0 Evaluaciones
ID

46128

Descripción

Principal Investigator: Gloria Pryhuber, University of Rochester Rochester, Rochester, NY, USA MeSH: Infant, Premature,Infant, Newborn,Premature Birth,Term Birth,Microbiota,Gastrointestinal Microbiome,T-Lymphocytes,Bronchopulmonary Dysplasia,Respiratory Tract Diseases https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001347 *Public health importance*: Babies born preterm, approximately 1 out of every 9 live births in the United States, have significant respiratory morbidity over the first two years of life, exacerbated by respiratory viral infections. Many (50%) return to pediatricians, emergency rooms and pulmonologists with symptoms of respiratory dysfunction (SRD): intermittent or chronic wheezing, poor growth and an excess of upper and lower respiratory tract infections (LRTI). SRD correlate inversely with gestational age and weight at birth and is more common in those with chronic lung disease of prematurity, yet its incidence and severity varies widely among both the prematurely born and those born at term. There is evidence from clinical studies and animal models that risks of LRTI and recurrent wheezing is influenced by gut and respiratory flora and by T cell responses to infection. Information gained from this study will be used to identify characteristics, risk factors and potential mechanisms for early and persistent lung disease in children born at term and born preterm. This Clinical Research Study will investigate the relationships between sequential respiratory viral infections, patterns of intestinal and respiratory bacterial colonization, and adaptive cellular immune phenotypes which are associated with increased susceptibility to respiratory infections and long term respiratory morbidity in preterm and full term infants. We hypothesize that the timing and acquisition of specific viral infections and bacterial species are directly related to respiratory morbidity in the first year of life as defined by SRD and by measures of pulmonary function. We hypothesize that cellular and molecular immuno-maturity are altered due to factors presented by premature birth in such a way as to promote chronic inflammatory and cytotoxic damage to the lung, with subsequent enhanced, damaging responses to infectious agents and environmental irritants. Our preliminary studies demonstrate both feasibility and expertise in mutiparameter immunophenotyping of small volume peripheral blood samples obtained from premature infants including gene expression arrays of flow cytometry sorted cells. We will use new technologies for known viral identification, as well as high-throughput metagenome sequencing of RNA and DNA virus like particles (VLP) to be used for viral discovery in infant respiratory sample and use of high-throughput pyrosequencing (454T) of bacterial 16S rRNA to determine shifts in bacterial community structure, occurring in pre-term (PT) as compared to full term (FT) infants, over the first year of life. Finally, we present statistical approaches to stratify disease risk predictors using multivariate logistic regression modeling approaches. We propose to evaluate T cell phenotypic and functional profiles relative to viral and predominant bacterial exposures according to highly complementary, but independent, Specific Objectives. *Objective 1*: To determine if viral respiratory infections and patterns of respiratory and gut bacterial community structure (microbiome) in prematurely born babies predict the rate and degree of immunologic maturation, and pulmonary dysfunction, measured from birth to 36 weeks corrected gestational age (CGA). *Objective 2*: To determine the relationship between respiratory viral infections and disease severity up to one year CGA, and the lymphocyte (Lc) phenotypes documented at term gestation (birth for term infants and 36 wks/NICU discharge in preterm infants) and at one year CGA. Three secondary outcomes of this objective will be to a) relate the quantity, type and severity of viral infections with pulmonary function at one and three years of life, b) relate the viral community structure to severity of viral infections and c) to seek evidence of modulation of viral susceptibility by bacterial respiratory and gut community structure (microbiome). The relationship of colonization with known and non-identified bacterial species in both the respiratory tract and the gut will be evaluated. Flow cytometry data corresponding to this study can be found within Immport study SDY1302. Positive and negative controls for microbiome samples are uploaded under SRA bioproject PRJNA474485. Microbiome samples corresponding to PRISM2 are distinguished from PRISM1 via "_PRISM2" appended to the sample name. Within the positive and negative controls, PRISM1 controls are uploaded as bam files and PRISM2 controls are uploaded as paired fastq. Samples ending in -08 correspond to TLDA qPCR results for a given sample. There is a column for each pathogen tested and a column to indicate where that pathogen was bacteria or virus.

Link

dbGaP study id = phs001347

Palabras clave

Versiones (1)
  1. 11/11/24 11/11/24 - Dr. Christian Niklas
Titular de derechos de autor

Gloria Pryhuber, University of Rochester Rochester, Rochester, NY, USA

Subido en

11 de noviembre de 2024

DOI

Para solicitar uno, por favor iniciar sesión.

Licencia

Creative Commons BY 4.0
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    dbGaP phs001347 Prematurity, Respiratory Outcomes, Immune System, and Microbiome Study (PRISM)

    Inglés

    This sample attributes table contains sample IDs, visit, postmenstrual ages at time of nsasal or rectal swab sampling, day of life of the nasal or rectal tests, body site, read counts, analyte type, tumor status, histological type, region of bacteria being sequenced, presence of bacteria or virus (Adenovirus, Bocavirus, Bordetella pertussis, Coronavirus 1-4, Chlamydophila pneumoniae, Enterobacteriaceae, Flu A, Flu B, Haemophilus influenzae, Human metapneumovirus, Moraxella, Mycoplasma hominis, Mycoplasma pneumoniae, parechovirus, PIV 1-3, Rhinovirus, RSV, Streptococcus pneumoniae, and Ureaplasma) within the sample, corresponding bacteria or virus classification, hospital admissions, due to wheezing or breathing problems, admitted to intensive care, admissions due to RSV, sick visits, sick visits due to wheezing or breathing problems or wheezing unknown, has baby chest sounded wheezy or whistling, occurred with or without colds, chest wheezy during daytime or nighttime, diagnosed with wheezing by doctor, cough without cold, coughing during daytime or nighttime, number of colds, breathing and heart rate monitor, oxygen therapy, CPAP or BIPAP, ventilator, trach or breathing tube, feeding tube in nose or stomach, other equipment used, is baby receiving breast milk, is baby receiving breast milk exclusively, did baby receive breast milk since last visit, for how many months did baby receive breast milk for more than half of feedings, does baby eat any non-milk foods, and what non-milk foods does baby eat.

