ID
46150
Descripción
Principal Investigator: Tari A King, MD, Memorial Sloan Kettering Cancer Center, New York, NY, USA MeSH: Carcinoma, Lobular,carcinoma in situ https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001006 This study comprises prospectively accrued, microdissected fresh frozen samples of multifocal lobular carcinoma *in situ* (LCIS), ductal carcinoma *in situ* (DCIS), invasive lobular carcinoma and invasive ductal carcinoma from patients undergoing prophylactic or therapeutic mastectomies after a diagnosis on LCIS diagnosed and managed at Memorial Sloan Kettering Cancer Center (MSKCC). Microdissected samples were subjected to paired-end whole exome sequencing on an Illumina HiSeq 2000. The data generated were used to define the landscape of somatic genetic alterations of LCIS, DCIS, invasive lobular carcinoma and invasive ductal carcinoma, to define clonal relatedness of these lesions and to investigate the clonal shifts in the progression from *in situ* to invasive breast cancer.
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Versiones (2)
- 26/10/23 26/10/23 - Simon Heim
- 29/1/25 29/1/25 - Akane Nishihara
Titular de derechos de autor
Tari A King, MD, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Subido en
29 de enero de 2025
DOI
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Licencia
Creative Commons BY 4.0
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dbGaP phs001006 Intra-Lesion Heterogeneity and Clonality of Lobular Carcinomas In Situ
Eligibility Criteria
- StudyEvent: dbGaP phs001006 Intra-Lesion Heterogeneity and Clonality of Lobular Carcinomas In Situ
- Eligibility Criteria
- The subject consent file includes subject IDs, consent information, and affection status of the subject for lobular or ductal carcinomas.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table contains subject ID, age, sex, type of surgery, year of surgery, stage of disease, adjuvant therapy, year of last follow-up, and status at last follow-up.
- This sample attributes table contains sample IDs, body site where sample was collected, analyte type, tumor status, histological type, laterality of the breast, quadrant of the breast, estrogen receptor status, progesterone receptor status, HER2 status, and name of the center which conducted sequencing.
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Eligibility Criteria
- StudyEvent: dbGaP phs001006 Intra-Lesion Heterogeneity and Clonality of Lobular Carcinomas In Situ
- Eligibility Criteria
- The subject consent file includes subject IDs, consent information, and affection status of the subject for lobular or ductal carcinomas.
- This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use.
- This subject phenotype table contains subject ID, age, sex, type of surgery, year of surgery, stage of disease, adjuvant therapy, year of last follow-up, and status at last follow-up.
- This sample attributes table contains sample IDs, body site where sample was collected, analyte type, tumor status, histological type, laterality of the breast, quadrant of the breast, estrogen receptor status, progesterone receptor status, HER2 status, and name of the center which conducted sequencing.
C0680251 (UMLS CUI [1,2])
C0262926 (UMLS CUI [1,2])
C0279563 (UMLS CUI [1,3])
C0087111 (UMLS CUI [1,4])
C0024881 (UMLS CUI [1,5])