ID

13664

Descripción

Background and Purpose: The purpose of the DESCRIBE study is to document the natural course of diseases in context of medical care of neurodegenerative disorders as well as cerebrovascular diseases and to perform phenotyping of the test persons. Disease-spanning analyses of the measured clincial data, the results of the imaging processes, results of the analysis of the biometerials including genetic analysis are planed. Principal Investigator: Prof. Klockgether, Dr. Spottke DZNE, Bonn. Source: DESCRIBE-Studie http://www.dzne.de/forschung/forschungsbereiche/klinische-forschung/studien/describe-bn006.html Participating Study Sites: Berlin, Bonn, Göttingen, Dresden, Köln, Magdeburg, München, Rostock/Greifswald, Tübingen

Link

http://www.dzne.de/forschung/forschungsbereiche/klinische-forschung/studien/describe-bn006.html

Palabras clave

Versiones (14)
  1. 24/2/16 24/2/16 -
  2. 1/3/16 1/3/16 -
  3. 2/3/16 2/3/16 -
  4. 3/3/16 3/3/16 -
  5. 3/3/16 3/3/16 -
  6. 4/3/16 4/3/16 - Julian Varghese
  7. 7/3/16 7/3/16 -
  8. 9/3/16 9/3/16 -
  9. 9/3/16 9/3/16 -
  10. 9/3/16 9/3/16 -
  11. 10/3/16 10/3/16 -
  12. 10/3/16 10/3/16 -
  13. 13/4/21 13/4/21 - Dr. rer. medic Philipp Neuhaus
  14. 20/9/21 20/9/21 -
Subido en

24 de febrero de 2016

DOI

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Licencia

Creative Commons BY-NC 3.0
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    DESCRIBE (DZNE – Clinical Register Study of neurodegenerative Disorders) CRF Diagnostic Criteria

    Inglés

    CRF Diagnostic Criteria

    1 formularios  
    Date of visit
    Descripción

    Date of visit

    Alias
    UMLS CUI-1
    C1320303
    Date of visit
    Descripción

    date of visit

    Tipo de datos

    date

    Alias
    UMLS CUI [1]
    C1320303
    Study-ID:
    Descripción

    study id

    Tipo de datos

    text

    Alias
    UMLS CUI [1]
    C2826693
    Visit:
    Descripción

    visit name

    Tipo de datos

    text

    Alias
    UMLS CUI [1]
    C2826704
    Mild cognitive impairment (MCI)
    Descripción

    Mild cognitive impairment (MCI)

    Alias
    UMLS CUI-1
    C1270972
    Is the patient currently diagnosed with a MCI according to Winblad & Petersen 2004?
    Descripción

    current MCI

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C1270972
    UMLS CUI [1,2]
    C0150312
    Cognitive Impairment 1. Subjective deterioration of cognition observed by the patient or an informant and/or...
    Descripción

    cognitive degration

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C1270972
    UMLS CUI [1,2]
    C0854193
    2. Evidence of degradation of cognition in time due to psychometric tests
    Descripción

    psychometric test proving cognitive degradation

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C1270972
    UMLS CUI [1,2]
    C0033920
    3. Ability to perform activities of everyday living/ minimal impairment of complex instrumental everyday functions
    Descripción

    everyday functioning

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0562507
    4. No signs of disturbed consciousness, of a delirium, of a dementia or of an amnesic aphasia that cannot be explained better by other psychotic illnesses (e.g. a disorder in connection with psychotropic substances or major depression).
    Descripción

    signs of disturbed consciousness

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0234428
    UMLS CUI [2]
    C0011206
    UMLS CUI [3]
    C0497327
    Operationalization 1. Wordlist - delayed word retrieval
    Descripción

    At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0456660
    2. Visuospatial ability - Drawing
    Descripción

    At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0814069
    UMLS CUI [2]
    C0565772
    3. Visuospatial ability - Delayed retrieval
    Descripción

    At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0814069
    4. Trial making test A or B
    Descripción

    At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0040604
    5. Semantic or phonetic fluency
    Descripción

    At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0233714
    6. Object naming
    Descripción

