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12 Resultados de la búsqueda.
Relevancia Evaluación Nuevo primero Antiguo primero

dbGaP phs001158 Human Dorsal Root Ganglion RNA Seq Profiling - Eligibility

- 5/6/23 - 5 formularios, 1 itemgroup, 2 items, 1 idioma
Itemgroup: IG.elig
Principal Investigator: Theodore J. Price, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA MeSH: Chronic Pain,Neuralgia https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001158 RNA sequencing was performed on human DRGs and relative gene abundances were calculated. Various analyses were performed: - Human DRG gene expression profiles were contrasted with a panel of gene expression profiles of relevant tissues in human and mouse ( integrating, among other sources, datasets from ENCODE and GTex ) in order to identify. ol type="a"- DRG-enriched gene expression, co-expression modules of DRG-expressed genes, and key transcriptional regulators in humans. - Contrasting the human and mouse DRG transcriptomes to identify DRG-enriched gene expression patterns that were conserved between human and mouse, identifying putative cell types of expression of these genes, and potential known drugs that might target the corresponding gene products. - Characterization of non-coding RNA profile of human and mouse DRGs. - Characterization of DRG-enriched alternative splicing and alternative transcription start site usage based transcript variants in humans and mouse, and the overlap between these two species. - Contrasting of human DRG and GTex human tibial nerve samples to identify putative axonally transported mRNAs in sensory neurons. - Human DRG transcriptomes from donors suffering from neuropathic and/or chronic pain were contrasted with controls to identify. ol type="a"- Differentially expressed genes, pathways and regulators path play a potential role in neuronal plasticity, electrophysiological activity, immune signaling and response. liPredictive models (Random Forests) were built to jointly predict the sex and pain state of samples based on information contained solely in autosomal gene expression profile./li liGene co-expression modules were identified and gene set enrichment analysis performed.to identify sample - pathway associations, and to broadly characterize plasticity in human DRG cell types./li /ol

pht005592.v2.p1

1 itemgroup 5 items

pht005593.v2.p1

1 itemgroup 5 items

pht005594.v2.p1

1 itemgroup 16 items

pht005595.v2.p1

1 itemgroup 10 items

Screening Information QTZ-EC-0004 ELEVATE NCT01713426

- 15/3/21 - 1 formulario, 5 itemgroups, 18 items, 1 idioma
Itemgroups: Screen Fail Status, Informed Consent, Demographics, Inclusion Criteria, Exclusion Criteria
QUTENZA™ versus Pregabalin in Subjects with Peripheral Neuropathic Pain: an Open-label, Randomized, Multicenter, Non-inferiority Efficacy and Tolerability Study Medicine or Vaccine (generic name) capsaicin Sponsor Identification Number QTZ-EC-0004 Trial Registry Identification Number(#'s) NCT01713426 EudraCT Number: 2011-005872-41

Eligibility Neuropathic Pain NCT00480181

- 15/8/17 - 1 formulario, 1 itemgroup, 11 items, 1 idioma
Itemgroup: Inclusion Criteria
Efficacy and Safety Evaluation of Nabilone as Adjunctive Therapy to Gabapentin for the Management of Neuropathic Pain in Multiple Sclerosis; ODM derived from: https://clinicaltrials.gov/show/NCT00480181

Eligibility Neuropathic Pain NCT00291148

- 17/5/17 - 1 formulario, 2 itemgroups, 11 items, 1 idioma
Itemgroups: Inclusion Criteria, Exclusion Criteria
Neuropathic Pain Assessment Comparing Pregabalin and Paroxetine in Management of MS-induced Neuropathic Pain; ODM derived from: https://clinicaltrials.gov/show/NCT00291148

Cover Page QTZ-EC-0004 ELEVATE NCT01713426

- 10/8/16 - 1 formulario, 1 itemgroup, 3 items, 1 idioma
Itemgroup: Patient Information
QUTENZA™ versus Pregabalin in Subjects with Peripheral Neuropathic Pain: an Open-label, Randomized, Multicenter, Non-inferiority Efficacy and Tolerability Study Medicine or Vaccine (generic name) capsaicin Sponsor Identification Number QTZ-EC-0004 Trial Registry Identification Number(#'s) NCT01713426 EudraCT Number: 2011-005872-41

Liver Abnormality QTZ-EC-0004 ELEVATE NCT01713426

- 10/8/16 - 1 formulario, 10 itemgroups, 78 items, 1 idioma
Itemgroups: Date of Visit, Unscheduled Event: Liver Abnormality, Alcohol History, Drug Abuse, Liver Imaging, Serology, Biochemistry - Liver Abnormality, Coagulation - Liver Abnormality, Study Drug Interruption, Comments
QUTENZA™ versus Pregabalin in Subjects with Peripheral Neuropathic Pain: an Open-label, Randomized, Multicenter, Non-inferiority Efficacy and Tolerability Study Medicine or Vaccine (generic name) capsaicin Sponsor Identification Number QTZ-EC-0004 Trial Registry Identification Number(#'s) NCT01713426 EudraCT Number: 2011-005872-41

