ID

46159

Beskrivning

Principal Investigator: Julia Segre, PhD, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA MeSH: Dermatitis, Atopic,Job's Syndrome,Wiskott-Aldrich Syndrome https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000266 The NIH Intramural Skin Microbiome Consortium (NISMC) is a collaboration of investigators with primary expertise in genomics, bioinformatics, large-scale DNA sequencing, dermatology, immunology, allergy, infectious disease, and clinical microbiology. Atopic dermatitis (AD, "eczema") is a chronic relapsing skin disorder that affects ~15% of U.S. children and is associated with $1 billion of medical costs annually. AD is characterized by dry, itchy skin, infiltrated with immune cells. Colonization by Staphylococcus aureus (S. aureus) is ten-fold more common in AD patients and is associated with disease flares. We hypothesize that, in addition to S. aureus, AD may also be associated with additional novel microbes and/or selective shifts of commensal microbes that are relevant to disease progression. The NISMC seeks to define the microbiota that resides in and on the skin and nares of three patient groups, all of whom have eczematous lesions and are currently seen at the NIH Clinical Center: (1) AD patients; (2) Wiskott-Aldrich syndrome (WAS) patients; and (3) Hyper IgE syndrome (HIES) syndrome patients. Examination of the microbiome of patients with WAS or HIES syndromes, both rare immunodeficiencies, will advance our understanding of how an individual's immune system shapes their cutaneous microbial community. We are performing a prospective longitudinal study that follows these groups of patient thorough the cycles of eczema flares, ascertaining clinical data and samples at each stage.

Länk

dbGaP study=phs000266

Nyckelord

Versioner (3)
  1. 2022-09-10 2022-09-10 - Simon Heim
  2. 2022-10-12 2022-10-12 - Adrian Schulz
  3. 2025-01-29 2025-01-29 - Akane Nishihara
Rättsinnehavare

Julia Segre, PhD, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA

Uppladdad den

29 januari 2025

DOI

För en begäran logga in.

Licens

Creative Commons BY 4.0
Modellkommentarer :

Här kan du kommentera modellen. Med hjälp av pratbubblor i Item-grupperna och Item kan du lägga in specifika kommentarer.

Tillbaka till modellkommentarer
Itemgroup-kommentar för :

Item-kommentar för :

Du måste vara inloggad för att kunna ladda ner formulär. Var vänlig logga in eller registrera dig utan kostnad.

dbGaP phs000266 Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency

Engelsk

Subject ID, sex, race, ethnicity, age at initial visit, case or control, minimal and maximal score of atopic dermatitis severity, subject weight, and body site of sample collection of participants with or without atopic dermatitis and involved in the "Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency" project.

6 Formulär  
  1. StudyEvent: dbGaP phs000266 Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency
    1. Eligibility Criteria
    2. Subject ID, consent group, clinical status of subject, subject source, and subject source ID of participants with or without atopic dermatitis and involved in the "Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency" project.
    3. Subject ID, sample ID, sample source, sample source ID, and sample use variable obtained from participants with or without atopic dermatitis and involved in the "Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency" project.
    4. Subject ID, sex, race, ethnicity, age at initial visit, case or control, minimal and maximal score of atopic dermatitis severity, subject weight, and body site of sample collection of participants with or without atopic dermatitis and involved in the "Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency" project.
    5. Sample ID and GeneBank ID of participants with or without atopic dermatitis and involved in the "Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency" project.
    6. Sample ID, body site where sample was collected, side of body where sample came from, sample collection method, sampling site classification with respect to disease state, analyte type, and tumor status of samples obtained from participants with or without atopic dermatitis and involved in the "Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency" project.
pht001266
Beskrivning

pht001266

De-identified subject's ID
Beskrivning

SUBJID

Datatyp

text

Alias
UMLS CUI [1,1]
C2348585
UMLS CUI [1,2]
C2346787
Gender of participant [Male; Female]
Beskrivning

sex

Datatyp

text

Alias
UMLS CUI [1,1]
C0079399
Race of participant [Hispanic or Latino; Not Hispanic or Latino]
Beskrivning

race

Datatyp

text

Alias
UMLS CUI [1,1]
C0086409
UMLS CUI [1,2]
C0086528
UMLS CUI [2,1]
C1518424
Ethnicity of participant [American Indian/ Alaska Native; Asian; Native Hawaiian or Other Pacific Islander; Black or African American; White]
Beskrivning

ethnicity

Datatyp

text

Alias
UMLS CUI [1,1]
C0015031
Age at initial visit
Beskrivning

AGE_STATUS

Datatyp

text

Måttenheter
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0205435
UMLS CUI [1,3]
C0545082
Years
Case or control?
Beskrivning

case_control

Datatyp

text

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [2,1]
C0009932
Minimum Score of atopic dermatitis severity
Beskrivning

Min_SCORAD_Obj

Datatyp

float

Måttenheter
  • severity
Alias
UMLS CUI [1,1]
C1524031
UMLS CUI [1,2]
C0449820
UMLS CUI [1,3]
C0011615
UMLS CUI [1,4]
C1319166
severity
Maximum score of atopic dermatitis severity
Beskrivning

