ID

46172

Descripción

Principal Investigator: Howard McLeod, Moffitt Cancer Center, Tampa, FL, USA MeSH: Prostatic Neoplasms,Neutropenia https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001002 The Cancer and Leukemia Group B (CALGB) 90401 trial compared docetaxel and prednisone with or without bevacizumab in men with metastatic castration-resistant prostate cancer. A genome-wide association study using clinical outcomes and toxicities was conducted on the basis of data from CALGB patients who provided consent for pharmacogenomic studies and usable DNA

Link

dbGaP study=phs001002

Palabras clave

Versiones (2)
  1. 09.11.23 09.11.23 - Simon Heim
  2. 29.01.25 29.01.25 - Akane Nishihara
Titular de derechos de autor

Howard McLeod, Moffitt Cancer Center, Tampa, FL, USA

Subido en

29. Januar 2025

DOI

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Licencia

Creative Commons BY 4.0
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dbGaP phs001002 Metastatic Castration-resistant Prostate Cancer GWAS

Inglés

Subject ID, neuropathy, neutropenia, genetic European status, age, sex, hemoglobin, palliative radiation, specimen(s) limitations, blood specimen, ethnicity, race, medical history of participant smoking and venous and arterial thromboembolism, arterial and or venous thromboembolism, BMI, diabetes, gastrointestinal tract, hemorrhage, Khorana risk status, anti-platelet or anti-coagulant use, and treatment arm assignment of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.

5 formularios  
  1. StudyEvent: dbGaP phs001002 Metastatic Castration-resistant Prostate Cancer GWAS
    1. Eligibility Criteria
    2. Subject ID, consent group, subject source, source subject ID, and affection status of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
    3. Subject ID, sample ID, sample source, source sample ID, and sample use variable obtained from participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
    4. Subject ID, neuropathy, neutropenia, genetic European status, age, sex, hemoglobin, palliative radiation, specimen(s) limitations, blood specimen, ethnicity, race, medical history of participant smoking and venous and arterial thromboembolism, arterial and or venous thromboembolism, BMI, diabetes, gastrointestinal tract, hemorrhage, Khorana risk status, anti-platelet or anti-coagulant use, and treatment arm assignment of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
    5. Sample ID, body site where sample was obtained, analyte type, tumor status of sample, histological type, and genotyping center of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
pht005044
Descripción

pht005044

Alias
UMLS CUI [1,1]
C3846158
De-identified subject ID
Descripción

SUBJECT_ID

Tipo de datos

string

Alias
UMLS CUI [1,1]
C4684638
UMLS CUI [1,2]
C2348585
BSA adjusted cumulative dose to neuropathy event
Descripción

Neuro

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0005902
UMLS CUI [1,2]
C2986497
UMLS CUI [1,3]
C0442874
Neuropathy case status
Descripción

NeuroCens

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0442874
UMLS CUI [1,2]
C5188927
UMLS CUI [1,3]
C1706256
BSA adjusted cumulative dose to neutropenia event
Descripción

Neut

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0005902
UMLS CUI [1,2]
C2986497
UMLS CUI [1,3]
C0027947
Neutropenia case status
Descripción

NeutCens

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0027947
UMLS CUI [1,2]
C1706256
UMLS CUI [1,3]
C5188927
Genetic European status
Descripción

genetic_euro

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0043157
Age of participant
Descripción

age

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
Years
Treatment arm assignment [Active, Placebo]
Descripción

arm

Tipo de datos

string

Alias
UMLS CUI [1,1]
C1522541
Race of participant [American Indian or Alaska Native, Asian, Black or African American, Native Hawaiian or Pacific Islander, White, Unknown]
Descripción

race

Tipo de datos

string

Alias
UMLS CUI [1,1]
C0034510
UMLS CUI [1,2]
C1515945
UMLS CUI [1,3]
C0085756
UMLS CUI [1,4]
C1513907
UMLS CUI [1,5]
C0078988
UMLS CUI [1,6]
C0043157
UMLS CUI [1,7]
C0439673
Gender of participant [Male]
Descripción

sex

Tipo de datos

string

Alias
UMLS CUI [1,1]
C0079399
Hemoglobin at baseline
Descripción

HGB

Tipo de datos

text

Unidades de medida
  • g/dL
Alias
UMLS CUI [1,1]
C0518015
UMLS CUI [1,2]
C1442488
g/dL
Indicator of palliative radiation
Descripción