Unscheduled Event QTZ-EC-0004 ELEVATE NCT01713426

- 8/8/16 - 1 formulario, 8 itemgroups, 34 items, 1 idioma
Itemgroups: Date of Visit, Unscheduled Event Checklist, Physical Examination, Vital signs, Pregnancy Test, Hematology, Biochemistry, Tolerability Assessment
QUTENZA™ versus Pregabalin in Subjects with Peripheral Neuropathic Pain: an Open-label, Randomized, Multicenter, Non-inferiority Efficacy and Tolerability Study Medicine or Vaccine (generic name) capsaicin Sponsor Identification Number QTZ-EC-0004 Trial Registry Identification Number(#'s) NCT01713426 EudraCT Number: 2011-005872-41

Cumulative QTZ-EC-0004 ELEVATE NCT01713426

- 7/8/16 - 1 formulario, 4 itemgroups, 58 items, 1 idioma
Itemgroups: Medication, Non-Medication Therapy, Adverse Event, Administration of Pregabalin
QUTENZA™ versus Pregabalin in Subjects with Peripheral Neuropathic Pain: an Open-label, Randomized, Multicenter, Non-inferiority Efficacy and Tolerability Study Medicine or Vaccine (generic name) capsaicin Sponsor Identification Number QTZ-EC-0004 Trial Registry Identification Number(#'s) NCT01713426 EudraCT Number: 2011-005872-41

Last Visit and End of Study QTZ-EC-0004 ELEVATE NCT01713426

- 7/8/16 - 1 formulario, 6 itemgroups, 23 items, 1 idioma
Itemgroups: Date of Visit, Biochemistry, Dynamic Mechanical Allodynia, Healthcare Resource Use, Tolerability Assessment, End of Study
QUTENZA™ versus Pregabalin in Subjects with Peripheral Neuropathic Pain: an Open-label, Randomized, Multicenter, Non-inferiority Efficacy and Tolerability Study Medicine or Vaccine (generic name) capsaicin Last Visit in Week 8 End of Study Sponsor Identification Number QTZ-EC-0004 Trial Registry Identification Number(#'s) NCT01713426 EudraCT Number: 2011-005872-41

Visit and Telephone Contact QTZ-EC-0004 ELEVATE NCT01713426

- 7/8/16 - 1 formulario, 5 itemgroups, 11 items, 1 idioma
Itemgroups: Date of Visit, Healthcare Resource Use, Tolerability Assessment, Telephone Contact: Date, Telephone Contact: Tolerability Assessment
QUTENZA™ versus Pregabalin in Subjects with Peripheral Neuropathic Pain: an Open-label, Randomized, Multicenter, Non-inferiority Efficacy and Tolerability Study Medicine or Vaccine (generic name) capsaicin Visit: Week 2 - 4 Telephone Contact in Week 6 Sponsor Identification Number QTZ-EC-0004 Trial Registry Identification Number(#'s) NCT01713426 EudraCT Number: 2011-005872-41

Baseline Visit QTZ-EC-0004 ELEVATE NCT01713426

- 1/8/16 - 1 formulario, 15 itemgroups, 62 items, 1 idioma
Itemgroups: Date of Visit, Inclusion Criteria, Exclusion Criteria, Physical Examination, Vital signs, Height and Weight, Pregnancy Test, Randomization, Painful Area: Change, Painful Area, Dynamic Mechanical Allodynia, Healthcare Resource Use, Application of Topical Anesthetic, Application of Qutenza, Tolerability Assessment
QUTENZA™ versus Pregabalin in Subjects with Peripheral Neuropathic Pain: an Open-label, Randomized, Multicenter, Non-inferiority Efficacy and Tolerability Study Medicine or Vaccine (generic name) capsaicin Sponsor Identification Number QTZ-EC-0004 Trial Registry Identification Number(#'s) NCT01713426 EudraCT Number: 2011-005872-41

Screening Procedure QTZ-EC-0004 ELEVATE NCT01713426

- 31/7/16 - 1 formulario, 11 itemgroups, 58 items, 1 idioma
Itemgroups: Date of Visit, Medical History, Primary Diganosis, Physical Examination, Vital signs, Height and Weight, Pregnancy Test, Hematology, Biochemistry, Painful Area, Healthcare Resource Use
QUTENZA™ versus Pregabalin in Subjects with Peripheral Neuropathic Pain: an Open-label, Randomized, Multicenter, Non-inferiority Efficacy and Tolerability Study Medicine or Vaccine (generic name) capsaicin Sponsor Identification Number QTZ-EC-0004 Trial Registry Identification Number(#'s) NCT01713426 EudraCT Number: 2011-005872-41

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