Melanoma Eligibility Interferon Alpha NCT00226408

18-17 Jahre

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Histological documented cutaneous malignant melanoma Stage IIIa, IIIb, IIIc (AJCC 2002)

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R0 resection dating back no longer than 56 days

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Performance status (ECOG 0-1)

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Bone marrow funktion: White cell count > 3000 cells/ul, platletts > 100000 cells/ul, hemoglobin > 10 g/dl

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Liver and kidney funktion: Serum creatinin < 1.5 times upper limit of normal, AST and ALT < 2.5 times upper limit of normal, Serum bilirubin < 2 times upper limit of normal

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Written inform consent

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Confirmed distant metastasis

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Choroid or mucosal melanoma

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Pregnant or lactating women and women of childbearing potential not using a reliable form of contraception

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Active autoimmun disease

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patients with history of neuropsychiatric disease requiring hospitalization

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Severe medical condition such us: Florid hepatitis, Severe acute infection, Myocardial infarction within the past year, symptomatic angina pectoris, Grade III to IV congestive heart failure, serious pulmonary disease, HIV-positive patients with an AIDS - defining condition

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treatment in another clinical drug trial within the last 30 days

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A history of hypersensitivity to interferon alfa

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History of maignant disease during the past 5 years (except for curatively treated skin carcinoma or in situ carcinoma)

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Prior high dose interferon alfa therapy.Prior adjuvant low dose or intermediate-dose interferon alfa therapy is allowed

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