ID

13664

Description

Background and Purpose: The purpose of the DESCRIBE study is to document the natural course of diseases in context of medical care of neurodegenerative disorders as well as cerebrovascular diseases and to perform phenotyping of the test persons. Disease-spanning analyses of the measured clincial data, the results of the imaging processes, results of the analysis of the biometerials including genetic analysis are planed. Principal Investigator: Prof. Klockgether, Dr. Spottke DZNE, Bonn. Source: DESCRIBE-Studie http://www.dzne.de/forschung/forschungsbereiche/klinische-forschung/studien/describe-bn006.html Participating Study Sites: Berlin, Bonn, Göttingen, Dresden, Köln, Magdeburg, München, Rostock/Greifswald, Tübingen

Link

http://www.dzne.de/forschung/forschungsbereiche/klinische-forschung/studien/describe-bn006.html

Keywords

Versions (14)
  1. 2/24/16 2/24/16 -
  2. 3/1/16 3/1/16 -
  3. 3/2/16 3/2/16 -
  4. 3/3/16 3/3/16 -
  5. 3/3/16 3/3/16 -
  6. 3/4/16 3/4/16 - Julian Varghese
  7. 3/7/16 3/7/16 -
  8. 3/9/16 3/9/16 -
  9. 3/9/16 3/9/16 -
  10. 3/9/16 3/9/16 -
  11. 3/10/16 3/10/16 -
  12. 3/10/16 3/10/16 -
  13. 4/13/21 4/13/21 - Dr. rer. medic Philipp Neuhaus
  14. 9/20/21 9/20/21 -
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February 24, 2016

DOI

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License

Creative Commons BY-NC 3.0
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DESCRIBE (DZNE – Clinical Register Study of neurodegenerative Disorders) CRF Diagnostic Criteria

English

CRF Diagnostic Criteria

1 forms  
Date of visit
Description

Date of visit

Alias
UMLS CUI-1
C1320303
Date of visit
Description

date of visit

Data type

date

Alias
UMLS CUI [1]
C1320303
Study-ID:
Description

study id

Data type

text

Alias
UMLS CUI [1]
C2826693
Visit:
Description

visit name

Data type

text

Alias
UMLS CUI [1]
C2826704
Mild cognitive impairment (MCI)
Description

Mild cognitive impairment (MCI)

Alias
UMLS CUI-1
C1270972
Is the patient currently diagnosed with a MCI according to Winblad & Petersen 2004?
Description

current MCI

Data type

boolean

Alias
UMLS CUI [1,1]
C1270972
UMLS CUI [1,2]
C0150312
Cognitive Impairment 1. Subjective deterioration of cognition observed by the patient or an informant and/or...
Description

cognitive degration

Data type

boolean

Alias
UMLS CUI [1,1]
C1270972
UMLS CUI [1,2]
C0854193
2. Evidence of degradation of cognition in time due to psychometric tests
Description

psychometric test proving cognitive degradation

Data type

boolean

Alias
UMLS CUI [1,1]
C1270972
UMLS CUI [1,2]
C0033920
3. Ability to perform activities of everyday living/ minimal impairment of complex instrumental everyday functions
Description

everyday functioning

Data type

boolean

Alias
UMLS CUI [1]
C0562507
4. No signs of disturbed consciousness, of a delirium, of a dementia or of an amnesic aphasia that cannot be explained better by other psychotic illnesses (e.g. a disorder in connection with psychotropic substances or major depression).
Description

signs of disturbed consciousness

Data type

boolean

Alias
UMLS CUI [1]
C0234428
UMLS CUI [2]
C0011206
UMLS CUI [3]
C0497327
Operationalization 1. Wordlist - delayed word retrieval
Description

At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

Data type

boolean

Alias
UMLS CUI [1]
C0456660
2. Visuospatial ability - Drawing
Description

At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

Data type

boolean

Alias
UMLS CUI [1]
C0814069
UMLS CUI [2]
C0565772
3. Visuospatial ability - Delayed retrieval
Description

At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

Data type

boolean

Alias
UMLS CUI [1]
C0814069
4. Trial making test A or B
Description

At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

Data type

boolean

Alias
UMLS CUI [1]
C0040604
5. Semantic or phonetic fluency
Description

At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

Data type

boolean

Alias
UMLS CUI [1]
C0233714
6. Object naming
Description

At least <= 1.5*SD deficit (in relation to age, gender and professional status), determined with Baseler CERAD Tools, scored in one of the following CERAD tests

