ID

46161

Descripción

Principal Investigator: Arul Chinnaiyan, M.D., Ph.D, University of Michigan MeSH: prostate cancer https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000443 Noncoding RNAs (ncRNAs) are emerging as key molecules in human cancer, with the potential to serve as novel markers of disease and to reveal uncharacterized aspects of tumor biology. Here we discover 121 unannotated prostate cancer-associated ncRNA transcripts (PCATs) by *ab initio* assembly of high-throughput sequencing of polyA+ RNA (RNA-Seq) from a cohort of 102 prostate tissues and cells lines. We characterized one ncRNA, PCAT-1, as a prostate-specific regulator of cell proliferation and show that it is a target of the polycomb repressive complex 2 (PRC2). We further found that patterns of PCAT-1 and PRC2 expression stratified patient tissues into molecular subtypes distinguished by expression signatures of PCAT-1-repressed target genes. Taken together, our findings suggest that PCAT-1 is a transcriptional repressor implicated in a subset of prostate cancer patients. These findings establish the utility of RNA-Seq to identify disease-associated ncRNAs that may improve the stratification of cancer subtypes.

Link

dbGaP study=phs000443

Palabras clave

  1. 22/7/22 22/7/22 - Chiara Middel
  2. 25/7/22 25/7/22 - Martin Dugas
  3. 12/10/22 12/10/22 - Adrian Schulz
  4. 29/1/25 29/1/25 - Akane Nishihara
Titular de derechos de autor

Arul Chinnaiyan, M.D., Ph.D, University of Michigan

Subido en

29 de enero de 2025

DOI

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Licencia

Creative Commons BY 4.0

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dbGaP phs000443 Molecular Profiling of Cancer

Sample ID, subject ID, sample sources, and sample use variables associated with participants affected with prostate cancer and involved in the "Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression" project.

pht002531
Descripción

pht002531

Subject ID
Descripción

SUBJID

Tipo de datos

string

Alias
UMLS CUI [1,1]
C2348585
Sample ID
Descripción

SAMPID

Tipo de datos

string

Alias
UMLS CUI [1,1]
C1299222
Source repository where samples originate
Descripción

SAMP_SOURCE

Tipo de datos

string

Alias
UMLS CUI [1,1]
C0449416
UMLS CUI [1,2]
C3847505
Sample ID used in the Source Repository
Descripción

SOURCE_SAMPID

Tipo de datos

string

Alias
UMLS CUI [1,1]
C1299222
UMLS CUI [1,2]
C0449416
UMLS CUI [1,3]
C3847505
Sample use [CTRNA_SRA=Custom target RNA sequencing]
Descripción

SAMPLE_USE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1524063
UMLS CUI [1,2]
C2347026

Similar models

Sample ID, subject ID, sample sources, and sample use variables associated with participants affected with prostate cancer and involved in the "Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression" project.

Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de datos
Alias
Item Group
pht002531
SUBJID
Item
Subject ID
string
C2348585 (UMLS CUI [1,1])
SAMPID
Item
Sample ID
string
C1299222 (UMLS CUI [1,1])
SAMP_SOURCE
Item
Source repository where samples originate
string
C0449416 (UMLS CUI [1,1])
C3847505 (UMLS CUI [1,2])
SOURCE_SAMPID
Item
Sample ID used in the Source Repository
string
C1299222 (UMLS CUI [1,1])
C0449416 (UMLS CUI [1,2])
C3847505 (UMLS CUI [1,3])
Item
Sample use [CTRNA_SRA=Custom target RNA sequencing]
text
C1524063 (UMLS CUI [1,1])
C2347026 (UMLS CUI [1,2])
Code List
Sample use [CTRNA_SRA=Custom target RNA sequencing]
CL Item
Custom target RNA sequencing (CTRNA_SRA)

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