ID
46161
Beskrivning
Principal Investigator: Arul Chinnaiyan, M.D., Ph.D, University of Michigan MeSH: prostate cancer https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000443 Noncoding RNAs (ncRNAs) are emerging as key molecules in human cancer, with the potential to serve as novel markers of disease and to reveal uncharacterized aspects of tumor biology. Here we discover 121 unannotated prostate cancer-associated ncRNA transcripts (PCATs) by *ab initio* assembly of high-throughput sequencing of polyA+ RNA (RNA-Seq) from a cohort of 102 prostate tissues and cells lines. We characterized one ncRNA, PCAT-1, as a prostate-specific regulator of cell proliferation and show that it is a target of the polycomb repressive complex 2 (PRC2). We further found that patterns of PCAT-1 and PRC2 expression stratified patient tissues into molecular subtypes distinguished by expression signatures of PCAT-1-repressed target genes. Taken together, our findings suggest that PCAT-1 is a transcriptional repressor implicated in a subset of prostate cancer patients. These findings establish the utility of RNA-Seq to identify disease-associated ncRNAs that may improve the stratification of cancer subtypes.
Länk
Nyckelord
Versioner (4)
- 2022-07-22 2022-07-22 - Chiara Middel
- 2022-07-25 2022-07-25 - Martin Dugas
- 2022-10-12 2022-10-12 - Adrian Schulz
- 2025-01-29 2025-01-29 - Akane Nishihara
Rättsinnehavare
Arul Chinnaiyan, M.D., Ph.D, University of Michigan
Uppladdad den
29 januari 2025
DOI
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Licens
Creative Commons BY 4.0
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dbGaP phs000443 Molecular Profiling of Cancer
Sample ID, subject ID, sample sources, and sample use variables associated with participants affected with prostate cancer and involved in the "Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression" project.
- StudyEvent: dbGaP phs000443 Molecular Profiling of Cancer
- Subject ID, consent group, and sources of subjects affected with prostate cancer and involved in the "Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression" project.
- Sample ID, subject ID, sample sources, and sample use variables associated with participants affected with prostate cancer and involved in the "Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression" project.
- Subject ID and gender of participants affected with prostate cancer and involved in the "Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression" project.
- Sample ID, analyte type , body site where from samples were collected, tumor status, and histological type of samples obtained from participants affected with prostate cancer and involved in the "Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression" project.
Similar models
Sample ID, subject ID, sample sources, and sample use variables associated with participants affected with prostate cancer and involved in the "Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression" project.
- StudyEvent: dbGaP phs000443 Molecular Profiling of Cancer
- Subject ID, consent group, and sources of subjects affected with prostate cancer and involved in the "Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression" project.
- Sample ID, subject ID, sample sources, and sample use variables associated with participants affected with prostate cancer and involved in the "Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression" project.
- Subject ID and gender of participants affected with prostate cancer and involved in the "Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression" project.
- Sample ID, analyte type , body site where from samples were collected, tumor status, and histological type of samples obtained from participants affected with prostate cancer and involved in the "Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression" project.
C3847505 (UMLS CUI [1,2])
C0449416 (UMLS CUI [1,2])
C3847505 (UMLS CUI [1,3])
C2347026 (UMLS CUI [1,2])