    5 formularios  
    1. StudyEvent: Prematurity Respiratory Outcomes Immune System and Microbiome Study
      1. Eligibility Criteria
      2. The subject consent file includes subject IDs, consent information, subject aliases, and study ID.
      3. This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
      4. This subject phenotype table contains subject IDs, cohort, sex, ethnic, race, gestational ages at birth and discharge, birth mode, bronchopulmonary dysplasia status, persistent repiratory disease after one year, oxygen AUC (Area Under the ROC curve) at 7 and 14 days, days on 7 variables (oxygen, mechanical ventilation, high frequency ventilation, cpap, nasal cannula gt 1 lmp, any respiratory support, and nasal cannula), maximum mean airway pressure, last PMA and DOL on ETT for GT 2 days in a row, exposure to furry animals in the home, asthma, allergies and eczema within siblings, BMI of the mother at the time of delivery, chlorioamnionitis, season of birth, derived respiratory severity score, oxygen AUC for first 14 days of life, and difference between FIO2 weeks 1 and 2.
      5. This sample attributes table contains sample IDs, visit, postmenstrual ages at time of nsasal or rectal swab sampling, day of life of the nasal or rectal tests, body site, read counts, analyte type, tumor status, histological type, region of bacteria being sequenced, presence of bacteria or virus (Adenovirus, Bocavirus, Bordetella pertussis, Coronavirus 1-4, Chlamydophila pneumoniae, Enterobacteriaceae, Flu A, Flu B, Haemophilus influenzae, Human metapneumovirus, Moraxella, Mycoplasma hominis, Mycoplasma pneumoniae, parechovirus, PIV 1-3, Rhinovirus, RSV, Streptococcus pneumoniae, and Ureaplasma) within the sample, corresponding bacteria or virus classification, hospital admissions, due to wheezing or breathing problems, admitted to intensive care, admissions due to RSV, sick visits, sick visits due to wheezing or breathing problems or wheezing unknown, has baby chest sounded wheezy or whistling, occurred with or without colds, chest wheezy during daytime or nighttime, diagnosed with wheezing by doctor, cough without cold, coughing during daytime or nighttime, number of colds, breathing and heart rate monitor, oxygen therapy, CPAP or BIPAP, ventilator, trach or breathing tube, feeding tube in nose or stomach, other equipment used, is baby receiving breast milk, is baby receiving breast milk exclusively, did baby receive breast milk since last visit, for how many months did baby receive breast milk for more than half of feedings, does baby eat any non-milk foods, and what non-milk foods does baby eat.
    pht006797
    Descripción

    pht006797

    Alias
    UMLS CUI [1,1]
    C3846158
    De-identified Sample ID
    Descripción

    SAMPLE_ID

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C4684638
    UMLS CUI [1,2]
    C1299222
    Label describing the purpose of the visit
    Descripción

    Visit

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C1704447
    Body site where sample was collected
    Descripción

    BODY_SITE

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0449705
    Cell or tissue type or subtype of sample
    Descripción

    HISTOLOGICAL_TYPE

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C2347026
    UMLS CUI [1,2]
    C0007634
    UMLS CUI [1,3]
    C0332307
    UMLS CUI [2,1]
    C2347026
    UMLS CUI [2,2]
    C0007634
    UMLS CUI [2,3]
    C0449560
    UMLS CUI [3,1]
    C1292533
    UMLS CUI [3,2]
    C0332307
    UMLS CUI [4,1]
    C1292533
    UMLS CUI [4,2]
    C0449560
    Analyte Type
    Descripción

    ANALYTE_TYPE

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C4744818
    Tumor status
    Descripción

    IS_TUMOR

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C0475752
    Region of bacteria being sequenced
    Descripción

    Region_16S

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0004611
    UMLS CUI [1,2]
    C0205147
    UMLS CUI [1,3]
    C1519249
    Number of reads measured in the sample
    Descripción

    OTU_ReadCount

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C2347026
    UMLS CUI [1,2]
    C0242485
    UMLS CUI [1,3]
    C0237753
    Postmenstrual Age (weeks) at time of nasal swab sampling
    Descripción

    nasalCGA

    Tipo de datos

    float

    Alias
    UMLS CUI [1,1]
    C3828508
    UMLS CUI [1,2]
    C3669207
    Day of life of the nasal test
    Descripción

    nasalDol

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3669207
    UMLS CUI [1,2]
    C5401457
    Postmenstrual Age (weeks) at time of rectal swab sampling
    Descripción

    rectalCGA

    Tipo de datos

    float

    Alias
    UMLS CUI [1,1]
    C3828508
    UMLS CUI [1,2]
    C0444215
    Day of life of the rectal test
    Descripción

    rectalDol

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C0444215
    UMLS CUI [1,2]
    C5401457
    Presence of Adenovirus within the sample
    Descripción

