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dbGaP phs001052 Multi-Dimensional ClinOmics for Precision Therapy - Eligibility

- 7/9/23 - 5 forms, 1 itemgroup, 1 item, 1 language
Itemgroup: IG.elig
Principal Investigator: MeSH: Neoplasms,Sarcoma,Sarcoma, Ewing,Rhabdomyosarcoma,Wilms Tumor,Desmoplastic Small Round Cell Tumor,Carcinoma, Transitional Cell,Rhabdoid Tumor,Sarcoma, Synovial,Neuroblastoma,Neuroendocrine tumors https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001052 The Center for Cancer Research (CCR), of the intramural NCI undertook a multidimensional clinical genomics study of children and adolescent young adults with relapsed and refractory cancers who were enrolled on other therapeutic trials to determine the feasibility of a genome guided precision therapy protocol in these patients.

pht005466.v2.p1

1 itemgroup 2 items

pht005467.v2.p1

1 itemgroup 3 items

pht005468.v2.p1

1 itemgroup 3 items

pht005469.v2.p1

1 itemgroup 6 items

dbGaP phs001228 Kids First Pediatric Research Program in Susceptibility to Ewing Sarcoma Based on Germline Risk and Familial History of Cancer - Eligibility

- 5/16/23 - 3 forms, 1 itemgroup, 1 item, 1 language
Itemgroup: IG.elig
Principal Investigator: Joshua D. Schiffman, MD, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA MeSH: Sarcoma, Ewing,Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001228 The Gabriella Miller Kids First Pediatric Research Program (Kids First) is a trans-NIH effort initiated in response to the 2014 Gabriella Miller Kids First Research Act and supported by the NIH Common Fund. This program focuses on gene discovery in pediatric cancers and structural birth defects and the development of the Gabriella Miller Kids First Pediatric Data Resource (Kids First Data Resource). Ewing sarcoma (EWS) is a deadly bone cancer that occurs in children and adolescents. Mounting evidence suggests that a genetic predisposition exists for this pediatric cancer, although the specific genetic contribution has yet to be identified. EWS has never been linked to a specific cancer predisposition syndrome, although several case reports have been published that describe siblings and cousins with EWS. Furthermore, neuroectodermal tumors appear to occur more commonly in families with EWS. The two consistent epidemiology findings in EWS include a very strong Caucasian predilection and increased rates of hernia in EWS patients and their family members. Finally, the role of genetic microsatellite repeats in EWS tumorigenesis has been recently described, and these GGAA microsatellites are polymorphic in repeat size and location across the genome. The study goals of this Kids First project include (1) To identify cancer predisposition genes in EWS trios increasing disease risk, (2) To identify genome-wide GGAA microsatellite repeats in EWS trios increasing disease risk, and (3) To identity de novo mutation and structural variant rates in EWS trios reflecting underlying DNA repair defects that increase disease risk. As part of the Kids First Common Fund initiative, this study proposal will further elucidate the genetic contribution to pediatric cancer development. Around 375 of these trios were selected for whole genome sequencing as part of the Gabriella Miller Kids First fund. The EWS trios have been collected as part of the Children's Oncology Group's AEPI10N5 Study ("Genetic Epidemiology of Ewing Sarcoma"), and each trio has associated phenotypic data including a detailed family history. We will interrogate the sequence data using our genomic analysis pipeline at the University of Utah and the Utah Science Technology and Research initiative's (USTAR) Center for Genetic Discovery. We will look for the genetic contribution to ES and the sequence data with be shared in a repository designated by the Kids First Common Fund. All of the WGS and phenotype data from this study is accessible through kidsfirstdrc.org, where other Kids First datasets can also be accessed. The WGS of these ~375 EWS trios will help us to understand the genetic origins of a deadly childhood cancer and may lead to novel strategies for prevention and treatment.

pht008133.v1.p1

1 itemgroup 2 items

pht008134.v1.p1

1 itemgroup 2 items

Ewing Study disease response VIDE DRKS00003588 NCT00824083 - Disease response VIDE Ewing Study NCT00824083

