0 Ratings
ID

46172

Description

Principal Investigator: Howard McLeod, Moffitt Cancer Center, Tampa, FL, USA MeSH: Prostatic Neoplasms,Neutropenia https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001002 The Cancer and Leukemia Group B (CALGB) 90401 trial compared docetaxel and prednisone with or without bevacizumab in men with metastatic castration-resistant prostate cancer. A genome-wide association study using clinical outcomes and toxicities was conducted on the basis of data from CALGB patients who provided consent for pharmacogenomic studies and usable DNA

Link

dbGaP study=phs001002

Keywords

Versions (2)
  1. 11/9/23 11/9/23 - Simon Heim
  2. 1/29/25 1/29/25 - Akane Nishihara
Copyright Holder

Howard McLeod, Moffitt Cancer Center, Tampa, FL, USA

Uploaded on

January 29, 2025

DOI

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Creative Commons BY 4.0
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    dbGaP phs001002 Metastatic Castration-resistant Prostate Cancer GWAS

    English

    Subject ID, neuropathy, neutropenia, genetic European status, age, sex, hemoglobin, palliative radiation, specimen(s) limitations, blood specimen, ethnicity, race, medical history of participant smoking and venous and arterial thromboembolism, arterial and or venous thromboembolism, BMI, diabetes, gastrointestinal tract, hemorrhage, Khorana risk status, anti-platelet or anti-coagulant use, and treatment arm assignment of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.

    5 forms  
    1. StudyEvent: dbGaP phs001002 Metastatic Castration-resistant Prostate Cancer GWAS
      1. Eligibility Criteria
      2. Subject ID, consent group, subject source, source subject ID, and affection status of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
      3. Subject ID, sample ID, sample source, source sample ID, and sample use variable obtained from participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
      4. Subject ID, neuropathy, neutropenia, genetic European status, age, sex, hemoglobin, palliative radiation, specimen(s) limitations, blood specimen, ethnicity, race, medical history of participant smoking and venous and arterial thromboembolism, arterial and or venous thromboembolism, BMI, diabetes, gastrointestinal tract, hemorrhage, Khorana risk status, anti-platelet or anti-coagulant use, and treatment arm assignment of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
      5. Sample ID, body site where sample was obtained, analyte type, tumor status of sample, histological type, and genotyping center of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
    pht005044
    Description

    pht005044

    Alias
    UMLS CUI [1,1]
    C3846158
    De-identified subject ID
    Description

    SUBJECT_ID

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C4684638
    UMLS CUI [1,2]
    C2348585
    BSA adjusted cumulative dose to neuropathy event
    Description

    Neuro

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0005902
    UMLS CUI [1,2]
    C2986497
    UMLS CUI [1,3]
    C0442874
    Neuropathy case status
    Description

    NeuroCens

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0442874
    UMLS CUI [1,2]
    C5188927
    UMLS CUI [1,3]
    C1706256
    BSA adjusted cumulative dose to neutropenia event
    Description

    Neut

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0005902
    UMLS CUI [1,2]
    C2986497
    UMLS CUI [1,3]
    C0027947
    Neutropenia case status
    Description

    NeutCens

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0027947
    UMLS CUI [1,2]
    C1706256
    UMLS CUI [1,3]
    C5188927
    Genetic European status
    Description

    genetic_euro

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0043157
    Age of participant
    Description

    age

    Data type

    text

    Measurement units
    • Years
    Alias
    UMLS CUI [1,1]
    C0001779
    Years
    Treatment arm assignment [Active, Placebo]
    Description

    arm

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C1522541
    Race of participant [American Indian or Alaska Native, Asian, Black or African American, Native Hawaiian or Pacific Islander, White, Unknown]
    Description

    race

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C0034510
    UMLS CUI [1,2]
    C1515945
    UMLS CUI [1,3]
    C0085756
    UMLS CUI [1,4]
    C1513907
    UMLS CUI [1,5]
    C0078988
    UMLS CUI [1,6]
    C0043157
    UMLS CUI [1,7]
    C0439673
    Gender of participant [Male]
    Description

    sex

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C0079399
    Hemoglobin at baseline
    Description