Data type

boolean

Alias
UMLS CUI [1]
C0451342
7. No abnormal finding FAQ
Description

normal finding FAQ

Data type

boolean

Alias
UMLS CUI [1,1]
C3827007
UMLS CUI [1,2]
C0205307
Classification a. Amnesic MCI single domain (only memory)
Description

amnesic MCI single domain

Data type

boolean

Alias
UMLS CUI [1]
C1270972
b. Amnesic MCI multi domain (memory and one additional area)
Description

amnesic MCI multi domain

Data type

boolean

Alias
UMLS CUI [1]
C1270972
c. Non-amnesic MCI single domain (one area, except memory)
Description

non-amnesic MCI single domain

Data type

boolean

Alias
UMLS CUI [1]
C1270972
d. Non-amnesic MCI multi domain (several areas, except memory)
Description

non-amnesic MCI multi domain

Data type

boolean

Alias
UMLS CUI [1]
C1270972
Dementia in Alzheimer's Disease (AD)
Description

Dementia in Alzheimer's Disease (AD)

Alias
UMLS CUI-1
C3665464
Is the patient currently diagnosed with AD according to NINCDS/ADRDA-Criteria (McKhann et al. 1984)?
Description

NINCDS/ADRDA-Criteria AD diagnosis

Data type

boolean

Alias
UMLS CUI [1,1]
C3665464
UMLS CUI [1,2]
C2828081
I. Necessary requirements Evidence of dementia in a clinical examination including neuropsychological tests
Description

Clinical probable AD

Data type

boolean

Alias
UMLS CUI [1]
C0497327
UMLS CUI [2]
C0027902
Deficits in at least two cognitive areas
Description

cognitive deficits

Data type

boolean

Alias
UMLS CUI [1]
C0009241
Progressive disturbance of memory and other cognitive functions
Description

progressive disturbance of memory

Data type

boolean

Alias
UMLS CUI [1,1]
C1864985
UMLS CUI [1,2]
C0025260
UMLS CUI [2,1]
C1864985
UMLS CUI [2,2]
C0392335
No consciousness disturbance
Description

no consciousness disturbance

Data type

boolean

Alias
UMLS CUI [1]
C0424525
Onset between age of 40 and 90, mostly 65 and older
Description

age at onset

Data type

boolean

Alias
UMLS CUI [1]
C0150907
No evidence of other system- or brain diseases as cause
Description

other system- or brain diseases

Data type

boolean

Alias
UMLS CUI [1]
C0442893
UMLS CUI [2]
C0006111
II. Subsidiary Findings Progressive deterioration of specific cognitive functions, e.g. of speech (aphasia), motor activity (apraxia) and perception (agnosia)
Description

progressive deterioration of specific cognitive functions

Data type

boolean

Alias
UMLS CUI [1,1]
C0854193
UMLS CUI [1,2]
C0205329
Impairment of everyday activities and emerging of behavior modifications
Description

impairment of everyday activities and behavioral change

Data type

boolean

Alias
UMLS CUI [1,1]
C0562507
UMLS CUI [1,2]
C0221099
UMLS CUI [2]
C0542299
Family history of similar disorders (especially if neurologically proven)
Description

family history of similar disorders

Data type

boolean

Alias
UMLS CUI [1]
C0241889
Results of additional examinations: Evidence of - progressively evolving in follow ups- cerebral atrophy due to imaging diagnostics
Description

cerebral atrophy

Data type

boolean

Alias
UMLS CUI [1]
C0235946
Normal finding or unspecific changes in EEG
Description

normal finding or unspecific changes in EEG

Data type

boolean

Alias
UMLS CUI [1,1]
C0234550
UMLS CUI [1,2]
C0205307
UMLS CUI [2,1]
C0234550
UMLS CUI [2,2]
C0750540
Normal finding of cerebrospinal fluid
Description

normal finding of cerebrospinal fluid

Data type

boolean

Alias
UMLS CUI [1,1]
C0007806
UMLS CUI [1,2]
C0205307
III. Matching with a probable diagnosis of Alzheimer's disease Temporal stagnation in course of disease
Description

diagnosis of Alzheimers disease

Data type

boolean

Alias
UMLS CUI [1,1]
C1848980
UMLS CUI [1,2]
C0242656
Attendant symptoms like depression, insomnia, incontinence, illusion, hallucination, delusion, sudden aggressive outbreaks, sexual dysfunction and weight loss
Description

