ID
46168
Descrição
Principal Investigator: Francesca Demichelis, PhD, Centre for Integrative Biology, University of Trento, Trento, Italy MeSH: Prostatic Neoplasms https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000487 Prostate cancer is a leading cause of cancer death in males throughout the world and has the largest estimated effect of heritability among the most common tumor types. Copy Number Variants (CNVs) are a recently recognized class of human germline polymorphisms (Iafrate AJ, et al. (2004) Nat Genet 36, 949-951; Sebat J, et al. (2004) Science 305, 525-528.) and are associated with a variety of human diseases, including cancer. This study characterized 1,903 individuals from the Tyrol Early Prostate Cancer Detection Program (Bartsch G, et al. (2008) BJU Int 101, 809-816) using a computational framework (Banerjee S, et al. (2011) PLoS One 29;6(3)). The study results establish non-coding and coding germline CNVs as significant risk factors for prostate cancer susceptibility and implicate their role in disease development and progression. The study "Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk," Demichelis F, Setlur SR, Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6686-91.
Link
https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000487
Palavras-chave
Versões (2)
- 23/01/2023 23/01/2023 - Dr. med. Lucy Kessler
- 29/01/2025 29/01/2025 - Akane Nishihara
Titular dos direitos
Francesca Demichelis, PhD, Centre for Integrative Biology, University of Trento, Trento, Italy
Transferido a
29 de janeiro de 2025
DOI
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Licença
Creative Commons BY 4.0
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dbGaP phs000487 Functionally Active Copy Number Variants Associated with Prostate Cancer Risk
Eligibility Criteria
- StudyEvent: dbGaP phs000487 Functionally Active Copy Number Variants Associated with Prostate Cancer Risk
- Eligibility Criteria
- Subject ID, subject source, subject source ID, consent group, and affection status of participants with or without prostate cancer and involved in the "Functionally Active Copy Number Variants Associated with Prostate Cancer Risk" project.
- Sample ID, subject ID, sample source, sample source ID, and sample use variables obtained from participants with or without prostate cancer and involved in the "Functionally Active Copy Number Variants Associated with Prostate Cancer Risk" project.
- Subject ID, case or control, age at diagnosis, age when individual was imputed, PSA, and Gleason score of participants with or without prostate cancer and involved in the "Functionally Active Copy Number Variants Associated with Prostate Cancer Risk" project.
- Sample ID, body site where sample was collected, analyte type of samples, tumor status, and histological type of samples obtained from participants with or without prostate cancer and involved in the "Functionally Active Copy Number Variants Associated with Prostate Cancer Risk" project.
Similar models
Eligibility Criteria
- StudyEvent: dbGaP phs000487 Functionally Active Copy Number Variants Associated with Prostate Cancer Risk
- Eligibility Criteria
- Subject ID, subject source, subject source ID, consent group, and affection status of participants with or without prostate cancer and involved in the "Functionally Active Copy Number Variants Associated with Prostate Cancer Risk" project.
- Sample ID, subject ID, sample source, sample source ID, and sample use variables obtained from participants with or without prostate cancer and involved in the "Functionally Active Copy Number Variants Associated with Prostate Cancer Risk" project.
- Subject ID, case or control, age at diagnosis, age when individual was imputed, PSA, and Gleason score of participants with or without prostate cancer and involved in the "Functionally Active Copy Number Variants Associated with Prostate Cancer Risk" project.
- Sample ID, body site where sample was collected, analyte type of samples, tumor status, and histological type of samples obtained from participants with or without prostate cancer and involved in the "Functionally Active Copy Number Variants Associated with Prostate Cancer Risk" project.
C0680251 (UMLS CUI [1,2])
C1704788 (UMLS CUI [1,2])
C0027365 (UMLS CUI [1,3])