    HGB

    Data type

    text

    Measurement units
    • g/dL
    Alias
    UMLS CUI [1,1]
    C0518015
    UMLS CUI [1,2]
    C1442488
    g/dL
    Indicator of palliative radiation
    Description

    PALLXRT

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C3898008
    Specimen(s) use for research unrelated to the patient's cancer
    Description

    consent2

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C1524063
    UMLS CUI [1,2]
    C0370003
    UMLS CUI [1,3]
    C0445356
    UMLS CUI [1,4]
    C0006826
    UMLS CUI [1,5]
    C0683933
    Specimen(s) use for future unknown research related to cancer
    Description

    consent6

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C1524063
    UMLS CUI [1,2]
    C0370003
    UMLS CUI [1,3]
    C0006826
    UMLS CUI [1,4]
    C0035168
    UMLS CUI [1,5]
    C2826292
    Blood specimen use for genetic research on patient's cancer
    Description

    consent7

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0178913
    UMLS CUI [1,2]
    C0042153
    UMLS CUI [1,3]
    C0243064
    UMLS CUI [1,4]
    C0006826
    Ethnicity of participant [Hispanic or Latino, Non-Hispanic, Unknown]
    Description

    ethnicity

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C5441552
    UMLS CUI [1,2]
    C0086409
    UMLS CUI [1,3]
    C1518424
    UMLS CUI [1,4]
    C0439673
    Prior history of ATE [Yes, No]
    Description

    prior_ate

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C0262926
    UMLS CUI [1,2]
    C3544094
    Prior history of VTE [Yes, No]
    Description

    prior_vte

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C0262926
    UMLS CUI [1,2]
    C1861172
    ANC value at baseline
    Description

    anc_baseline

    Data type

    text

    Measurement units
    • cells/muL
    Alias
    UMLS CUI [1,1]
    C0948762
    UMLS CUI [1,2]
    C1442488
    cells/muL
    History of smoking
    Description

    priorsmoke

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C1519384
    Current smoking status
    Description

    currentsmoke

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C1519386
    Anti-platelet or anti-coagulant use
    Description

    anti_plat_coag

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C5395451
    UMLS CUI [1,2]
    C0003280
    Pre-existing GI or GU perforation or bleeding episode
    Description

    bld_gi_gu

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C2347662
    UMLS CUI [1,2]
    C0151664
    UMLS CUI [1,3]
    C0341163
    UMLS CUI [1,4]
    C1970394
    Pre-existing stomach or duodenal ulcer
    Description

    ulcer

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C2347662
    UMLS CUI [1,2]
    C0038358
    UMLS CUI [1,3]
    C0013295
    Body Mass Index at baseline
    Description

    BMI

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C1305855
    UMLS CUI [1,2]
    C1442488
    Khorana risk status [Low, Intermediate, High, NA]
    Description

    risk_score

    Data type

    string

    Alias
    UMLS CUI [1,1]
    C1319831
    UMLS CUI [1,2]
    C3846158
    Indicator of diabetes
    Description

    Diabetes

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0011849
    Neutropenia case status during cycles 1 and 2 of therapy
    Description

    anc_cy1cy2

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0027947
    UMLS CUI [1,2]
    C3274646
    UMLS CUI [1,3]
    C5237784
    Case status for venous thromboembolism
    Description

    VTE

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C3274646
    UMLS CUI [1,2]
    C1861172
    Case status for hemorrhage
    Description

    Hemorrhage

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C3274646
    UMLS CUI [1,2]
    C0019080
    Case status for Arterial thromboembolism
    Description

    ATE

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C3274646
    UMLS CUI [1,2]
    C3544094
    Back to the top of the page

    Similar models

    Subject ID, neuropathy, neutropenia, genetic European status, age, sex, hemoglobin, palliative radiation, specimen(s) limitations, blood specimen, ethnicity, race, medical history of participant smoking and venous and arterial thromboembolism, arterial and or venous thromboembolism, BMI, diabetes, gastrointestinal tract, hemorrhage, Khorana risk status, anti-platelet or anti-coagulant use, and treatment arm assignment of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.