    Adeno

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C0001483
    UMLS CUI [1,3]
    C2347026
    Hardcoded to virus, needed for analysis
    Descripción

    Adeno classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0001483
    UMLS CUI [1,3]
    C0936012
    Presence of Bocavirus within the sample
    Descripción

    Boca

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C1641393
    Hardcoded to virus, needed for analysis
    Descripción

    Boca classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C1641393
    Presence of Bordetella pertussis within the sample
    Descripción

    B. pert

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0006017
    Hardcoded to bacteria needed for analysis
    Descripción

    B. pert classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0006017
    Presence of Coronavirus 1 within the sample
    Descripción

    Corona 1

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0332307
    UMLS CUI [1,4]
    C0206422
    UMLS CUI [1,5]
    C0205447
    Hardcoded to virus, needed for analysis
    Descripción

    Corona 1 classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0206422
    UMLS CUI [1,4]
    C0332307
    UMLS CUI [1,5]
    C0205447
    Presence of Coronavirus 2 within the sample
    Descripción

    Corona 2

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0206422
    UMLS CUI [1,4]
    C0332307
    UMLS CUI [1,5]
    C0205448
    Hardcoded to virus, needed for analysis
    Descripción

    Corona 2 classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0206422
    UMLS CUI [1,4]
    C0332307
    UMLS CUI [1,5]
    C0205448
    Presence of Coronavirus 3 within the sample
    Descripción

    Corona 3

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0206422
    UMLS CUI [1,4]
    C0332307
    UMLS CUI [1,5]
    C0205449
    Hardcoded to virus, needed for analysis
    Descripción

    Corona 3 classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0206422
    UMLS CUI [1,4]
    C0332307
    UMLS CUI [1,5]
    C0205449
    Presence of Coronavirus 4 within the sample
    Descripción

    Corona 4

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0206422
    UMLS CUI [1,4]
    C0332307
    UMLS CUI [1,5]
    C0205450
    Hardcoded to virus, needed for analysis
    Descripción

    Corona 4 classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0206422
    UMLS CUI [1,4]
    C0332307
    UMLS CUI [1,5]
    C0205450
    Presence of Chlamydophila pneumoniae within the sample
    Descripción

    C. pneu

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0887972
    Hardcoded to bacteria needed for analysis
    Descripción

    C. pneu classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0887972
    Presence of Enterobacteriaceae within the sample
    Descripción

    Entero XL

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0014346
    Hardcoded to bacteria needed for analysis
    Descripción

    Entero XL classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0014346
    Presence of Flu A within the sample
    Descripción

    Flu A

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0029347
    Hardcoded to virus, needed for analysis
    Descripción

    Flu A classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0029347
    Presence of Flu B within the sample
    Descripción

    Flu B

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0029348
    Hardcoded to virus, needed for analysis
    Descripción

    Flu B classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0029348
    Presence of Haemophilus influenzae within the sample
    Descripción

    H. influ

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0018483
    Hardcoded to bacteria needed for analysis
    Descripción

    H. influ classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0018483
    Presence of Human metapneumovirus within the sample
    Descripción

    hMPV

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0949907
    Hardcoded to virus, needed for analysis
    Descripción

    hMPV classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0949907
    Presence of Mycoplasma hominis within the sample
    Descripción

    M. hom

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0317838
    Hardcoded to bacteria needed for analysis
    Descripción

    M. hom classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0317838
    Presence of Mycoplasma pneumoniae within the sample
    Descripción

    M. pneu

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0026941
    Hardcoded to bacteria needed for analysis
    Descripción

    M. pneu classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0026941
    Presence of parechovirus within the sample
    Descripción

    Parecho

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0950102
    Hardcoded to virus, needed for analysis
    Descripción

    Parecho classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0950102
    Presence of PIV 1 within the sample
    Descripción

    PIV 1

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0600289
    Hardcoded to virus, needed for analysis
    Descripción

    PIV 1 classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0600289
    Presence of PIV 2 within the sample
    Descripción

    PIV 2

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0030391
    Hardcoded to virus, needed for analysis
    Descripción

    PIV 2 classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0030391
    Presence of PIV 3 within the sample
    Descripción

    PIV 3

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0030392
    Hardcoded to virus, needed for analysis
    Descripción

    PIV 3 classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0030392
    Presence of Rhinovirus within the sample
    Descripción

    Rhino

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0035473
    Hardcoded to bacteria needed for analysis
    Descripción

    Rhino classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0035473
    Presence of RSV within the sample
    Descripción

    RSV

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0035236
    Hardcoded to virus, needed for analysis
    Descripción

    RSV classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0035236
    Presence of Streptococcus pneumoniae within the sample
    Descripción

    S. pneu

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0038410
    Hardcoded to virus, needed for analysis
    Descripción

    S. pneu classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0038410
    Presence of Ureaplasma within the sample
    Descripción

    Urea

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0041944
    Hardcoded to bacteria needed for analysis
    Descripción

