ID
13429
Beschrijving
Antibiotic-associated diarrhoea (AAD) is a frequent condition in hospitalised patients receiving antibiotic treatment. The same is true for Clostridium difficile-associated diarrhoea (CDAD) with even more grave consequences of increased morbidity and mortality. The development and evaluation of preventive strategies is one key public health challenge. In the absence of clinically evaluated alternatives, probiotics have been suggested to be beneficial for the prevention of AAD and CDAD. However, data have so far been inconclusive and recently published meta-analyses strongly recommended large state-of-the-art clinical trials on probiotic substances for the prevention of AAD and CDAD. Since the efficacy, side-effects and modes of action of different probiotic bacteria and yeast are strain specific, benefits and risks cannot be generalised. The non-pathogenic yeast Saccharomyces cerevisiae var. boulardii (Sac. boulardii) is considered the most promising probiotic substance for the prevention of AAD and CDAD. We carry out a randomised, placebo controlled, double blind multicentre clinical trial to evaluate Sac. boulardii for the indication of prevention of AAD and CDAD in 1520 adult, hospitalised patients.
Trefwoorden
Versies (2)
- 08-02-16 08-02-16 -
- 11-02-16 11-02-16 -
Geüploaded op
11 februari 2016
DOI
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Licentie
Creative Commons BY-NC 3.0
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SacBo PZ: Case Report Form First Visit CRP, Leukocytes DRKS00000084 NCT01143272
SacBo PZ: Case Report Form First Visit CRP, Leukocytes NCT01143272
Beschrijving
CRP
Alias
- UMLS CUI-1
- C0201657
Beschrijving
CRP value
Datatype
integer
Alias
- UMLS CUI [1]
- C0201657
Beschrijving
CRP measurement not done
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0201657
- UMLS CUI [1,2]
- C1272696
Beschrijving
Unit mg/L
Datatype
boolean
Alias
- UMLS CUI [1]
- C0439268
Beschrijving
Unit mg/dL
Datatype
boolean
Alias
- UMLS CUI [1]
- C0439269
Beschrijving
Different unit
Datatype
boolean
Alias
- UMLS CUI [1]
- C1519795
Beschrijving
Different unit specification
Datatype
text
Alias
- UMLS CUI [1]
- C1519795
Beschrijving
Leukocytes
Alias
- UMLS CUI-1
- C0023516
Beschrijving
Leukocytes value
Datatype
text
Alias
- UMLS CUI [1]
- C0023508
Beschrijving
Leukocyte measurement not performed
Datatype
boolean
Alias
- UMLS CUI [1,1]
- C0023508
- UMLS CUI [1,2]
- C1272696
Beschrijving
Unit 10**9/L
Datatype
boolean
Alias
- UMLS CUI [1]
- C0456615
Beschrijving
Unit /mcL = /mm3
Datatype
boolean
Alias
- UMLS CUI [1]
- C1300557
Beschrijving
Different unit
Datatype
boolean
Alias
- UMLS CUI [1]
- C1519795
Beschrijving
Different unit specification
Datatype
text
Alias
- UMLS CUI [1]
- C1519795
Similar models
SacBo PZ: Case Report Form First Visit CRP, Leukocytes NCT01143272
C1272696 (UMLS CUI [1,2])
C1272696 (UMLS CUI [1,2])