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dbGaP phs000720 Genomic sequencing of Pediatric Rhabdomyosarcoma - Eligibility

- 29.01.25 - 5 Formulare, 1 Itemgruppe, 1 Datenelement, 1 Sprache
Itemgruppe: IG.elig
Principal Investigator: Javed Khan, MD, National Institutes of Health, Bethesda, MD, USA MeSH: Rhabdomyosarcoma,Rhabdomyosarcoma, Alveolar,Rhabdomyosarcoma, Embryonal https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000720 Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood accounting for approximately 350 newly diagnosed cases yearly in the United States. With the development of multimodal chemotherapy regimens, relapse-free survival rates have improved to 70-80% in patients with localized disease albeit with significant toxicity. Unfortunately, despite aggressive treatment, patients with metastatic or recurrent disease continue to suffer from high mortality. Further characterization of the genetic events underlying this tumor type is critical for the development of more effective diagnostic, prognostic and therapeutic strategies. In a collaborative effort between the National Cancer Institute, the Children's Oncology Group, and the Broad Institute, we use a combination of whole-genome and whole-exome sequencing to characterize the landscape of somatic alterations in 147 tumor/normal pairs.

pht003878.v2.p1

1 Itemgruppe 3 Datenelemente

pht003879.v4.p1

1 Itemgruppe 3 Datenelemente

pht003881.v2.p1

1 Itemgruppe 7 Datenelemente

pht003880.v2.p1

1 Itemgruppe 5 Datenelemente

dbGaP phs001052 Multi-Dimensional ClinOmics for Precision Therapy - Eligibility

- 09.07.23 - 5 Formulare, 1 Itemgruppe, 1 Datenelement, 1 Sprache
Itemgruppe: IG.elig
Principal Investigator: MeSH: Neoplasms,Sarcoma,Sarcoma, Ewing,Rhabdomyosarcoma,Wilms Tumor,Desmoplastic Small Round Cell Tumor,Carcinoma, Transitional Cell,Rhabdoid Tumor,Sarcoma, Synovial,Neuroblastoma,Neuroendocrine tumors https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001052 The Center for Cancer Research (CCR), of the intramural NCI undertook a multidimensional clinical genomics study of children and adolescent young adults with relapsed and refractory cancers who were enrolled on other therapeutic trials to determine the feasibility of a genome guided precision therapy protocol in these patients.

pht005466.v2.p1

1 Itemgruppe 2 Datenelemente

pht005467.v2.p1

1 Itemgruppe 3 Datenelemente

pht005468.v2.p1

1 Itemgruppe 3 Datenelemente

pht005469.v2.p1

1 Itemgruppe 6 Datenelemente

Rhabdomyosarcoma treatment CWS-2007-HR DRKS00003774 NCT00876031 - Treatment B4 - Block 6 O-TE Rhabdomyosarcoma NCT00876031

- 11.06.15 - 1 Formular, 11 Itemgruppen, 30 Datenelemente, 2 Sprachen
Itemgruppen: Block O-TE, Toxicity common, Toxicity hematology, Toxicity infection, Toxicity gastrointestinal, Toxicity kidney, Toxicity neurology, Toxicity liver, Toxicity Herz, Toxicity other, Toxicity comment
CWS-2007-HR: A randomised phase-III trial of the Cooperative Soft-Tissue-Study-Group for localised high-risk rhabdomyosarcoma and localised Rhabdomyosarcoma-like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de

Rhabdomyosarcoma treatment CWS-2007-HR DRKS00003774 NCT00876031 - Treatment B4 - Block 4 O-TE Rhabdomyosarcoma NCT00876031

- 11.06.15 - 1 Formular, 11 Itemgruppen, 30 Datenelemente, 2 Sprachen
Itemgruppen: Block O-TE, Toxicity common, Toxicity hematology, Toxicity infection, Toxicity gastrointestinal, Toxicity kidney, Toxicity neurology, Toxicity liver, Toxicity Herz, Toxicity other, Toxicity comment
CWS-2007-HR: A randomised phase-III trial of the Cooperative Soft-Tissue-Study-Group for localised high-risk rhabdomyosarcoma and localised Rhabdomyosarcoma-like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de

Rhabdomyosarcoma Treatment CWS-2007-HR DRKS00003774 NCT00876031 - Treatment Rhabdomyosarcoma B4 - Block 5 O-TI NCT00876031

- 11.06.15 - 1 Formular, 12 Itemgruppen, 33 Datenelemente, 2 Sprachen
Itemgruppen: O-TIE body dimensions, Block O-TI , Toxicity common, Hematologic toxicity, Toxicity infection, Toxicity gastrointestinal, Toxicity kidney, Toxicity neurology, Toxicity liver, Toxicity Herz, Toxicity other, Toxicity comment
CWS-2007-HR: A randomised phase-III trial of the Cooperative Soft-Tissue-Study-Group for localised high-risk rhabdomyosarcoma and localised Rhabdomyosarcoma-like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de

Rhabdomyosarcoma Treatment CWS-2007-HR DRKS00003774 NCT00876031 - Treatment B4 - Block 2 O-TE Rhabdomyosarcoma NCT00876031