- 9/20/21 - 1 form, 3 itemgroups, 16 items, 2 languages
Itemgroups: VIDE Response, Primary tumor, Metastasis
EWING 2008, EudraCT 2008-003658-13, http://clinicaltrials.gov/ct2/show/NCT00824083

VIDE course Ewing Study DRKS00003588 NCT00824083 - VIDE course Ewing Study NCT00824083

- 7/25/15 - 1 form, 7 itemgroups, 29 items, 2 languages
Itemgroups: Body dimensions, VIDE course, Schedule deviation CTC-Code, VIDE adminstration of chemotherapy, VIDE adminstration of CYC, VIDE Other drug substitution, Supportive drug treatment
EWING 2008, EudraCT 2008-003658-13, http://clinicaltrials.gov/ct2/show/NCT00824083

Ewing Study Medical History DRKS00003588 NCT00824083 - Anamnese Ewing Studie NCT00824083

- 6/27/15 - 1 form, 2 itemgroups, 14 items, 2 languages
Itemgroups: Allgemeine Anamnese, Time to diagnosis
EWING 2008, EudraCT 2008-003658-13, http://clinicaltrials.gov/ct2/show/NCT00824083

Ewing Study DRKS00003588 - Add-on R1

- 6/25/15 - 1 form, 3 itemgroups, 13 items, 2 languages
Itemgroups: Body dimensions, Add-on Kurs, Schedule deviation CTC-Code
EWING 2008, EudraCT 2008-003658-13, http://clinicaltrials.gov/ct2/show/NCT00824083

Ewing Study DRKS00003588 - VAI and/or VAC Courses

- 6/25/15 - 1 form, 6 itemgroups, 27 items, 2 languages
Itemgroups: Body dimensions, VAI/VAC course, Schedule deviation CTC-Code, Adminstration of VAI or VAC chemotherapy, Other cytotoxic drug, Supportive drug treatment
EWING 2008, EudraCT 2008-003658-13, http://clinicaltrials.gov/ct2/show/NCT00824083

Ewing Study DRKS00003588 - Administration of high dose chemotherapy

- 6/25/15 - 1 form, 6 itemgroups, 27 items, 2 languages
Itemgroups: Body dimensions, High dose chemotherapy course, High dose chemotherapy regimen, Deviation of high dose chemotherapy, Adminstration of high dose chemotherapy, Other cytotoxic drug
EWING 2008, EudraCT 2008-003658-13, http://clinicaltrials.gov/ct2/show/NCT00824083

Ewing Study primary tumor DRKS00003588 NCT00824083 - Primary tumor Ewing Study NCT00824083

- 6/5/15 - 1 form, 2 itemgroups, 14 items, 2 languages
Itemgroups: Tumor location, Volumetry of primary tumor
EWING 2008, EudraCT 2008-003658-13, http://clinicaltrials.gov/ct2/show/NCT00824083

Ewing 2008 Study KOF/Status DRKS00003588 NCT00824083 - KOF/Status Ewing NCT00824083

- 6/5/15 - 1 form, 2 itemgroups, 6 items, 2 languages
Itemgroups: Body Surface Area, Karnofsky
EWING 2008, EudraCT 2008-003658-13, http://clinicaltrials.gov/ct2/show/NCT00824083

Ewing Study Randomisierung DRKS00003588 - Randomisierung

- 8/4/14 - 1 form, 6 itemgroups, 52 items, 2 languages
Itemgroups: Show identification of patient, Anforderung/Risikogruppe, R1, R2loc, R2pulm, R3
EWING 2008, EudraCT 2008-003658-13, http://clinicaltrials.gov/ct2/show/NCT00824083

Ewing Study Rando ergebnis DRKS00003588 - Rando ergebnis

- 8/4/14 - 1 form, 2 itemgroups, 3 items, 2 languages
Itemgroups: Show identification of patient, Ergebnis
EWING 2008, EudraCT 2008-003658-13, http://clinicaltrials.gov/ct2/show/NCT00824083

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