ID

46173

Descrizione

Principal Investigator: Steven Kittner, MD, University of Maryland School of Medicine, Baltimore, MD, USA MeSH: Cerebral infarction https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000615 The NINDS Stroke Genetics Network (SiGN) is a large international collaboration designed to detect genetic variants that predispose to subtypes of ischemic stroke. The study implements a genome wide association study (GWAS) methodology with all stroke cases undergoing phenotypic and stroke-subtype classification using the same web-based Causative Classification of Stroke (CCS) system, with data entered by trained and certified adjudicators at participating Research Centers (GRC's). SiGN includes ischemic stroke cases from 24 GRC's, 13 from the US and 11 from Europe. Each GRC has access to well-characterized ischemic stroke cases in which extensive phenotype data and high-quality DNA was available. Genome-wide data was available for many cases and for those without, new genome-wide genotyping, including exome chip genotyping of rare variants, was done through the Center for Inherited Diseases Research (CIDR). To maximize power for subtype analyses, genotyping resources were allocated almost exclusively to cases. With few exceptions, controls were drawn from studies with publicly available genome-wide data.

collegamento

dbGaP study=phs000615

Keywords

versioni (2)

1. 15/11/22 15/11/22 - Simon Heim
2. 29/01/25 29/01/25 - Akane Nishihara

Titolare del copyright

Steven Kittner, MD, University of Maryland School of Medicine, Baltimore, MD, USA

Caricato su

29 gennaio 2025

DOI

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