    Urea classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0041944
    Number hospital admissions
    Descripción

    huadmit

    Tipo de datos

    float

    Alias
    UMLS CUI [1,1]
    C1265611
    UMLS CUI [1,2]
    C0184666
    Due to wheezing or breathing problems
    Descripción

    huwheeze

    Tipo de datos

    float

    Alias
    UMLS CUI [1,1]
    C0678226
    UMLS CUI [1,2]
    C0043144
    UMLS CUI [2,1]
    C0678226
    UMLS CUI [2,2]
    C3641913
    Admitted to intensive care
    Descripción

    huicu

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0583239
    Admissions due to RSV
    Descripción

    hursv

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0184666
    UMLS CUI [1,2]
    C0678226
    UMLS CUI [1,3]
    C0035236
    Sick visits
    Descripción

    huervt

    Tipo de datos

    float

    Alias
    UMLS CUI [1,1]
    C2010702
    UMLS CUI [1,2]
    C0545082
    Sick visits unknown
    Descripción

    huervtunk

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C2010702
    UMLS CUI [1,2]
    C0545082
    UMLS CUI [1,3]
    C0439673
    Sick visits due to wheezing or breathing problems
    Descripción

    huerwz

    Tipo de datos

    float

    Alias
    UMLS CUI [1,1]
    C2010702
    UMLS CUI [1,2]
    C0545082
    UMLS CUI [1,3]
    C0678226
    UMLS CUI [1,4]
    C0043144
    UMLS CUI [2,1]
    C2010702
    UMLS CUI [2,2]
    C0545082
    UMLS CUI [2,3]
    C0678226
    UMLS CUI [2,4]
    C3641913
    Sick visits due to wheezing unk
    Descripción

    huerwzunk

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C2010702
    UMLS CUI [1,2]
    C0545082
    UMLS CUI [1,3]
    C0678226
    UMLS CUI [1,4]
    C0043144
    UMLS CUI [1,5]
    C0439673
    Has baby chest sounded wheezy or whistling
    Descripción

    sswheeze

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0021270
    UMLS CUI [1,2]
    C0817096
    UMLS CUI [1,3]
    C0043144
    UMLS CUI [2,1]
    C0021270
    UMLS CUI [2,2]
    C0817096
    UMLS CUI [2,3]
    C0425483
    Occurred with colds
    Descripción

    sscold

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C2745955
    UMLS CUI [1,2]
    C0009443
    Occurred apart from colds
    Descripción

    ssacold

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C2745955
    UMLS CUI [1,2]
    C1705847
    UMLS CUI [1,3]
    C0009443
    Chest wheezy during daytime
    Descripción

    sswday

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0817096
    UMLS CUI [1,2]
    C0043144
    UMLS CUI [1,3]
    C0332169
    Chest wheezy during nighttime
    Descripción

    sswnight

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0817096
    UMLS CUI [1,2]
    C0043144
    UMLS CUI [1,3]
    C0240526
    Diagnosed with wheezing by doctor
    Descripción

    ssdxw

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0031831
    UMLS CUI [1,2]
    C0011900
    UMLS CUI [1,3]
    C0043144
    Cough without cold
    Descripción

    sscough

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0010200
    UMLS CUI [1,2]
    C0332288
    UMLS CUI [1,3]
    C0009443
    Coughing during daytime
    Descripción

    sscday

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0010200
    UMLS CUI [1,2]
    C0332169
    Coughing during nighttime
    Descripción

    sscnight

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0010200
    UMLS CUI [1,2]
    C0240526
    Number of colds
    Descripción

    sshcold

    Tipo de datos

    float

    Alias
    UMLS CUI [1,1]
    C1265611
    UMLS CUI [1,2]
    C0009443
    Breathing and Heart Rate Monitor
    Descripción

    qsmonitor

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C4551528
    UMLS CUI [2,1]
    C0513707
    Oxygen Therapy
    Descripción

    qsoxygen_fup

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0184633
    CPAP or BIPAP
    Descripción

    qscpaphome

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0199451
    UMLS CUI [2,1]
    C1956423
    Ventilator
    Descripción

    qsventhome

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0087153
    Trach or breathing tube
    Descripción

    qstrachfup

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0184106
    Feeding tube in nose
    Descripción

    qsngtb

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0192456
    Feeding tube in stomach
    Descripción

    qsgastro

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0349717
    Other equipment used
    Descripción

    qsoths

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0014672
    Describe other equipment
    Descripción

    qothtechs

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0014672
    UMLS CUI [1,3]
    C0678257
    Is baby receiving breast milk
    Descripción

    fup1_bmilk

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0006147
    Is baby receiving breast milk exclusively
    Descripción

    fup1_bmilk_excl

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0006147
    UMLS CUI [1,2]
    C1548966
    Did baby receive breast milk since last visit
    Descripción

    dymilkhome1

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0006147
    UMLS CUI [1,2]
    C1711239
    UMLS CUI [1,3]
    C1517741
    UMLS CUI [1,4]
    C0545082
    For how many months did baby receive breast milk for more than half of feedings
    Descripción

    dyfeedhome1

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0040223
    UMLS CUI [1,2]
    C0006147
    UMLS CUI [1,3]
    C5549115
    UMLS CUI [1,4]
    C2148613
    Does baby eat any non-milk foods
    Descripción

    fup1_nonmilk

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C2148613
    UMLS CUI [1,2]
    C0205394
    UMLS CUI [1,3]
    C0006147
    What non-milk foods does baby eat
    Descripción

    fup1_nonmilk_log

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0016452
    UMLS CUI [1,2]
    C2348235
    UMLS CUI [1,3]
    C0205394
    UMLS CUI [1,4]
    C0006147
    Hardcoded to bacteria needed for analysis
    Descripción

