0 Bedömningar

ID

46127

Beskrivning

Principal Investigator: Ying-Hui Fu, PhD, University of California San Francisco, San Francisco, CA, USA MeSH: Sleep Wake Disorders,Short Sleeper Syndrome,Long Sleeper Syndrome,CLOCK Proteins,Circadian Clocks https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001270 Sleep is essential for life. A good night's sleep is pleasurable and sleep deprivation is stressful. Prolonged sleep loss impairs temperature control, metabolism, immunity, and ultimately leads to death. Extensive observational and epidemiological evidence indicates that optimal sleep duration of 8 hours is associated with the maintenance of good health. In our society, however, most people only get 6.5 - 7 hours. Suboptimal sleep duration has a strong association with mortality and morbidity. Lack of sleep has been linked to cardiovascular diseases, obesity, hypertension, type 2 diabetes, and other health/cognition conditions. It is clear that the biological need for sleep varies dramatically among humans. Sleep and circadian disorders can include Familial Advanced Sleep Phase (FASP), Delayed Sleep Phase (DSP), Advanced Sleep Phase (ASP), Natural Short Sleepers (NSS) or Long Sleeping. In example, Natural Short Sleepers (NSS) have a lifelong tendency to sleep only 4 - 6 hours per night and to awaken refreshed and energetic. Natural Long Sleepers biologically require 9 - 10 hours/night to feel well rested. The 'Sleep and Circadian Disorders Study' (SACDS) at the University of California San Francisco, set out to investigate the mechanisms involved in regulating sleep duration, patterns and sleep quality regulation by identifying and characterization of individuals and families with unusual sleep and circadian rhythm behavior patterns. SACDS participants were screened with a "General Sleep Questionnaire" that inquired about multiple aspects of sleep, including habitual work-day versus non-work day sleep-wake schedules, permits calculation of subjective habitual initial sleep onset, final sleep offset, and number of awakenings. There was an additional screening process including demographic data, sleep, mood, behavioral and general medical questionnaires, plus the study consent. After the extensive screening of 117 participants, blood samples were collected from 38 individuals and of those 10 samples were chosen for whole exome sequencing analysis.

Länk

dbGaP study id = phs001270

Nyckelord

  1. 2024-11-11 2024-11-11 - Dr. Christian Niklas
Rättsinnehavare

Ying-Hui Fu, PhD, University of California San Francisco, San Francisco, CA, USA

Uppladdad den

11 november 2024

DOI

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Licens

Creative Commons BY 4.0

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    dbGaP phs001270 Sleep and Circadian Disorders Study (SACDS)

    This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use and sample aliases.

    pht006251
    Beskrivning

    pht006251

    Alias
    UMLS CUI [1,1]
    C1283195
    Subject ID
    Beskrivning

    SUBJECT_ID

    Datatyp

    text

    Alias
    UMLS CUI [1,1]
    C2348585
    Sample ID
    Beskrivning

    SAMPLE_ID

    Datatyp

    string

    Alias
    UMLS CUI [1,1]
    C1299222
    Source repository where samples originate
    Beskrivning

    SAMPLE_SOURCE

    Datatyp

    string

    Alias
    UMLS CUI [1,1]
    C3847505
    UMLS CUI [1,2]
    C0449416
    UMLS CUI [1,3]
    C2347026
    DNA Sample ID used in the Source Repository
    Beskrivning

    SOURCE_SAMPLE_ID

    Datatyp

    string

    Alias
    UMLS CUI [1,1]
    C1299222
    UMLS CUI [1,2]
    C3847505
    UMLS CUI [1,3]
    C0449416
    Sample use. Seq_DNA_SNP_CNV: SNP and CNV genotypes derived from sequence data; Seq_DNA_WholeExome: Whole exome sequencing
    Beskrivning

    SAMPLE_USE

    Datatyp

    text

    Alias
    UMLS CUI [1,1]
    C2347026
    UMLS CUI [1,2]
    C1524063

    Similar models

    This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs. The data table also includes sample use and sample aliases.

    Name
    Typ
    Description | Question | Decode (Coded Value)
    Datatyp
    Alias
    Item Group
    pht006251
    C1283195 (UMLS CUI [1,1])
    SUBJECT_ID
    Item
    Subject ID
    text
    C2348585 (UMLS CUI [1,1])
    SAMPLE_ID
    Item
    Sample ID
    string
    C1299222 (UMLS CUI [1,1])
    Item
    Source repository where samples originate
    string
    C3847505 (UMLS CUI [1,1])
    C0449416 (UMLS CUI [1,2])
    C2347026 (UMLS CUI [1,3])
    Code List
    Source repository where samples originate
    CL Item
    no data (0)
    Item
    DNA Sample ID used in the Source Repository
    string
    C1299222 (UMLS CUI [1,1])
    C3847505 (UMLS CUI [1,2])
    C0449416 (UMLS CUI [1,3])
    Code List
    DNA Sample ID used in the Source Repository
    CL Item
    no data (0)
    Item
    Sample use. Seq_DNA_SNP_CNV: SNP and CNV genotypes derived from sequence data; Seq_DNA_WholeExome: Whole exome sequencing
    text
    C2347026 (UMLS CUI [1,1])
    C1524063 (UMLS CUI [1,2])
    Code List
    Sample use. Seq_DNA_SNP_CNV: SNP and CNV genotypes derived from sequence data; Seq_DNA_WholeExome: Whole exome sequencing
    CL Item
    no data (0)

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