attendant symptoms

Data type

boolean

Alias
UMLS CUI [1]
C0011581
UMLS CUI [2]
C0917801
UMLS CUI [3]
C0021167
UMLS CUI [4]
C0020903
UMLS CUI [5]
C0018524
UMLS CUI [6]
C0011253
UMLS CUI [7]
C0001807
UMLS CUI [8]
C0549622
UMLS CUI [9]
C0936227
Neurological distinctive feature (particularly in case of advanced disease) like elevated muscle tonus, myoclonus or gait disturbance
Description

neurological distinctive feature

Data type

boolean

Alias
UMLS CUI [1,1]
C1704258
UMLS CUI [1,2]
C0205494
UMLS CUI [2]
C0026841
UMLS CUI [3]
C0027066
UMLS CUI [4]
C1856566
Epileptic seizure (in case of advanced disease)
Description

epileptic seizure

Data type

boolean

Alias
UMLS CUI [1]
C1411824
CT commensurate with age
Description

CT commensurate with age

Data type

boolean

Alias
UMLS CUI [1,1]
C0040405
UMLS CUI [1,2]
C0001783
IV. Exclusion Criteria Sudden, apoplectic onset
Description

sudden apoplectic onset

Data type

boolean

Alias
UMLS CUI [1,1]
C1388315
UMLS CUI [1,2]
C1276802
Focal neurological signs like hemiparesis, sensorial failures, visual field defects or problems with coordination in early stage of disease
Description

focal neurological signs

Data type

boolean

Alias
UMLS CUI [1]
C0018989
UMLS CUI [2]
C0152027
UMLS CUI [3]
C0004134
UMLS CUI [4]
C3887875
Epileptic seizures or gait disturbance at onset or in early stage of disease
Description

epileptic seizures or gait disturbance

Data type

boolean

Alias
UMLS CUI [1]
C1411824
UMLS CUI [2]
C1856566
V. Clinical possible AD Dementia syndrome with atypical symptomatic with regard to onset, course and deficit profile, in absence of other neurological, psychiatric or internal disease that could cause the dementia syndrome
Description

dementia syndrome with atypical symptomatic

Data type

boolean

Alias
UMLS CUI [1,1]
C0497327
UMLS CUI [1,2]
C0231220
Second systemic or brain disease that could cause dementia, but is commonly not regarded as a substantial cause
Description

second systemic or brain disease

Data type

boolean

Alias
UMLS CUI [1]
C0442893
UMLS CUI [2]
C0006111
Progressive severe cognitive deficit without notable different cause
Description

progressive severe cognitive deficit

Data type

boolean

Alias
UMLS CUI [1,1]
C0009241
UMLS CUI [1,2]
C0205329
UMLS CUI [1,3]
C0205082
Posterior cortical atrophy (PCA)
Description

Posterior cortical atrophy (PCA)

Alias
UMLS CUI-1
C0235946
UMLS CUI-2
C0205095
Is the patient currently diagnosed with PCA according to the criteria of Mendez et.al. 2002?
Description

PCA diagnosis

Data type

boolean

Alias
UMLS CUI [1,1]
C0235946
UMLS CUI [1,2]
C0205095
Main symptoms (all symptoms have to be present) A. Insidious onset and gradual progression
Description

insidious onset and gradual progression

Data type

boolean

Alias
UMLS CUI [1]
C1298634
UMLS CUI [2]
C1854645
B. Presentation with visual disorders while visual function intact
Description

visual disorders

Data type

boolean

Alias
UMLS CUI [1]
C0042790
C. Evidence of prominent complex visual deficits
Description

prominent complex visual deficits

Data type

boolean

Alias
UMLS CUI [1,1]
C3665347
UMLS CUI [1,2]
C0205402
UMLS CUI [1,3]
C0439855
Elements of Balint syndrome
Description