    At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0451342
    7. No abnormal finding FAQ
    Descripción

    normal finding FAQ

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C3827007
    UMLS CUI [1,2]
    C0205307
    Classification a. Amnesic MCI single domain (only memory)
    Descripción

    amnesic MCI single domain

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C1270972
    b. Amnesic MCI multi domain (memory and one additional area)
    Descripción

    amnesic MCI multi domain

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C1270972
    c. Non-amnesic MCI single domain (one area, except memory)
    Descripción

    non-amnesic MCI single domain

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C1270972
    d. Non-amnesic MCI multi domain (several areas, except memory)
    Descripción

    non-amnesic MCI multi domain

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C1270972
    Dementia in Alzheimer's Disease (AD)
    Descripción

    Dementia in Alzheimer's Disease (AD)

    Alias
    UMLS CUI-1
    C3665464
    Is the patient currently diagnosed with AD according to NINCDS/ADRDA-Criteria (McKhann et al. 1984)?
    Descripción

    NINCDS/ADRDA-Criteria AD diagnosis

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C3665464
    UMLS CUI [1,2]
    C2828081
    I. Necessary requirements Evidence of dementia in a clinical examination including neuropsychological tests
    Descripción

    Clinical probable AD

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0497327
    UMLS CUI [2]
    C0027902
    Deficits in at least two cognitive areas
    Descripción

    cognitive deficits

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0009241
    Progressive disturbance of memory and other cognitive functions
    Descripción

    progressive disturbance of memory

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C1864985
    UMLS CUI [1,2]
    C0025260
    UMLS CUI [2,1]
    C1864985
    UMLS CUI [2,2]
    C0392335
    No consciousness disturbance
    Descripción

    no consciousness disturbance

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0424525
    Onset between age of 40 and 90, mostly 65 and older
    Descripción

    age at onset

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0150907
    No evidence of other system- or brain diseases as cause
    Descripción

    other system- or brain diseases

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0442893
    UMLS CUI [2]
    C0006111
    II. Subsidiary Findings Progressive deterioration of specific cognitive functions, e.g. of speech (aphasia), motor activity (apraxia) and perception (agnosia)
    Descripción

    progressive deterioration of specific cognitive functions

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C0854193
    UMLS CUI [1,2]
    C0205329
    Impairment of everyday activities and emerging of behavior modifications
    Descripción

    impairment of everyday activities and behavioral change

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C0562507
    UMLS CUI [1,2]
    C0221099
    UMLS CUI [2]
    C0542299
    Family history of similar disorders (especially if neurologically proven)
    Descripción

    family history of similar disorders

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0241889
    Results of additional examinations: Evidence of - progressively evolving in follow ups- cerebral atrophy due to imaging diagnostics
    Descripción

    cerebral atrophy

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0235946
    Normal finding or unspecific changes in EEG
    Descripción

    normal finding or unspecific changes in EEG

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C0234550
    UMLS CUI [1,2]
    C0205307
    UMLS CUI [2,1]
    C0234550
    UMLS CUI [2,2]
    C0750540
    Normal finding of cerebrospinal fluid
    Descripción

    normal finding of cerebrospinal fluid

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C0007806
    UMLS CUI [1,2]
    C0205307
    III. Matching with a probable diagnosis of Alzheimer's disease Temporal stagnation in course of disease
    Descripción

    diagnosis of Alzheimers disease

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C1848980
    UMLS CUI [1,2]
    C0242656
    Attendant symptoms like depression, insomnia, incontinence, illusion, hallucination, delusion, sudden aggressive outbreaks, sexual dysfunction and weight loss
    Descripción

    attendant symptoms

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0011581
    UMLS CUI [2]
    C0917801
    UMLS CUI [3]
    C0021167
    UMLS CUI [4]
    C0020903
    UMLS CUI [5]
    C0018524
    UMLS CUI [6]
    C0011253
    UMLS CUI [7]
    C0001807
    UMLS CUI [8]
    C0549622
    UMLS CUI [9]
    C0936227
    Neurological distinctive feature (particularly in case of advanced disease) like elevated muscle tonus, myoclonus or gait disturbance
    Descripción

    neurological distinctive feature

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C1704258
    UMLS CUI [1,2]
    C0205494
    UMLS CUI [2]
    C0026841
    UMLS CUI [3]
    C0027066
    UMLS CUI [4]
    C1856566
    Epileptic seizure (in case of advanced disease)
    Descripción

    epileptic seizure

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C1411824
    CT commensurate with age
    Descripción

