C0517961 (UMLS CUI [1])
praxia
Item
Praxia
boolean
C0871470 (UMLS CUI [1,1])
C0234621 (UMLS CUI [1,2])
everyday activities
Item
Activities of daily living
boolean
C0001288 (UMLS CUI [1])
disturbed consciousness
Item
Exclusion criteria Disturbed consciousness
boolean
C0549249 (UMLS CUI [1])
delirium
Item
Delirium
boolean
C0011206 (UMLS CUI [1])
psychosis
Item
Psychosis
boolean
C0033975 (UMLS CUI [1])
severe aphasia
Item
Severe aphasia
boolean
C0003537 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
sensomotoric disorder
Item
Prominent sensomotoric disorder, which makes testing impossible
boolean
C0036675 (UMLS CUI [1])
systemic or other brain diseases
Item
Systemic or other brain diseases, that can cause cognitive disorders for their part
boolean
C2874347 (UMLS CUI [1])
cerebrovascular disease
Item
II. Cerebrovascular disease Central focal neurological signs with or without anamnestic stroke and signs of relevant cerebrovascular disease in CT/MRT
boolean
C1392298 (UMLS CUI [1])
C0038454 (UMLS CUI [2])
C0007820 (UMLS CUI [3])
bilateral artery cerebri anterior
Item
A. cerebri anterior, bilateral
boolean
C0149561 (UMLS CUI [1,1])
C0238767 (UMLS CUI [1,2])
anterior cerebral artery
Item
A. cerebri anterior
boolean
C0149561 (UMLS CUI [1])
parietotemporal or temporoparietal association complex
Item
Parietotemporal or temporoparietal association complex
boolean
C3498498 (UMLS CUI [1])
C3495412 (UMLS CUI [2])
watershed infarction
Item
Superiore frontale and parietal watershed zone
boolean
C0333557 (UMLS CUI [1])
basal ganglia and frontal lacuna of white matter
Item
Disease of small vessels: Basal ganglia and frontal lacuna of white matter
boolean
C0152295 (UMLS CUI [1,1])
C1459585 (UMLS CUI [1,2])
C0004781 (UMLS CUI [1,3])
C0152295 (UMLS CUI [2,1])
C1459585 (UMLS CUI [2,2])
C0016733 (UMLS CUI [2,3])
periventricular white matter lesions
Item
Broad periventricular white matter lesions
boolean
C2675929 (UMLS CUI [1,1])
C0228157 (UMLS CUI [1,2])
bilateral thalamus lesions
Item
Bilateral thalamus lesions
boolean
C2026261 (UMLS CUI [1,1])
C0238767 (UMLS CUI [1,2])
great vessel lesions
Item
Severity: great vessel lesions in dominant hemisphere
boolean
C0221198 (UMLS CUI [1,1])
C3641002 (UMLS CUI [1,2])
C0228465 (UMLS CUI [1,3])
C1527180 (UMLS CUI [1,4])
bilateral lesions of great vessel
Item
Bilateral lesions of great vessel in hemisphere
boolean
C0221198 (UMLS CUI [1,1])
C3641002 (UMLS CUI [1,2])
C0228465 (UMLS CUI [1,3])
C0238767 (UMLS CUI [1,4])
leukoencephalopathy
Item
Leukoencephalopathy => 25% of white matter
boolean
C0023524 (UMLS CUI [1])
onset of dementia
Item
III. Combination of I. and II. Onset of dementia within three months after stroke
boolean
C0011269 (UMLS CUI [1,1])
C0332162 (UMLS CUI [1,2])
abrupt degeneration of cognitive functions
Item
Abrupt degeneration of cognitive functions
boolean
C0338656 (UMLS CUI [1,1])
C1276802 (UMLS CUI [1,2])
progression of cognitive deficits
Item
Fluctuating or gradual progression of cognitive deficits
boolean
C1854645 (UMLS CUI [1,1])
C0338656 (UMLS CUI [1,2])
C0338656 (UMLS CUI [2,1])
C0231241 (UMLS CUI [2,2])
gait disturbance
Item
Supporting Symptoms: Early occuring gait disturbance
boolean
C1856566 (UMLS CUI [1,1])
C0596473 (UMLS CUI [1,2])
motoric instability and frequent support
Item
Motoric instability and frequent support
boolean
C0260026 (UMLS CUI [1])
C2197383 (UMLS CUI [2])
bladder problem
Item
Bladder problem (frequent urge to urinate, not urological explainable)
boolean
C0579152 (UMLS CUI [1])
pseudobulbar paralysis
Item
Pseudobulbar paralysis
boolean
C1390905 (UMLS CUI [1])
personality disorder or mood alteration
Item
Personality disorder or mood alteration
boolean
C0031212 (UMLS CUI [1])
C2939186 (UMLS CUI [2])
abulia
Item
Abulia
boolean
C0919974 (UMLS CUI [1])
depression
Item
Depression
boolean
C0011581 (UMLS CUI [1])
emotional incontinence
Item
Emotional incontinence
boolean
C1142234 (UMLS CUI [1])
other subcortical deficits
Item
Other subcortical deficits
boolean
C2987487 (UMLS CUI [1,1])
C0815275 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
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