Balint syndrome

Data type

boolean

Alias
UMLS CUI [1]
C0270706
Visual agnosia
Description

visual agnosia

Data type

boolean

Alias
UMLS CUI [1]
C0234502
Dressing apraxis
Description

dressing apraxia

Data type

boolean

Alias
UMLS CUI [1]
C0234529
Topographic disorientation
Description

topographic disorientation

Data type

boolean

Alias
UMLS CUI [1,1]
C0233407
UMLS CUI [1,2]
C1639223
D. Relatively small memory deficits and word fluency deficits
Description

relatively small deficits of memory and word fluency

Data type

boolean

Alias
UMLS CUI [1,1]
C0233794
UMLS CUI [1,2]
C1843272
UMLS CUI [2,1]
C2018029
UMLS CUI [2,2]
C1843272
E. Relatively good awareness of disability with or without depression
Description

relatively good awareness of disability

Data type

boolean

Alias
UMLS CUI [1,1]
C0424227
UMLS CUI [1,2]
C0205170
Subsidiary diagnosis A. Presenile onset
Description

presenile onset

Data type

boolean

Alias
UMLS CUI [1]
C0750901
B. Alexia
Description

alexia

Data type

boolean

Alias
UMLS CUI [1]
C0002018
C. Elements of Gerstmann syndrome
Description

Gerstmann syndrome

Data type

boolean

Alias
UMLS CUI [1]
C0017494
D. Ideomotor apraxia
Description

ideomotor apraxia

Data type

boolean

Alias
UMLS CUI [1]
C0234523
E. Physical examination within the norms
Description

physical examination

Data type

boolean

Alias
UMLS CUI [1]
C0031809
F. Neuropsychiatric: Prominent impairment of perceptual functions
Description

impairment of perceptual functions

Data type

boolean

Alias
UMLS CUI [1]
C0233746
Imaging: Prominent occipitoparietal abnormality (especially in functional imaging) with relative recess of frontal and mesiotemporal regions
Description

occipitoparietal abnormality

Data type

boolean

Alias
UMLS CUI [1,1]
C1704258
UMLS CUI [1,2]
C1184145
UMLS CUI [1,3]
C0442030
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Similar models