    CT commensurate with age

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C0040405
    UMLS CUI [1,2]
    C0001783
    IV. Exclusion Criteria Sudden, apoplectic onset
    Descripción

    sudden apoplectic onset

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C1388315
    UMLS CUI [1,2]
    C1276802
    Focal neurological signs like hemiparesis, sensorial failures, visual field defects or problems with coordination in early stage of disease
    Descripción

    focal neurological signs

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0018989
    UMLS CUI [2]
    C0152027
    UMLS CUI [3]
    C0004134
    UMLS CUI [4]
    C3887875
    Epileptic seizures or gait disturbance at onset or in early stage of disease
    Descripción

    epileptic seizures or gait disturbance

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C1411824
    UMLS CUI [2]
    C1856566
    V. Clinical possible AD Dementia syndrome with atypical symptomatic with regard to onset, course and deficit profile, in absence of other neurological, psychiatric or internal disease that could cause the dementia syndrome
    Descripción

    dementia syndrome with atypical symptomatic

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C0497327
    UMLS CUI [1,2]
    C0231220
    Second systemic or brain disease that could cause dementia, but is commonly not regarded as a substantial cause
    Descripción

    second systemic or brain disease

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0442893
    UMLS CUI [2]
    C0006111
    Progressive severe cognitive deficit without notable different cause
    Descripción

    progressive severe cognitive deficit

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C0009241
    UMLS CUI [1,2]
    C0205329
    UMLS CUI [1,3]
    C0205082
    Posterior cortical atrophy (PCA)
    Descripción

    Posterior cortical atrophy (PCA)

    Alias
    UMLS CUI-1
    C0235946
    UMLS CUI-2
    C0205095
    Is the patient currently diagnosed with PCA according to the criteria of Mendez et.al. 2002?
    Descripción

    PCA diagnosis

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C0235946
    UMLS CUI [1,2]
    C0205095
    Main symptoms (all symptoms have to be present) A. Insidious onset and gradual progression
    Descripción

    insidious onset and gradual progression

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C1298634
    UMLS CUI [2]
    C1854645
    B. Presentation with visual disorders while visual function intact
    Descripción

    visual disorders

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0042790
    C. Evidence of prominent complex visual deficits
    Descripción

    prominent complex visual deficits

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C3665347
    UMLS CUI [1,2]
    C0205402
    UMLS CUI [1,3]
    C0439855
    Elements of Balint syndrome
    Descripción

    Balint syndrome

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0270706
    Visual agnosia
    Descripción

    visual agnosia

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0234502
    Dressing apraxis
    Descripción

    dressing apraxia

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0234529
    Topographic disorientation
    Descripción

    topographic disorientation

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C0233407
    UMLS CUI [1,2]
    C1639223
    D. Relatively small memory deficits and word fluency deficits
    Descripción

    relatively small deficits of memory and word fluency

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C0233794
    UMLS CUI [1,2]
    C1843272
    UMLS CUI [2,1]
    C2018029
    UMLS CUI [2,2]
    C1843272
    E. Relatively good awareness of disability with or without depression
    Descripción

    relatively good awareness of disability

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C0424227
    UMLS CUI [1,2]
    C0205170
    Subsidiary diagnosis A. Presenile onset
    Descripción

    presenile onset

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0750901
    B. Alexia
    Descripción

    alexia

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0002018
    C. Elements of Gerstmann syndrome
    Descripción

    Gerstmann syndrome

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0017494
    D. Ideomotor apraxia
    Descripción

    ideomotor apraxia

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0234523
    E. Physical examination within the norms
    Descripción

    physical examination

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0031809
    F. Neuropsychiatric: Prominent impairment of perceptual functions
    Descripción

    impairment of perceptual functions

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1]
    C0233746
    Imaging: Prominent occipitoparietal abnormality (especially in functional imaging) with relative recess of frontal and mesiotemporal regions
    Descripción

    occipitoparietal abnormality

    Tipo de datos

    boolean

    Alias
    UMLS CUI [1,1]
    C1704258
    UMLS CUI [1,2]
    C1184145
    UMLS CUI [1,3]
    C0442030
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    Similar models

