ID

46166

Beschrijving

Principal Investigator: Craig Wong, MD, MPH, University of New Mexico, Health Sciences Center and UNM Children's Hospital, Albuquerque, NM, USA MeSH: Kidney Diseases,Renal Insufficiency,Renal Insufficiency, Chronic https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000650 The Pediatric Investigation for Genetic Factors Associated with Renal Progression (PediGFR) (RO1-DK082394) is an international collaborative study among three large prospective cohort studies of children with chronic kidney disease. The participating parent cohort studies are the "Chronic Kidney Disease in Children (CKiD)", the "Effect of Strict Blood Pressure Control and ACE Inhibition on CRF Progression in Pediatric Patients (ESCAPE)", and the "Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C)" study. In these cohorts, pediatric subjects with CKD have been prospectively followed with standardized measurements for renal progression. The current version of the upload includes the genotype and baseline phenotype for the CKiD cohort. In brief the CKiD study is a prospective study of children with chronic kidney disease (CKD) between the ages of 1 year to 16 years of age and an estimated glomerular filtration rate (eGFR) by Schwartz equation between 30 and 75 ml/min per 1.73msup2/sup. Included in this upload are the phenotypic data for anemia traits utilized for the sub-study, "Role of Genetic Variation in the Anemia of Chronic Kidney Disease" (K24DK078737), with the RBC trait and anemia data pertaining to CKiD as well.

Link

dbGaP study=phs000650

Trefwoorden

  1. 24-01-23 24-01-23 - Simon Heim
  2. 29-01-25 29-01-25 - Akane Nishihara
Houder van rechten

Craig Wong, MD, MPH, University of New Mexico, Health Sciences Center and UNM Children's Hospital, Albuquerque, NM, USA

Geüploaded op

29 januari 2025

DOI

Voor een aanvraag inloggen.

Licentie

Creative Commons BY 4.0

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dbGaP phs000650 Genetic Factors Linked with Renal Progression (PediGFR) - CKiD

The data inform about type of kidney disease diagnosed, blood/urine analysis values, measurements of height/weight, Tanner stage of subjects, and provide general socio-demographic data. There has been no change in data compared to study version 1, but the study has become a substudy of phs000842 , the PediGFR cohort study.

pht003486
Beschrijving

pht003486

Alias
UMLS CUI [1,1]
C3846158
Subject ID
Beschrijving

KID

Datatype

string

Alias
UMLS CUI [1,1]
C2348585
Child's gender
Beschrijving

MALE1FE0

Datatype

text

Alias
UMLS CUI [1,1]
C0079399
Primary diagnosis of Chronic Kidney Disease
Beschrijving

PRIMDX

Datatype

text

Alias
UMLS CUI [1,1]
C0332137
UMLS CUI [1,2]
C1561643
Child's Primary Diagnosis (Grouped categories, diseases affecting the glomerulous vs. no)
Beschrijving

GNGDIAG

Datatype

text

Alias
UMLS CUI [1,1]
C0008059
UMLS CUI [1,2]
C0332137
UMLS CUI [1,3]
C0683312
UMLS CUI [1,4]
C0268731
Average Height
Beschrijving

AVHEIGHT

Datatype

float

Maateenheden
  • cm
Alias
UMLS CUI [1,1]
C1510992
UMLS CUI [1,2]
C0005890
cm
Average Weight
Beschrijving

AVWEIGHT

Datatype

text

Maateenheden
  • kg
Alias
UMLS CUI [1,1]
C1510992
UMLS CUI [1,2]
C0005910
kg
Tanner Stage
Beschrijving

TANNER

Datatype

text

Alias
UMLS CUI [1,1]
C2826146
IGFR (GFR4, GFR3 or GFR2)
Beschrijving

iGFR

Datatype

float

Alias
UMLS CUI [1,1]
C1334088
Serum Creatinine
Beschrijving

SCr

Datatype

float

Alias
UMLS CUI [1,1]
C0600061
Cystatin
Beschrijving

CYC_DB

Datatype

float

Alias
UMLS CUI [1,1]
C0010646
BUN, collected from L05 (CBL)
Beschrijving

BUN

Datatype

text

Alias
UMLS CUI [1,1]
C0005845
UMLS CUI [1,2]
C0812242
Urine Protein/Creatinine
Beschrijving

upcratio

Datatype

float

Alias
UMLS CUI [1,1]
C1316828
Child's race
Beschrijving

RACE

Datatype

text

Alias
UMLS CUI [1,1]
C0034510
UMLS CUI [1,2]
C0008059
Child of Hispanic/Latino
Beschrijving

HISP

Datatype

text

Alias
UMLS CUI [1,1]
C0008059
UMLS CUI [1,2]
C0086409
UMLS CUI [1,3]
C0086528
Whether genotyping is performed on the subject?
Beschrijving

genotyped

Datatype

text

Alias
UMLS CUI [1,1]
C1285573
UMLS CUI [1,2]
C0884358
Hemoglobin concentration
Beschrijving

Hemoglobin

Datatype

float

Maateenheden
  • g/dL
Alias
UMLS CUI [1,1]
C1318517
g/dL
Hematocrit
Beschrijving

Hematocrit

Datatype

float

Maateenheden
  • %
Alias
UMLS CUI [1,1]
C0518014
%
Mean corpuscular hemoglobin
Beschrijving