CRF Diagnostic Criteria

1 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Date of visit
C1320303 (UMLS CUI-1)
date of visit
Item
Date of visit
date
C1320303 (UMLS CUI [1])
study id
Item
Study-ID:
text
C2826693 (UMLS CUI [1])
visit name
Item
Visit:
text
C2826704 (UMLS CUI [1])
Item Group
Mild cognitive impairment (MCI)
C1270972 (UMLS CUI-1)
current MCI
Item
Is the patient currently diagnosed with a MCI according to Winblad & Petersen 2004?
boolean
C1270972 (UMLS CUI [1,1])
C0150312 (UMLS CUI [1,2])
cognitive degration
Item
Cognitive Impairment 1. Subjective deterioration of cognition observed by the patient or an informant and/or...
boolean
C1270972 (UMLS CUI [1,1])
C0854193 (UMLS CUI [1,2])
psychometric test proving cognitive degradation
Item
2. Evidence of degradation of cognition in time due to psychometric tests
boolean
C1270972 (UMLS CUI [1,1])
C0033920 (UMLS CUI [1,2])
everyday functioning
Item
3. Ability to perform activities of everyday living/ minimal impairment of complex instrumental everyday functions
boolean
C0562507 (UMLS CUI [1])
signs of disturbed consciousness
Item
4. No signs of disturbed consciousness, of a delirium, of a dementia or of an amnesic aphasia that cannot be explained better by other psychotic illnesses (e.g. a disorder in connection with psychotropic substances or major depression).
boolean
C0234428 (UMLS CUI [1])
C0011206 (UMLS CUI [2])
C0497327 (UMLS CUI [3])
wordlist
Item
Operationalization 1. Wordlist - delayed word retrieval
boolean
C0456660 (UMLS CUI [1])
visuospatial ability
Item
2. Visuospatial ability - Drawing
boolean
C0814069 (UMLS CUI [1])
C0565772 (UMLS CUI [2])
visuospatial ability delayed
Item
3. Visuospatial ability - Delayed retrieval
boolean
C0814069 (UMLS CUI [1])
trail making test
Item
4. Trial making test A or B
boolean
C0040604 (UMLS CUI [1])
semantic or phonetic fluency
Item
5. Semantic or phonetic fluency
boolean
C0233714 (UMLS CUI [1])
object naming
Item
6. Object naming
boolean
C0451342 (UMLS CUI [1])
normal finding FAQ
Item
7. No abnormal finding FAQ
boolean
C3827007 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
amnesic MCI single domain
Item
Classification a. Amnesic MCI single domain (only memory)
boolean
C1270972 (UMLS CUI [1])
amnesic MCI multi domain
Item
b. Amnesic MCI multi domain (memory and one additional area)
boolean
C1270972 (UMLS CUI [1])
non-amnesic MCI single domain
Item
c. Non-amnesic MCI single domain (one area, except memory)
boolean
C1270972 (UMLS CUI [1])
non-amnesic MCI multi domain
Item
d. Non-amnesic MCI multi domain (several areas, except memory)
boolean
C1270972 (UMLS CUI [1])
Item Group
Dementia in Alzheimer's Disease (AD)
C3665464 (UMLS CUI-1)
NINCDS/ADRDA-Criteria AD diagnosis
Item
Is the patient currently diagnosed with AD according to NINCDS/ADRDA-Criteria (McKhann et al. 1984)?
boolean
C3665464 (UMLS CUI [1,1])
C2828081 (UMLS CUI [1,2])
dementia
Item
I. Necessary requirements Evidence of dementia in a clinical examination including neuropsychological tests
boolean
C0497327 (UMLS CUI [1])
C0027902 (UMLS CUI [2])
cognitive deficits
Item
Deficits in at least two cognitive areas
boolean
C0009241 (UMLS CUI [1])
progressive disturbance of memory
Item
Progressive disturbance of memory and other cognitive functions
boolean
C1864985 (UMLS CUI [1,1])
C0025260 (UMLS CUI [1,2])
C1864985 (UMLS CUI [2,1])
C0392335 (UMLS CUI [2,2])
no consciousness disturbance
Item
No consciousness disturbance
boolean
C0424525 (UMLS CUI [1])
age at onset
Item
Onset between age of 40 and 90, mostly 65 and older
boolean
C0150907 (UMLS CUI [1])
other system- or brain diseases
Item
No evidence of other system- or brain diseases as cause
boolean
C0442893 (UMLS CUI [1])
C0006111 (UMLS CUI [2])
progressive deterioration of specific cognitive functions
Item
II. Subsidiary Findings Progressive deterioration of specific cognitive functions, e.g. of speech (aphasia), motor activity (apraxia) and perception (agnosia)
boolean
C0854193 (UMLS CUI [1,1])
C0205329 (UMLS CUI [1,2])
impairment of everyday activities and behavioral change
Item
Impairment of everyday activities and emerging of behavior modifications
boolean
C0562507 (UMLS CUI [1,1])
C0221099 (UMLS CUI [1,2])
C0542299 (UMLS CUI [2])
family history of similar disorders
Item
Family history of similar disorders (especially if neurologically proven)
boolean
C0241889 (UMLS CUI [1])
cerebral atrophy
Item
Results of additional examinations: Evidence of - progressively evolving in follow ups- cerebral atrophy due to imaging diagnostics
boolean
C0235946 (UMLS CUI [1])
normal finding or unspecific changes in EEG
Item
Normal finding or unspecific changes in EEG
boolean
C0234550 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C0234550 (UMLS CUI [2,1])
C0750540 (UMLS CUI [2,2])
normal finding of cerebrospinal fluid
Item
Normal finding of cerebrospinal fluid
boolean