    5 forms
    1. StudyEvent: dbGaP phs001002 Metastatic Castration-resistant Prostate Cancer GWAS
      1. Eligibility Criteria
      2. Subject ID, consent group, subject source, source subject ID, and affection status of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
      3. Subject ID, sample ID, sample source, source sample ID, and sample use variable obtained from participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
      4. Subject ID, neuropathy, neutropenia, genetic European status, age, sex, hemoglobin, palliative radiation, specimen(s) limitations, blood specimen, ethnicity, race, medical history of participant smoking and venous and arterial thromboembolism, arterial and or venous thromboembolism, BMI, diabetes, gastrointestinal tract, hemorrhage, Khorana risk status, anti-platelet or anti-coagulant use, and treatment arm assignment of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
      5. Sample ID, body site where sample was obtained, analyte type, tumor status of sample, histological type, and genotyping center of participants with metastatic castration-resistant prostate cancer and involved in the "A Genome-Wide Association Study of CALGB 90401: Randomized, Double-Blind, Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone with or without Bevacizumab in Men with Metastatic Castration-Resistant Prostate Cancer" project.
    Name
    Type
    Description | Question | Decode (Coded Value)
    Data type
    Alias
    Item Group
    pht005044
    C3846158 (UMLS CUI [1,1])
    SUBJECT_ID
    Item
    De-identified subject ID
    string
    C4684638 (UMLS CUI [1,1])
    C2348585 (UMLS CUI [1,2])
    Neuro
    Item
    BSA adjusted cumulative dose to neuropathy event
    text
    C0005902 (UMLS CUI [1,1])
    C2986497 (UMLS CUI [1,2])
    C0442874 (UMLS CUI [1,3])
    NeuroCens
    Item
    Neuropathy case status
    text
    C0442874 (UMLS CUI [1,1])
    C5188927 (UMLS CUI [1,2])
    C1706256 (UMLS CUI [1,3])
    Neut
    Item
    BSA adjusted cumulative dose to neutropenia event
    text
    C0005902 (UMLS CUI [1,1])
    C2986497 (UMLS CUI [1,2])
    C0027947 (UMLS CUI [1,3])
    NeutCens
    Item
    Neutropenia case status
    text
    C0027947 (UMLS CUI [1,1])
    C1706256 (UMLS CUI [1,2])
    C5188927 (UMLS CUI [1,3])
    genetic_euro
    Item
    Genetic European status
    text
    C0043157 (UMLS CUI [1,1])
    age
    Item
    Age of participant
    text
    C0001779 (UMLS CUI [1,1])
    arm
    Item
    Treatment arm assignment [Active, Placebo]
    string
    C1522541 (UMLS CUI [1,1])
    race
    Item
    Race of participant [American Indian or Alaska Native, Asian, Black or African American, Native Hawaiian or Pacific Islander, White, Unknown]
    string
    C0034510 (UMLS CUI [1,1])
    C1515945 (UMLS CUI [1,2])
    C0085756 (UMLS CUI [1,3])
    C1513907 (UMLS CUI [1,4])
    C0078988 (UMLS CUI [1,5])
    C0043157 (UMLS CUI [1,6])
    C0439673 (UMLS CUI [1,7])
    sex
    Item
    Gender of participant [Male]
    string
    C0079399 (UMLS CUI [1,1])
    HGB
    Item
    Hemoglobin at baseline
    text
    C0518015 (UMLS CUI [1,1])
    C1442488 (UMLS CUI [1,2])
    PALLXRT
    Item
    Indicator of palliative radiation
    text
    C3898008 (UMLS CUI [1,1])
    Item
    Specimen(s) use for research unrelated to the patient's cancer
    text
    C1524063 (UMLS CUI [1,1])