PALLXRT

Tipo de datos

text

Alias
UMLS CUI [1,1]
C3898008
Specimen(s) use for research unrelated to the patient's cancer
Descripción

consent2

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1524063
UMLS CUI [1,2]
C0370003
UMLS CUI [1,3]
C0445356
UMLS CUI [1,4]
C0006826
UMLS CUI [1,5]
C0683933
Specimen(s) use for future unknown research related to cancer
Descripción

consent6

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1524063
UMLS CUI [1,2]
C0370003
UMLS CUI [1,3]
C0006826
UMLS CUI [1,4]
C0035168
UMLS CUI [1,5]
C2826292
Blood specimen use for genetic research on patient's cancer
Descripción

consent7

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0178913
UMLS CUI [1,2]
C0042153
UMLS CUI [1,3]
C0243064
UMLS CUI [1,4]
C0006826
Ethnicity of participant [Hispanic or Latino, Non-Hispanic, Unknown]
Descripción

ethnicity

Tipo de datos

string

Alias
UMLS CUI [1,1]
C5441552
UMLS CUI [1,2]
C0086409
UMLS CUI [1,3]
C1518424
UMLS CUI [1,4]
C0439673
Prior history of ATE [Yes, No]
Descripción

prior_ate

Tipo de datos

string

Alias
UMLS CUI [1,1]
C0262926
UMLS CUI [1,2]
C3544094
Prior history of VTE [Yes, No]
Descripción

prior_vte

Tipo de datos

string

Alias
UMLS CUI [1,1]
C0262926
UMLS CUI [1,2]
C1861172
ANC value at baseline
Descripción

anc_baseline

Tipo de datos

text

Unidades de medida
  • cells/muL
Alias
UMLS CUI [1,1]
C0948762
UMLS CUI [1,2]
C1442488
cells/muL
History of smoking
Descripción

priorsmoke

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1519384
Current smoking status
Descripción

currentsmoke

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1519386
Anti-platelet or anti-coagulant use
Descripción

anti_plat_coag

Tipo de datos

text

Alias
UMLS CUI [1,1]
C5395451
UMLS CUI [1,2]
C0003280
Pre-existing GI or GU perforation or bleeding episode
Descripción

bld_gi_gu

Tipo de datos

text

Alias
UMLS CUI [1,1]
C2347662
UMLS CUI [1,2]
C0151664
UMLS CUI [1,3]
C0341163
UMLS CUI [1,4]
C1970394
Pre-existing stomach or duodenal ulcer
Descripción

ulcer

Tipo de datos

text

Alias
UMLS CUI [1,1]
C2347662
UMLS CUI [1,2]
C0038358
UMLS CUI [1,3]
C0013295
Body Mass Index at baseline
Descripción

BMI

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1305855
UMLS CUI [1,2]
C1442488
Khorana risk status [Low, Intermediate, High, NA]
Descripción

risk_score

Tipo de datos

string

Alias
UMLS CUI [1,1]
C1319831
UMLS CUI [1,2]
C3846158
Indicator of diabetes
Descripción

Diabetes

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0011849
Neutropenia case status during cycles 1 and 2 of therapy
Descripción

anc_cy1cy2

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0027947
UMLS CUI [1,2]
C3274646
UMLS CUI [1,3]
C5237784
Case status for venous thromboembolism
Descripción

VTE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C3274646
UMLS CUI [1,2]
C1861172
Case status for hemorrhage
Descripción

Hemorrhage

Tipo de datos

text

Alias
UMLS CUI [1,1]
C3274646
UMLS CUI [1,2]
C0019080
Case status for Arterial thromboembolism
Descripción

ATE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C3274646
UMLS CUI [1,2]
C3544094
Volver a la parte superior de la página

Similar models

Subject ID, neuropathy, neutropenia, genetic European status, age, sex, hemoglobin, palliative radiation, specimen(s) limitations, blood specimen, ethnicity, race, medical history of participant smoking and venous and arterial thromboembolism, arterial and or venous thromboembolism, BMI, diabetes, gastrointestinal tract, hemorrhage, Khorana risk status, anti-platelet or anti-coagulant use, and treatment arm assignment of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.

