ID

13433

Descrição

Antibiotic-associated diarrhoea (AAD) is a frequent condition in hospitalised patients receiving antibiotic treatment. The same is true for Clostridium difficile-associated diarrhoea (CDAD) with even more grave consequences of increased morbidity and mortality. The development and evaluation of preventive strategies is one key public health challenge. In the absence of clinically evaluated alternatives, probiotics have been suggested to be beneficial for the prevention of AAD and CDAD. However, data have so far been inconclusive and recently published meta-analyses strongly recommended large state-of-the-art clinical trials on probiotic substances for the prevention of AAD and CDAD. Since the efficacy, side-effects and modes of action of different probiotic bacteria and yeast are strain specific, benefits and risks cannot be generalised. The non-pathogenic yeast Saccharomyces cerevisiae var. boulardii (Sac. boulardii) is considered the most promising probiotic substance for the prevention of AAD and CDAD. We carry out a randomised, placebo controlled, double blind multicentre clinical trial to evaluate Sac. boulardii for the indication of prevention of AAD and CDAD in 1520 adult, hospitalised patients.

Palavras-chave

  1. 09/02/2016 09/02/2016 -
  2. 11/02/2016 11/02/2016 -
Transferido a

11 de fevereiro de 2016

DOI

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Licença

Creative Commons BY-NC 3.0

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SacBo PZ: Case Report Form Hospitalization Diarrhea or AAD or CDAD DRKS00000084 NCT01143272

SacBo PZ: Case Report Form Hospitalization Diarrhea or AAD or CDAD NCT01143272

Current hospitalization
Descrição

Current hospitalization

Was there diarrhea/AAD/CDAD at current hospitalization?
Descrição

Diarrhea/AAD/CDAD

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0011991
UMLS CUI [2]
C0578159
UMLS CUI [3]
C0235952

Similar models

SacBo PZ: Case Report Form Hospitalization Diarrhea or AAD or CDAD NCT01143272

Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
Item Group
Current hospitalization
Diarrhea/AAD/CDAD
Item
Was there diarrhea/AAD/CDAD at current hospitalization?
boolean
C0011991 (UMLS CUI [1])
C0578159 (UMLS CUI [2])
C0235952 (UMLS CUI [3])

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