ID
13429
Beschreibung
Antibiotic-associated diarrhoea (AAD) is a frequent condition in hospitalised patients receiving antibiotic treatment. The same is true for Clostridium difficile-associated diarrhoea (CDAD) with even more grave consequences of increased morbidity and mortality. The development and evaluation of preventive strategies is one key public health challenge. In the absence of clinically evaluated alternatives, probiotics have been suggested to be beneficial for the prevention of AAD and CDAD. However, data have so far been inconclusive and recently published meta-analyses strongly recommended large state-of-the-art clinical trials on probiotic substances for the prevention of AAD and CDAD. Since the efficacy, side-effects and modes of action of different probiotic bacteria and yeast are strain specific, benefits and risks cannot be generalised. The non-pathogenic yeast Saccharomyces cerevisiae var. boulardii (Sac. boulardii) is considered the most promising probiotic substance for the prevention of AAD and CDAD. We carry out a randomised, placebo controlled, double blind multicentre clinical trial to evaluate Sac. boulardii for the indication of prevention of AAD and CDAD in 1520 adult, hospitalised patients.
Stichworte
Versionen (2)
- 08.02.16 08.02.16 -
- 11.02.16 11.02.16 -
Hochgeladen am
11. Februar 2016
DOI
Für eine Beantragung loggen Sie sich ein.
Lizenz
Creative Commons BY-NC 3.0
Modell Kommentare :
Hier können Sie das Modell kommentieren. Über die Sprechblasen an den Itemgruppen und Items können Sie diese spezifisch kommentieren.
Itemgroup Kommentare für :
Item Kommentare für :
Um Formulare herunterzuladen müssen Sie angemeldet sein. Bitte loggen Sie sich ein oder registrieren Sie sich kostenlos.
SacBo PZ: Case Report Form First Visit CRP, Leukocytes DRKS00000084 NCT01143272
SacBo PZ: Case Report Form First Visit CRP, Leukocytes NCT01143272
Beschreibung
CRP
Alias
- UMLS CUI-1
- C0201657
Beschreibung
CRP value
Datentyp
integer
Alias
- UMLS CUI [1]
- C0201657
Beschreibung
CRP measurement not done
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0201657
- UMLS CUI [1,2]
- C1272696
Beschreibung
Unit mg/L
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0439268
Beschreibung
Unit mg/dL
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0439269
Beschreibung
Different unit
Datentyp
boolean
Alias
- UMLS CUI [1]
- C1519795
Beschreibung
Different unit specification
Datentyp
text
Alias
- UMLS CUI [1]
- C1519795
Beschreibung
Leukocytes
Alias
- UMLS CUI-1
- C0023516
Beschreibung
Leukocytes value
Datentyp
text
Alias
- UMLS CUI [1]
- C0023508
Beschreibung
Leukocyte measurement not performed
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0023508
- UMLS CUI [1,2]
- C1272696
Beschreibung
Unit 10**9/L
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0456615
Beschreibung
Unit /mcL = /mm3
Datentyp
boolean
Alias
- UMLS CUI [1]
- C1300557
Beschreibung
Different unit
Datentyp
boolean
Alias
- UMLS CUI [1]
- C1519795
Beschreibung
Different unit specification
Datentyp
text
Alias
- UMLS CUI [1]
- C1519795
Ähnliche Modelle
SacBo PZ: Case Report Form First Visit CRP, Leukocytes NCT01143272
C1272696 (UMLS CUI [1,2])
C1272696 (UMLS CUI [1,2])