5 formularios
  1. StudyEvent: dbGaP phs001002 Metastatic Castration-resistant Prostate Cancer GWAS
    1. Eligibility Criteria
    2. Subject ID, consent group, subject source, source subject ID, and affection status of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
    3. Subject ID, sample ID, sample source, source sample ID, and sample use variable obtained from participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
    4. Subject ID, neuropathy, neutropenia, genetic European status, age, sex, hemoglobin, palliative radiation, specimen(s) limitations, blood specimen, ethnicity, race, medical history of participant smoking and venous and arterial thromboembolism, arterial and or venous thromboembolism, BMI, diabetes, gastrointestinal tract, hemorrhage, Khorana risk status, anti-platelet or anti-coagulant use, and treatment arm assignment of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
    5. Sample ID, body site where sample was obtained, analyte type, tumor status of sample, histological type, and genotyping center of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de datos
Alias
Item Group
pht005044
C3846158 (UMLS CUI [1,1])
SUBJECT_ID
Item
De-identified subject ID
string
C4684638 (UMLS CUI [1,1])
C2348585 (UMLS CUI [1,2])
Neuro
Item
BSA adjusted cumulative dose to neuropathy event
text
C0005902 (UMLS CUI [1,1])
C2986497 (UMLS CUI [1,2])
C0442874 (UMLS CUI [1,3])
NeuroCens
Item
Neuropathy case status
text
C0442874 (UMLS CUI [1,1])
C5188927 (UMLS CUI [1,2])
C1706256 (UMLS CUI [1,3])
Neut
Item
BSA adjusted cumulative dose to neutropenia event
text
C0005902 (UMLS CUI [1,1])
C2986497 (UMLS CUI [1,2])
C0027947 (UMLS CUI [1,3])
NeutCens
Item
Neutropenia case status
text
C0027947 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C5188927 (UMLS CUI [1,3])
genetic_euro
Item
Genetic European status
text
C0043157 (UMLS CUI [1,1])
age
Item
Age of participant
text
C0001779 (UMLS CUI [1,1])
arm
Item
Treatment arm assignment [Active, Placebo]
string
C1522541 (UMLS CUI [1,1])
race
Item
Race of participant [American Indian or Alaska Native, Asian, Black or African American, Native Hawaiian or Pacific Islander, White, Unknown]
string
C0034510 (UMLS CUI [1,1])
C1515945 (UMLS CUI [1,2])
C0085756 (UMLS CUI [1,3])
C1513907 (UMLS CUI [1,4])
C0078988 (UMLS CUI [1,5])
C0043157 (UMLS CUI [1,6])
C0439673 (UMLS CUI [1,7])
sex
Item
Gender of participant [Male]
string
C0079399 (UMLS CUI [1,1])
HGB
Item
Hemoglobin at baseline
text
C0518015 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
PALLXRT
Item
Indicator of palliative radiation
text
C3898008 (UMLS CUI [1,1])
Item
Specimen(s) use for research unrelated to the patient's cancer
text
C1524063 (UMLS CUI [1,1])
C0370003 (UMLS CUI [1,2])
C0445356 (UMLS CUI [1,3])
C0006826 (UMLS CUI [1,4])
C0683933 (UMLS CUI [1,5])
consent2
Code List
Specimen(s) use for research unrelated to the patient's cancer
CL Item
Blood specimen use for genetic research on patient's cancer (2)
Item
Specimen(s) use for future unknown research related to cancer
text
C1524063 (UMLS CUI [1,1])
C0370003 (UMLS CUI [1,2])
C0006826 (UMLS CUI [1,3])
C0035168 (UMLS CUI [1,4])
C2826292 (UMLS CUI [1,5])
consent6
Code List
Specimen(s) use for future unknown research related to cancer
CL Item
Specimen(s) use for future unknown research related to cancer (6)
Item
Blood specimen use for genetic research on patient's cancer
text
C0178913 (UMLS CUI [1,1])
C0042153 (UMLS CUI [1,2])
C0243064 (UMLS CUI [1,3])
C0006826 (UMLS CUI [1,4])
consent7
Code List
Blood specimen use for genetic research on patient's cancer
CL Item
Blood specimen use for genetic research on patient's cancer (7)
ethnicity
Item
Ethnicity of participant [Hispanic or Latino, Non-Hispanic, Unknown]
string
C5441552 (UMLS CUI [1,1])
C0086409 (UMLS CUI [1,2])
C1518424 (UMLS CUI [1,3])
C0439673 (UMLS CUI [1,4])
prior_ate
Item
Prior history of ATE [Yes, No]
string
C0262926 (UMLS CUI [1,1])
C3544094 (UMLS CUI [1,2])
prior_vte
Item
Prior history of VTE [Yes, No]
string
C0262926 (UMLS CUI [1,1])
C1861172 (UMLS CUI [1,2])
anc_baseline
Item
ANC value at baseline
text
C0948762 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
priorsmoke
Item
History of smoking
text
C1519384 (UMLS CUI [1,1])
currentsmoke
Item
Current smoking status
text
C1519386 (UMLS CUI [1,1])
anti_plat_coag
Item
Anti-platelet or anti-coagulant use
text
C5395451 (UMLS CUI [1,1])
C0003280 (UMLS CUI [1,2])
bld_gi_gu
Item
Pre-existing GI or GU perforation or bleeding episode
text
C2347662 (UMLS CUI [1,1])
C0151664 (UMLS CUI [1,2])
C0341163 (UMLS CUI [1,3])
C1970394 (UMLS CUI [1,4])
ulcer
Item
Pre-existing stomach or duodenal ulcer
text
C2347662 (UMLS CUI [1,1])
C0038358 (UMLS CUI [1,2])
C0013295 (UMLS CUI [1,3])
BMI
Item
Body Mass Index at baseline
text
C1305855 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
risk_score
Item
Khorana risk status [Low, Intermediate, High, NA]
string
C1319831 (UMLS CUI [1,1])
C3846158 (UMLS CUI [1,2])
Diabetes
Item
Indicator of diabetes
text
C0011849 (UMLS CUI [1,1])
anc_cy1cy2
Item
Neutropenia case status during cycles 1 and 2 of therapy
text
C0027947 (UMLS CUI [1,1])
C3274646 (UMLS CUI [1,2])
C5237784 (UMLS CUI [1,3])
VTE
Item
Case status for venous thromboembolism
text
C3274646 (UMLS CUI [1,1])
C1861172 (UMLS CUI [1,2])
Hemorrhage
Item
Case status for hemorrhage
text
C3274646 (UMLS CUI [1,1])
C0019080 (UMLS CUI [1,2])
ATE
Item
Case status for Arterial thromboembolism
text
C3274646 (UMLS CUI [1,1])
C3544094 (UMLS CUI [1,2])
Volver a la parte superior de la página 

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