    CRF Diagnostic Criteria

    1 formularios
    Name
    Tipo
    Description | Question | Decode (Coded Value)
    Tipo de datos
    Alias
    Item Group
    Date of visit
    C1320303 (UMLS CUI-1)
    date of visit
    Item
    Date of visit
    date
    C1320303 (UMLS CUI [1])
    study id
    Item
    Study-ID:
    text
    C2826693 (UMLS CUI [1])
    visit name
    Item
    Visit:
    text
    C2826704 (UMLS CUI [1])
    Item Group
    Mild cognitive impairment (MCI)
    C1270972 (UMLS CUI-1)
    current MCI
    Item
    Is the patient currently diagnosed with a MCI according to Winblad & Petersen 2004?
    boolean
    C1270972 (UMLS CUI [1,1])
    C0150312 (UMLS CUI [1,2])
    cognitive degration
    Item
    Cognitive Impairment 1. Subjective deterioration of cognition observed by the patient or an informant and/or...
    boolean
    C1270972 (UMLS CUI [1,1])
    C0854193 (UMLS CUI [1,2])
    psychometric test proving cognitive degradation
    Item
    2. Evidence of degradation of cognition in time due to psychometric tests
    boolean
    C1270972 (UMLS CUI [1,1])
    C0033920 (UMLS CUI [1,2])
    everyday functioning
    Item
    3. Ability to perform activities of everyday living/ minimal impairment of complex instrumental everyday functions
    boolean
    C0562507 (UMLS CUI [1])
    signs of disturbed consciousness
    Item
    4. No signs of disturbed consciousness, of a delirium, of a dementia or of an amnesic aphasia that cannot be explained better by other psychotic illnesses (e.g. a disorder in connection with psychotropic substances or major depression).
    boolean
    C0234428 (UMLS CUI [1])
    C0011206 (UMLS CUI [2])
    C0497327 (UMLS CUI [3])
    wordlist
    Item
    Operationalization 1. Wordlist - delayed word retrieval
    boolean
    C0456660 (UMLS CUI [1])
    visuospatial ability
    Item
    2. Visuospatial ability - Drawing
    boolean
    C0814069 (UMLS CUI [1])
    C0565772 (UMLS CUI [2])
    visuospatial ability delayed
    Item
    3. Visuospatial ability - Delayed retrieval
    boolean
    C0814069 (UMLS CUI [1])
    trail making test
    Item
    4. Trial making test A or B
    boolean
    C0040604 (UMLS CUI [1])
    semantic or phonetic fluency
    Item
    5. Semantic or phonetic fluency
    boolean
    C0233714 (UMLS CUI [1])
    object naming
    Item
    6. Object naming
    boolean
    C0451342 (UMLS CUI [1])
    normal finding FAQ
    Item
    7. No abnormal finding FAQ
    boolean
    C3827007 (UMLS CUI [1,1])
    C0205307 (UMLS CUI [1,2])
    amnesic MCI single domain
    Item
    Classification a. Amnesic MCI single domain (only memory)
    boolean
    C1270972 (UMLS CUI [1])
    amnesic MCI multi domain
    Item
    b. Amnesic MCI multi domain (memory and one additional area)
    boolean
    C1270972 (UMLS CUI [1])
    non-amnesic MCI single domain
    Item
    c. Non-amnesic MCI single domain (one area, except memory)
    boolean
    C1270972 (UMLS CUI [1])
    non-amnesic MCI multi domain
    Item
    d. Non-amnesic MCI multi domain (several areas, except memory)
    boolean
    C1270972 (UMLS CUI [1])
    Item Group
    Dementia in Alzheimer's Disease (AD)
    C3665464 (UMLS CUI-1)
    NINCDS/ADRDA-Criteria AD diagnosis
    Item
    Is the patient currently diagnosed with AD according to NINCDS/ADRDA-Criteria (McKhann et al. 1984)?
    boolean
    C3665464 (UMLS CUI [1,1])
    C2828081 (UMLS CUI [1,2])
    dementia
    Item
    I. Necessary requirements Evidence of dementia in a clinical examination including neuropsychological tests
    boolean
    C0497327 (UMLS CUI [1])
    C0027902 (UMLS CUI [2])
    cognitive deficits
    Item
    Deficits in at least two cognitive areas
    boolean
    C0009241 (UMLS CUI [1])