Max_SCORAD_Obj

Datatyp

float

Måttenheter
  • severity
Alias
UMLS CUI [1,1]
C0806909
UMLS CUI [1,2]
C0449820
UMLS CUI [1,3]
C1319166
UMLS CUI [1,4]
C0011615
severity
Subject's weight
Beskrivning

weight_kg

Datatyp

float

Måttenheter
  • kg
Alias
UMLS CUI [1,1]
C0005910
kg
Site of sample collection [skin; nose; stool; oral]
Beskrivning

body_site

Datatyp

string

Alias
UMLS CUI [1,1]
C2825164
UMLS CUI [1,2]
C0200345
Tillbaka till toppen

Similar models

Subject ID, sex, race, ethnicity, age at initial visit, case or control, minimal and maximal score of atopic dermatitis severity, subject weight, and body site of sample collection of participants with or without atopic dermatitis and involved in the "Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency" project.

6 Formulär
  1. StudyEvent: dbGaP phs000266 Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency
    1. Eligibility Criteria
    2. Subject ID, consent group, clinical status of subject, subject source, and subject source ID of participants with or without atopic dermatitis and involved in the "Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency" project.
    3. Subject ID, sample ID, sample source, sample source ID, and sample use variable obtained from participants with or without atopic dermatitis and involved in the "Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency" project.
    4. Subject ID, sex, race, ethnicity, age at initial visit, case or control, minimal and maximal score of atopic dermatitis severity, subject weight, and body site of sample collection of participants with or without atopic dermatitis and involved in the "Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency" project.
    5. Sample ID and GeneBank ID of participants with or without atopic dermatitis and involved in the "Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency" project.
    6. Sample ID, body site where sample was collected, side of body where sample came from, sample collection method, sampling site classification with respect to disease state, analyte type, and tumor status of samples obtained from participants with or without atopic dermatitis and involved in the "Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency" project.
Name
Typ
Description | Question | Decode (Coded Value)
Datatyp
Alias
Item Group
pht001266
SUBJID
Item
De-identified subject's ID
text
C2348585 (UMLS CUI [1,1])
C2346787 (UMLS CUI [1,2])
Item
Gender of participant [Male; Female]
text
C0079399 (UMLS CUI [1,1])
CL.5
Code List
Gender of participant [Male; Female]
CL Item
Female (1)
C0086287 (UMLS CUI [1,1])
CL Item
Male (2)
C0086582 (UMLS CUI [1,1])
Item
Race of participant [Hispanic or Latino; Not Hispanic or Latino]
text
C0086409 (UMLS CUI [1,1])
C0086528 (UMLS CUI [1,2])
C1518424 (UMLS CUI [2,1])
race
Code List
Race of participant [Hispanic or Latino; Not Hispanic or Latino]
CL Item
Hispanic or Latino (6666)
C0086409 (UMLS CUI [1,1])
CL Item
Not Hispanic or Latino (9999)
C1518424 (UMLS CUI [1,1])
ethnicity
Item
Ethnicity of participant [American Indian/ Alaska Native; Asian; Native Hawaiian or Other Pacific Islander; Black or African American; White]
text
C0015031 (UMLS CUI [1,1])
AGE_STATUS
Item
Age at initial visit
text
C0001779 (UMLS CUI [1,1])
C0205435 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
Item
Case or control?
text
C1706256 (UMLS CUI [1,1])
C0009932 (UMLS CUI [2,1])
case_control
Code List
Case or control?
CL Item
Control (1)
C0009932 (UMLS CUI [1,1])
CL Item
Atopic dermatitis (2)
C0011615 (UMLS CUI [1,1])
CL Item
HyperIgE Syndrome (3)
C3887645 (UMLS CUI [1,1])
CL Item
Wiskott Aldrich Syndrome (4)
C0043194 (UMLS CUI [1,1])
CL Item
Hyper IgE syndrome, DOCK8 (5)
C3887645 (UMLS CUI [1,1])
C0021051 (UMLS CUI [1,2])
Min_SCORAD_Obj
Item
Minimum Score of atopic dermatitis severity
float
C1524031 (UMLS CUI [1,1])
C0449820 (UMLS CUI [1,2])
C0011615 (UMLS CUI [1,3])
C1319166 (UMLS CUI [1,4])
Max_SCORAD_Obj
Item
Maximum score of atopic dermatitis severity
float
C0806909 (UMLS CUI [1,1])
C0449820 (UMLS CUI [1,2])
C1319166 (UMLS CUI [1,3])
C0011615 (UMLS CUI [1,4])
weight_kg
Item
Subject's weight
float
C0005910 (UMLS CUI [1,1])
body_site
Item
Site of sample collection [skin; nose; stool; oral]
string
C2825164 (UMLS CUI [1,1])
C0200345 (UMLS CUI [1,2])
Tillbaka till toppen 

Kontakt

Använd detta formulär för feedback, frågor och förslag på förbättringar.

Fält markerade med * är obligatoriska.

Hjälp

Do you need help on how to use the search function? Please watch the corresponding tutorial video for more details and learn how to use the search function most efficiently.

Watch Tutorial