MCH

Datatype

float

Maateenheden
  • pg
Alias
UMLS CUI [1,1]
C0474535
pg
Mean corpuscular hemoglobin concentration
Beschrijving

MCHC

Datatype

float

Maateenheden
  • g/dL
Alias
UMLS CUI [1,1]
C0474535
g/dL
Mean corpuscular volume
Beschrijving

MCV

Datatype

float

Maateenheden
  • fL
Alias
UMLS CUI [1,1]
C1948043
fL
Red blood cell count
Beschrijving

RBCCount

Datatype

float

Maateenheden
  • MIL/L
Alias
UMLS CUI [1,1]
C0014772
MIL/L

Similar models

The data inform about type of kidney disease diagnosed, blood/urine analysis values, measurements of height/weight, Tanner stage of subjects, and provide general socio-demographic data. There has been no change in data compared to study version 1, but the study has become a substudy of phs000842 , the PediGFR cohort study.

Name
Type
Description | Question | Decode (Coded Value)
Datatype
Alias
Item Group
pht003486
C3846158 (UMLS CUI [1,1])
KID
Item
Subject ID
string
C2348585 (UMLS CUI [1,1])
Item
Child's gender
text
C0079399 (UMLS CUI [1,1])
Code List
Child's gender
CL Item
Missing (-9)
CL Item
Female (0)
C0086287 (UMLS CUI [1,1])
CL Item
Male (1)
C0086582 (UMLS CUI [1,1])
PRIMDX
Item
Primary diagnosis of Chronic Kidney Disease
text
C0332137 (UMLS CUI [1,1])
C1561643 (UMLS CUI [1,2])
Item
Child's Primary Diagnosis (Grouped categories, diseases affecting the glomerulous vs. no)
text
C0008059 (UMLS CUI [1,1])
C0332137 (UMLS CUI [1,2])
C0683312 (UMLS CUI [1,3])
C0268731 (UMLS CUI [1,4])
Code List
Child's Primary Diagnosis (Grouped categories, diseases affecting the glomerulous vs. no)
CL Item
Glom (HUS) (1)
CL Item
Glom (NOT HUS) (2)
CL Item
Non-glom (GU, Cystic, Hereditary) (3)
CL Item
Non-glom (NOT GU, NOT Cystic, NOT Hereditary) (4)
AVHEIGHT
Item
Average Height
float
C1510992 (UMLS CUI [1,1])
C0005890 (UMLS CUI [1,2])
AVWEIGHT
Item
Average Weight
text
C1510992 (UMLS CUI [1,1])
C0005910 (UMLS CUI [1,2])
Item
Tanner Stage
text
C2826146 (UMLS CUI [1,1])
Code List
Tanner Stage
CL Item
Missing (-9)
CL Item
Stage 1 (1)
CL Item
Stage 2 (2)
CL Item
Stage 3 (3)
CL Item
Stage 4 (4)
CL Item
Stage 5 (5)
iGFR
Item
IGFR (GFR4, GFR3 or GFR2)
float
C1334088 (UMLS CUI [1,1])
SCr
Item
Serum Creatinine
float
C0600061 (UMLS CUI [1,1])
CYC_DB
Item
Cystatin
float
C0010646 (UMLS CUI [1,1])
BUN
Item
BUN, collected from L05 (CBL)
text
C0005845 (UMLS CUI [1,1])
C0812242 (UMLS CUI [1,2])
upcratio
Item
Urine Protein/Creatinine
float
C1316828 (UMLS CUI [1,1])
Item
Child's race
text
C0034510 (UMLS CUI [1,1])
C0008059 (UMLS CUI [1,2])
Code List
Child's race
CL Item
Missing (-9)
CL Item
Caucasian (1)
CL Item
African-American (2)
CL Item
American Indian (3)
CL Item
Native Hawaiian (4)
CL Item
Asian (5)
CL Item
Other (6)
CL Item
More than one race (excluding AA race) (7)
C0034510 (UMLS CUI [1,1])
CL Item
More than one race (including AA race) (8)
C0034510 (UMLS CUI [1,1])
Item
Child of Hispanic/Latino
text
C0008059 (UMLS CUI [1,1])
C0086409 (UMLS CUI [1,2])
C0086528 (UMLS CUI [1,3])
Code List
Child of Hispanic/Latino
CL Item
No (0)
CL Item
Yes (1)
CL Item
Missing (-9)
Item
Whether genotyping is performed on the subject?
text
C1285573 (UMLS CUI [1,1])
C0884358 (UMLS CUI [1,2])
Code List
Whether genotyping is performed on the subject?
CL Item
No (0)
CL Item
Yes (1)
Hemoglobin
Item
Hemoglobin concentration
float
C1318517 (UMLS CUI [1,1])
Hematocrit
Item
Hematocrit
float
C0518014 (UMLS CUI [1,1])
MCH
Item
Mean corpuscular hemoglobin
float
C0474535 (UMLS CUI [1,1])
MCHC
Item
Mean corpuscular hemoglobin concentration
float
C0474535 (UMLS CUI [1,1])
MCV
Item
Mean corpuscular volume
float
C1948043 (UMLS CUI [1,1])
RBCCount
Item
Red blood cell count
float
C0014772 (UMLS CUI [1,1])

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