    progressive disturbance of memory
    Item
    Progressive disturbance of memory and other cognitive functions
    boolean
    C1864985 (UMLS CUI [1,1])
    C0025260 (UMLS CUI [1,2])
    C1864985 (UMLS CUI [2,1])
    C0392335 (UMLS CUI [2,2])
    no consciousness disturbance
    Item
    No consciousness disturbance
    boolean
    C0424525 (UMLS CUI [1])
    age at onset
    Item
    Onset between age of 40 and 90, mostly 65 and older
    boolean
    C0150907 (UMLS CUI [1])
    other system- or brain diseases
    Item
    No evidence of other system- or brain diseases as cause
    boolean
    C0442893 (UMLS CUI [1])
    C0006111 (UMLS CUI [2])
    progressive deterioration of specific cognitive functions
    Item
    II. Subsidiary Findings Progressive deterioration of specific cognitive functions, e.g. of speech (aphasia), motor activity (apraxia) and perception (agnosia)
    boolean
    C0854193 (UMLS CUI [1,1])
    C0205329 (UMLS CUI [1,2])
    impairment of everyday activities and behavioral change
    Item
    Impairment of everyday activities and emerging of behavior modifications
    boolean
    C0562507 (UMLS CUI [1,1])
    C0221099 (UMLS CUI [1,2])
    C0542299 (UMLS CUI [2])
    family history of similar disorders
    Item
    Family history of similar disorders (especially if neurologically proven)
    boolean
    C0241889 (UMLS CUI [1])
    cerebral atrophy
    Item
    Results of additional examinations: Evidence of - progressively evolving in follow ups- cerebral atrophy due to imaging diagnostics
    boolean
    C0235946 (UMLS CUI [1])
    normal finding or unspecific changes in EEG
    Item
    Normal finding or unspecific changes in EEG
    boolean
    C0234550 (UMLS CUI [1,1])
    C0205307 (UMLS CUI [1,2])
    C0234550 (UMLS CUI [2,1])
    C0750540 (UMLS CUI [2,2])
    normal finding of cerebrospinal fluid
    Item
    Normal finding of cerebrospinal fluid
    boolean
    C0007806 (UMLS CUI [1,1])
    C0205307 (UMLS CUI [1,2])
    diagnosis of Alzheimers disease
    Item
    III. Matching with a probable diagnosis of Alzheimer's disease Temporal stagnation in course of disease
    boolean
    C1848980 (UMLS CUI [1,1])
    C0242656 (UMLS CUI [1,2])
    attendant symptoms
    Item
    Attendant symptoms like depression, insomnia, incontinence, illusion, hallucination, delusion, sudden aggressive outbreaks, sexual dysfunction and weight loss
    boolean
    C0011581 (UMLS CUI [1])
    C0917801 (UMLS CUI [2])
    C0021167 (UMLS CUI [3])
    C0020903 (UMLS CUI [4])
    C0018524 (UMLS CUI [5])
    C0011253 (UMLS CUI [6])
    C0001807 (UMLS CUI [7])
    C0549622 (UMLS CUI [8])
    C0936227 (UMLS CUI [9])
    neurological distinctive feature
    Item
    Neurological distinctive feature (particularly in case of advanced disease) like elevated muscle tonus, myoclonus or gait disturbance
    boolean
    C1704258 (UMLS CUI [1,1])
    C0205494 (UMLS CUI [1,2])
    C0026841 (UMLS CUI [2])
    C0027066 (UMLS CUI [3])
    C1856566 (UMLS CUI [4])
    epileptic seizure
    Item
    Epileptic seizure (in case of advanced disease)
    boolean
    C1411824 (UMLS CUI [1])
    CT commensurate with age
    Item
    CT commensurate with age
    boolean
    C0040405 (UMLS CUI [1,1])
    C0001783 (UMLS CUI [1,2])
    sudden apoplectic onset
    Item
    IV. Exclusion Criteria Sudden, apoplectic onset
    boolean
    C1388315 (UMLS CUI [1,1])
    C1276802 (UMLS CUI [1,2])
    focal neurological signs
    Item
    Focal neurological signs like hemiparesis, sensorial failures, visual field defects or problems with coordination in early stage of disease
    boolean
    C0018989 (UMLS CUI [1])
    C0152027 (UMLS CUI [2])
    C0004134 (UMLS CUI [3])
    C3887875 (UMLS CUI [4])
