ID

11717

Description

The purpose of this study is to test the hypothesis that the inhibition of the renin-angiotensin-aldosterone system (RAAS) with the angiotensin receptor blocker valsartan or the renin antagonist aliskiren will improve ventricular hemodynamics, as reflected by a greater reduction in levels of N-terminal proB-type natriuretic peptide (NT-proBNP) compared to placebo in subjects stabilized following acute coronary syndrome (ACS) who are determined to be at high risk due to an elevated concentration of natriuretic peptides. https://clinicaltrials.gov/ct2/show/NCT00409578

Link

https://clinicaltrials.gov/ct2/show/NCT00409578

Keywords

Versions (1)
  1. 7/28/15 7/28/15 -
Uploaded on

July 28, 2015

DOI

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License

Creative Commons BY 4.0
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Eligibility Aliskiren and Valsartan Acute Coronary Syndrome NCT00409578

English

Eligibility Criteria

1 forms  
  1. StudyEvent: ODM
    1. Eligibility Criteria
Inclusion Criteria
Description

Inclusion Criteria

Male or female outpatients
Description

Male or female outpatients

Data type

boolean

Alias
UMLS CUI-1
C0079399
18 years old or older
Description

18 years old or older

Data type

boolean

Alias
UMLS CUI-1
C0001779
Final diagnosis of acute coronary syndrome
Description

Final diagnosis of acute coronary syndrome

Data type

boolean

Alias
UMLS CUI-1
C0948089
ischemic chest discomfort
Description

ischemic chest discomfort

Data type

boolean

Alias
UMLS CUI-1
C0008031
Elevated concentrations of natriuretic peptide 3-10 days after admission for their qualifying acute coronary syndrome event
Description

Elevated concentrations of natriuretic peptide 3-10 days after admission for their qualifying acute coronary syndrome event

Data type

boolean

Alias
UMLS CUI-1
C1095989
Exclusion criteria
Description

Exclusion criteria

Presence of clinically overt heart failure
Description

Presence of clinically overt heart failure

Data type

boolean

Alias
UMLS CUI-1
C0018801
Known evidence of left ventricular systolic dysfunction
Description

Known evidence of left ventricular systolic dysfunction

Data type

boolean

Alias
UMLS CUI-1
C1277187
Percutaneous coronary intervention (PCI) less than 24 hours before randomization
Description

Percutaneous coronary intervention (PCI) less than 24 hours before randomization

Data type

boolean

Alias
UMLS CUI-1
C1532338
chronic ACEI therapy
Description

chronic ACEI therapy

Data type

boolean

Alias
UMLS CUI-1
C0003015
chronic ARB therapy
Description

chronic ARB therapy

Data type

boolean

Alias
UMLS CUI-1
C0521942
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Similar models

Eligibility Criteria

1 forms
  1. StudyEvent: ODM
    1. Eligibility Criteria
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion Criteria
Gender
Item
Male or female outpatients
boolean
C0079399 (UMLS CUI-1)
Age
Item
18 years old or older
boolean
C0001779 (UMLS CUI-1)
Acute coronary syndrome
Item
Final diagnosis of acute coronary syndrome
boolean
C0948089 (UMLS CUI-1)
Chest pain
Item
ischemic chest discomfort
boolean
C0008031 (UMLS CUI-1)
BNP
Item
Elevated concentrations of natriuretic peptide 3-10 days after admission for their qualifying acute coronary syndrome event
boolean
C1095989 (UMLS CUI-1)
Item Group
Exclusion criteria
Heart failure
Item
Presence of clinically overt heart failure
boolean
C0018801 (UMLS CUI-1)
Left ventricular systolic dysfunction
Item
Known evidence of left ventricular systolic dysfunction
boolean
C1277187 (UMLS CUI-1)
PCI
Item
Percutaneous coronary intervention (PCI) less than 24 hours before randomization
boolean
C1532338 (UMLS CUI-1)
ACE inhibitors
Item
chronic ACEI therapy
boolean
C0003015 (UMLS CUI-1)
ARB
Item
chronic ARB therapy
boolean
C0521942 (UMLS CUI-1)
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