ID
46177
Beschreibung
Principal Investigator: James T. Elder, Department of Dermatology, University of Michigan, Ann Arbor, MI, USA MeSH: Arthritis, Psoriatic https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000982 This study is a genome-wide study of genetic associations with psoriatic arthritis (PsA), an inflammatory musculoskeletal condition that develops in up to 30% of people who have chronic psoriasis skin lesions. 1,526 cases affected with psoriatic arthritis and 1,508 unaffected controls were recruited and typed on the Illumina HumanOmni1-Quad BeadChip array. After application of quality control measures to both samples and SNPs, genotypes for 791,217 autosomal SNPs were available for 1,430 PsA cases and 1,417 controls. Imputation using phased haplotypes for the EUR subpopulation of release 3, phase 1 of the 1000 Genomes Project as a reference, resulted in genotypes for 11,532,644 SNPs and 918,976 indels passing our imputation quality threshold (Mach rsup2/sup ≥ 0.3) that were available for downstream analysis. Association at a genome-wide threshold of significance was found for five regions (near genes *TNIP1*, *IL12B*, *HLA-C*, *TRAF3IP2*, and *TYK2*).
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Stichworte
Versionen (2)
- 01.02.23 01.02.23 - Dr. med. Lucy Kessler
- 06.02.25 06.02.25 - Dr. Christian Niklas
Rechteinhaber
James T. Elder, Department of Dermatology, University of Michigan, Ann Arbor, MI, USA
Hochgeladen am
6. Februar 2025
DOI
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Lizenz
Creative Commons BY 4.0
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dbGaP phs000982 Genetic Analysis of Psoriasis and Psoriatic Arthritis
Eligibility Criteria
- StudyEvent: dbGaP phs000982 Genetic Analysis of Psoriasis and Psoriatic Arthritis
- Eligibility Criteria
- This subject consent data table contains subject IDs, consent group information, and case control status of subjects for psoriatic arthritis (PsA).
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype data table includes subject cohort (collection center), sex, race, and case control status for psoriatic arthritis (PsA).
- This sample attributes data table includes body site where sample was collected, analyte type, tumor status, histological type, and genotyping center.
Ähnliche Modelle
Eligibility Criteria
- StudyEvent: dbGaP phs000982 Genetic Analysis of Psoriasis and Psoriatic Arthritis
- Eligibility Criteria
- This subject consent data table contains subject IDs, consent group information, and case control status of subjects for psoriatic arthritis (PsA).
- This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype data table includes subject cohort (collection center), sex, race, and case control status for psoriatic arthritis (PsA).
- This sample attributes data table includes body site where sample was collected, analyte type, tumor status, histological type, and genotyping center.
C0680251 (UMLS CUI [1,2])