    Moraxella classification

    Tipo de datos

    string

    Alias
    UMLS CUI [1,1]
    C0008902
    UMLS CUI [1,2]
    C0936012
    UMLS CUI [1,3]
    C0026536
    Presence of Moraxella within the sample
    Descripción

    Moraxella

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C3854307
    UMLS CUI [1,2]
    C2347026
    UMLS CUI [1,3]
    C0026536
    Number of reads measured in the sample within the PRISM2 study
    Descripción

    OTU_ReadCount2

    Tipo de datos

    text

    Alias
    UMLS CUI [1,1]
    C2347026
    UMLS CUI [1,2]
    C0242485
    UMLS CUI [1,3]
    C0237753
    UMLS CUI [1,4]
    C0332285
    UMLS CUI [1,5]
    C0008976
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    Similar models

    This sample attributes table contains sample IDs, visit, postmenstrual ages at time of nsasal or rectal swab sampling, day of life of the nasal or rectal tests, body site, read counts, analyte type, tumor status, histological type, region of bacteria being sequenced, presence of bacteria or virus (Adenovirus, Bocavirus, Bordetella pertussis, Coronavirus 1-4, Chlamydophila pneumoniae, Enterobacteriaceae, Flu A, Flu B, Haemophilus influenzae, Human metapneumovirus, Moraxella, Mycoplasma hominis, Mycoplasma pneumoniae, parechovirus, PIV 1-3, Rhinovirus, RSV, Streptococcus pneumoniae, and Ureaplasma) within the sample, corresponding bacteria or virus classification, hospital admissions, due to wheezing or breathing problems, admitted to intensive care, admissions due to RSV, sick visits, sick visits due to wheezing or breathing problems or wheezing unknown, has baby chest sounded wheezy or whistling, occurred with or without colds, chest wheezy during daytime or nighttime, diagnosed with wheezing by doctor, cough without cold, coughing during daytime or nighttime, number of colds, breathing and heart rate monitor, oxygen therapy, CPAP or BIPAP, ventilator, trach or breathing tube, feeding tube in nose or stomach, other equipment used, is baby receiving breast milk, is baby receiving breast milk exclusively, did baby receive breast milk since last visit, for how many months did baby receive breast milk for more than half of feedings, does baby eat any non-milk foods, and what non-milk foods does baby eat.