    epileptic seizures or gait disturbance
    Item
    Epileptic seizures or gait disturbance at onset or in early stage of disease
    boolean
    C1411824 (UMLS CUI [1])
    C1856566 (UMLS CUI [2])
    dementia syndrome with atypical symptomatic
    Item
    V. Clinical possible AD Dementia syndrome with atypical symptomatic with regard to onset, course and deficit profile, in absence of other neurological, psychiatric or internal disease that could cause the dementia syndrome
    boolean
    C0497327 (UMLS CUI [1,1])
    C0231220 (UMLS CUI [1,2])
    second systemic or brain disease
    Item
    Second systemic or brain disease that could cause dementia, but is commonly not regarded as a substantial cause
    boolean
    C0442893 (UMLS CUI [1])
    C0006111 (UMLS CUI [2])
    progressive severe cognitive deficit
    Item
    Progressive severe cognitive deficit without notable different cause
    boolean
    C0009241 (UMLS CUI [1,1])
    C0205329 (UMLS CUI [1,2])
    C0205082 (UMLS CUI [1,3])
    Item Group
    Posterior cortical atrophy (PCA)
    C0235946 (UMLS CUI-1)
    C0205095 (UMLS CUI-2)
    PCA diagnosis
    Item
    Is the patient currently diagnosed with PCA according to the criteria of Mendez et.al. 2002?
    boolean
    C0235946 (UMLS CUI [1,1])
    C0205095 (UMLS CUI [1,2])
    insidious onset and gradual progression
    Item
    Main symptoms (all symptoms have to be present) A. Insidious onset and gradual progression
    boolean
    C1298634 (UMLS CUI [1])
    C1854645 (UMLS CUI [2])
    visual disorders
    Item
    B. Presentation with visual disorders while visual function intact
    boolean
    C0042790 (UMLS CUI [1])
    prominent complex visual deficits
    Item
    C. Evidence of prominent complex visual deficits
    boolean
    C3665347 (UMLS CUI [1,1])
    C0205402 (UMLS CUI [1,2])
    C0439855 (UMLS CUI [1,3])
    Balint syndrome
    Item
    Elements of Balint syndrome
    boolean
    C0270706 (UMLS CUI [1])
    visual agnosia
    Item
    Visual agnosia
    boolean
    C0234502 (UMLS CUI [1])
    dressing apraxia
    Item
    Dressing apraxis
    boolean
    C0234529 (UMLS CUI [1])
    topographic disorientation
    Item
    Topographic disorientation
    boolean
    C0233407 (UMLS CUI [1,1])
    C1639223 (UMLS CUI [1,2])
    relatively small deficits of memory and word fluency
    Item
    D. Relatively small memory deficits and word fluency deficits
    boolean
    C0233794 (UMLS CUI [1,1])
    C1843272 (UMLS CUI [1,2])
    C2018029 (UMLS CUI [2,1])
    C1843272 (UMLS CUI [2,2])
    relatively good awareness of disability
    Item
    E. Relatively good awareness of disability with or without depression
    boolean
    C0424227 (UMLS CUI [1,1])
    C0205170 (UMLS CUI [1,2])
    presenile onset
    Item
    Subsidiary diagnosis A. Presenile onset
    boolean
    C0750901 (UMLS CUI [1])
    alexia
    Item
    B. Alexia
    boolean
    C0002018 (UMLS CUI [1])
    Gerstmann syndrome
    Item
    C. Elements of Gerstmann syndrome
    boolean
    C0017494 (UMLS CUI [1])
    ideomotor apraxia
    Item
    D. Ideomotor apraxia
    boolean
    C0234523 (UMLS CUI [1])
    physical examination
    Item
    E. Physical examination within the norms
    boolean
    C0031809 (UMLS CUI [1])
    impairment of perceptual functions
    Item
    F. Neuropsychiatric: Prominent impairment of perceptual functions
    boolean
    C0233746 (UMLS CUI [1])
    occipitoparietal abnormality
    Item
    Imaging: Prominent occipitoparietal abnormality (especially in functional imaging) with relative recess of frontal and mesiotemporal regions
    boolean
    C1704258 (UMLS CUI [1,1])
    C1184145 (UMLS CUI [1,2])
    C0442030 (UMLS CUI [1,3])
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