ID

45998

Descripción

Principal Investigator: Esteban Burchard, MD, MPH, University of California, San Francisco, CA, USA MeSH: Lung Diseases https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000920 This is a case-only pharmacogenetic study of bronchodilator drug response among racially admixed Latino children with asthma. Each participant had two spirometry measurements using the KoKo PFT System. With the first spirometry test, participant was administered with 4 puffs of HFA Albuterol. The second albuterol measurement was based on age, for participants under 16 years of age, additional 2 puffs were administered and for those over 16 years of age, additional 4 puffs were administered. The overall goal is to identify genetic factors which are predictive of drug response in children with asthma. The principal tools include a questionnaire and biological specimen collection. Participants are 8-21 years old at time of recruitment. Children with asthma have physician-diagnosed asthma, symptoms and medications. Comprehensive phenotypic data for GALAII study participants are available through dbGaP phs001180.

Link

dbGaP study=phs000920

Palabras clave

  1. 18/4/24 18/4/24 - Madita Rudolph
Titular de derechos de autor

Esteban Burchard, MD, MPH, University of California, San Francisco, CA, USA

Subido en

18 de abril de 2024

DOI

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Licencia

Creative Commons BY 4.0

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dbGaP phs000920 NHLBI TOPMed - NHGRI CCDG: Genes-Environments and Admixture in Latino Asthmatics (GALA II)

Eligibility Criteria

Inclusion and exclusion criteria
Descripción

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0680251
*Eligibility*
Descripción

Elig.phs000920.v5.p3.1

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C1516637
UMLS CUI [1,2]
C2348563
Subjects meeting the following criteria will be eligible for participation: Ages between 8 and 21 years old
Descripción

Elig.phs000920.v5.p3.2

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C0001779
Parents and Grandparents of the same ethnicity [self-identified]
Descripción

Elig.phs000920.v5.p3.3

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C0015031
UMLS CUI [1,2]
C0030551
UMLS CUI [1,3]
C0337471
History of asthma [physician diagnosed or currently taking asthma medication]
Descripción

Elig.phs000920.v5.p3.4

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C0262926
UMLS CUI [1,2]
C0004096
Having experienced symptoms of coughing, wheezing or shortness of breath in the past 2 years
Descripción

Elig.phs000920.v5.p3.5

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C1457887
UMLS CUI [1,2]
C1444637
UMLS CUI [1,3]
C0010200
UMLS CUI [1,4]
C0043144
UMLS CUI [1,5]
C0013404
No respiratory infections for ≥ 6 weeks
Descripción

Elig.phs000920.v5.p3.6

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C0035243
UMLS CUI [1,2]
C0549184
No asthma exacerbations for ≥ 6 weeks
Descripción

Elig.phs000920.v5.p3.7

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C0349790
UMLS CUI [1,2]
C0549184
≤ 10 pack year smoking history, no smoking in the last year
Descripción

Elig.phs000920.v5.p3.8

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C1519384
UMLS CUI [1,2]
C1277691
UMLS CUI [2,1]
C0543414
UMLS CUI [2,2]
C5142833
If pregnant, < 3rd trimester
Descripción

Elig.phs000920.v5.p3.9

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C0032961
UMLS CUI [1,2]
C0332152
UMLS CUI [1,3]
C0032981
No other history of lung diseases
Descripción

Elig.phs000920.v5.p3.10

Tipo de datos

boolean

Alias
UMLS CUI [1,1]
C0262926
UMLS CUI [1,2]
C0024115
UMLS CUI [1,3]
C0549184

Similar models

Eligibility Criteria

Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de datos
Alias
Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Elig.phs000920.v5.p3.1
Item
*Eligibility*
boolean
C1516637 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
Elig.phs000920.v5.p3.2
Item
Subjects meeting the following criteria will be eligible for participation: Ages between 8 and 21 years old
boolean
C0001779 (UMLS CUI [1,1])
Elig.phs000920.v5.p3.3
Item
Parents and Grandparents of the same ethnicity [self-identified]
boolean
C0015031 (UMLS CUI [1,1])
C0030551 (UMLS CUI [1,2])
C0337471 (UMLS CUI [1,3])
Elig.phs000920.v5.p3.4
Item
History of asthma [physician diagnosed or currently taking asthma medication]
boolean
C0262926 (UMLS CUI [1,1])
C0004096 (UMLS CUI [1,2])
Elig.phs000920.v5.p3.5
Item
Having experienced symptoms of coughing, wheezing or shortness of breath in the past 2 years
boolean
C1457887 (UMLS CUI [1,1])
C1444637 (UMLS CUI [1,2])
C0010200 (UMLS CUI [1,3])
C0043144 (UMLS CUI [1,4])
C0013404 (UMLS CUI [1,5])
Elig.phs000920.v5.p3.6
Item
No respiratory infections for &#8805; 6 weeks
boolean
C0035243 (UMLS CUI [1,1])
C0549184 (UMLS CUI [1,2])
Elig.phs000920.v5.p3.7
Item
No asthma exacerbations for &#8805; 6 weeks
boolean
C0349790 (UMLS CUI [1,1])
C0549184 (UMLS CUI [1,2])
Elig.phs000920.v5.p3.8
Item
&#8804; 10 pack year smoking history, no smoking in the last year
boolean
C1519384 (UMLS CUI [1,1])
C1277691 (UMLS CUI [1,2])
C0543414 (UMLS CUI [2,1])
C5142833 (UMLS CUI [2,2])
Elig.phs000920.v5.p3.9
Item
If pregnant, < 3rd trimester
boolean
C0032961 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C0032981 (UMLS CUI [1,3])
Elig.phs000920.v5.p3.10
Item
No other history of lung diseases
boolean
C0262926 (UMLS CUI [1,1])
C0024115 (UMLS CUI [1,2])
C0549184 (UMLS CUI [1,3])

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