    5 formularios
    1. StudyEvent: Prematurity Respiratory Outcomes Immune System and Microbiome Study
      1. Eligibility Criteria
      2. The subject consent file includes subject IDs, consent information, subject aliases, and study ID.
      3. This data table contains a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
      4. This subject phenotype table contains subject IDs, cohort, sex, ethnic, race, gestational ages at birth and discharge, birth mode, bronchopulmonary dysplasia status, persistent repiratory disease after one year, oxygen AUC (Area Under the ROC curve) at 7 and 14 days, days on 7 variables (oxygen, mechanical ventilation, high frequency ventilation, cpap, nasal cannula gt 1 lmp, any respiratory support, and nasal cannula), maximum mean airway pressure, last PMA and DOL on ETT for GT 2 days in a row, exposure to furry animals in the home, asthma, allergies and eczema within siblings, BMI of the mother at the time of delivery, chlorioamnionitis, season of birth, derived respiratory severity score, oxygen AUC for first 14 days of life, and difference between FIO2 weeks 1 and 2.
      5. This sample attributes table contains sample IDs, visit, postmenstrual ages at time of nsasal or rectal swab sampling, day of life of the nasal or rectal tests, body site, read counts, analyte type, tumor status, histological type, region of bacteria being sequenced, presence of bacteria or virus (Adenovirus, Bocavirus, Bordetella pertussis, Coronavirus 1-4, Chlamydophila pneumoniae, Enterobacteriaceae, Flu A, Flu B, Haemophilus influenzae, Human metapneumovirus, Moraxella, Mycoplasma hominis, Mycoplasma pneumoniae, parechovirus, PIV 1-3, Rhinovirus, RSV, Streptococcus pneumoniae, and Ureaplasma) within the sample, corresponding bacteria or virus classification, hospital admissions, due to wheezing or breathing problems, admitted to intensive care, admissions due to RSV, sick visits, sick visits due to wheezing or breathing problems or wheezing unknown, has baby chest sounded wheezy or whistling, occurred with or without colds, chest wheezy during daytime or nighttime, diagnosed with wheezing by doctor, cough without cold, coughing during daytime or nighttime, number of colds, breathing and heart rate monitor, oxygen therapy, CPAP or BIPAP, ventilator, trach or breathing tube, feeding tube in nose or stomach, other equipment used, is baby receiving breast milk, is baby receiving breast milk exclusively, did baby receive breast milk since last visit, for how many months did baby receive breast milk for more than half of feedings, does baby eat any non-milk foods, and what non-milk foods does baby eat.
    Name
    Tipo
    Description | Question | Decode (Coded Value)
    Tipo de datos
    Alias
    Item Group
    pht006797
    C3846158 (UMLS CUI [1,1])
    SAMPLE_ID
    Item
    De-identified Sample ID
    string
    C4684638 (UMLS CUI [1,1])
    C1299222 (UMLS CUI [1,2])
    Visit
    Item
    Label describing the purpose of the visit
    string
    C1704447 (UMLS CUI [1,1])
    BODY_SITE
    Item
    Body site where sample was collected
    string
    C0449705 (UMLS CUI [1,1])
    HISTOLOGICAL_TYPE
    Item
    Cell or tissue type or subtype of sample
    string
    C2347026 (UMLS CUI [1,1])
    C0007634 (UMLS CUI [1,2])
    C0332307 (UMLS CUI [1,3])
    C2347026 (UMLS CUI [2,1])
    C0007634 (UMLS CUI [2,2])
    C0449560 (UMLS CUI [2,3])
    C1292533 (UMLS CUI [3,1])
    C0332307 (UMLS CUI [3,2])
    C1292533 (UMLS CUI [4,1])
    C0449560 (UMLS CUI [4,2])
    ANALYTE_TYPE
    Item
    Analyte Type
    string
    C4744818 (UMLS CUI [1,1])
    Item
    Tumor status
    text
    C0475752 (UMLS CUI [1,1])
    IS_TUMOR
    Code List
    Tumor status
    CL Item
    Is not a tumor (N)
    C0027651 (UMLS CUI [1,1])
    C1518422 (UMLS CUI [1,2])
    CL Item
    Is Tumor (TRUE)
    C0027651 (UMLS CUI [1,1])
    Region_16S
    Item
    Region of bacteria being sequenced
    string
    C0004611 (UMLS CUI [1,1])
    C0205147 (UMLS CUI [1,2])
    C1519249 (UMLS CUI [1,3])
    OTU_ReadCount
    Item
    Number of reads measured in the sample
    text
    C2347026 (UMLS CUI [1,1])
    C0242485 (UMLS CUI [1,2])
    C0237753 (UMLS CUI [1,3])
    nasalCGA
    Item
    Postmenstrual Age (weeks) at time of nasal swab sampling
    float
    C3828508 (UMLS CUI [1,1])
    C3669207 (UMLS CUI [1,2])
    nasalDol
    Item
    Day of life of the nasal test
    text
    C3669207 (UMLS CUI [1,1])
    C5401457 (UMLS CUI [1,2])
    rectalCGA
    Item
    Postmenstrual Age (weeks) at time of rectal swab sampling
    float
    C3828508 (UMLS CUI [1,1])
    C0444215 (UMLS CUI [1,2])
    rectalDol
    Item
    Day of life of the rectal test
    text
    C0444215 (UMLS CUI [1,1])
    C5401457 (UMLS CUI [1,2])
    Item
    Presence of Adenovirus within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C0001483 (UMLS CUI [1,2])
    C2347026 (UMLS CUI [1,3])
    Adeno
    Code List
    Presence of Adenovirus within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    Adeno classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0001483 (UMLS CUI [1,2])
    C0936012 (UMLS CUI [1,3])
    Item
    Presence of Bocavirus within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C1641393 (UMLS CUI [1,3])
    Boca
    Code List
    Presence of Bocavirus within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    Boca classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C1641393 (UMLS CUI [1,3])
    Item
    Presence of Bordetella pertussis within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0006017 (UMLS CUI [1,3])
    B. pert
    Code List
    Presence of Bordetella pertussis within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    B. pert classification
    Item
    Hardcoded to bacteria needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0006017 (UMLS CUI [1,3])
    Item
    Presence of Coronavirus 1 within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0332307 (UMLS CUI [1,3])
    C0206422 (UMLS CUI [1,4])
    C0205447 (UMLS CUI [1,5])
    Corona 1
    Code List
    Presence of Coronavirus 1 within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    Corona 1 classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0206422 (UMLS CUI [1,3])
    C0332307 (UMLS CUI [1,4])
    C0205447 (UMLS CUI [1,5])