    C0370003 (UMLS CUI [1,2])
    C0445356 (UMLS CUI [1,3])
    C0006826 (UMLS CUI [1,4])
    C0683933 (UMLS CUI [1,5])
    consent2
    Code List
    Specimen(s) use for research unrelated to the patient's cancer
    CL Item
    Blood specimen use for genetic research on patient's cancer (2)
    Item
    Specimen(s) use for future unknown research related to cancer
    text
    C1524063 (UMLS CUI [1,1])
    C0370003 (UMLS CUI [1,2])
    C0006826 (UMLS CUI [1,3])
    C0035168 (UMLS CUI [1,4])
    C2826292 (UMLS CUI [1,5])
    consent6
    Code List
    Specimen(s) use for future unknown research related to cancer
    CL Item
    Specimen(s) use for future unknown research related to cancer (6)
    Item
    Blood specimen use for genetic research on patient's cancer
    text
    C0178913 (UMLS CUI [1,1])
    C0042153 (UMLS CUI [1,2])
    C0243064 (UMLS CUI [1,3])
    C0006826 (UMLS CUI [1,4])
    consent7
    Code List
    Blood specimen use for genetic research on patient's cancer
    CL Item
    Blood specimen use for genetic research on patient's cancer (7)
    ethnicity
    Item
    Ethnicity of participant [Hispanic or Latino, Non-Hispanic, Unknown]
    string
    C5441552 (UMLS CUI [1,1])
    C0086409 (UMLS CUI [1,2])
    C1518424 (UMLS CUI [1,3])
    C0439673 (UMLS CUI [1,4])
    prior_ate
    Item
    Prior history of ATE [Yes, No]
    string
    C0262926 (UMLS CUI [1,1])
    C3544094 (UMLS CUI [1,2])
    prior_vte
    Item
    Prior history of VTE [Yes, No]
    string
    C0262926 (UMLS CUI [1,1])
    C1861172 (UMLS CUI [1,2])
    anc_baseline
    Item
    ANC value at baseline
    text
    C0948762 (UMLS CUI [1,1])
    C1442488 (UMLS CUI [1,2])
    priorsmoke
    Item
    History of smoking
    text
    C1519384 (UMLS CUI [1,1])
    currentsmoke
    Item
    Current smoking status
    text
    C1519386 (UMLS CUI [1,1])
    anti_plat_coag
    Item
    Anti-platelet or anti-coagulant use
    text
    C5395451 (UMLS CUI [1,1])
    C0003280 (UMLS CUI [1,2])
    bld_gi_gu
    Item
    Pre-existing GI or GU perforation or bleeding episode
    text
    C2347662 (UMLS CUI [1,1])
    C0151664 (UMLS CUI [1,2])
    C0341163 (UMLS CUI [1,3])
    C1970394 (UMLS CUI [1,4])
    ulcer
    Item
    Pre-existing stomach or duodenal ulcer
    text
    C2347662 (UMLS CUI [1,1])
    C0038358 (UMLS CUI [1,2])
    C0013295 (UMLS CUI [1,3])
    BMI
    Item
    Body Mass Index at baseline
    text
    C1305855 (UMLS CUI [1,1])
    C1442488 (UMLS CUI [1,2])
    risk_score
    Item
    Khorana risk status [Low, Intermediate, High, NA]
    string
    C1319831 (UMLS CUI [1,1])
    C3846158 (UMLS CUI [1,2])
    Diabetes
    Item
    Indicator of diabetes
    text
    C0011849 (UMLS CUI [1,1])
    anc_cy1cy2
    Item
    Neutropenia case status during cycles 1 and 2 of therapy
    text
    C0027947 (UMLS CUI [1,1])
    C3274646 (UMLS CUI [1,2])
    C5237784 (UMLS CUI [1,3])
    VTE
    Item
    Case status for venous thromboembolism
    text
    C3274646 (UMLS CUI [1,1])
    C1861172 (UMLS CUI [1,2])
    Hemorrhage
    Item
    Case status for hemorrhage
    text
    C3274646 (UMLS CUI [1,1])
    C0019080 (UMLS CUI [1,2])
    ATE
    Item
    Case status for Arterial thromboembolism
    text
    C3274646 (UMLS CUI [1,1])
    C3544094 (UMLS CUI [1,2])
    Back to the top of the page 

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