- 06.06.15 - 1 Formular, 11 Itemgruppen, 30 Datenelemente, 2 Sprachen
Itemgruppen: Block O-TE, Toxicity common, Toxicity hematology, Toxicity infection, Toxicity gastrointestinal, Toxicity kidney, Toxicity neurology, Toxicity liver, Toxicity Herz, Toxicity other, Toxicity comment
CWS-2007-HR: A randomised phase-III trial of the Cooperative Soft-Tissue-Study-Group for localised high-risk rhabdomyosarcoma and localised Rhabdomyosarcoma-like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de

Rhabdomyosarcoma treatment CWS-2007-HR DRKS00003774 NCT00876031 - Treatment B4 - Block 8 O-TE Rhabdomyosarcoma NCT00876031

- 11.06.15 - 1 Formular, 11 Itemgruppen, 30 Datenelemente, 2 Sprachen
Itemgruppen: Block O-TE, Toxicity common, Toxicity hematology, Toxicity infection, Toxicity gastrointestinal, Toxicity kidney, Toxicity neurology, Toxicity liver, Toxicity Herz, Toxicity other, Toxicity comment
CWS-2007-HR: A randomised phase-III trial of the Cooperative Soft-Tissue-Study-Group for localised high-risk rhabdomyosarcoma and localised Rhabdomyosarcoma-like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de CWS-2007-HR B4 - Block 8 O-TE

Rhabdomyosarcoma treatment CWS-2007-HR DRKS00003774 NCT00876031 - Treatment B4 - Block 1 O-TI Rhabdomyosarcoma NCT00876031

- 11.06.15 - 1 Formular, 13 Itemgruppen, 34 Datenelemente, 2 Sprachen
Itemgruppen: Datum 1. Block, O-TIE body dimensions, Block O-TI , Toxicity common, Toxicity hematology, Toxicity infection, Toxicity gastrointestinal, Toxicity kidney, Toxicity neurology, Toxicity liver, Toxicity Herz, Toxicity other, Toxicity comment
CWS-2007-HR: A randomised phase-III trial of the Cooperative Soft-Tissue-Study-Group for localised high-risk rhabdomyosarcoma and localised Rhabdomyosarcoma-like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de CWS-2007-HR B4 - Block 1 O-TI

Rhabdomyosarcoma CWS-2007-HR DRKS00003774 NCT00876031 - Treatment B4 -Block 7 O-TI Rhabdomyosarcoma NCT00876031

- 11.06.15 - 1 Formular, 11 Itemgruppen, 30 Datenelemente, 2 Sprachen
Itemgruppen: Block O-TI , Toxicity common, Toxicity hematology, Toxicity infection, Toxicity gastrointestinal, Toxicity kidney, Toxicity neurology, Toxicity liver, Toxicity Herz, Toxicity other, Toxicity comment
CWS-2007-HR: A randomised phase-III trial of the Cooperative Soft-Tissue-Study-Group for localised high-risk rhabdomyosarcoma and localised Rhabdomyosarcoma-like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de CWS-2007-HR B4 -Block 7 O-TI

Rhabdomyosarcoma Treatment CWS-2007-HR DRKS00003774 NCT00876031 - Treatment B4 - Block 3 O-TI Rhabdomyosarcoma NCT00876031

- 07.06.15 - 1 Formular, 11 Itemgruppen, 30 Datenelemente, 2 Sprachen
Itemgruppen: Block O-TI , Toxicity common, Toxicity hematology, Toxicity infection, Toxicity gastrointestinal, Toxicity kidney, Toxicity neurology, Toxicity liver, Toxicity Herz, Toxicity other, Toxicity comment
CWS-2007-HR: A randomised phase-III trial of the Cooperative Soft-Tissue-Study-Group for localised high-risk rhabdomyosarcoma and localised Rhabdomyosarcoma-like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de CWS-2007-HR B4 - Block 3 O-TI

CWS-2007-HR B3 - Primaere Standardtherapie DRKS00003774 - B3 - Primaere Standardtherapie

- 06.08.14 - 1 Formular, 5 Itemgruppen, 21 Datenelemente, 2 Sprachen
Itemgruppen: Anzeige Namen auf Formular, Primäre Chemotherapie, Primäre Radiotherapie, Sekundäre Resektion, Remissionsstatus
CWS-2007-HR: A randomised phase-​III trial of the Cooperative Soft-​Tissue-​Study-​Group for localised high-​risk rhabdomyosarcoma and localised Rhabdomyosarcoma-​like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de

CWS-2007-HR B3 - Primaere Diagnostik DRKS00003774 - B3 - Primaere Diagnostik

- 06.08.14 - 1 Formular, 6 Itemgruppen, 34 Datenelemente, 2 Sprachen
Itemgruppen: Anzeige Namen auf Formular, Primäres chirurgisches Vorgehen, pTNM Klassifikation, Histologische Untersuchung, Molekulargenetische Untersuchungen in CWS, IRS-Stadium und Risikogruppe bei Diagnosestellung
CWS-2007-HR: A randomised phase-​III trial of the Cooperative Soft-​Tissue-​Study-​Group for localised high-​risk rhabdomyosarcoma and localised Rhabdomyosarcoma-​like Soft Tissue Sarcoma in children, adolescents, and young adults http://clinicaltrials.gov/show/NCT00876031 http://www.cws.olgahospital-stuttgart.de

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