    Item
    Presence of Coronavirus 2 within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0206422 (UMLS CUI [1,3])
    C0332307 (UMLS CUI [1,4])
    C0205448 (UMLS CUI [1,5])
    Corona 2
    Code List
    Presence of Coronavirus 2 within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    Corona 2 classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0206422 (UMLS CUI [1,3])
    C0332307 (UMLS CUI [1,4])
    C0205448 (UMLS CUI [1,5])
    Item
    Presence of Coronavirus 3 within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0206422 (UMLS CUI [1,3])
    C0332307 (UMLS CUI [1,4])
    C0205449 (UMLS CUI [1,5])
    Corona 3
    Code List
    Presence of Coronavirus 3 within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    Corona 3 classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0206422 (UMLS CUI [1,3])
    C0332307 (UMLS CUI [1,4])
    C0205449 (UMLS CUI [1,5])
    Item
    Presence of Coronavirus 4 within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0206422 (UMLS CUI [1,3])
    C0332307 (UMLS CUI [1,4])
    C0205450 (UMLS CUI [1,5])
    Corona 4
    Code List
    Presence of Coronavirus 4 within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    Corona 4 classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0206422 (UMLS CUI [1,3])
    C0332307 (UMLS CUI [1,4])
    C0205450 (UMLS CUI [1,5])
    Item
    Presence of Chlamydophila pneumoniae within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0887972 (UMLS CUI [1,3])
    C. pneu
    Code List
    Presence of Chlamydophila pneumoniae within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    C. pneu classification
    Item
    Hardcoded to bacteria needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0887972 (UMLS CUI [1,3])
    Item
    Presence of Enterobacteriaceae within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0014346 (UMLS CUI [1,3])
    Entero XL
    Code List
    Presence of Enterobacteriaceae within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    Entero XL classification
    Item
    Hardcoded to bacteria needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0014346 (UMLS CUI [1,3])
    Item
    Presence of Flu A within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0029347 (UMLS CUI [1,3])
    Flu A
    Code List
    Presence of Flu A within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    Flu A classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0029347 (UMLS CUI [1,3])
    Item
    Presence of Flu B within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0029348 (UMLS CUI [1,3])
    Flu B
    Code List
    Presence of Flu B within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    Flu B classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0029348 (UMLS CUI [1,3])
    Item
    Presence of Haemophilus influenzae within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0018483 (UMLS CUI [1,3])
    H. influ
    Code List
    Presence of Haemophilus influenzae within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    H. influ classification
    Item
    Hardcoded to bacteria needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0018483 (UMLS CUI [1,3])
    Item
    Presence of Human metapneumovirus within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0949907 (UMLS CUI [1,3])
    hMPV
    Code List
    Presence of Human metapneumovirus within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    hMPV classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0949907 (UMLS CUI [1,3])
    Item
    Presence of Mycoplasma hominis within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0317838 (UMLS CUI [1,3])
    M. hom
    Code List
    Presence of Mycoplasma hominis within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    M. hom classification
    Item
    Hardcoded to bacteria needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0317838 (UMLS CUI [1,3])
    Item
    Presence of Mycoplasma pneumoniae within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0026941 (UMLS CUI [1,3])
    M. pneu
    Code List
    Presence of Mycoplasma pneumoniae within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    M. pneu classification
    Item
    Hardcoded to bacteria needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0026941 (UMLS CUI [1,3])
    Item
    Presence of parechovirus within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0950102 (UMLS CUI [1,3])
    Parecho
    Code List
    Presence of parechovirus within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    Parecho classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0950102 (UMLS CUI [1,3])
    Item
    Presence of PIV 1 within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0600289 (UMLS CUI [1,3])
    PIV 1
    Code List
    Presence of PIV 1 within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    PIV 1 classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0600289 (UMLS CUI [1,3])
    Item
    Presence of PIV 2 within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0030391 (UMLS CUI [1,3])
    PIV 2
    Code List
    Presence of PIV 2 within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    PIV 2 classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0030391 (UMLS CUI [1,3])
    Item
    Presence of PIV 3 within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0030392 (UMLS CUI [1,3])
    PIV 3
    Code List
    Presence of PIV 3 within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    PIV 3 classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0030392 (UMLS CUI [1,3])
    Item
    Presence of Rhinovirus within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0035473 (UMLS CUI [1,3])
    Rhino
    Code List
    Presence of Rhinovirus within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    Rhino classification
    Item
    Hardcoded to bacteria needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0035473 (UMLS CUI [1,3])
    Item
    Presence of RSV within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0035236 (UMLS CUI [1,3])
    RSV
    Code List
    Presence of RSV within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    RSV classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0035236 (UMLS CUI [1,3])
    Item