C0007806 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
diagnosis of Alzheimers disease
Item
III. Matching with a probable diagnosis of Alzheimer's disease Temporal stagnation in course of disease
boolean
C1848980 (UMLS CUI [1,1])
C0242656 (UMLS CUI [1,2])
attendant symptoms
Item
Attendant symptoms like depression, insomnia, incontinence, illusion, hallucination, delusion, sudden aggressive outbreaks, sexual dysfunction and weight loss
boolean
C0011581 (UMLS CUI [1])
C0917801 (UMLS CUI [2])
C0021167 (UMLS CUI [3])
C0020903 (UMLS CUI [4])
C0018524 (UMLS CUI [5])
C0011253 (UMLS CUI [6])
C0001807 (UMLS CUI [7])
C0549622 (UMLS CUI [8])
C0936227 (UMLS CUI [9])
neurological distinctive feature
Item
Neurological distinctive feature (particularly in case of advanced disease) like elevated muscle tonus, myoclonus or gait disturbance
boolean
C1704258 (UMLS CUI [1,1])
C0205494 (UMLS CUI [1,2])
C0026841 (UMLS CUI [2])
C0027066 (UMLS CUI [3])
C1856566 (UMLS CUI [4])
epileptic seizure
Item
Epileptic seizure (in case of advanced disease)
boolean
C1411824 (UMLS CUI [1])
CT commensurate with age
Item
CT commensurate with age
boolean
C0040405 (UMLS CUI [1,1])
C0001783 (UMLS CUI [1,2])
sudden apoplectic onset
Item
IV. Exclusion Criteria Sudden, apoplectic onset
boolean
C1388315 (UMLS CUI [1,1])
C1276802 (UMLS CUI [1,2])
focal neurological signs
Item
Focal neurological signs like hemiparesis, sensorial failures, visual field defects or problems with coordination in early stage of disease
boolean
C0018989 (UMLS CUI [1])
C0152027 (UMLS CUI [2])
C0004134 (UMLS CUI [3])
C3887875 (UMLS CUI [4])
epileptic seizures or gait disturbance
Item
Epileptic seizures or gait disturbance at onset or in early stage of disease
boolean
C1411824 (UMLS CUI [1])
C1856566 (UMLS CUI [2])
dementia syndrome with atypical symptomatic
Item
V. Clinical possible AD Dementia syndrome with atypical symptomatic with regard to onset, course and deficit profile, in absence of other neurological, psychiatric or internal disease that could cause the dementia syndrome
boolean
C0497327 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
second systemic or brain disease
Item
Second systemic or brain disease that could cause dementia, but is commonly not regarded as a substantial cause
boolean
C0442893 (UMLS CUI [1])
C0006111 (UMLS CUI [2])
progressive severe cognitive deficit
Item
Progressive severe cognitive deficit without notable different cause
boolean
C0009241 (UMLS CUI [1,1])
C0205329 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,3])
Item Group
Posterior cortical atrophy (PCA)
C0235946 (UMLS CUI-1)
C0205095 (UMLS CUI-2)
PCA diagnosis
Item
Is the patient currently diagnosed with PCA according to the criteria of Mendez et.al. 2002?
boolean
C0235946 (UMLS CUI [1,1])
C0205095 (UMLS CUI [1,2])
insidious onset and gradual progression
Item
Main symptoms (all symptoms have to be present) A. Insidious onset and gradual progression
boolean
C1298634 (UMLS CUI [1])
C1854645 (UMLS CUI [2])
visual disorders
Item
B. Presentation with visual disorders while visual function intact
boolean
C0042790 (UMLS CUI [1])
prominent complex visual deficits
Item
C. Evidence of prominent complex visual deficits
boolean
C3665347 (UMLS CUI [1,1])
C0205402 (UMLS CUI [1,2])
C0439855 (UMLS CUI [1,3])
Balint syndrome
Item
Elements of Balint syndrome
boolean
C0270706 (UMLS CUI [1])
visual agnosia
Item
Visual agnosia
boolean
C0234502 (UMLS CUI [1])
dressing apraxia
Item
Dressing apraxis
boolean
C0234529 (UMLS CUI [1])
topographic disorientation
Item
Topographic disorientation
boolean
C0233407 (UMLS CUI [1,1])
C1639223 (UMLS CUI [1,2])
relatively small deficits of memory and word fluency
Item
D. Relatively small memory deficits and word fluency deficits
boolean
C0233794 (UMLS CUI [1,1])
C1843272 (UMLS CUI [1,2])
C2018029 (UMLS CUI [2,1])
C1843272 (UMLS CUI [2,2])
relatively good awareness of disability
Item
E. Relatively good awareness of disability with or without depression
boolean
C0424227 (UMLS CUI [1,1])
C0205170 (UMLS CUI [1,2])
presenile onset
Item
Subsidiary diagnosis A. Presenile onset
boolean
C0750901 (UMLS CUI [1])
alexia
Item
B. Alexia
boolean
C0002018 (UMLS CUI [1])
Gerstmann syndrome
Item
C. Elements of Gerstmann syndrome
boolean
C0017494 (UMLS CUI [1])
ideomotor apraxia
Item
D. Ideomotor apraxia
boolean
C0234523 (UMLS CUI [1])
physical examination
Item
E. Physical examination within the norms
boolean
C0031809 (UMLS CUI [1])
impairment of perceptual functions
Item
F. Neuropsychiatric: Prominent impairment of perceptual functions
boolean
C0233746 (UMLS CUI [1])
occipitoparietal abnormality
Item
Imaging: Prominent occipitoparietal abnormality (especially in functional imaging) with relative recess of frontal and mesiotemporal regions
boolean
C1704258 (UMLS CUI [1,1])
C1184145 (UMLS CUI [1,2])
C0442030 (UMLS CUI [1,3])
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