    Presence of Streptococcus pneumoniae within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0038410 (UMLS CUI [1,3])
    S. pneu
    Code List
    Presence of Streptococcus pneumoniae within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    S. pneu classification
    Item
    Hardcoded to virus, needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0038410 (UMLS CUI [1,3])
    Item
    Presence of Ureaplasma within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0041944 (UMLS CUI [1,3])
    Urea
    Code List
    Presence of Ureaplasma within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    Urea classification
    Item
    Hardcoded to bacteria needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0041944 (UMLS CUI [1,3])
    huadmit
    Item
    Number hospital admissions
    float
    C1265611 (UMLS CUI [1,1])
    C0184666 (UMLS CUI [1,2])
    huwheeze
    Item
    Due to wheezing or breathing problems
    float
    C0678226 (UMLS CUI [1,1])
    C0043144 (UMLS CUI [1,2])
    C0678226 (UMLS CUI [2,1])
    C3641913 (UMLS CUI [2,2])
    huicu
    Item
    Admitted to intensive care
    string
    C0583239 (UMLS CUI [1,1])
    hursv
    Item
    Admissions due to RSV
    string
    C0184666 (UMLS CUI [1,1])
    C0678226 (UMLS CUI [1,2])
    C0035236 (UMLS CUI [1,3])
    huervt
    Item
    Sick visits
    float
    C2010702 (UMLS CUI [1,1])
    C0545082 (UMLS CUI [1,2])
    huervtunk
    Item
    Sick visits unknown
    string
    C2010702 (UMLS CUI [1,1])
    C0545082 (UMLS CUI [1,2])
    C0439673 (UMLS CUI [1,3])
    huerwz
    Item
    Sick visits due to wheezing or breathing problems
    float
    C2010702 (UMLS CUI [1,1])
    C0545082 (UMLS CUI [1,2])
    C0678226 (UMLS CUI [1,3])
    C0043144 (UMLS CUI [1,4])
    C2010702 (UMLS CUI [2,1])
    C0545082 (UMLS CUI [2,2])
    C0678226 (UMLS CUI [2,3])
    C3641913 (UMLS CUI [2,4])
    huerwzunk
    Item
    Sick visits due to wheezing unk
    string
    C2010702 (UMLS CUI [1,1])
    C0545082 (UMLS CUI [1,2])
    C0678226 (UMLS CUI [1,3])
    C0043144 (UMLS CUI [1,4])
    C0439673 (UMLS CUI [1,5])
    sswheeze
    Item
    Has baby chest sounded wheezy or whistling
    string
    C0021270 (UMLS CUI [1,1])
    C0817096 (UMLS CUI [1,2])
    C0043144 (UMLS CUI [1,3])
    C0021270 (UMLS CUI [2,1])
    C0817096 (UMLS CUI [2,2])
    C0425483 (UMLS CUI [2,3])
    sscold
    Item
    Occurred with colds
    string
    C2745955 (UMLS CUI [1,1])
    C0009443 (UMLS CUI [1,2])
    ssacold
    Item
    Occurred apart from colds
    string
    C2745955 (UMLS CUI [1,1])
    C1705847 (UMLS CUI [1,2])
    C0009443 (UMLS CUI [1,3])
    sswday
    Item
    Chest wheezy during daytime
    string
    C0817096 (UMLS CUI [1,1])
    C0043144 (UMLS CUI [1,2])
    C0332169 (UMLS CUI [1,3])
    sswnight
    Item
    Chest wheezy during nighttime
    string
    C0817096 (UMLS CUI [1,1])
    C0043144 (UMLS CUI [1,2])
    C0240526 (UMLS CUI [1,3])
    ssdxw
    Item
    Diagnosed with wheezing by doctor
    string
    C0031831 (UMLS CUI [1,1])
    C0011900 (UMLS CUI [1,2])
    C0043144 (UMLS CUI [1,3])
    sscough
    Item
    Cough without cold
    string
    C0010200 (UMLS CUI [1,1])
    C0332288 (UMLS CUI [1,2])
    C0009443 (UMLS CUI [1,3])
    sscday
    Item
    Coughing during daytime
    string
    C0010200 (UMLS CUI [1,1])
    C0332169 (UMLS CUI [1,2])
    sscnight
    Item
    Coughing during nighttime
    string
    C0010200 (UMLS CUI [1,1])
    C0240526 (UMLS CUI [1,2])
    sshcold
    Item
    Number of colds
    float
    C1265611 (UMLS CUI [1,1])
    C0009443 (UMLS CUI [1,2])
    qsmonitor
    Item
    Breathing and Heart Rate Monitor
    string
    C4551528 (UMLS CUI [1,1])
    C0513707 (UMLS CUI [2,1])
    qsoxygen_fup
    Item
    Oxygen Therapy
    string
    C0184633 (UMLS CUI [1,1])
    qscpaphome
    Item
    CPAP or BIPAP
    string
    C0199451 (UMLS CUI [1,1])
    C1956423 (UMLS CUI [2,1])
    qsventhome
    Item
    Ventilator
    string
    C0087153 (UMLS CUI [1,1])
    qstrachfup
    Item
    Trach or breathing tube
    string
    C0184106 (UMLS CUI [1,1])
    qsngtb
    Item
    Feeding tube in nose
    string
    C0192456 (UMLS CUI [1,1])
    qsgastro
    Item
    Feeding tube in stomach
    string
    C0349717 (UMLS CUI [1,1])
    qsoths
    Item
    Other equipment used
    string
    C0205394 (UMLS CUI [1,1])
    C0014672 (UMLS CUI [1,2])
    qothtechs
    Item
    Describe other equipment
    string
    C0205394 (UMLS CUI [1,1])
    C0014672 (UMLS CUI [1,2])
    C0678257 (UMLS CUI [1,3])
    fup1_bmilk
    Item
    Is baby receiving breast milk
    string
    C0006147 (UMLS CUI [1,1])
    fup1_bmilk_excl
    Item
    Is baby receiving breast milk exclusively
    string
    C0006147 (UMLS CUI [1,1])
    C1548966 (UMLS CUI [1,2])
    dymilkhome1
    Item
    Did baby receive breast milk since last visit
    string
    C0006147 (UMLS CUI [1,1])
    C1711239 (UMLS CUI [1,2])
    C1517741 (UMLS CUI [1,3])
    C0545082 (UMLS CUI [1,4])
    dyfeedhome1
    Item
    For how many months did baby receive breast milk for more than half of feedings
    string
    C0040223 (UMLS CUI [1,1])
    C0006147 (UMLS CUI [1,2])
    C5549115 (UMLS CUI [1,3])
    C2148613 (UMLS CUI [1,4])
    fup1_nonmilk
    Item
    Does baby eat any non-milk foods
    string
    C2148613 (UMLS CUI [1,1])
    C0205394 (UMLS CUI [1,2])
    C0006147 (UMLS CUI [1,3])
    fup1_nonmilk_log
    Item
    What non-milk foods does baby eat
    string
    C0016452 (UMLS CUI [1,1])
    C2348235 (UMLS CUI [1,2])
    C0205394 (UMLS CUI [1,3])
    C0006147 (UMLS CUI [1,4])
    Moraxella classification
    Item
    Hardcoded to bacteria needed for analysis
    string
    C0008902 (UMLS CUI [1,1])
    C0936012 (UMLS CUI [1,2])
    C0026536 (UMLS CUI [1,3])
    Item
    Presence of Moraxella within the sample
    text
    C3854307 (UMLS CUI [1,1])
    C2347026 (UMLS CUI [1,2])
    C0026536 (UMLS CUI [1,3])
    Moraxella
    Code List
    Presence of Moraxella within the sample
    CL Item
    no (0)
    CL Item
    yes (1)
    OTU_ReadCount2
    Item
    Number of reads measured in the sample within the PRISM2 study
    text
    C2347026 (UMLS CUI [1,1])
    C0242485 (UMLS CUI [1,2])
    C0237753 (UMLS CUI [1,3])
    C0332285 (UMLS CUI [1,4])
    C0008976 (UMLS CUI [1,5])
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